| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthias Brendel, Julia Sauerbeck, Sonja Greven, Sebastian Kotz, Franziska Scheiwein, Janusch Blautzik, Andreas Delker, Oliver Pogarell, Kazunari Ishii, Peter Bartenstein, Axel Rominge. Serotonin Selective Reuptake Inhibitor Treatment Improves Cognition and Grey Matter Atrophy but not Amyloid Burden During Two-Year Follow-Up in Mild Cognitive Impairment and Alzheimer's Disease Patients with Depressive Symptoms. Journal of Alzheimer's disease : JAD. vol 65. issue 3. 2019-08-19. PMID:30010116. |
serotonin selective reuptake inhibitor treatment improves cognition and grey matter atrophy but not amyloid burden during two-year follow-up in mild cognitive impairment and alzheimer's disease patients with depressive symptoms. |
2019-08-19 |
2023-08-13 |
human |
| Ramakrishna Nirogi, Renny Abraham, Vijay Benade, Rajesh B Medapati, Pradeep Jayarajan, Gopinadh Bhyrapuneni, NageswaraRao Muddana, Venkat R Mekala, Ramkumar Subramanian, Anil Shinde, Ramasastry Kambhampati, Venkat Jast. SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization. Behavioural pharmacology. vol 30. issue 1. 2019-08-06. PMID:29847336. |
serotonin 6 (5-ht6) receptor has long been pursued as a potential target for the symptomatic treatment of alzheimer's disease. |
2019-08-06 |
2023-08-13 |
Not clear |
| Oluwatomi E S Akingbade, Claire Gibson, Raj N Kalaria, Elizabeta B Mukaetova-Ladinsk. Platelets: Peripheral Biomarkers of Dementia? Journal of Alzheimer's disease : JAD. vol 63. issue 4. 2019-06-10. PMID:29843245. |
current platelet protein biomarkers that have been investigated for their clinical utility in the diagnosis of dementia, in particular alzheimer's disease, include amyloid-β protein precursor (aβpp), the aβpp secretases (bace1 and adam10), α-synuclein, tau protein, serotonin, cholesterol, phospholipases, clusterin, igg, surface receptors, mao-b, and coated platelets. |
2019-06-10 |
2023-08-13 |
Not clear |
| Ramakrishna Nirogi, Abdul Rasheed Mohammed, Anil K Shinde, Shankar Reddy Gagginapally, Durga Malleshwari Kancharla, Vanaja Reddy Middekadi, Narsimha Bogaraju, Srinivasa Rao Ravella, Pooja Singh, Sumit Raosaheb Birangal, Ramkumar Subramanian, Raghava Choudary Palacharla, Vijay Benade, Nageswararao Muddana, Pradeep Jayaraja. Synthesis, Structure-Activity Relationships, and Preclinical Evaluation of Heteroaromatic Amides and 1,3,4-Oxadiazole Derivatives as 5-HT Journal of medicinal chemistry. vol 61. issue 11. 2019-05-20. PMID:29763304. |
synthesis, structure-activity relationships, and preclinical evaluation of heteroaromatic amides and 1,3,4-oxadiazole derivatives as 5-ht alzheimer's disease (ad) is a neurodegenerative disorder that has a higher prevalence and incidence in people older than 60 years. |
2019-05-20 |
2023-08-13 |
Not clear |
| Nasrin Hashemi-Firouzi, Siamak Shahidi, Sara Soleimani-Asl, Alireza Komak. 5-Hydroxytryptamine receptor 6 antagonist, SB258585 exerts neuroprotection in a rat model of Streptozotocin-induced Alzheimer's disease. Metabolic brain disease. vol 33. issue 4. 2019-04-01. PMID:29667108. |
5-hydroxytryptamine receptor 6 antagonist, sb258585 exerts neuroprotection in a rat model of streptozotocin-induced alzheimer's disease. |
2019-04-01 |
2023-08-13 |
rat |
| Katrine Skovgård, Claus Agerskov, Kristi A Kohlmeier, Kjartan F Herri. The 5-HT Neuropharmacology. vol 143. 2019-02-25. PMID:30243914. |
the 5-ht cognitive impairments in alzheimer's disease (ad) have been associated with alterations in neuronal oscillatory activity, of which hippocampal theta and gamma oscillations are essential for the coordination of neuronal networks during cognitive functions. |
2019-02-25 |
2023-08-13 |
Not clear |
