| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sherri Cofield Kroll, Carole Frances Bennett, Tarah Winter Klinefelte. Update on Neurodegenerative Diseases and Glutamate: A PMHNP Single Case Study Report of a Diagnostically Complex Adult Patient, Interventions, and Unexpected Outcomes. Journal of the American Psychiatric Nurses Association. 2021-07-09. PMID:34238041. |
while dysfunction of serotonin and dopamine neurotransmitters has been studied in depth, in regard to the etiology of mental illness, the neurotransmitter glutamate and its dysfunction is now being explored as contributing to neurodegenerative psychiatric diseases, schizophrenia, autism, depression, and alzheimer's disease. |
2021-07-09 |
2023-08-13 |
Not clear |
| Zehui Sun, Bingjie Wang, Chen Chen, Chenjian Li, Yan Zhan. 5-HT6R null mutatrion induces synaptic and cognitive defects. Aging cell. vol 20. issue 6. 2021-06-26. PMID:33960602. |
serotonin 6 receptor (5-ht6r) is a promising target for a variety of human diseases, such as alzheimer's disease (ad) and schizophrenia. |
2021-06-26 |
2023-08-13 |
human |
| Luke Whiley, Katie E Chappell, Ellie D'Hondt, Matthew R Lewis, Beatriz Jiménez, Stuart G Snowden, Hilkka Soininen, Iwona Kłoszewska, Patrizia Mecocci, Magda Tsolaki, Bruno Vellas, Jonathan R Swann, Abdul Hye, Simon Lovestone, Cristina Legido-Quigley, Elaine Holme. Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease. Alzheimer's research & therapy. vol 13. issue 1. 2021-06-24. PMID:33422142. |
metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with alzheimer's disease. |
2021-06-24 |
2023-08-13 |
Not clear |
| Aldineia P da Silva, Laise P A Chiari, Amanda R Guimaraes, Kathia M Honorio, Albérico B F da Silv. Drug design of new 5-HT Journal of molecular graphics & modelling. vol 104. 2021-06-21. PMID:33529936. |
drug design of new 5-ht alzheimer's disease (ad) is the most frequent illness and cause of death amongst the age related-neurodegenerative disorders. |
2021-06-21 |
2023-08-13 |
Not clear |
| Aldineia P da Silva, Laise P A Chiari, Amanda R Guimaraes, Kathia M Honorio, Albérico B F da Silv. Drug design of new 5-HT Journal of molecular graphics & modelling. vol 104. 2021-06-21. PMID:33529936. |
the alzheimer's disease international (adi) reported in 2019 that over 50 million people were living with dementia in the world and this number could potentially be around 152 million by 2050.5-hydroxtryptamine subtype 6 receptor (5-ht |
2021-06-21 |
2023-08-13 |
Not clear |
| Naveen Singh, RamaRao Golime, Jyothiranjan Acharya, Meehir Pali. Quantitative Proteomic Changes after Organophosphorous Nerve Agent Exposure in the Rat Hippocampus. ACS chemical neuroscience. vol 11. issue 17. 2021-06-18. PMID:32702963. |
bioinformatics analysis revealed soman-induced broad-range proteomic changes in key pathways related to glutamate, acetylcholine, gaba, 5-hydroxytryptamine, and adrenergic receptors, g-protein signaling, chemokine and cytokine-mediated inflammation, cytoskeleton, neurodegeneration (parkinson's and alzheimer's), wnt signaling, synaptic vesicle trafficking, map kinases, proteosome degradation, metabolism, and cell death. |
2021-06-18 |
2023-08-13 |
rat |
| Yehong Gong, Chendi Zhan, Yu Zou, Zhenyu Qian, Guanghong Wei, Qingwen Zhan. Serotonin and Melatonin Show Different Modes of Action on Aβ ACS chemical neuroscience. vol 12. issue 4. 2021-06-18. PMID:33533252. |
