| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Davide Seripa, Marilisa Franceschi, Grazia D'Onofrio, Francesco Panza, Leandro Cascavilla, Francesco Paris, Giuliana Placentino, Maria Giovanna Matera, Vincenzo Solfrizzi, Alberto Pilott. Polymorphism C in the serotonin transporter gene (SLC6A4) in questionable dementia and Alzheimer's disease. Neuroscience letters. vol 438. issue 3. 2008-09-26. PMID:18490109. |
polymorphism c in the serotonin transporter gene (slc6a4) in questionable dementia and alzheimer's disease. |
2008-09-26 |
2023-08-12 |
human |
| E Marchetti, M Jacquet, H Jeltsch, M Migliorati, E Nivet, J C Cassel, F S Roma. Complete recovery of olfactory associative learning by activation of 5-HT4 receptors after dentate granule cell damage in rats. Neurobiology of learning and memory. vol 90. issue 1. 2008-09-03. PMID:18485752. |
activation of 5-ht(4) receptors by a selective agonist such as sl65.0155 might therefore provide an opportunity to reduce learning and memory deficits associated with temporal lobe damage, and could be useful for the symptomatic treatment of memory dysfunctions related to pathological aging such as alzheimer's disease. |
2008-09-03 |
2023-08-12 |
rat |
| Beatriz Marcos, Mónica García-Alloza, Francisco J Gil-Bea, Tsu T Chuang, Paul T Francis, Christopher P Chen, Shirley W T Y Tsang, Mitchell K P Lai, María J Ramire. Involvement of an altered 5-HT -{6} receptor function in behavioral symptoms of Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 14. issue 1. 2008-08-18. PMID:18525126. |
involvement of an altered 5-ht -{6} receptor function in behavioral symptoms of alzheimer's disease. |
2008-08-18 |
2023-08-12 |
Not clear |
| L Truchot, N Costes, L Zimmer, B Laurent, D Le Bars, C Thomas-Antérion, B Mercier, M Hermier, A Vighetto, P Krolak-Salmo. A distinct [18F]MPPF PET profile in amnestic mild cognitive impairment compared to mild Alzheimer's disease. NeuroImage. vol 40. issue 3. 2008-06-17. PMID:18313943. |
to date, two positron emission tomography (pet) studies have explored 5-ht(1a) receptor density in the hippocampus of alzheimer's disease (ad) patients. |
2008-06-17 |
2023-08-12 |
Not clear |
| Matthew S Milak, Alin J Severance, R Todd Ogden, Jaya Prabhakaran, J S Dileep Kumar, Vattoly J Majo, J John Mann, Ramin V Parse. Modeling considerations for 11C-CUMI-101, an agonist radiotracer for imaging serotonin 1A receptor in vivo with PET. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. vol 49. issue 4. 2008-05-30. PMID:18344443. |
several lines of evidence demonstrate involvement of serotonin 1a receptors (5-ht1ars) in the pathophysiology of neuropsychiatric disorders such as depression, suicidal behavior, schizophrenia, and alzheimer's disease. |
2008-05-30 |
2023-08-12 |
Not clear |
| Leea H Muhonen, Jouko Lönnqvist, Kati Juva, Hannu Alh. Double-blind, randomized comparison of memantine and escitalopram for the treatment of major depressive disorder comorbid with alcohol dependence. The Journal of clinical psychiatry. vol 69. issue 3. 2008-05-22. PMID:18348597. |
the efficacy of memantine, a noncompetitive glutamate n-methyl-d-aspartate (nmda)-receptor blocker used for the treatment of moderate to severe alzheimer's disease, was compared with that of escitalopram, a selective serotonin reuptake inhibitor antidepressant. |
2008-05-22 |
2023-08-12 |
Not clear |
| Sylvain J Robert, Frank Lezoualc'. Distinct functional effects of human 5-HT4 receptor isoforms on beta-amyloid secretion. Neuro-degenerative diseases. vol 5. issue 3-4. 2008-05-15. PMID:18322379. |
the serotonin 5-ht(4) receptor is of potential interest for the treatment of alzheimer's disease because it increases memory and learning and influences amyloid precursor protein (app) processing. |
2008-05-15 |
2023-08-12 |
human |
| Ninoslav Mimica, Dorotea Mück-Seler, Nela Pivac, Maja Mustapić, Martina Dezeljin, Tamara Stipcević, Paola Presecki, Elizabeta Radonić, Vera Folnegović-Smal. Platelet serotonin and monoamine oxidase in Alzheimer's disease with psychotic features. Collegium antropologicum. vol 32 Suppl 1. 2008-05-01. PMID:18405069. |
platelet serotonin and monoamine oxidase in alzheimer's disease with psychotic features. |
2008-05-01 |
2023-08-12 |
human |
| M Cachard-Chastel, S Devers, S Sicsic, M Langlois, F Lezoualc'h, A M Gardier, C Belzun. Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice. Behavioural brain research. vol 187. issue 2. 2008-04-07. PMID:18061284. |
it is known that 5-ht(4) receptor agonists increase sappalpha levels in the cortex and hippocampus of mice as well as in a model of alzheimer's disease (ad). |
2008-04-07 |
2023-08-12 |
mouse |
| Hye-Jung Kim, Munikumar Reddy Doddareddy, Hyunah Choo, Yong Seo Cho, Kyoung Tai No, Woo-Kyu Park, Ae Nim Pa. New serotonin 5-HT(6) ligands from common feature pharmacophore hypotheses. Journal of chemical information and modeling. vol 48. issue 1. 2008-04-02. PMID:18044950. |
serotonin 5-ht6 receptor antagonists are thought to play an important role in the treatment of psychiatry, alzheimer's disease, and probably obesity. |
