| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yasuomi Ouchi, Etsuji Yoshikawa, Masami Futatsubashi, Shunsuke Yagi, Takatoshi Ueki, Kazuhiko Nakamur. Altered brain serotonin transporter and associated glucose metabolism in Alzheimer disease. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 50. issue 8. 2009-09-28. PMID:19617327. |
altered brain serotonin transporter and associated glucose metabolism in alzheimer disease. |
2009-09-28 |
2023-08-12 |
Not clear |
| Werner J Geldenhuys, Cornelis J Van der Schy. The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease. Expert review of neurotherapeutics. vol 9. issue 7. 2009-09-21. PMID:19589055. |
the serotonin 5-ht6 receptor: a viable drug target for treating cognitive deficits in alzheimer's disease. |
2009-09-21 |
2023-08-12 |
Not clear |
| Werner J Geldenhuys, Cornelis J Van der Schy. The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease. Expert review of neurotherapeutics. vol 9. issue 7. 2009-09-21. PMID:19589055. |
the serotonin 6 receptor is attracting attention as an etiological contributor in cognition deficits in diseases such as alzheimer's disease, anxiety/depression and schizophrenia. |
2009-09-21 |
2023-08-12 |
Not clear |
| Mark S J Elliott, Clive G Ballard, Rajesh N Kalaria, Robert Perry, Tibor Hortobágyi, Paul T Franci. Increased binding to 5-HT1A and 5-HT2A receptors is associated with large vessel infarction and relative preservation of cognition. Brain : a journal of neurology. vol 132. issue Pt 7. 2009-09-09. PMID:19433439. |
we have determined, using saturation radioligand binding, the binding parameters (affinity and maximal binding) of ((3)h)-way 100635 binding to 5-ht(1a) receptors and ((3)h)-ketanserin binding to 5-ht(2a) receptors in post-mortem tissue from the frontal and temporal cortices of patients with either multi-infarct vascular dementia, sub-cortical ischaemic vascular dementia, mixed alzheimer's disease/vascular dementia or stroke no dementia (snd). |
2009-09-09 |
2023-08-12 |
Not clear |
| Kevin G Liu, Jennifer R Lo, Thomas A Comery, Guo Ming Zhang, Jean Y Zhang, Dianne M Kowal, Deborah L Smith, Li Di, Edward H Kerns, Lee E Schechter, Albert J Robichau. 1-Sulfonylindazoles as potent and selective 5-HT6 ligands. Bioorganic & medicinal chemistry letters. vol 19. issue 9. 2009-08-21. PMID:19345582. |
as part of our continuing efforts to identify therapeutics for cns diseases, such as schizophrenia and alzheimer's disease (ad), we have been focused on the 5-ht(6) receptor in an attempt to identify ligands as a potential treatment for cognitive dysfunction. |
2009-08-21 |
2023-08-12 |
rat |
| Francesco Angelucci, Sergio Bernardini, Paolo Gravina, Lorenza Bellincampi, Alberto Trequattrini, Fulvia Di Iulio, Diego Vanni, Giorgio Federici, Carlo Caltagirone, Paola Bossù, Gianfranco Spallett. Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study. Journal of Alzheimer's disease : JAD. vol 17. issue 1. 2009-08-12. PMID:19494443. |
in a 3-year follow-up study, we evaluated the association of serotonin (5-ht) receptor 5-ht2a 102t/c polymorphism (allelic variants cc, ct and tt) with psychotic symptom severity and response to treatment with atypical antipsychotics (risperidone, olanzapine and quietapine) in 80 patients with a diagnosis of probable alzheimer's disease. |
2009-08-12 |
2023-08-12 |
Not clear |
| Haroon Siddique, Linda S Hynan, Myron F Weine. Effect of a serotonin reuptake inhibitor on irritability, apathy, and psychotic symptoms in patients with Alzheimer's disease. The Journal of clinical psychiatry. vol 70. issue 6. 2009-07-20. PMID:19422762. |
effect of a serotonin reuptake inhibitor on irritability, apathy, and psychotic symptoms in patients with alzheimer's disease. |
2009-07-20 |
2023-08-12 |
Not clear |
| Katsuyoshi Mizukami, Kimitaka Hatanaka, Yoshiro Tanaka, Shinji Sato, Takashi Asad. Therapeutic effects of the selective serotonin noradrenaline reuptake inhibitor milnacipran on depressive symptoms in patients with Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 2. 2009-06-02. PMID:19166899. |
therapeutic effects of the selective serotonin noradrenaline reuptake inhibitor milnacipran on depressive symptoms in patients with alzheimer's disease. |
2009-06-02 |
2023-08-12 |
Not clear |
| Olivier Russo, Marthe Cachard-Chastel, Céline Rivière, Mireille Giner, Jean-Louis Soulier, Magali Berthouze, Tristan Richard, Jean-Pierre Monti, Sames Sicsic, Frank Lezoualc'h, Isabelle Berque-Beste. Design, synthesis, and biological evaluation of new 5-HT4 receptor agonists: application as amyloid cascade modulators and potential therapeutic utility in Alzheimer's disease. Journal of medicinal chemistry. vol 52. issue 8. 2009-05-06. PMID:19334715. |
serotonin 5-ht(4) receptor (5-ht(4)r) agonists are of particular interest for the treatment of alzheimer's disease because of their ability to ameliorate cognitive deficits and to modulate production of amyloid beta-protein (abeta). |
2009-05-06 |
2023-08-12 |
mouse |
