| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| J R Seckl, K L French, D O'Donnell, M J Meaney, N P Nair, C M Yates, G Fin. Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease. Brain research. Molecular brain research. vol 18. issue 3. 1993-06-24. PMID:8497185. |
glucocorticoid receptor gene expression is unaltered in hippocampal neurons in alzheimer's disease. |
1993-06-24 |
2023-08-12 |
human |
| J R Seckl, K L French, D O'Donnell, M J Meaney, N P Nair, C M Yates, G Fin. Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease. Brain research. Molecular brain research. vol 18. issue 3. 1993-06-24. PMID:8497185. |
however, we have recently found that lesions of the cholinergic innervation of the hippocampus--known to be severely affected in alzheimer's disease--increase corticosteroid receptor gene expression in the rat hippocampus. |
1993-06-24 |
2023-08-12 |
human |
| J R Seckl, K L French, D O'Donnell, M J Meaney, N P Nair, C M Yates, G Fin. Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease. Brain research. Molecular brain research. vol 18. issue 3. 1993-06-24. PMID:8497185. |
we have now examined both glucocorticoid (gr) and mineralocorticoid (mr) receptor gene expression in individual neurons in human postmortem hippocampus, using in situ hybridization histochemistry in 5 patients with alzheimer's disease (81 +/- 3 years) and 7 controls (81 +/- 7 years) without neurological disease. |
1993-06-24 |
2023-08-12 |
human |
| J R Seckl, K L French, D O'Donnell, M J Meaney, N P Nair, C M Yates, G Fin. Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease. Brain research. Molecular brain research. vol 18. issue 3. 1993-06-24. PMID:8497185. |
the distribution and intensity of mr and gr mrna expression in the hippocampus of alzheimer's disease were similar to that in control tissue, with high expression in dentate gyrus and ca2-4, but significantly lower expression in ca1. |
1993-06-24 |
2023-08-12 |
human |
| J R Seckl, K L French, D O'Donnell, M J Meaney, N P Nair, C M Yates, G Fin. Glucocorticoid receptor gene expression is unaltered in hippocampal neurons in Alzheimer's disease. Brain research. Molecular brain research. vol 18. issue 3. 1993-06-24. PMID:8497185. |
these data do not suggest a primary deficiency of biosynthesis of hippocampal corticosteroid receptors in alzheimer's disease. |
1993-06-24 |
2023-08-12 |
human |
| D W Dickson, W K Liu, Y Kress, J Ku, O DeJesus, S H Ye. Phosphorylated tau immunoreactivity of granulovacuolar bodies (GVB) of Alzheimer's disease: localization of two amino terminal tau epitopes in GVB. Acta neuropathologica. vol 85. issue 5. 1993-06-15. PMID:7684177. |
an immunocytochemical study of alzheimer's disease hippocampus with a panel of anti-tau antibodies revealed two antibodies that stained granulovacuolar bodies (gvb) in pyramidal neurons of ammon's horn. |
1993-06-15 |
2023-08-12 |
human |
| P A Lapchak, D M Araujo, F Heft. Systemic interleukin-1 beta decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation. Neuroscience. vol 53. issue 2. 1993-06-11. PMID:8492907. |
thus, if the same occurs in vivo, it is possible that the accumulation of interleukin-1 in alzheimer's disease hippocampus may be responsible for altered hippocampal neuron synaptic plasticity. |
1993-06-11 |
2023-08-12 |
rat |
| P A Lapchak, D M Araujo, F Heft. Systemic interleukin-1 beta decreases brain-derived neurotrophic factor messenger RNA expression in the rat hippocampal formation. Neuroscience. vol 53. issue 2. 1993-06-11. PMID:8492907. |
the reason(s) for the decrease of brain-derived neurotrophic factor mrna is not known, but one possibility may be associated with the enhanced expression of interleukin-1 in the hippocampus of alzheimer's disease patients. |
1993-06-11 |
2023-08-12 |
rat |
| Y Maneesub, Y Sanvarinda, P Govitrapon. Partial restoration of choline acetyltransferase activities in aging and AF64A-lesioned rat brains by vitamin E. Neurochemistry international. vol 22. issue 5. 1993-06-10. PMID:8485454. |
partial restoration of choline acetyltransferase activities in aging and af64a-lesioned rat brains by vitamin e. it has been suggested that the activity of the enzyme responsible for the synthesis of acetylcholine, choline acetyltransferase (chat), is substantially reduced in the neocortex and hippocampus of alzheimer's and other aging brains. |
1993-06-10 |
2023-08-12 |
rat |
| M K Sutherland, L Wong, M J Somerville, L K Yoong, C Bergeron, M Parmentier, D R McLachla. Reduction of calbindin-28k mRNA levels in Alzheimer as compared to Huntington hippocampus. Brain research. Molecular brain research. vol 18. issue 1-2. 1993-05-21. PMID:8479289. |
reduction of calbindin-28k mrna levels in alzheimer as compared to huntington hippocampus. |
1993-05-21 |
2023-08-12 |
Not clear |
| M K Sutherland, L Wong, M J Somerville, L K Yoong, C Bergeron, M Parmentier, D R McLachla. Reduction of calbindin-28k mRNA levels in Alzheimer as compared to Huntington hippocampus. Brain research. Molecular brain research. vol 18. issue 1-2. 1993-05-21. PMID:8479289. |
