| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| W Wallace, V Haroutunia. Using the subcortically lesioned rat cortex to understand the physiological role of amyloid precursor protein. Behavioural brain research. vol 57. issue 2. 1994-04-06. PMID:8117425. |
alzheimer's disease pathology is characterized by the presence of neuritic plaques and neurofibrillary tangles and specific neurotransmitter deficits in the cortex and hippocampus. |
1994-04-06 |
2023-08-12 |
mouse |
| C Bancher, H Braak, P Fischer, K A Jellinge. Neuropathological staging of Alzheimer lesions and intellectual status in Alzheimer's and Parkinson's disease patients. Neuroscience letters. vol 162. issue 1-2. 1994-04-04. PMID:8121624. |
in both alzheimer's disease (ad) and parkinson's disease (pd), neurofibrillary tangles (nft), in contrast to amyloid deposits, show a hierarchical spreading pattern from the allocortex to isocortical association areas with early involvement of the entorhinal region, a major relay station between hippocampus and isocortex. |
1994-04-04 |
2023-08-12 |
human |
| W A Dornan, D E Kang, A McCampbell, E E Kan. Bilateral injections of beta A(25-35) + IBO into the hippocampus disrupts acquisition of spatial learning in the rat. Neuroreport. vol 5. issue 2. 1994-03-31. PMID:8111004. |
focal deposits of beta-amyloid (beta a) in the hippocampus have been implicated in alzheimer's disease. |
1994-03-31 |
2023-08-12 |
rat |
| L Svennerholm, C G Gottfrie. Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II). Journal of neurochemistry. vol 62. issue 3. 1994-03-28. PMID:8113790. |
major membrane lipids were quantified in frontal (brodmann area 9) and temporal (brodmann areas 21 and 22) cortices, caudate nucleus, hippocampus, and frontal white matter of 12 cases with alzheimer's disease (ad) type i (early onset), 21 cases with ad type ii (late onset), and 20 age-matched controls. |
1994-03-28 |
2023-08-12 |
Not clear |
| M Ikeda, H Tanabe, Y Nakagawa, H Kazui, H Oi, H Yamazaki, K Harada, T Nishimur. MRI-based quantitative assessment of the hippocampal region in very mild to moderate Alzheimer's disease. Neuroradiology. vol 36. issue 1. 1994-03-22. PMID:8108005. |
mri-based quantitative assessment of the hippocampal region in very mild to moderate alzheimer's disease. |
1994-03-22 |
2023-08-12 |
Not clear |
| M Ikeda, H Tanabe, Y Nakagawa, H Kazui, H Oi, H Yamazaki, K Harada, T Nishimur. MRI-based quantitative assessment of the hippocampal region in very mild to moderate Alzheimer's disease. Neuroradiology. vol 36. issue 1. 1994-03-22. PMID:8108005. |
we investigated the hippocampal region in six patients diagnosed with possible alzheimer's disease (ad), eight patients with probable ad, and eight age-matched controls, using a high-resolution magnetic resonance imaging technique. |
1994-03-22 |
2023-08-12 |
Not clear |
| A D Snow, R T Sekiguchi, D Nochlin, R N Kalaria, K Kimat. Heparan sulfate proteoglycan in diffuse plaques of hippocampus but not of cerebellum in Alzheimer's disease brain. The American journal of pathology. vol 144. issue 2. 1994-03-17. PMID:8311117. |
heparan sulfate proteoglycan in diffuse plaques of hippocampus but not of cerebellum in alzheimer's disease brain. |
1994-03-17 |
2023-08-12 |
Not clear |
| D Nochlin, G van Belle, T D Bird, S M Sum. Comparison of the severity of neuropathologic changes in familial and sporadic Alzheimer's disease. Alzheimer disease and associated disorders. vol 7. issue 4. 1994-03-11. PMID:8305189. |
we compared the density of neurofibrillary tangles (nt) and neuritic (senile) plaques (np) in 10 cortical areas, the amygdala, the hippocampus, the parahippocampal gyrus, and the cerebellum in patients with familial (fad) and sporadic (sad) alzheimer's disease with early (< 55 years), intermediate (55-70 years) and late (> 70 years) ages of onset of dementia and age-matched controls. |
1994-03-11 |
2023-08-12 |
Not clear |
| R A Armstrong, D Myers, C U Smit. The ratio of diffuse to mature beta/A4 deposits in Alzheimer's disease varies in cases with and without pronounced congophilic angiopathy. Dementia (Basel, Switzerland). vol 4. issue 5. 1994-01-27. PMID:8261022. |
the density of diffuse, primitive, classic and compact beta/a4 deposits was estimated in the cortex and hippocampus in alzheimer's disease (ad) cases with and without pronounced congophilic angiopathy (ca). |
1994-01-27 |
2023-08-12 |
Not clear |
| B M Ross, M McLaughlin, M Roberts, G Milligan, J McCulloch, J T Knowle. Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease. Brain research. vol 622. issue 1-2. 1994-01-06. PMID:8242380. |