| Heike Rebholz, Eitan Friedman, Julia Castell. Alterations of Expression of the Serotonin 5-HT4 Receptor in Brain Disorders. International journal of molecular sciences. vol 19. issue 11. 2019-02-12. PMID:30428567. |
the serotonin 4 receptor, 5-ht₄r, represents one of seven different serotonin receptor families and is implicated in a variety of physiological functions and their pathophysiological variants, such as mood and depression or anxiety, food intake and obesity or anorexia, or memory and memory loss in alzheimer's disease. |
2019-02-12 |
2023-08-13 |
Not clear |
| Sinda Makhlouf, Mariem Messelmani, Jamel Zaouali, Ridha Mriss. Cognitive impairment in celiac disease and non-celiac gluten sensitivity: review of literature on the main cognitive impairments, the imaging and the effect of gluten free diet. Acta neurologica Belgica. vol 118. issue 1. 2018-09-07. PMID:29247390. |
several mechanisms were proposed to explain the deleterious influence of gluten-related pathologies on cognitive functions: nutritional deficiencies, elevation of circulating cytokine levels due to systemic inflammation, low brain serotonin levels… several types of dementia such as alzheimer dementia, vascular dementia, frontotemporal dementia were reported in association with cd. |
2018-09-07 |
2023-08-13 |
Not clear |
| Kevin Baranger, Patrizia Giannoni, Stéphane D Girard, Sarah Girot, Florence Gaven, Delphine Stephan, Martine Migliorati, Michel Khrestchatisky, Joël Bockaert, Evelyne Marchetti-Gauthier, Santiago Rivera, Sylvie Claeysen, François S Roma. Chronic treatments with a 5-HT Neuropharmacology. vol 126. 2018-06-12. PMID:28844596. |
chronic treatments with a 5-ht alzheimer's disease (ad) is the main cause of dementia and a major health issue worldwide. |
2018-06-12 |
2023-08-13 |
Not clear |
| Lili Hu, Bingjie Wang, Yan Zhan. Serotonin 5-HT6 receptors affect cognition in a mouse model of Alzheimer's disease by regulating cilia function. Alzheimer's research & therapy. vol 9. issue 1. 2018-05-17. PMID:28931427. |
serotonin 5-ht6 receptors affect cognition in a mouse model of alzheimer's disease by regulating cilia function. |
2018-05-17 |
2023-08-13 |
mouse |
| Gwenn S Smith, Frederick S Barrett, Jin Hui Joo, Najlla Nassery, Alena Savonenko, Devin J Sodums, Christopher M Marano, Cynthia A Munro, Jason Brandt, Michael A Kraut, Yun Zhou, Dean F Wong, Clifford I Workma. Molecular imaging of serotonin degeneration in mild cognitive impairment. Neurobiology of disease. vol 105. 2018-04-18. PMID:28511918. |
reduced serotonin transporter availability was observed in mild cognitive impairment compared to controls in cortical and limbic areas typically affected by alzheimer's disease pathology, as well as in sensory and motor areas, striatum and thalamus that are relatively spared in alzheimer's disease. |
2018-04-18 |
2023-08-13 |
human |
| Mathieu Verdurand, Luc Zimme. Hippocampal 5-HT Neuropharmacology. vol 123. 2018-04-17. PMID:28647411. |
hippocampal 5-ht there is increasing evidence that the serotonergic system is highly dysfunctional in alzheimer's disease (ad), and this could be related to cognitive impairments associated with dementia. |
2018-04-17 |
2023-08-13 |
Not clear |
| Jing Ma, Yuan Gao, Lin Jiang, Feng-Lei Chao, Wei Huang, Chun-Ni Zhou, Wei Tang, Lei Zhang, Chun-Xia Huang, Yi Zhang, Yan-Min Luo, Qian Xiao, Hua-Rong Yu, Rong Jiang, Yong Tan. Fluoxetine attenuates the impairment of spatial learning ability and prevents neuron loss in middle-aged APPswe/PSEN1dE9 double transgenic Alzheimer's disease mice. Oncotarget. vol 8. issue 17. 2018-04-03. PMID:28430602. |
selective serotonin reuptake inhibitors (ssris) have been reported to increase cognitive performance in some clinical studies of alzheimer's disease (ad). |
