| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M K Lai, S W Tsang, J T Alder, J Keene, T Hope, M M Esiri, P T Francis, C P Che. Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer's disease. Psychopharmacology. vol 179. issue 3. 2005-08-18. PMID:15551121. |
loss of serotonin 5-ht2a receptors in the postmortem temporal cortex correlates with rate of cognitive decline in alzheimer's disease. |
2005-08-18 |
2023-08-12 |
Not clear |
| M K Lai, S W Tsang, J T Alder, J Keene, T Hope, M M Esiri, P T Francis, C P Che. Loss of serotonin 5-HT2A receptors in the postmortem temporal cortex correlates with rate of cognitive decline in Alzheimer's disease. Psychopharmacology. vol 179. issue 3. 2005-08-18. PMID:15551121. |
previous studies have demonstrated reductions of serotonin 5-ht 2a receptors in the neocortex of alzheimer's disease (ad) patients. |
2005-08-18 |
2023-08-12 |
Not clear |
| Nadine Norton, Michael J Owe. HTR2A: association and expression studies in neuropsychiatric genetics. Annals of medicine. vol 37. issue 2. 2005-08-11. PMID:16026119. |
over the last decade the gene encoding 5-hydroxytryptamine (serotonin) receptor 2a (htr2a) has been implicated as a functional candidate in many neuropsychiatric phenotypes including: schizophrenia, attention deficit hyperactivity disorder (adhd), affective disorders, eating disorders, anxiety disorders, obsessive-compulsive disorder, suicide and alzheimer's disease (ad). |
2005-08-11 |
2023-08-12 |
Not clear |
| Marjorie Maillet, Sylvain J Robert, Frank Lezoualc'. New insights into serotonin 5-HT4 receptors : a novel therapeutic target for Alzheimer's disease? Current Alzheimer research. vol 1. issue 2. 2005-07-21. PMID:15975071. |
new insights into serotonin 5-ht4 receptors : a novel therapeutic target for alzheimer's disease? |
2005-07-21 |
2023-08-12 |
Not clear |
| Sam Medhat Salah, Anna Katharina Jäge. Screening of traditionally used Lebanese herbs for neurological activities. Journal of ethnopharmacology. vol 97. issue 1. 2005-05-26. PMID:15652288. |
aqueous, ethanol and ethyl acetate extracts of seven lebanese plants that are used traditionally for neurological disorders as alzheimer's disease, epilepsy and affective disorders as depression were tested for inhibition of acetylcholinesterase and affinity to the gaba(a)-benzodiazepine site and to the serotonin transporter. |
2005-05-26 |
2023-08-12 |
Not clear |
| Sylvain Robert, Marjorie Maillet, Eric Morel, Jean-Marie Launay, Rodolphe Fischmeister, Luc Mercken, Frank Lezoualc'. Regulation of the amyloid precursor protein ectodomain shedding by the 5-HT4 receptor and Epac. FEBS letters. vol 579. issue 5. 2005-04-05. PMID:15710402. |
the serotonin 5-hydroxytryptamine (5-ht4) receptor is of potential interest for the treatment of alzheimer's disease because it increases memory and learning. |
2005-04-05 |
2023-08-12 |
Not clear |
| Rui Kan, Binbin Wang, Chuanfang Zhang, Ze Yang, Shun Ji, Zeping Lu, Chenguang Zheng, Feng Jin, Li Wan. Association of the HTR6 polymorphism C267T with late-onset Alzheimer's disease in Chinese. Neuroscience letters. vol 372. issue 1-2. 2005-01-14. PMID:15531082. |
and 5-ht(6) receptor gene (htr6) variants may be a genetic risk factor for late-onset alzheimer's disease (load). |
2005-01-14 |
2023-08-12 |
Not clear |
| Mark P Mattson, Stuart Maudsley, Bronwen Marti. BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders. Trends in neurosciences. vol 27. issue 10. 2004-11-30. PMID:15374669. |
impaired 5-ht and bdnf signaling is central to depression and anxiety disorders, but could also play important roles in the pathogenesis of several age-related disorders, including insulin resistance syndrome, alzheimer's disease and huntington's disease. |
2004-11-30 |
2023-08-12 |
Not clear |
| Frédéric Assal, Maricela Alarcón, Esther C Solomon, Donna Masterman, Daniel H Geschwind, Jeffrey L Cumming. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. Archives of neurology. vol 61. issue 8. 2004-09-07. PMID:15313842. |
association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in alzheimer disease. |
2004-09-07 |
2023-08-12 |
Not clear |
| Frédéric Assal, Maricela Alarcón, Esther C Solomon, Donna Masterman, Daniel H Geschwind, Jeffrey L Cumming. Association of the serotonin transporter and receptor gene polymorphisms in neuropsychiatric symptoms in Alzheimer disease. Archives of neurology. vol 61. issue 8. 2004-09-07. PMID:15313842. |
serotonin has been linked to neuropsychiatric symptoms in alzheimer disease, mainly agitation/aggression, depression, and psychosis. |
2004-09-07 |
2023-08-12 |
Not clear |
| Linda Chiu Wa Lam, Nelson Leung Sang Tang, Suk Ling Ma, Weimin Zhang, Helen Fung Kum Chi. 5-HT2A T102C receptor polymorphism and neuropsychiatric symptoms in Alzheimer's disease. International journal of geriatric psychiatry. vol 19. issue 6. 2004-07-23. PMID:15211529. |
