| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Eunice D Farfán-García, Ricardo Márquez-Gómez, Mónica Barrón-González, Teresa Pérez-Capistran, Martha C Rosales-Hernández, Rodolfo Pinto-Almazán, Marvin A Soriano-Ursú. Monoamines and their Derivatives on GPCRs: Potential Therapy for Alzheimer's Disease. Current Alzheimer research. vol 16. issue 10. 2020-10-06. PMID:30963972. |
albeit cholinergic depletion remains the key event in alzheimer's disease (ad), recent information describes stronger links between monoamines (trace amines, catecholamines, histamine, serotonin, and melatonin) and ad than those known in the past century. |
2020-10-06 |
2023-08-13 |
Not clear |
| Mary Angela O'Nea. Neurologic diseases in women: Five new things. Neurology. Clinical practice. vol 3. issue 3. 2020-09-30. PMID:29473629. |
this review highlights some of the new epidemiologic information concerning sex differences involving combined oral contraceptives and stroke, depression and selective serotonin reuptake inhibitors use during pregnancy, emerging knowledge of the teratogenicity and cognitive effects of anticonvulsants during pregnancy, demyelinating disorders in pregnancy, and the influence of timing of hormonal exposure on the risk of alzheimer disease. |
2020-09-30 |
2023-08-13 |
Not clear |
| Jennifer N K Nyarko, Maa O Quartey, Ryan M Heistad, Paul R Pennington, Lisa J Poon, Kaeli J Knudsen, Odette Allonby, Amr M El Zawily, Andrew Freywald, Gail Rauw, Glen B Baker, Darrell D Moussea. Glycosylation States of Pre- and Post-synaptic Markers of 5-HT Neurons Differ With Sex and 5-HTTLPR Genotype in Cortical Autopsy Samples. Frontiers in neuroscience. vol 12. 2020-09-30. PMID:30147642. |
the serotonin (5-hydroxytryptamine, 5-ht) transporter (5-htt) gene-linked polymorphic region (5-httlpr) is thought to alter 5-ht signaling and contribute to behavioral and cognitive phenotypes in depression as well as alzheimer disease (ad). |
2020-09-30 |
2023-08-13 |
Not clear |
| Bernadette Mdawar, Elias Ghossoub, Rita Khour. Selective serotonin reuptake inhibitors and Alzheimer's disease. Neural regeneration research. vol 15. issue 1. 2020-09-30. PMID:31535641. |
selective serotonin reuptake inhibitors and alzheimer's disease. |
2020-09-30 |
2023-08-13 |
mouse |
| Hridya Jayamohananan, Maneesha Kalappurackal Manoj Kumar, Aneesh T . 5-HIAA as a Potential Biological Marker for Neurological and Psychiatric Disorders. Advanced pharmaceutical bulletin. vol 9. issue 3. 2020-09-30. PMID:31592064. |
many theories suggest that the variations in serotonin level could lead to the development of many neurological and psychiatric disorders like alzheimer's disease (ad), schizophrenia, depression and so on. |
2020-09-30 |
2023-08-13 |
Not clear |
| Maurizio Severino, Mithula Sivasaravanaparan, Louise Ø Olesen, Christian U von Linstow, Athanasios Metaxas, Elena V Bouzinova, Asif Manzoor Khan, Kate L Lambertsen, Alicia A Babcock, Jan Bert Gramsbergen, Ove Wiborg, Bente Finse. Established amyloid-β pathology is unaffected by chronic treatment with the selective serotonin reuptake inhibitor paroxetine. Alzheimer's & dementia (New York, N. Y.). vol 4. 2020-09-29. PMID:29955664. |
treatment with selective serotonin reuptake inhibitors has been suggested to mitigate amyloid-β (aβ) pathology in alzheimer's disease, in addition to an antidepressant mechanism of action. |
2020-09-29 |
2023-08-13 |
Not clear |
