| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Kunugi, A Ueki, M Otsuka, K Isse, H Hirasawa, N Kato, T Nabika, S Kobayashi, S Nank. Alzheimer's disease and 5-HTTLPR polymorphism of the serotonin transporter gene: no evidence for an association. American journal of medical genetics. vol 96. issue 3. 2000-08-10. PMID:10898905. |
recently two independent research groups consistently reported a significant association between the serotonin transporter (5-htt) gene and late-onset sporadic alzheimer's disease (ad). |
2000-08-10 |
2023-08-12 |
Not clear |
| P Zill, F Padberg, S de Jonge, H Hampel, K Bürger, S Stübner, T Boetsch, H Jürgen Möller, M Ackenheil, B Bond. Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients. Neuroscience letters. vol 284. issue 1-2. 2000-07-03. PMID:10771175. |
several studies have attempted to confirm an association between a deletion/insertion polymorphism within the promoter region of the serotonin transporter gene (5-htt) and alzheimer's disease independent from the apolipoprotein e (apoe) varepsilon4 status. |
2000-07-03 |
2023-08-12 |
Not clear |
| P Zill, F Padberg, S de Jonge, H Hampel, K Bürger, S Stübner, T Boetsch, H Jürgen Möller, M Ackenheil, B Bond. Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients. Neuroscience letters. vol 284. issue 1-2. 2000-07-03. PMID:10771175. |
we examined this deletion/insertion polymorphism of the serotonin transporter gene in a sample of 222 consecutively recruited gerontopsychiatric patients which was divided into four different diagnostic groups: alzheimer's disease (n=84), mild cognitive impairment (n=29), subjective cognitive complaints (n=49), depression/other psychiatric disorders (n=56) and 118 healthy, non-demented controls. |
2000-07-03 |
2023-08-12 |
Not clear |
| P Zill, F Padberg, S de Jonge, H Hampel, K Bürger, S Stübner, T Boetsch, H Jürgen Möller, M Ackenheil, B Bond. Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patients. Neuroscience letters. vol 284. issue 1-2. 2000-07-03. PMID:10771175. |
this finding indicates that the serotonin transporter does not appear to be a major susceptibility factor in the pathophysiology of alzheimer's disease and other psychogeriatric disorders. |
2000-07-03 |
2023-08-12 |
Not clear |
| R J Porter, B S Lunn, L L Walker, J M Gray, C G Ballard, J T O'Brie. Cognitive deficit induced by acute tryptophan depletion in patients with Alzheimer's disease. The American journal of psychiatry. vol 157. issue 4. 2000-04-20. PMID:10739429. |
the study assessed the effects on global cognitive function and mood of a reduction of brain serotonin by means of acute tryptophan depletion in 16 patients with dementia of the alzheimer type and in 16 cognitively intact comparison subjects. |
2000-04-20 |
2023-08-12 |
human |
| R Seidl, S T Kaehler, H Prast, N Singewald, N Cairns, M Gratzer, G Lube. Serotonin (5-HT) in brains of adult patients with Down syndrome. Journal of neural transmission. Supplementum. vol 57. 2000-04-12. PMID:10666678. |
as the serotonergic system plays a well known role in integrating emotion, cognition and motor function, serotonin (5-ht) and its main metabolite, 5-hydroxyindol-3-acetic acid (5-hiaa) were investigated in post-mortem tissue samples from temporal cortex, thalamus, caudate nucleus, occipital cortex and cerebellum of adult patients with ds, alzheimer's disease (ad) and controls by use of high performance liquid chromatography (hplc). |
2000-04-12 |
2023-08-12 |
Not clear |
| M K Osterlund, C Halldin, Y L Hur. Effects of chronic 17beta-estradiol treatment on the serotonin 5-HT(1A) receptor mRNA and binding levels in the rat brain. Synapse (New York, N.Y.). vol 35. issue 1. 2000-01-05. PMID:10579806. |
consequently, estradiol modulation of 5-ht(1a) receptor circuits might be a possible pathway for the estrogen influence in the expression of psychiatric and neurological disorders such as alzheimer's disease, affective disorders, and schizophrenia. |
2000-01-05 |
2023-08-12 |
rat |
| C C Meltzer, J C Price, C A Mathis, P J Greer, M N Cantwell, P R Houck, B H Mulsant, D Ben-Eliezer, B Lopresti, S T DeKosky, C F Reynold. PET imaging of serotonin type 2A receptors in late-life neuropsychiatric disorders. The American journal of psychiatry. vol 156. issue 12. 1999-12-14. PMID:10588399. |
to determine whether there are abnormalities in the in vivo status of the serotonin type 2a (5-ht2a) receptor in late-life depression and alzheimer's disease, the authors used positron emission tomography (pet) to assess patients with these two conditions and healthy subjects. |
1999-12-14 |
2023-08-12 |
human |
| G Fink, B Sumner, R Rosie, H Wilson, J McQuee. Androgen actions on central serotonin neurotransmission: relevance for mood, mental state and memory. Behavioural brain research. vol 105. issue 1. 1999-12-10. PMID:10553690. |
these findings are discussed in relation to the possible role of interactions between sex steroids and serotonin mechanisms in mood disorders, schizophrenia and alzheimer's disease. |
1999-12-10 |
2023-08-12 |
human |