2018-04-03 |
2023-08-13 |
mouse |
| Daniel Kondziell. The Top 5 Neurotransmitters from a Clinical Neurologist's Perspective. Neurochemical research. vol 42. issue 6. 2018-03-19. PMID:27822666. |
from our point of view the most important neurotransmitters are, in alphabetical order, acetylcholine (associated with alzheimer's disease and myasthenia gravis), dopamine (parkinson's disease), glutamate and gaba (epilepsy and seizures), and serotonin (major depression; although this is arguably the domain of psychiatrists). |
2018-03-19 |
2023-08-13 |
Not clear |
| Janet L Mace, Richard J Porter, John C Dalrymple-Alford, Chris Collins, Tim J Anderso. Acute tryptophan depletion and Lewy body dementias. International psychogeriatrics. vol 28. issue 9. 2018-02-22. PMID:26987723. |
studies using acute tryptophan depletion (atd) to examine the effects of a rapid reduction in serotonin function have shown a reduction in global cognitive status during atd in alzheimer's disease (ad) and parkinson's disease (pd). |
2018-02-22 |
2023-08-13 |
Not clear |
| Hilda Ferrero, Maite Solas, Paul T Francis, Maria J Ramire. Serotonin 5-HT CNS drugs. vol 31. issue 1. 2018-02-07. PMID:27914038. |
serotonin 5-ht alzheimer's disease (ad) is the most common cause of dementia in elderly people. |
2018-02-07 |
2023-08-13 |
Not clear |
| Walid Tajeddinn, Seyed-Mohammad Fereshtehnejad, Mohammed Seed Ahmed, Takashi Yoshitake, Jan Kehr, Tasmin Shahnaz, Micha Milovanovic, Homira Behbahani, Kina Höglund, Bengt Winblad, Angel Cedazo-Minguez, Vesna Jelic, Petter Järemo, Dag Aarslan. Association of Platelet Serotonin Levels in Alzheimer's Disease with Clinical and Cerebrospinal Fluid Markers. Journal of Alzheimer's disease : JAD. vol 53. issue 2. 2018-01-25. PMID:27163811. |
association of platelet serotonin levels in alzheimer's disease with clinical and cerebrospinal fluid markers. |
2018-01-25 |
2023-08-13 |
Not clear |
| Walid Tajeddinn, Seyed-Mohammad Fereshtehnejad, Mohammed Seed Ahmed, Takashi Yoshitake, Jan Kehr, Tasmin Shahnaz, Micha Milovanovic, Homira Behbahani, Kina Höglund, Bengt Winblad, Angel Cedazo-Minguez, Vesna Jelic, Petter Järemo, Dag Aarslan. Association of Platelet Serotonin Levels in Alzheimer's Disease with Clinical and Cerebrospinal Fluid Markers. Journal of Alzheimer's disease : JAD. vol 53. issue 2. 2018-01-25. PMID:27163811. |
serotonin (5-ht) is involved in the pathology of alzheimer's disease (ad). |
2018-01-25 |
2023-08-13 |
Not clear |
| Kiyohiro Yamazaki, Yuta Yoshino, Takaaki Mori, Mitsuo Okita, Taku Yoshida, Yoko Mori, Yuki Ozaki, Tomoko Sao, Jun-Ichi Iga, Shu-Ichi Uen. Association Study and Meta-Analysis of Polymorphisms, Methylation Profiles, and Peripheral mRNA Expression of the Serotonin Transporter Gene in Patients with Alzheimer's Disease. Dementia and geriatric cognitive disorders. vol 41. issue 5-6. 2018-01-24. PMID:27414430. |
association study and meta-analysis of polymorphisms, methylation profiles, and peripheral mrna expression of the serotonin transporter gene in patients with alzheimer's disease. |
2018-01-24 |
2023-08-13 |
Not clear |
| Kiyohiro Yamazaki, Yuta Yoshino, Takaaki Mori, Mitsuo Okita, Taku Yoshida, Yoko Mori, Yuki Ozaki, Tomoko Sao, Jun-Ichi Iga, Shu-Ichi Uen. Association Study and Meta-Analysis of Polymorphisms, Methylation Profiles, and Peripheral mRNA Expression of the Serotonin Transporter Gene in Patients with Alzheimer's Disease. Dementia and geriatric cognitive disorders. vol 41. issue 5-6. 2018-01-24. PMID:27414430. |
the aim of this study was to elucidate the relationship between alzheimer's disease (ad) and the serotonin transporter gene (slc6a4). |
2018-01-24 |
2023-08-13 |
Not clear |