| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Letizia Polito, Francesca Prato, Serena Rodilossi, Eleonora Ateri, Daniela Galimberti, Elio Scarpini, Francesca Clerici, Claudio Mariani, Gianluigi Forloni, Diego Alban. A novel study and meta-analysis of the genetic variation of the serotonin transporter promoter in the italian population do not support a large effect on Alzheimer's disease risk. International journal of Alzheimer's disease. vol 2011. 2011-07-14. PMID:21660253. |
a novel study and meta-analysis of the genetic variation of the serotonin transporter promoter in the italian population do not support a large effect on alzheimer's disease risk. |
2011-07-14 |
2023-08-12 |
Not clear |
| T Takahashi, M Miyazaw. Serotonin derivatives as inhibitors of beta-secretase (BACE 1). Die Pharmazie. vol 66. issue 4. 2011-06-15. PMID:21612159. |
these serotonin derivatives, which have anti-oxidative effects as well are expected to be useful in the study of the mechanisms of alzheimer's disease. |
2011-06-15 |
2023-08-12 |
Not clear |
| Tiffany W Chow, Bruce G Pollock, Norton W Milgra. Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer's disease. Neuropsychiatric disease and treatment. vol 3. issue 5. 2011-05-17. PMID:19300592. |
selective serotonin reuptake inhibitors (ssris) have increased cognitive performance in some clinical studies of alzheimer's disease (ad), but it is has been difficult to dissociate whether this is due to direct effects on cognition (neurochemical or disease-modifying) or a secondary effect of mood stabilization. |
2011-05-17 |
2023-08-12 |
human |
| Mathieu Verdurand, Anne Bérod, Didier Le Bars, Luc Zimme. Effects of amyloid-β peptides on the serotoninergic 5-HT1A receptors in the rat hippocampus. Neurobiology of aging. vol 32. issue 1. 2011-03-14. PMID:19249128. |
a recent [(18)f]mppf-positron emission tomography study has highlighted an overexpression of 5-ht(1a) receptors in the hippocampus of patients with mild cognitive impairment compared to a decrease in those with alzheimer's disease (ad) [truchot, l., costes, s.n., zimmer, l., laurent, b., le bars, d., thomas-antérion, c., croisile, b., mercier, b., hermier, m., vighetto, a., krolak-salmon, p., 2007. |
2011-03-14 |
2023-08-12 |
rat |
| Yiyun Huang, Ming-Qiang Zheng, John M Gerde. Development of effective PET and SPECT imaging agents for the serotonin transporter: has a twenty-year journey reached its destination? Current topics in medicinal chemistry. vol 10. issue 15. 2011-02-16. PMID:20583995. |
the serotonin transporter (sert) has been implicated in a variety of neuropsychiatric disorders including depression, schizophrenia, substance abuse, alcoholism, and alzheimer's disease. |
2011-02-16 |
2023-08-12 |
Not clear |
| A G Franke, K Lie. [Pharmacological neuroenhancement and brain doping : Chances and risks]. Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz. vol 53. issue 8. 2011-01-14. PMID:20700786. |
this subcategory includes psychostimulants (e.g., amphetamines, methylphenidate), modafinil, antidementia drugs (acetylcholine-esterase inhibitors, memantine), and antidepressants (selective serotonin reuptake inhibitors) which are being prescribed for the treatment of adhd (attention deficit/hyperactivity disorder), alzheimer's disease, and depression. |
2011-01-14 |
2023-08-12 |
human |
| H N Noristani, M Olabarria, A Verkhratsky, J J Rodrígue. Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer's disease. The European journal of neuroscience. vol 32. issue 1. 2011-01-13. PMID:20576032. |
serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the ca1 area of hippocampus in a triple transgenic mouse model of alzheimer's disease. |
2011-01-13 |
2023-08-12 |
mouse |
| Luis Segu, Marie-José Lecomte, Mathieu Wolff, Julie Santamaria, René Hen, Aline Dumuis, Sylvie Berrard, Joël Bockaert, Marie-Christine Buhot, Valérie Compa. Hyperfunction of muscarinic receptor maintains long-term memory in 5-HT4 receptor knock-out mice. PloS one. vol 5. issue 3. 2011-01-11. PMID:20209108. |
patients suffering from dementia of alzheimer's type express less serotonin 4 receptors (5-htr(4)), but whether an absence of these receptors modifies learning and memory is unexplored. |
2011-01-11 |
2023-08-12 |
mouse |
| D J Veltman, H G Ruhé, J Booi. Investigating serotonergic function using positron emission tomography: overview and recent findings. Current pharmaceutical design. vol 16. issue 18. 2010-10-08. PMID:20370665. |
over the last two decades, pet has been used to investigate 5-ht function in several neuropsychiatric disorders, in particular mood and anxiety disorders, schizophrenia, alzheimer's disease, and impulse control disorders. |
2010-10-08 |
2023-08-12 |
Not clear |
| Mark Reid, Ian Carlyle, Wilson L Caulfield, Tom R Clarkson, Fiona Cusick, Ola Epemolu, Robert Gilfillan, Richard Goodwin, David Jaap, Elise C O'Donnell, Jeremy Presland, Zoran Rankovic, Daniel Spinks, Gayle Spinks, Anne M Thomson, Fiona Thomson, James Strain, Grant Wishar. The discovery and SAR of indoline-3-carboxamides--a new series of 5-HT6 antagonists. Bioorganic & medicinal chemistry letters. vol 20. issue 12. 2010-09-13. PMID:20471831. |
