| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luiza Conceição Amorim Martins, Natália Pessoa Rocha, Karen Cecília Lima Torres, Rodrigo Ribeiro Dos Santos, Giselle Sabrina França, Edgar Nunes de Moraes, Marat Alexandrovich Mukhamedyarov, Andrey Lvovich Zefirov, Albert Anatolyevich Rizvanov, Andrey Pavlovich Kiyasov, Luciene Bruno Vieira, Melissa Monteiro Guimarães, Mehmet Emir Yalvaç, Antônio Lúcio Teixeira, Maria Aparecida Camargo Bicalho, Zoltán Janka, Marco Aurélio Romano-Silva, András Palotás, Helton José Rei. Disease-specific expression of the serotonin-receptor 5-HT(2C) in natural killer cells in Alzheimer's dementia. Journal of neuroimmunology. vol 251. issue 1-2. 2012-11-16. PMID:22766135. |
disease-specific expression of the serotonin-receptor 5-ht(2c) in natural killer cells in alzheimer's dementia. |
2012-11-16 |
2023-08-12 |
human |
| Lisbeth Marner, Vibe G Frokjaer, Jan Kalbitzer, Szabolcs Lehel, Karine Madsen, William F C Baaré, Gitte M Knudsen, Steen G Hasselbalc. Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined [11C]DASB and [18F]altanserin-PET study. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:20510480. |
loss of serotonin 2a receptors exceeds loss of serotonergic projections in early alzheimer's disease: a combined [11c]dasb and [18f]altanserin-pet study. |
2012-09-28 |
2023-08-12 |
human |
| Lisbeth Marner, Vibe G Frokjaer, Jan Kalbitzer, Szabolcs Lehel, Karine Madsen, William F C Baaré, Gitte M Knudsen, Steen G Hasselbalc. Loss of serotonin 2A receptors exceeds loss of serotonergic projections in early Alzheimer's disease: a combined [11C]DASB and [18F]altanserin-PET study. Neurobiology of aging. vol 33. issue 3. 2012-09-28. PMID:20510480. |
in patients with alzheimer's disease (ad), postmortem and imaging studies have revealed early and prominent reductions in cerebral serotonin 2a (5-ht(2a)) receptors. |
2012-09-28 |
2023-08-12 |
human |
| David E Johnson, Elena Drummond, Sarah Grimwood, Aarti Sawant-Basak, Emily Miller, Elaine Tseng, Laura L McDowell, Michelle A Vanase-Frawley, Katherine E Fisher, David M Rubitski, Kim J Stutzman-Engwall, Robin T Nelson, Weldon E Horner, Roxanne R Gorczyca, Mihaly Hajos, Chester J Sio. The 5-hydroxytryptamine4 receptor agonists prucalopride and PRX-03140 increase acetylcholine and histamine levels in the rat prefrontal cortex and the power of stimulated hippocampal θ oscillations. The Journal of pharmacology and experimental therapeutics. vol 341. issue 3. 2012-09-24. PMID:22408061. |
5-hydroxytryptamine (5-ht)(4) receptor agonists reportedly stimulate brain acetylcholine (ach) release, a property that might provide a new pharmacological approach for treating cognitive deficits associated with alzheimer's disease. |
2012-09-24 |
2023-08-12 |
human |
| Yunqi Xu, Junqiang Yan, Peng Zhou, Jiejie Li, Huimin Gao, Ying Xia, Qing Wan. Neurotransmitter receptors and cognitive dysfunction in Alzheimer's disease and Parkinson's disease. Progress in neurobiology. vol 97. issue 1. 2012-08-08. PMID:22387368. |
specific roles of serotonin, adrenaline, acetylcholine, dopamine receptors, and n-methyl-d-aspartate receptors in alzheimer's disease and parkinson's disease will be interactively discussed. |
2012-08-08 |
2023-08-12 |
human |
| Lisbeth Marne. Communication among neurons. Danish medical journal. vol 59. issue 4. 2012-08-02. PMID:22459725. |
furthermore, a pet study of patients with alzheimer's disease with the serotonin transporter ligand [11c]dasb showed relatively preserved serotonergic projections, despite a marked decrease in 5-ht2a receptor binding. |
2012-08-02 |
2023-08-12 |
human |