| M Nova Raditya, A M Made Bagus, Ulayatul Kustiati, Hevi Wihadmadyatami, Dwi Liliek Kusindart. Data of The Expression of Serotonin in Alzheimer's Disease (AD) Rat Model Under Treatment of Ethanolic Extract Ocimum sanctum Linn. Data in brief. vol 30. 2020-09-28. PMID:32395598. |
data of the expression of serotonin in alzheimer's disease (ad) rat model under treatment of ethanolic extract ocimum sanctum linn. |
2020-09-28 |
2023-08-13 |
rat |
| Masoud Neshan, Arezoo Campbell, Seyed Kazem Malakouti, Mahsa Zareii, Ghasem Ahangar. Gene expression of serotonergic markers in peripheral blood mononuclear cells of patients with late-onset Alzheimer's disease. Heliyon. vol 6. issue 8. 2020-09-28. PMID:32904297. |
pathological changes in metabolism or functional imbalance of 5-ht has been associated with alzheimer's disease (ad). |
2020-09-28 |
2023-08-13 |
Not clear |
| Masoud Neshan, Arezoo Campbell, Seyed Kazem Malakouti, Mahsa Zareii, Ghasem Ahangar. Gene expression of serotonergic markers in peripheral blood mononuclear cells of patients with late-onset Alzheimer's disease. Heliyon. vol 6. issue 8. 2020-09-28. PMID:32904297. |
the current study measured the relative expression of 5-ht receptors (5-htr2a and 5-htr3a) as well as the 5-ht catalytic enzyme, monoamine oxidase a (mao-a) mrna in peripheral blood mononuclear cells (pbmcs) of patients with late-onset alzheimer's disease (load) and age-matched controls. |
2020-09-28 |
2023-08-13 |
Not clear |
| Richard J Elsworthy, Sarah Aldre. Depression in Alzheimer's Disease: An Alternative Role for Selective Serotonin Reuptake Inhibitors? Journal of Alzheimer's disease : JAD. vol 69. issue 3. 2020-09-18. PMID:31104017. |
depression in alzheimer's disease: an alternative role for selective serotonin reuptake inhibitors? |
2020-09-18 |
2023-08-13 |
Not clear |
| Simin Afshar, Siamak Shahidi, Ali Haeri Rohani, Sara Soleimani Asl, Alireza Komak. Protective effects of 5-HT Journal of chemical neuroanatomy. vol 96. 2020-06-15. PMID:30684605. |
protective effects of 5-ht alzheimer's disease (ad) is a neurodegenerative disorder and neuropathologically characterized by the aggregation of amyloid-beta (aβ) plaques, neurofibrillary tangles, enhanced oxidative stress and neurodegeneration. |
2020-06-15 |
2023-08-13 |
Not clear |
| John Wesson Ashfor. Treatment of Alzheimer's Disease: Trazodone, Sleep, Serotonin, Norepinephrine, and Future Directions. Journal of Alzheimer's disease : JAD. vol 67. issue 3. 2020-06-01. PMID:30776014. |
treatment of alzheimer's disease: trazodone, sleep, serotonin, norepinephrine, and future directions. |
2020-06-01 |
2023-08-13 |
human |
| Athanasios Metaxas, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M Landau, Bente Finse. Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease. Alzheimer's research & therapy. vol 11. issue 1. 2020-05-08. PMID:31043179. |
neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (sert) activity in a transgenic model of familial alzheimer's disease. |
2020-05-08 |
2023-08-13 |
Not clear |
| Athanasios Metaxas, Marco Anzalone, Ramanan Vaitheeswaran, Sussanne Petersen, Anne M Landau, Bente Finse. Neuroinflammation and amyloid-beta 40 are associated with reduced serotonin transporter (SERT) activity in a transgenic model of familial Alzheimer's disease. Alzheimer's research & therapy. vol 11. issue 1. 2020-05-08. PMID:31043179. |
discrepant and often contradictory results have accumulated regarding the antidepressant and pro-cognitive effects of serotonin transporter (sert) antagonists in alzheimer's disease. |