to investigate the association between 5-ht(2a) receptor polymorphism and neuropsychiatric (np) symptoms in chinese elderly with alzheimer's disease (ad). |
2004-07-23 |
2023-08-12 |
Not clear |
| Yasuyuki Abe, Atsushi Aoyagi, Takao Hara, Kazumi Abe, Reina Yamazaki, Yoshihiro Kumagae, Shunji Naruto, Kazuo Koyama, Shinji Marumoto, Keiko Tago, Narihiro Toda, Kazuko Takami, Naho Yamada, Mayuko Ori, Hiroshi Kogen, Tsugio Kanek. Pharmacological characterization of RS-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of Alzheimer's disease. Journal of pharmacological sciences. vol 93. issue 1. 2004-07-09. PMID:14501158. |
pharmacological characterization of rs-1259, an orally active dual inhibitor of acetylcholinesterase and serotonin transporter, in rodents: possible treatment of alzheimer's disease. |
2004-07-09 |
2023-08-12 |
mouse |
| Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, Hiroshi Koge. A conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease. Bioorganic & medicinal chemistry. vol 11. issue 20. 2004-06-01. PMID:13129577. |
a conformational restriction approach to the development of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for alzheimer's disease. |
2004-06-01 |
2023-08-12 |
Not clear |
| M Garcia-Alloza, W D Hirst, C P L-H Chen, B Lasheras, P T Francis, M J Ramíre. Differential involvement of 5-HT(1B/1D) and 5-HT6 receptors in cognitive and non-cognitive symptoms in Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 29. issue 2. 2004-04-27. PMID:14571255. |
differential involvement of 5-ht(1b/1d) and 5-ht6 receptors in cognitive and non-cognitive symptoms in alzheimer's disease. |
2004-04-27 |
2023-08-12 |
Not clear |
| Klaus Schott, Jacques-Emmanuel Schaefer, Elke Richartz, Anil Batra, Beate Eusterschulte, Reinhild Klein, Peter Alfred Berg, Mathias Bartels, Karl Mann, Gerhard Buchkreme. Autoantibodies to serotonin in serum of patients with psychiatric disorders. Psychiatry research. vol 121. issue 1. 2004-04-21. PMID:14572623. |
antibodies to serotonin in serum were investigated by elisa in patients with paranoid schizophrenia (n=27), schizoaffective psychosis (n=38), depression (n=67), alzheimer's disease (n=21), chronic alcoholism (n=43), rheumatoid arthritis (n=25), and multiple sclerosis (n=16), and in healthy volunteers (n=60). |
2004-04-21 |
2023-08-12 |
human |
| Wieland Gsell, Gerd Jungkunz, Peter Riedere. Functional neurochemistry of Alzheimer's disease. Current pharmaceutical design. vol 10. issue 3. 2004-04-16. PMID:14754387. |
acetylcholine, serotonin, noradrenaline, dopamine, glutamate, and gaba in alzheimer's disease is presented. |
2004-04-16 |
2023-08-12 |
human |
| Monika Z Wrona, Xiang-Rong Jiang, Yashige Kotake, Glenn Dryhurs. Stability of the putative neurotoxin tryptamine-4,5-dione. Chemical research in toxicology. vol 16. issue 4. 2004-03-23. PMID:12703966. |
tryptamine-4,5-dione (1) is formed by oxidation of the neurotransmitter 5-hydroxytryptamine by reactive oxygen and reactive nitrogen species, and on the basis of in vitro and in vivo studies, it has been proposed to be a neurotoxin that may contribute to the selective neurodegeneration in alzheimer's disease and the serotonergic neurotoxicity of methamphetamine. |
2004-03-23 |
2023-08-12 |
Not clear |
| J Marksteiner, T Walch, T Bodner, P Gurka, E Donnemille. Fluoxetine in Alzheimer's disease with severe obsessive compulsive symptoms and a low density of serotonin transporter sites. Pharmacopsychiatry. vol 36. issue 5. 2004-03-12. PMID:14571357. |
fluoxetine in alzheimer's disease with severe obsessive compulsive symptoms and a low density of serotonin transporter sites. |
2004-03-12 |
2023-08-12 |
Not clear |
| Margrit Klingner, Jenny Apelt, Ashok Kumar, Dietlind Sorger, Osama Sabri, Jörg Steinbach, Matthias Scheunemann, Reinhard Schlieb. Alterations in cholinergic and non-cholinergic neurotransmitter receptor densities in transgenic Tg2576 mouse brain with beta-amyloid plaque pathology. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 21. issue 7. 2004-01-09. PMID:14599482. |
cholinergic deficits in alzheimer's disease are accompanied by a number of alterations in other transmitter systems including glutamate, noradrenaline and serotonin, suggesting the involvement also of other neurotransmitter systems in the pathogenesis of the disease. |
2004-01-09 |
2023-08-12 |
mouse |
| Narihiro Toda, Keiko Tago, Shinji Marumoto, Kazuko Takami, Mayuko Ori, Naho Yamada, Kazuo Koyama, Shunji Naruto, Kazumi Abe, Reina Yamazaki, Takao Hara, Atsushi Aoyagi, Yasuyuki Abe, Tsugio Kaneko, Hiroshi Koge. Design, synthesis and structure-activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for Alzheimer's disease. Bioorganic & medicinal chemistry. vol 11. issue 9. 2003-12-12. PMID:12670645. |
design, synthesis and structure-activity relationships of dual inhibitors of acetylcholinesterase and serotonin transporter as potential agents for alzheimer's disease. |
2003-12-12 |
2023-08-12 |
mouse |