| Katsuyoshi Mizukami, Masanori Ishikawa, Hiroyasu Akatsu, Eric E Abrahamson, Milos D Ikonomovic, Takashi Asad. An immunohistochemical study of the serotonin 1A receptor in the hippocampus of subjects with Alzheimer's disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 5. 2012-07-23. PMID:21269332. |
an immunohistochemical study of the serotonin 1a receptor in the hippocampus of subjects with alzheimer's disease. |
2012-07-23 |
2023-08-12 |
human |
| Alexis Ciro, Joon Park, Gary Burkhard, Nicole Yan, Changiz Geul. Biochemical differentiation of cholinesterases from normal and Alzheimer's disease cortex. Current Alzheimer research. vol 9. issue 1. 2012-06-14. PMID:21244353. |
using biochemical assays of acetylcholinesterase and butyrylcholinesterase activities, we demonstrate here that serotonin and bacitracin result in a significantly greater and dose-dependent inhibition of cholinesterases in alzheimer's disease cortex when compared with age-matched controls. |
2012-06-14 |
2023-08-12 |
Not clear |
| Clément Menuet, Peter Borghgraef, Valéry Matarazzo, Lies Gielis, Anne-Marie Lajard, Nicolas Voituron, Christian Gestreau, Mathias Dutschmann, Fred Van Leuven, Gérard Hilair. Raphé tauopathy alters serotonin metabolism and breathing activity in terminal Tau.P301L mice: possible implications for tauopathies and Alzheimer's disease. Respiratory physiology & neurobiology. vol 178. issue 2. 2012-06-11. PMID:21763469. |
raphé tauopathy alters serotonin metabolism and breathing activity in terminal tau.p301l mice: possible implications for tauopathies and alzheimer's disease. |
2012-06-11 |
2023-08-12 |
mouse |
| Clément Menuet, Peter Borghgraef, Valéry Matarazzo, Lies Gielis, Anne-Marie Lajard, Nicolas Voituron, Christian Gestreau, Mathias Dutschmann, Fred Van Leuven, Gérard Hilair. Raphé tauopathy alters serotonin metabolism and breathing activity in terminal Tau.P301L mice: possible implications for tauopathies and Alzheimer's disease. Respiratory physiology & neurobiology. vol 178. issue 2. 2012-06-11. PMID:21763469. |
then, 5-ht deficits contribute to the moribund phenotype of tau.p301l mice, and possibly in patients suffering from tauopathies, including alzheimer's disease. |
2012-06-11 |
2023-08-12 |
mouse |
| Louise Witten, Benny Bang-Andersen, Søren Møller Nielsen, Silke Miller, Claus Tornby Christoffersen, Tine Bryan Stensbøl, Lise Tøttrup Brennum, Jørn Arn. Characterization of [³H]Lu AE60157 ([³H]8-(4-methylpiperazin-1-yl)-3-phenylsulfonylquinoline) binding to 5-hydroxytryptamine₆ (5-HT₆) receptors in vivo. European journal of pharmacology. vol 676. issue 1-3. 2012-05-18. PMID:22155399. |
the serotonin6 (5-ht(6)) receptor has received attention for its proposed role in cognitive impairments associated with schizophrenia and alzheimer's disease. |
2012-05-18 |
2023-08-12 |
mouse |
| Karine Madsen, Wolf-Julian Neumann, Klaus Holst, Lisbeth Marner, Mette Thorlund Haahr, Szabolcs Lehel, Gitte Moos Knudsen, Steen Gregers Hasselbalc. Cerebral serotonin 4 receptors and amyloid-β in early Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 26. issue 3. 2012-01-11. PMID:21673407. |
cerebral serotonin 4 receptors and amyloid-β in early alzheimer's disease. |
2012-01-11 |
2023-08-12 |
Not clear |
| Werner J Geldenhuys, Cornelis J Van der Schy. Role of serotonin in Alzheimer's disease: a new therapeutic target? CNS drugs. vol 25. issue 9. 2011-12-20. PMID:21870888. |
role of serotonin in alzheimer's disease: a new therapeutic target? |
2011-12-20 |
2023-08-12 |
Not clear |
| Werner J Geldenhuys, Cornelis J Van der Schy. Role of serotonin in Alzheimer's disease: a new therapeutic target? CNS drugs. vol 25. issue 9. 2011-12-20. PMID:21870888. |