2020-05-08 |
2023-08-13 |
Not clear |
| Jana Janssens, Sawal D Atmosoerodjo, Yannick Vermeiren, Anthony R Absalom, Izaak den Daas, Peter P De Dey. Sampling issues of cerebrospinal fluid and plasma monoamines: Investigation of the circadian rhythm and rostrocaudal concentration gradient. Neurochemistry international. vol 128. 2020-04-24. PMID:31034914. |
monoamines such as dopamine, (nor)adrenaline, serotonin (5-hydroxytryptamine or 5-ht), and their respective metabolites homovanillic acid (hva) and 3,4-dihydroxyphenylacetic acid, 3-methoxy-4-hydroxyphenylglycol (mhpg), and 5-hydroxyindoleacetic acid (5-hiaa), were shown to be altered in dementia, including alzheimer's disease (ad). |
2020-04-24 |
2023-08-13 |
human |
| Robert Siblerud, Joachim Mutter, Elaine Moore, Johannes Naumann, Harald Walac. A Hypothesis and Evidence That Mercury May be an Etiological Factor in Alzheimer's Disease. International journal of environmental research and public health. vol 16. issue 24. 2020-03-23. PMID:31861093. |
neurotransmitters such as acetylcholine, serotonin, dopamine, glutamate, and norepinephrine are inhibited in patients with alzheimer's disease, with the same inhibition occurring in mercury toxicity. |
2020-03-23 |
2023-08-13 |
Not clear |
| Muhammad Adnan Bashir, Arif-Ullah Khan, Haroon Badshah, Edson Rodrigues-Filho, Zia Ud Din, Aslam Kha. Synthesis, characterization, molecular docking evaluation, antidepressant, and anti-Alzheimer effects of dibenzylidene ketone derivatives. Drug development research. vol 80. issue 5. 2020-01-27. PMID:30964563. |
both a1k1 and a2k2 showed high binding affinities against various proteins involved in depression and alzheimer's mechanisms like monoamine oxidase b, acetylcholinesterase, norepinephrine transporter 2, serotonin transporter, dopamine receptor, serotonin receptor modulator, and beta-amyloid targets. |
2020-01-27 |
2023-08-13 |
mouse |
| Caroline Lanthier, Hugo Payan, Irene Liparulo, Bérénice Hatat, Cédric Lecoutey, Marc Since, Audrey Davis, Christian Bergamini, Sylvie Claeysen, Patrick Dallemagne, Maria-Laura Bolognesi, Christophe Rochai. Novel multi target-directed ligands targeting 5-HT European journal of medicinal chemistry. vol 182. 2019-11-21. PMID:31419776. |
novel multi target-directed ligands targeting 5-ht facing the complexity of alzheimer's disease (ad), it is now currently admitted that a therapeutic pleiotropic intervention is needed to alter its progression. |
2019-11-21 |
2023-08-13 |
Not clear |
| Higgins, Kilpatric. 5-HT(3) receptor antagonists. Expert opinion on investigational drugs. vol 8. issue 12. 2019-11-20. PMID:11139847. |
many selective 5-ht(3) receptor antagonists have been developed; animal studies with such compounds suggested their potential therapeutic value in combating emesis and a wide range of cns diseases including anxiety, schizophrenia, drug dependence and alzheimer's disease. |
2019-11-20 |
2023-08-12 |
Not clear |
| William J Burke, David G Folks, William H Roccaforte, Steven P Wenge. Serotonin Reuptake Inhibitors for the Treatment of Coexisting Depression and Psychosis in Dementia of the Alzheimer Type. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 2. issue 4. 2019-11-20. PMID:28530986. |
serotonin reuptake inhibitors for the treatment of coexisting depression and psychosis in dementia of the alzheimer type. |
2019-11-20 |
2023-08-13 |
Not clear |