| Hideyuki Hattor. [Elderly depression and depressive state with Alzheimer's disease]. Nihon rinsho. Japanese journal of clinical medicine. vol 67. issue 4. 2009-05-05. PMID:19348250. |
against depressive state with alzheimer's disease, in addition to donepezil hydrochloride, selective serotonin reuptake inhibitors (ssri) and serotonin-noradrenaline reuptake inhibitors (snri) are effective, and a small dose of sulpiride is also expected to be effective. |
2009-05-05 |
2023-08-12 |
Not clear |
| Davide Quaranta, Alessandra Bizzarro, Camillo Marra, Maria Gabriella Vita, Davide Seripa, Alberto Pilotto, Valeria Sebastiani, Patrizia Mecocci, Carlo Masull. Psychotic symptoms in Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: evidence for an association. Journal of Alzheimer's disease : JAD. vol 16. issue 1. 2009-03-27. PMID:19158433. |
psychotic symptoms in alzheimer's disease and 5-httlpr polymorphism of the serotonin transporter gene: evidence for an association. |
2009-03-27 |
2023-08-12 |
human |
| Kevin G Liu, Jennifer R Lo, Thomas A Comery, Guo Ming Zhang, Jean Y Zhang, Dianne M Kowal, Deborah L Smith, Li Di, Edward H Kerns, Lee E Schechter, Albert J Robichau. Identification of a series of benzoxazoles as potent 5-HT6 ligands. Bioorganic & medicinal chemistry letters. vol 19. issue 4. 2009-03-10. PMID:19152787. |
as part of our continuing efforts to identify therapeutics for cns diseases such as schizophrenia and alzheimer's disease (ad), we have been focused on the 5-ht(6) receptor in order to identify potent and selective ligands as a potential treatment for cognitive dysfunction. |
2009-03-10 |
2023-08-12 |
Not clear |
| S G Hasselbalch, K Madsen, C Svarer, L H Pinborg, S Holm, O B Paulson, G Waldemar, G M Knudse. Reduced 5-HT2A receptor binding in patients with mild cognitive impairment. Neurobiology of aging. vol 29. issue 12. 2009-01-23. PMID:17544547. |
previous studies of patients with alzheimer's disease (ad) have described reduced brain serotonin 2a (5-ht(2a)) receptor density. |
2009-01-23 |
2023-08-12 |
human |
| Kimmo A Michelsen, Jos Prickaerts, Harry W M Steinbusc. The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer's disease. Progress in brain research. vol 172. 2009-01-15. PMID:18772036. |
the dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and alzheimer's disease. |
2009-01-15 |
2023-08-12 |
Not clear |
| Kimmo A Michelsen, Jos Prickaerts, Harry W M Steinbusc. The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer's disease. Progress in brain research. vol 172. 2009-01-15. PMID:18772036. |
special emphasis is put on serotonin and its central role in neuroplasticity, which is proving to be of high priority in unraveling the full picture of the cellular mechanisms and their interconnections in the etiology of major depression and alzheimer's disease. |
2009-01-15 |
2023-08-12 |
Not clear |
| Alvin V Terry, Jerry J Buccafusco, Christina Wilso. Cognitive dysfunction in neuropsychiatric disorders: selected serotonin receptor subtypes as therapeutic targets. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18241938. |
in addition, there is also some evidence to suggest that 5-ht function in the brain may be important (particularly in the behavioral disturbances) in various forms of dementia including alzheimer's disease. |
2009-01-12 |
2023-08-12 |
Not clear |
| Antonella Gasbarri, Agata Cifariello, Assunta Pompili, Alfredo Menese. Effect of 5-HT(7) antagonist SB-269970 in the modulation of working and reference memory in the rat. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18308404. |
this conclusion has a major implication in the context that 5-ht receptors play an important role under amnesia states (e.g., alzheimer's disease) or when the learning is complex. |
2009-01-12 |
2023-08-12 |
rat |
| Jacqueline Bor. Molecular imaging of the 5-HT(1A) receptor in relation to human cognition. Behavioural brain research. vol 195. issue 1. 2009-01-12. PMID:18606193. |
positron emission tomography (pet) imaging of the 5-ht(1a) receptor in patients with alzheimer's disease, schizophrenia and depression implicate an alteration in 5-ht(1a) receptor binding compared to control subjects, but it is yet unknown whether these alterations are related to the cognitive impairment associated with these disorders. |
2009-01-12 |
2023-08-12 |
human |
| Werner J Geldenhuys, Cornelis J Van der Schy. Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 8. issue 12. 2008-10-27. PMID:18691131. |
serotonin 5-ht6 receptor antagonists for the treatment of alzheimer's disease. |
2008-10-27 |
2023-08-12 |
Not clear |
| Werner J Geldenhuys, Cornelis J Van der Schy. Serotonin 5-HT6 receptor antagonists for the treatment of Alzheimer's disease. Current topics in medicinal chemistry. vol 8. issue 12. 2008-10-27. PMID:18691131. |
recently, the serotonin 5-ht(6) receptor has been identified as a drug target for attenuating cognitive deficits associated with alzheimer's disease (ad). |
2008-10-27 |
2023-08-12 |
Not clear |