also, while many of these compounds will likely find application as adjuvant therapy in the symptomatic treatment of alzheimer's disease, there are currently only a few drug entities with activity against serotonin receptors that may offer the potential to alter the progression of the disease. |
2011-12-20 |
2023-08-12 |
Not clear |
| Cristina Lorenzi, Alessandra Marcone, Adele Pirovano, Elena Marino, Francesco Cordici, Chiara Cerami, Dario Delmonte, Stefano F Cappa, Placido Bramanti, Enrico Smerald. Serotonin transporter and saitohin genes in risk of Alzheimer's disease and frontotemporal lobar dementia: preliminary findings. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 31. issue 6. 2011-09-28. PMID:20852909. |
serotonin transporter and saitohin genes in risk of alzheimer's disease and frontotemporal lobar dementia: preliminary findings. |
2011-09-28 |
2023-08-12 |
human |
| Teresa Riccioni, Fabio Bordi, Patrizia Minetti, Gilberto Spadoni, Hyung-Mun Yun, Bo-Hye Im, Giorgio Tarzia, Hyewhon Rhim, Franco Borsin. ST1936 stimulates cAMP, Ca2+, ERK1/2 and Fyn kinase through a full activation of cloned human 5-HT6 receptors. European journal of pharmacology. vol 661. issue 1-3. 2011-09-20. PMID:21549693. |
5-ht(6) receptor is one of the most recently cloned serotonin receptors, and it might play important roles in alzheimer's disease, depression, and learning and memory disorders. |
2011-09-20 |
2023-08-12 |
human |
| Marieke Liem-Moolenaar, Mandana Rad, Stefano Zamuner, Adam F Cohen, Francesca Lemme, Kari L Franson, Joop M A van Gerven, Emilio Merlo Pic. Central nervous system effects of the interaction between risperidone (single dose) and the 5-HT6 antagonist SB742457 (repeated doses) in healthy men. British journal of clinical pharmacology. vol 71. issue 6. 2011-09-14. PMID:21223356. |
risperidone, commonly used to control agitation and psychotic features in both schizophrenia and alzheimer's disease, is a d(2)/5-ht(2a ) antagonist with low affinity for 5-ht(6) receptors and limited effects on cognitive parameters. |
2011-09-14 |
2023-08-12 |
Not clear |
| Eeva Toivari, Tiina Manninen, Amit K Nahata, Tuula O Jalonen, Marja-Leena Linn. Effects of transmitters and amyloid-beta peptide on calcium signals in rat cortical astrocytes: Fura-2AM measurements and stochastic model simulations. PloS one. vol 6. issue 3. 2011-08-25. PMID:21483471. |
astrocytes are known to become reactive in alzheimer's disease and their ionic equilibrium can be disturbed by interaction of the released and accumulated transmitters, such as serotonin, and peptides, including amyloid- peptides (a). |
2011-08-25 |
2023-08-12 |
rat |
| Karine Madsen, Mette T Haahr, Lisbeth Marner, Sune H Keller, William F Baaré, Claus Svarer, Steen G Hasselbalch, Gitte M Knudse. Age and sex effects on 5-HT(4) receptors in the human brain: a [(11)C]SB207145 PET study. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 31. issue 6. 2011-08-23. PMID:21364600. |
experimental studies indicate that the 5-ht(4) receptor activation influence cognitive function, affective symptoms, and the development of alzheimer's disease (ad). |
2011-08-23 |
2023-08-12 |
human |
| Joël Bockaert, Sylvie Claeysen, Valérie Compan, Aline Dumui. 5-HT(4) receptors, a place in the sun: act two. Current opinion in pharmacology. vol 11. issue 1. 2011-07-25. PMID:21342787. |
several major devastating illnesses could benefit from 5-ht(4) receptors-directed therapy such as alzheimer's disease, feeding-associated diseases such as anorexia and major depressive disorders. |
2011-07-25 |
2023-08-12 |
Not clear |