| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jinli Zhang, Xiaohui Zheng, Zhenying Zha. A systematic review and meta-analysis on the efficacy outcomes of selective serotonin reuptake inhibitors in depression in Alzheimer's disease. BMC neurology. vol 23. issue 1. 2023-05-31. PMID:37259037. |
a systematic review and meta-analysis on the efficacy outcomes of selective serotonin reuptake inhibitors in depression in alzheimer's disease. |
2023-05-31 |
2023-08-14 |
Not clear |
| Yuxiao Chen, Jie Sun, Zhen Yang, Hongyan B. Efficacy and safety of negative allosteric modulators of 5-hydroxytryptamine 2A receptors in the treatment of Alzheimer's disease psychosis: A systematic review and meta-analysis. Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 2023-05-11. PMID:37166012. |
efficacy and safety of negative allosteric modulators of 5-hydroxytryptamine 2a receptors in the treatment of alzheimer's disease psychosis: a systematic review and meta-analysis. |
2023-05-11 |
2023-08-14 |
Not clear |
| Jing Tian, Chase Stucky, Tienju Wang, Nancy A Muma, Michael Johnson, Heng D. Mitochondrial Dysfunction Links to Impaired Hippocampal Serotonin Release in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-04-17. PMID:37066917. |
deprivation of extracellular serotonin has been linked to cognitive decline and neuropsychiatric disturbances in alzheimer's disease (ad). |
2023-04-17 |
2023-08-14 |
mouse |
| Jing Tian, Chase Stucky, Tienju Wang, Nancy A Muma, Michael Johnson, Heng D. Mitochondrial Dysfunction Links to Impaired Hippocampal Serotonin Release in a Mouse Model of Alzheimer's Disease. Journal of Alzheimer's disease : JAD. 2023-04-17. PMID:37066917. |
mitochondrial dysfunction links to impaired hippocampal serotonin release in a mouse model of alzheimer's disease. |
2023-04-17 |
2023-08-14 |
mouse |
| Ramakrishna Nirogi, Venkata Ramalingayya Grandhi, Rajeshbabu Medapati, Narender Ganuga, Renny Abraham, Jagadeesh Babu Thentu, Veera Raghava Chowdary Palacharla, Surendra Petlu, Maheshwari Srirangavaram, Ramkumar Subramanian, Srinivasa Rao Ravella, Shankar Reddy Gagginapally, Vijay Benade, Pradeep Jayarajan, Abdul Rasheed Mohamme. Usmarapride (SUVN-D4010), a 5-HT European journal of pharmacology. 2023-03-30. PMID:36997046. |
usmarapride (suvn-d4010), a 5-ht alzheimer's disease (ad) is a progressive neurodegenerative disorder which affects cognitive functions with negative impact on day to day activities and an ultimate loss of independent living. |
2023-03-30 |
2023-08-14 |
Not clear |
| Li-Fen Liu, Yu-Tong Liu, Dan-Dan Wu, Jie Cheng, Na-Na Li, Ya-Ni Zheng, Liang Huang, Qiong-Lan Yua. Inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of Alzheimer's disease. Neural regeneration research. vol 18. issue 9. 2023-03-17. PMID:36926728. |
inhibiting 5-hydroxytryptamine receptor 3 alleviates pathological changes of a mouse model of alzheimer's disease. |
2023-03-17 |
2023-08-14 |
mouse |
| Dorota Łażewska, Małgorzata Więcek, Grzegorz Satała, Paulina Chałupnik, Ewa Żesławska, Ewelina Honkisz-Orzechowska, Monika Tarasek, Gniewomir Latacz, Wojciech Nitek, Ewa Szymańska, Jadwiga Handzli. New Triazine Derivatives as Serotonin 5-HT Molecules (Basel, Switzerland). vol 28. issue 3. 2023-02-11. PMID:36770774. |
new triazine derivatives as serotonin 5-ht since the number of people with alzheimer's disease (ad) continues to rise, new and effective drugs are urgently needed to not only slow down the progression of the disease, but to stop or even prevent its development. |
2023-02-11 |
2023-08-14 |
Not clear |