2008-04-02 |
2023-08-12 |
Not clear |
| Antonia L Pritchard, Judith Harris, Colin W Pritchard, John Coates, Sayeed Haque, Roger Holder, Peter Bentham, Corinne L Lendo. Role of 5HT 2A and 5HT 2C polymorphisms in behavioural and psychological symptoms of Alzheimer's disease. Neurobiology of aging. vol 29. issue 3. 2008-03-27. PMID:17098333. |
role of 5ht 2a and 5ht 2c polymorphisms in behavioural and psychological symptoms of alzheimer's disease. |
2008-03-27 |
2023-08-12 |
Not clear |
| Akinori Ueki, Hideo Ueno, Noriko Sato, Hidetaka Shinjo, Yoshio Morit. Serotonin transporter gene polymorphism and BPSD in mild Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 12. issue 3. 2008-03-19. PMID:18057558. |
serotonin transporter gene polymorphism and bpsd in mild alzheimer's disease. |
2008-03-19 |
2023-08-12 |
Not clear |
| Akinori Ueki, Hideo Ueno, Noriko Sato, Hidetaka Shinjo, Yoshio Morit. Serotonin transporter gene polymorphism and BPSD in mild Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 12. issue 3. 2008-03-19. PMID:18057558. |
the purpose of the present study was to confirm an association of functional polymorphism within the serotonin transporter (5-htt) gene with alzheimer's disease (ad) and behavioral and psychological symptoms of dementia (bpsd) in mild ad. |
2008-03-19 |
2023-08-12 |
Not clear |
| J S Dileep Kumar, J John Man. PET tracers for 5-HT(1A) receptors and uses thereof. Drug discovery today. vol 12. issue 17-18. 2008-03-04. PMID:17826688. |
the serotonin 5-ht(1a) receptor is implicated in the pathophysiology of major neuropsychiatric disorders, including depression, suicidal behavior, panic disorder, epilepsy, bulimia, schizophrenia, parkinson's disease, and alzheimer's disease and is, therefore, an important target for drug therapy. |
2008-03-04 |
2023-08-12 |
Not clear |
| Maurizio Severino, Anja F Pedersen, Viktorija Trajkovska, Ellen Christensen, Rasmus Lohals, Lone M Veng, Gitte M Knudsen, Susana Azna. Selective immunolesion of cholinergic neurons leads to long-term changes in 5-HT2A receptor levels in hippocampus and frontal cortex. Neuroscience letters. vol 428. issue 1. 2008-02-25. PMID:17945418. |
although loss of cholinergic neurons in the basal forebrain is considered a key initial feature in alzheimer's disease (ad), changes in other transmitter systems, including serotonin and 5-ht(2a) receptors, are also associated with early ad. |
2008-02-25 |
2023-08-12 |
rat |
| Dean F Wong, Gerhard Gründer, James Robert Brasi. Brain imaging research: does the science serve clinical practice? International review of psychiatry (Abingdon, England). vol 19. issue 5. 2008-01-23. PMID:17896234. |
brain imaging research currently facilitates the elucidation of dysfunction of dopamine, serotonin, acetylcholine, and other substances in people with alzheimer's and parkinson's diseases, schizophrenia, alcoholism and other substance abuse disorders, attention deficit/hyperactivity disorder, and the syndromes of restless legs, lesch-nyhan, rett, and tourette. |
2008-01-23 |
2023-08-12 |
Not clear |
| Krista L Lanctôt, Doug F Hussey, Nathan Herrmann, Sandra E Black, Pablo M Rusjan, Alan A Wilson, Sylvain Houle, Nicole Kozloff, Nicholaas Paul L G Verhoeff, Shitij Kapu. A positron emission tomography study of 5-hydroxytryptamine-1A receptors in Alzheimer disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. vol 15. issue 10. 2008-01-02. PMID:17567932. |
postmortem studies suggest decreased 5-ht(1a) receptors in patients with alzheimer disease (ad), but this has not been confirmed in vivo. |
2008-01-02 |
2023-08-12 |
Not clear |
| Arash Mowla, Masoud Mosavinasab, Hasan Haghshenas, Afshin Borhani Haghigh. Does serotonin augmentation have any effect on cognition and activities of daily living in Alzheimer's dementia? A double-blind, placebo-controlled clinical trial. Journal of clinical psychopharmacology. vol 27. issue 5. 2008-01-02. PMID:17873681. |
does serotonin augmentation have any effect on cognition and activities of daily living in alzheimer's dementia? |
2008-01-02 |
2023-08-12 |
Not clear |
| Arash Mowla, Masoud Mosavinasab, Hasan Haghshenas, Afshin Borhani Haghigh. Does serotonin augmentation have any effect on cognition and activities of daily living in Alzheimer's dementia? A double-blind, placebo-controlled clinical trial. Journal of clinical psychopharmacology. vol 27. issue 5. 2008-01-02. PMID:17873681. |
the aim of this study is to survey the effect of serotonin augmentation on cognition and activities of daily living in patients with alzheimer's disease. |
2008-01-02 |
2023-08-12 |
Not clear |
| Antonia L Pritchard, Colin W Pritchard, Peter Bentham, Corinne L Lendo. Role of serotonin transporter polymorphisms in the behavioural and psychological symptoms in probable Alzheimer disease patients. Dementia and geriatric cognitive disorders. vol 24. issue 3. 2007-10-29. PMID:17690552. |
role of serotonin transporter polymorphisms in the behavioural and psychological symptoms in probable alzheimer disease patients. |
2007-10-29 |
2023-08-12 |
Not clear |