serotonin and melatonin show different modes of action on aβ alzheimer's disease (ad) is associated with the aberrant self-assembly of amyloid-β (aβ) protein into fibrillar deposits. |
2021-06-18 |
2023-08-13 |
Not clear |
| Vittorio Canale, Katarzyna Grychowska, Rafał Kurczab, Mateusz Ryng, Abdul Raheem Keeri, Grzegorz Satała, Agnieszka Olejarz-Maciej, Paulina Koczurkiewicz, Marcin Drop, Klaudia Blicharz, Kamil Piska, Elżbieta Pękala, Paulina Janiszewska, Martyna Krawczyk, Maria Walczak, Severine Chaumont-Dubel, Andrzej J Bojarski, Philippe Marin, Piotr Popik, Paweł Zajde. A dual-acting 5-HT European journal of medicinal chemistry. vol 208. 2021-05-26. PMID:32949963. |
a dual-acting 5-ht the complex etiology of alzheimer's disease has initiated a quest for multi-target ligands to address the multifactorial causes of this neurodegenerative disorder. |
2021-05-26 |
2023-08-13 |
Not clear |
| Alejandro Castro-Alvarez, Emigdio Chávez-Ángel, Ronald Nelso. Understanding the Molecular Basis of 5-HT International journal of molecular sciences. vol 22. issue 7. 2021-05-14. PMID:33808456. |
understanding the molecular basis of 5-ht alzheimer's disease (ad) is a neurodegenerative disorder whose prevalence has an incidence in senior citizens. |
2021-05-14 |
2023-08-13 |
Not clear |
| Carla M Yuede, Clare E Wallace, Todd A Davis, Woodrow D Gardiner, Jane C Hettinger, Hannah M Edwards, Rachel D Hendrix, Brookelyn M Doherty, Kayla M Yuede, Ethan S Burstein, John R Cirrit. Pimavanserin, a 5HT Journal of neurochemistry. vol 156. issue 5. 2021-05-04. PMID:33278025. |
pimavanserin, a 5ht amyloid-β (aβ) peptide aggregation into soluble oligomers and insoluble plaques is a precipitating event in the pathogenesis of alzheimer's disease (ad). |
2021-05-04 |
2023-08-13 |
Not clear |
| Gerhard Gründer, Paul Cummin. Serotonin and amyloid deposition: A link between depression and Alzheimer's disease?: An Editorial Highlight on "Pimavanserin, a 5HT Journal of neurochemistry. vol 156. issue 5. 2021-04-28. PMID:33459383. |
serotonin and amyloid deposition: a link between depression and alzheimer's disease? |
2021-04-28 |
2023-08-13 |
Not clear |
| François-Xavier Toublet, Julien Lalut, Bérénice Hatat, Cédric Lecoutey, Audrey Davis, Marc Since, Sophie Corvaisier, Thomas Freret, Jana Sopková-de Oliveira Santos, Sylvie Claeysen, Michel Boulouard, Patrick Dallemagne, Christophe Rochai. Pleiotropic prodrugs: Design of a dual butyrylcholinesterase inhibitor and 5-HT European journal of medicinal chemistry. vol 210. 2021-04-22. PMID:33310288. |
pleiotropic prodrugs: design of a dual butyrylcholinesterase inhibitor and 5-ht beside acetylcholinesterase, butyrylcholinesterase could be considered as a putative target of interest for the symptomatic treatment of alzheimer's disease (ad). |
2021-04-22 |
2023-08-13 |
Not clear |
| Yi Xie, Pei-Pei Liu, Ya-Jun Lian, Hong-Bo Liu, Jian-Sheng Kan. The effect of selective serotonin reuptake inhibitors on cognitive function in patients with Alzheimer's disease and vascular dementia: focusing on fluoxetine with long follow-up periods. Signal transduction and targeted therapy. vol 4. 2021-01-29. PMID:31637010. |
the effect of selective serotonin reuptake inhibitors on cognitive function in patients with alzheimer's disease and vascular dementia: focusing on fluoxetine with long follow-up periods. |
2021-01-29 |
2023-08-13 |
Not clear |