| Debora Cutuli, Giacomo Giacovazzo, Davide Decandia, Roberto Coccurell. Alzheimer's disease and depression in the elderly: A trajectory linking gut microbiota and serotonin signaling. Frontiers in psychiatry. vol 13. 2022-12-19. PMID:36532180. |
antidepressants (i.e., serotonin reuptake inhibitors) or tryptophan dietary supplementation have been shown to reduce amyloid β-loading, reinstate microbial diversity and reduce the abundance of bacterial taxa dominant in depression and alzheimer's disease. |
2022-12-19 |
2023-08-14 |
Not clear |
| Debora Cutuli, Giacomo Giacovazzo, Davide Decandia, Roberto Coccurell. Alzheimer's disease and depression in the elderly: A trajectory linking gut microbiota and serotonin signaling. Frontiers in psychiatry. vol 13. 2022-12-19. PMID:36532180. |
this review briefly examines this trajectory by discussing the dysfunction of gut microbiota composition, selected bacterial taxa, and alteration of tryptophan and serotonin metabolism/neurotransmission as overlapping in-common mechanisms involved with depression, alzheimer's disease, and unhealthy aging. |
2022-12-19 |
2023-08-14 |
Not clear |
| Debora Cutuli, Giacomo Giacovazzo, Davide Decandia, Roberto Coccurell. Alzheimer's disease and depression in the elderly: A trajectory linking gut microbiota and serotonin signaling. Frontiers in psychiatry. vol 13. 2022-12-19. PMID:36532180. |
alzheimer's disease and depression in the elderly: a trajectory linking gut microbiota and serotonin signaling. |
2022-12-19 |
2023-08-14 |
Not clear |
| Margarita Neganova, Junqi Liu, Yulia Aleksandrova, Natalia Vasilieva, Alexey Semakov, Ekaterina Yandulova, Olga Sukocheva, Konstantin Balakin, Sergey Klochkov, Ruitai Fa. Development of Neuroprotective Agents for the Treatment of Alzheimer's Disease Using Conjugates of Serotonin with Sesquiterpene Lactones. Current medicinal chemistry. 2022-11-28. PMID:36437724. |
in conclusion, the obtained results indicate that serotonin conjugates to sesquiterpene lactones are promising agents for the treatment of symptoms associated with alzheimer's disease. |
2022-11-28 |
2023-08-14 |
Not clear |
| Margarita Neganova, Junqi Liu, Yulia Aleksandrova, Natalia Vasilieva, Alexey Semakov, Ekaterina Yandulova, Olga Sukocheva, Konstantin Balakin, Sergey Klochkov, Ruitai Fa. Development of Neuroprotective Agents for the Treatment of Alzheimer's Disease Using Conjugates of Serotonin with Sesquiterpene Lactones. Current medicinal chemistry. 2022-11-28. PMID:36437724. |
development of neuroprotective agents for the treatment of alzheimer's disease using conjugates of serotonin with sesquiterpene lactones. |
2022-11-28 |
2023-08-14 |
Not clear |
| Margarita Neganova, Junqi Liu, Yulia Aleksandrova, Natalia Vasilieva, Alexey Semakov, Ekaterina Yandulova, Olga Sukocheva, Konstantin Balakin, Sergey Klochkov, Ruitai Fa. Development of Neuroprotective Agents for the Treatment of Alzheimer's Disease Using Conjugates of Serotonin with Sesquiterpene Lactones. Current medicinal chemistry. 2022-11-28. PMID:36437724. |
the aim of this experimental synthesis was to generate potential treatment agents for alzheimer's disease using serotonin conjugated with natural sesquiterpene lactones. |
2022-11-28 |
2023-08-14 |
Not clear |
| Ruizhuo Li, Mengjuan Deng, Yuhong Lin, Wenjing Gao, Bohao Liu, Huimin Xi. Genetically predicted circulating levels of glycine, glutamate, and serotonin in relation to the risks of three major neurodegenerative diseases: A Mendelian randomization analysis. Frontiers in aging neuroscience. vol 14. 2022-09-26. PMID:36158554. |