mrna levels for calbindin-28k were reduced by 35% in ca1 and ca2 regions of alzheimer hippocampus, as compared to huntington control. |
1993-05-21 |
2023-08-12 |
Not clear |
| B Lemmer, L Langer, T Ohm, J Boh. Beta-adrenoceptor density and subtype distribution in cerebellum and hippocampus from patients with Alzheimer's disease. Naunyn-Schmiedeberg's archives of pharmacology. vol 347. issue 2. 1993-05-20. PMID:8097284. |
beta-adrenoceptor density and subtype distribution in cerebellum and hippocampus from patients with alzheimer's disease. |
1993-05-20 |
2023-08-12 |
Not clear |
| N J Cairns, A Chadwick, P L Lantos, R Levy, M N Rosso. Beta A4 protein deposition in familial Alzheimer's disease with the mutation in codon 717 of the beta A4 amyloid precursor protein gene and sporadic Alzheimer's disease. Neuroscience letters. vol 149. issue 2. 1993-05-17. PMID:8474686. |
beta a4 protein immunoreactivity in the neocortex and hippocampus of familial alzheimer's disease (ad) including the case with the beta a4 amyloid precursor protein (app) gene mutation in codon 717 (app717 val-->ile) and sporadic cases of ad is described. |
1993-05-17 |
2023-08-12 |
Not clear |
| b' R J Mayer, J Lowe, M Landon, H McDermott, L L\\xc3\\xa1szl\\xc3\\xb. The role of protein ubiquitination in neurodegenerative disease. Acta biologica Hungarica. vol 42. issue 1-3. 1993-04-21. PMID:1668896.' |
ubiquitin-protein conjugates are also found in vacuoles in areas of granulovacuolar degeneration in hippocampal neurones in alzheimer's disease and in granulovacuoles in neurones of scrapie infected mouse brain. |
1993-04-21 |
2023-08-11 |
mouse |
| E Masliah, M Mallory, L Hansen, M Alford, R DeTeresa, R Terr. An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease. The American journal of pathology. vol 142. issue 3. 1993-04-16. PMID:8456946. |
we studied axonal damage in alzheimer's disease frontal cortex and hippocampus with a novel monoclonal antibody (smi 312) against phosphorylated neurofilaments. |
1993-04-16 |
2023-08-12 |
Not clear |
| J Ułas, L C Brunner, L Nguyen, C W Cotma. Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in Alzheimer hippocampus: a quantitative autoradiographic study. Neuroscience. vol 52. issue 4. 1993-04-15. PMID:8450977. |
reduced density of adenosine a1 receptors and preserved coupling of adenosine a1 receptors to g proteins in alzheimer hippocampus: a quantitative autoradiographic study. |
1993-04-15 |
2023-08-12 |
human |
| J Ułas, L C Brunner, L Nguyen, C W Cotma. Reduced density of adenosine A1 receptors and preserved coupling of adenosine A1 receptors to G proteins in Alzheimer hippocampus: a quantitative autoradiographic study. Neuroscience. vol 52. issue 4. 1993-04-15. PMID:8450977. |
binding to adenosine a1 receptors and the status of their coupling to g proteins were studied in the hippocampus and parahippocampal gyrus of alzheimer individuals and age-matched controls. |
1993-04-15 |
2023-08-12 |
human |
| A Blokland, J Jolle. Spatial learning deficit and reduced hippocampal ChAT activity in rats after an ICV injection of streptozotocin. Pharmacology, biochemistry, and behavior. vol 44. issue 2. 1993-04-07. PMID:8446683. |
the correlation between spatial discrimination performance in the morris task and the decrease in hippocampal chat activity resembles the relation between cognitive and biochemical changes observed in alzheimer's disease. |
1993-04-07 |
2023-08-12 |
rat |
| M Xu, H Shibayama, H Kobayashi, K Yamada, R Ishihara, P Zhao, T Takeuchi, K Yoshida, T Inagaki, K Nokur. Granulovacuolar degeneration in the hippocampal cortex of aging and demented patients--a quantitative study. Acta neuropathologica. vol 85. issue 1. 1993-03-11. PMID:1285490. |
the occurrence and topographic analysis of granulovacuolar degeneration (gvd) in the hippocampal cortex of mentally normal controls (75 cases) and patients with alzheimer's dementia (ad; 17 cases which included alzheimer's disease and senile dementia of alzheimer type), multi-infarct dementia (mid; 16 cases), pick's disease (pd; 5 cases) and atypical dementia [5 cases; non-alzheimer, non-pick dementia with fahr's syndrome (nanpdf)] were investigated. |
1993-03-11 |
2023-08-11 |
human |
| D G Munoz, D Wang, B D Greenber. Hirano bodies accumulate C-terminal sequences of beta-amyloid precursor protein (beta-APP) epitopes. Journal of neuropathology and experimental neurology. vol 52. issue 1. 1993-03-02. PMID:7678852. |
in cryostat sections of the hippocampus from both alzheimer's disease and normal patients, hb were decorated by two antisera raised against different sequences of the cytoplasmic domain of beta-amyloid precursor protein (beta-app), and two antisera against the beta/a4 sequence of beta-app, but not by two antisera directed against ectodomain (n-terminal) sequences of beta-app. |
1993-03-02 |
2023-08-12 |
Not clear |