| J R Oliveira, M Zat. The study of genetic polymorphisms related to serotonin in Alzheimer's disease: a new perspective in a heterogenic disorder. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. vol 32. issue 4. 1999-09-09. PMID:10347811. |
the study of genetic polymorphisms related to serotonin in alzheimer's disease: a new perspective in a heterogenic disorder. |
1999-09-09 |
2023-08-12 |
Not clear |
| J M Brezun, A Daszut. Depletion in serotonin decreases neurogenesis in the dentate gyrus and the subventricular zone of adult rats. Neuroscience. vol 89. issue 4. 1999-07-22. PMID:10362289. |
indeed, lack of 5-hydroxytryptamine in the hippocampus has been associated with cognitive disorders, such as depression, schizophrenia and alzheimer's disease. |
1999-07-22 |
2023-08-12 |
human |
| J Mintzer, O Brawman-Mintzer, D F Mirski, R Unger, P Nietert, A Meeks, R Sampso. Fenfluramine challenge test as a marker of serotonin activity in patients with Alzheimer's dementia and agitation. Biological psychiatry. vol 44. issue 9. 1999-05-04. PMID:9807649. |
fenfluramine challenge test as a marker of serotonin activity in patients with alzheimer's dementia and agitation. |
1999-05-04 |
2023-08-12 |
Not clear |
| J Mintzer, O Brawman-Mintzer, D F Mirski, R Unger, P Nietert, A Meeks, R Sampso. Fenfluramine challenge test as a marker of serotonin activity in patients with Alzheimer's dementia and agitation. Biological psychiatry. vol 44. issue 9. 1999-05-04. PMID:9807649. |
changes in serotonin (5-ht) have been described in both alzheimer's disease (ad) and aggressive/agitated behaviors. |
1999-05-04 |
2023-08-12 |
Not clear |
| A Menese. Physiological, pathophysiological and therapeutic roles of 5-HT systems in learning and memory. Reviews in the neurosciences. vol 9. issue 4. 1999-03-23. PMID:9886142. |
emerging evidence also indicates that 5-ht1a and 5-ht4 receptor agonists, as well as, 5-ht1a antagonists, 5-ht2 antagonists, 5-ht3 antagonists and 5-ht uptake inhibitors may have therapeutic utility in the treatment of alzheimer's disease and amnesia. |
1999-03-23 |
2023-08-12 |
Not clear |
| L Naylor, B Dean, A Pereira, A Mackinnon, A Kouzmenko, D Copolo. No association between the serotonin transporter-linked promoter region polymorphism and either schizophrenia or density of the serotonin transporter in human hippocampus. Molecular medicine (Cambridge, Mass.). vol 4. issue 10. 1999-03-04. PMID:9848084. |
allelic association case-control analysis of a deletion/insertion polymorphism in the serotonin transporter-linked polymorphic region (5-httlpr) has suggested associations with unipolar disorder, bipolar disorder, depression, and alzheimer's disease. |
1999-03-04 |
2023-08-12 |
human |
| S Bonaccorso, A Lin, C Song, R Verkerk, G Kenis, E Bosmans, S Scharpe, M Vandewoude, A Dossche, M Mae. Serotonin-immune interactions in elderly volunteers and in patients with Alzheimer's disease (DAT): lower plasma tryptophan availability to the brain in the elderly and increased serum interleukin-6 in DAT. Aging (Milan, Italy). vol 10. issue 4. 1999-02-16. PMID:9825023. |
the aims of this study were to examine the plasma availability of tryptophan, the precursor of 5-hydroxytryptamine (5-ht), and serum cytokines, such as interleukin-6 (il-6) and il-8, in normal elderly volunteers and in patients with alzheimer's disease (dat). |
1999-02-16 |
2023-08-12 |
human |
| J R Oliveira, R M Gallindo, L G Maia, P R Brito-Marques, P A Otto, M R Passos-Bueno, M A Morais, M Zat. The short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset Alzheimer's disease. Molecular psychiatry. vol 3. issue 5. 1998-12-14. PMID:9774779. |
the short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset alzheimer's disease. |
1998-12-14 |
2023-08-12 |
human |
| J R Oliveira, R M Gallindo, L G Maia, P R Brito-Marques, P A Otto, M R Passos-Bueno, M A Morais, M Zat. The short variant of the polymorphism within the promoter region of the serotonin transporter gene is a risk factor for late onset Alzheimer's disease. Molecular psychiatry. vol 3. issue 5. 1998-12-14. PMID:9774779. |
we analyzed a deletion/insertion polymorphism within the promoter region of the serotonin transporter gene (5-httplr) in 81 patients with late onset alzheimer's (ad) disease (mean age 70.02 +/- 8.13 years). |
1998-12-14 |
2023-08-12 |
human |
| M A Raskin. Psychopharmacology of noncognitive abnormal behaviors in Alzheimer's disease. The Journal of clinical psychiatry. vol 59 Suppl 9. 1998-08-28. PMID:9720484. |
trials of serotonin selective reuptake inhibitors suggest they may be effective for emotional disturbances complicating alzheimer's disease. |
1998-08-28 |
2023-08-12 |
Not clear |
| C C Meltzer, G Smith, S T DeKosky, B G Pollock, C A Mathis, R Y Moore, D J Kupfer, C F Reynold. Serotonin in aging, late-life depression, and Alzheimer's disease: the emerging role of functional imaging. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 18. issue 6. 1998-06-23. PMID:9571651. |
serotonin in aging, late-life depression, and alzheimer's disease: the emerging role of functional imaging. |
1998-06-23 |
2023-08-12 |
human |