| J J van der Zande, M Joling, I G Happach, C Vriend, Ph Scheltens, J Booij, A W Lemstr. Serotonergic deficits in dementia with Lewy bodies with concomitant Alzheimer's disease pathology: An NeuroImage. Clinical. vol 25. 2021-01-11. PMID:31790878. |
serotonergic deficits in dementia with lewy bodies with concomitant alzheimer's disease pathology: an to study the influence of concomitant alzheimer's disease (ad) pathology in dementia with lewy bodies (dlb) on dopamine transporter (dat) and serotonin transporter (sert) availability, using |
2021-01-11 |
2023-08-13 |
Not clear |
| Weam W Ibrahim, Noha F Abdelkader, Hesham M Ismail, Mahmoud M Khatta. Escitalopram Ameliorates Cognitive Impairment in D-Galactose-Injected Ovariectomized Rats: Modulation of JNK, GSK-3β, and ERK Signalling Pathways. Scientific reports. vol 9. issue 1. 2020-11-09. PMID:31296935. |
though selective serotonin reuptake inhibitors (ssris) have been found to increase cognitive performance in some studies on patients and animal models of alzheimer's disease (ad), other studies have reported contradictory results, and the mechanism of action has not been fully described. |
2020-11-09 |
2023-08-13 |
rat |
| Mehmet Bostancıklıoğl. Optogenetic stimulation of serotonin nuclei retrieve the lost memory in Alzheimer's disease. Journal of cellular physiology. vol 235. issue 2. 2020-10-13. PMID:31332785. |
optogenetic stimulation of serotonin nuclei retrieve the lost memory in alzheimer's disease. |
2020-10-13 |
2023-08-13 |
Not clear |
| Mehmet Bostancıklıoğl. Optogenetic stimulation of serotonin nuclei retrieve the lost memory in Alzheimer's disease. Journal of cellular physiology. vol 235. issue 2. 2020-10-13. PMID:31332785. |
the majority of treatment studies has based on the manipulation of the cholinergic system; however, although serotonin has mnemonic effects, its role in the pathogenesis of alzheimer's disease has not been investigated as much as the cholinergic system. |
2020-10-13 |
2023-08-13 |
Not clear |
| Mehmet Bostancıklıoğl. Optogenetic stimulation of serotonin nuclei retrieve the lost memory in Alzheimer's disease. Journal of cellular physiology. vol 235. issue 2. 2020-10-13. PMID:31332785. |
here we show how serotonin affects the pathogenesis of alzheimer's disease in a comprehensive perspective and we suggest that the optogenetics manipulation of serotonin nuclei retrieve the lost memory by closing the inward-rectifier potassium channel kir2 on the memory engram cells. |
2020-10-13 |
2023-08-13 |
Not clear |
| Mehmet Bostancıklıoğl. Optogenetic stimulation of serotonin nuclei retrieve the lost memory in Alzheimer's disease. Journal of cellular physiology. vol 235. issue 2. 2020-10-13. PMID:31332785. |
also, we raise the possible effects of serotonin on the memory engram cells and the interactions between the amyloid-centric hypothesis of alzheimer's disease and the memory engram hypothesis to explain the pathophysiology of memory loss in alzheimer's disease. |
2020-10-13 |
2023-08-13 |
Not clear |
| Khadga Raj, Pooja Chawla, Shamsher Sing. Neurobehavioral Consequences Associated with Long Term Tramadol Utilization and Pathological Mechanisms. CNS & neurological disorders drug targets. vol 18. issue 10. 2020-10-13. PMID:31721720. |
long term utilization of tramadol is associated with various neurological disorders like seizures, serotonin syndrome, alzheimer's disease and parkinson's disease. |
2020-10-13 |
2023-08-13 |
Not clear |