antagonists of the 5-ht(6) receptor have been shown to improve cognitive function in a wide range of animal models and as such may prove to be attractive agents for the symptomatic treatment of cognitive disorders such as alzheimer's disease (ad) and schizophrenia. |
2010-09-13 |
2023-08-12 |
Not clear |
| Narihiro Toda, Tsugio Kaneko, Hiroshi Koge. Development of an efficient therapeutic agent for Alzheimer's disease: design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter. Chemical & pharmaceutical bulletin. vol 58. issue 3. 2010-06-15. PMID:20190429. |
development of an efficient therapeutic agent for alzheimer's disease: design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter. |
2010-06-15 |
2023-08-12 |
mouse |
| Narihiro Toda, Tsugio Kaneko, Hiroshi Koge. Development of an efficient therapeutic agent for Alzheimer's disease: design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter. Chemical & pharmaceutical bulletin. vol 58. issue 3. 2010-06-15. PMID:20190429. |
since patients of alzheimer's disease often exhibit depression as well as memory impairment, dual inhibitors of ache and serotonin transporter (sert) would be a better therapeutic method. |
2010-06-15 |
2023-08-12 |
mouse |
| Lisbeth Marner, Nic Gillings, Karine Madsen, David Erritzoe, William F C Baaré, Claus Svarer, Steen G Hasselbalch, Gitte M Knudse. Brain imaging of serotonin 4 receptors in humans with [11C]SB207145-PET. NeuroImage. vol 50. issue 3. 2010-06-08. PMID:20096787. |
pharmacological stimulation of the serotonin 4 (5-ht(4)) receptor has shown promise for treatment of alzheimer's disease and major depression. |
2010-06-08 |
2023-08-12 |
human |
| Diego Albani, Francesca Prato, Mauro Tettamanti, Carlo Lovati, Daniela Galimberti, Ilaria Restelli, Claudio Mariani, Pier Luigi Quadri, Elio Scarpini, Ugo Lucca, Gianluigi Forlon. The serotonin transporter promoter polymorphic region is not a risk factor for Alzheimer's disease related behavioral disturbances. Journal of Alzheimer's disease : JAD. vol 18. issue 1. 2010-06-04. PMID:19625753. |
the serotonin transporter promoter polymorphic region is not a risk factor for alzheimer's disease related behavioral disturbances. |
2010-06-04 |
2023-08-12 |
human |
| Hyung-Mun Yun, Ja-Hyun Baik, Insug Kang, Changbae Jin, Hyewhon Rhi. Physical interaction of Jab1 with human serotonin 6 G-protein-coupled receptor and their possible roles in cell survival. The Journal of biological chemistry. vol 285. issue 13. 2010-04-26. PMID:20093369. |
the 5-ht(6) receptor (5-ht(6)r) is one of the most recently cloned serotonin receptors, and it plays important roles in alzheimer disease, depression, and learning and memory disorders. |
2010-04-26 |
2023-08-12 |
human |
| Luca Rozzini, Barbara Vicini Chilovi, Marta Conti, Erik Bertoletti, Marina Zanetti, Marco Trabucchi, Alessandro Padovan. Efficacy of SSRIs on cognition of Alzheimer's disease patients treated with cholinesterase inhibitors. International psychogeriatrics. vol 22. issue 1. 2010-03-22. PMID:19552831. |
this study examines the joint effect on cognition of selective serotonin re-uptake inhibitors (ssris) and cholinesterase inhibitors (acheis) in depressed patients affected by alzheimer's disease (ad) living at home. |
2010-03-22 |
2023-08-12 |
Not clear |
| P J West, V R Marcy, M J Marino, H Schaffhause. Activation of the 5-HT(6) receptor attenuates long-term potentiation and facilitates GABAergic neurotransmission in rat hippocampus. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19660530. |
antagonists of the 5-ht(6) receptor improve cognitive performance in a number of preclinical models and have recently been found to be effective in alzheimer's disease patients. |
2010-02-12 |
2023-08-12 |
rat |
| Dorotea Muck-Seler, Paola Presecki, Ninoslav Mimica, Maja Mustapic, Nela Pivac, Ana Babic, Gordana Nedic, Vera Folnegovic-Smal. Platelet serotonin concentration and monoamine oxidase type B activity in female patients in early, middle and late phase of Alzheimer's disease. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 7. 2009-11-17. PMID:19602426. |
platelet serotonin concentration and monoamine oxidase type b activity in female patients in early, middle and late phase of alzheimer's disease. |
2009-11-17 |
2023-08-12 |
human |
| Lekshmi Santhosh, Kristina M Estok, Rebecca S Vogel, Gilles D Tamagnan, Ronald M Baldwin, Effie M Mitsis, Martha G Macavoy, Julie K Staley, Christopher H van Dyc. Regional distribution and behavioral correlates of 5-HT(2A) receptors in Alzheimer's disease with [(18)F]deuteroaltanserin and PET. Psychiatry research. vol 173. issue 3. 2009-10-20. PMID:19682865. |
regional distribution and behavioral correlates of 5-ht(2a) receptors in alzheimer's disease with [(18)f]deuteroaltanserin and pet. |
2009-10-20 |
2023-08-12 |
Not clear |
| Lekshmi Santhosh, Kristina M Estok, Rebecca S Vogel, Gilles D Tamagnan, Ronald M Baldwin, Effie M Mitsis, Martha G Macavoy, Julie K Staley, Christopher H van Dyc. Regional distribution and behavioral correlates of 5-HT(2A) receptors in Alzheimer's disease with [(18)F]deuteroaltanserin and PET. Psychiatry research. vol 173. issue 3. 2009-10-20. PMID:19682865. |
postmortem studies show reductions in brain serotonin 2a (5-ht(2a)) receptors in alzheimer's disease (ad). |
2009-10-20 |
2023-08-12 |
Not clear |