here, a mendelian randomization (mr) study was conducted to explore whether genetically predicted concentrations of glycine, glutamate and serotonin were associated with risks of alzheimer's disease (ad), parkinson's disease (pd), and amyotrophic lateral sclerosis (als). |
2022-09-26 |
2023-08-14 |
Not clear |
| Krzysztof Więckowski, Natalia Szałaj, Beata Gryzło, Tomasz Wichur, Izabella Góral, Emilia Sługocka, Joanna Sniecikowska, Gniewomir Latacz, Agata Siwek, Justyna Godyń, Adam Bucki, Marcin Kołaczkowski, Anna Więckowsk. Serotonin 5-HT International journal of molecular sciences. vol 23. issue 16. 2022-08-26. PMID:36012707. |
serotonin 5-ht neurodegeneration leading to alzheimer's disease results from a complex interplay of a variety of processes including misfolding and aggregation of amyloid beta and tau proteins, neuroinflammation or oxidative stress. |
2022-08-26 |
2023-08-14 |
Not clear |
| Kinga Czarnota-Łydka, Katarzyna Kucwaj-Brysz, Patryk Pyka, Wawrzyniec Haberek, Sabina Podlewska, Jadwiga Handzli. Multitargeting the Action of 5-HT International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955902. |
multitargeting the action of 5-ht in view of the unsatisfactory treatment of cognitive disorders, in particular alzheimer's disease (ad), the aim of this review was to perform a computer-aided analysis of the state of the art that will help in the search for innovative polypharmacology-based therapeutic approaches to fight against ad. |
2022-08-12 |
2023-08-14 |
Not clear |
| Kinga Czarnota-Łydka, Katarzyna Kucwaj-Brysz, Patryk Pyka, Wawrzyniec Haberek, Sabina Podlewska, Jadwiga Handzli. Multitargeting the Action of 5-HT International journal of molecular sciences. vol 23. issue 15. 2022-08-12. PMID:35955902. |
apart from 20-year unrenewed cholinesterase- or nmda-based ad therapy, the hope of effectively treating alzheimer's disease has been placed on serotonin 5-ht |
2022-08-12 |
2023-08-14 |
Not clear |
| Syed Nasir Abbas Bukhari, Mervat Abdelaziz Elsherif, Kashaf Junaid, Hasan Ejaz, Pravej Alam, Abdul Samad, Rahul D Jawarkar, Vijay H Masan. Perceiving the Concealed and Unreported Pharmacophoric Features of the 5-Hydroxytryptamine Receptor Using Balanced QSAR Analysis. Pharmaceuticals (Basel, Switzerland). vol 15. issue 7. 2022-07-27. PMID:35890133. |
the 5-hydroxytryptamine receptor 6 (5-ht6) has gained attention as a target for developing therapeutics for alzheimer's disease, schizophrenia, cognitive dysfunctions, anxiety, and depression, to list a few. |
2022-07-27 |
2023-08-14 |
Not clear |
| Ruchi Sharma, Rajeev K Singla, Subhadip Banerjee, Baivab Sinha, Bairong Shen, Rohit Sharm. Role of Shankhpushpi (Convolvulus pluricaulis) in Neurological Disorders: An Umbrella Review Covering Evidence from Ethnopharmacology to Clinical Studies. Neuroscience and biobehavioral reviews. 2022-07-25. PMID:35878793. |
network pharmacology results indicate that compounds from c. pluricaulis interact with various proteins, neuro synapses, signaling pathways, and serotonergic synapse which plays a crucial role in neurotransmission, alzheimer's disease, long-term depression, addictions to alcohol, cognitive disorders, psychological conditions, and increasing serotonin concentration in synapses. |
2022-07-25 |
2023-08-14 |
Not clear |
| R J Elsworthy, J A Crowe, M C King, C Dunleavy, E Fisher, A Ludlam, H R Parri, E J Hill, S Aldre. The effect of citalopram treatment on amyloid-β precursor protein processing and oxidative stress in human hNSC-derived neurons. Translational psychiatry. vol 12. issue 1. 2022-07-19. PMID:35851379. |
selective serotonin reuptake inhibitors (ssris) may hold therapeutic benefits for people with alzheimer's disease (ad). |
2022-07-19 |
2023-08-14 |
human |