however the activity of the g-protein associated enzyme, high affinity gtpase, was found to be reduced in the frontal cortex (reduced by 25%) and by a similar magnitude in the hippocampus (reduced by 27%) of alzheimer subjects. |
1994-01-06 |
2023-08-12 |
human |
| B M Ross, M McLaughlin, M Roberts, G Milligan, J McCulloch, J T Knowle. Alterations in the activity of adenylate cyclase and high affinity GTPase in Alzheimer's disease. Brain research. vol 622. issue 1-2. 1994-01-06. PMID:8242380. |
basal enzyme activity was not significantly altered in alzheimer diseased hippocampus, but was markedly reduced (by 45%) in the frontal cortex. |
1994-01-06 |
2023-08-12 |
human |
| R M Booze, C F Mactutus, C R Gutman, J N Davi. Frequency analysis of catecholamine axonal morphology in human brain. II. Alzheimer's disease and hippocampal sympathetic ingrowth. Journal of the neurological sciences. vol 119. issue 1. 1994-01-05. PMID:7902423. |
alzheimer's disease and hippocampal sympathetic ingrowth. |
1994-01-05 |
2023-08-12 |
human |
| R M Booze, C F Mactutus, C R Gutman, J N Davi. Frequency analysis of catecholamine axonal morphology in human brain. II. Alzheimer's disease and hippocampal sympathetic ingrowth. Journal of the neurological sciences. vol 119. issue 1. 1994-01-05. PMID:7902423. |
the axon classification from patients with alzheimer's disease significantly differed from those of an age-matched control population in the hippocampus. |
1994-01-05 |
2023-08-12 |
human |
| R M Booze, C F Mactutus, C R Gutman, J N Davi. Frequency analysis of catecholamine axonal morphology in human brain. II. Alzheimer's disease and hippocampal sympathetic ingrowth. Journal of the neurological sciences. vol 119. issue 1. 1994-01-05. PMID:7902423. |
these selective quantitative shifts in hippocampal catecholaminergic axon morphology are consistent with the hypothesis that sympathetic noradrenergic axons invade the hippocampus of patients with alzheimer's disease. |
1994-01-05 |
2023-08-12 |
human |
| R M Booze, C F Mactutus, C R Gutman, J N Davi. Frequency analysis of catecholamine axonal morphology in human brain. II. Alzheimer's disease and hippocampal sympathetic ingrowth. Journal of the neurological sciences. vol 119. issue 1. 1994-01-05. PMID:7902423. |
in summary, the use of quantitative neuroanatomical measures of catecholamine axonal morphologies in alzheimer's disease brain tissue identified a specific frequency shift which may represent hippocampal sympathetic ingrowth and this unique measure was found to have predictive utility with respect to alzheimer's disease. |
1994-01-05 |
2023-08-12 |
human |
| K R Brunden, N J Richter-Cook, N Chaturvedi, R C Frederickso. pH-dependent binding of synthetic beta-amyloid peptides to glycosaminoglycans. Journal of neurochemistry. vol 61. issue 6. 1993-12-23. PMID:8245966. |
the senile plaques found within the cerebral cortex and hippocampus of the alzheimer disease brain contain beta-amyloid peptide (a beta) fibrils that are associated with a variety of macromolecular species, including dermatan sulfate proteoglycan and heparan sulfate proteoglycan. |
1993-12-23 |
2023-08-12 |
Not clear |
| P C May, L N Boggs, K S Fuso. Neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to Alzheimer's disease amyloid-beta neurotoxicity. Journal of neurochemistry. vol 61. issue 6. 1993-12-23. PMID:8245987. |
neurotoxicity of human amylin in rat primary hippocampal cultures: similarity to alzheimer's disease amyloid-beta neurotoxicity. |
1993-12-23 |
2023-08-12 |
human |
| G Bartzokis, J Mintz, P Marx, D Osborn, D Gutkind, F Chiang, C K Phelan, S R Marde. Reliability of in vivo volume measures of hippocampus and other brain structures using MRI. Magnetic resonance imaging. vol 11. issue 7. 1993-12-16. PMID:8231683. |
volume reductions of the hippocampus are associated with alzheimer's disease, schizophrenia, and epilepsy. |
1993-12-16 |
2023-08-12 |
human |
| K L Jansen, R L Faull, P Storey, R A Lesli. Loss of sigma binding sites in the CA1 area of the anterior hippocampus in Alzheimer's disease correlates with CA1 pyramidal cell loss. Brain research. vol 623. issue 2. 1993-12-13. PMID:8221112. |
loss of sigma binding sites in the ca1 area of the anterior hippocampus in alzheimer's disease correlates with ca1 pyramidal cell loss. |
1993-12-13 |
2023-08-12 |
Not clear |
| N A Simonian, B T Hyma. Functional alterations in Alzheimer's disease: diminution of cytochrome oxidase in the hippocampal formation. Journal of neuropathology and experimental neurology. vol 52. issue 6. 1993-12-08. PMID:8229076. |
using cytochrome oxidase histochemistry, we found a change in the distribution of cytochrome oxidase in the molecular layer of the dentate gyrus and a decrease in activity in both the dentate gyrus and hippocampal subfields in alzheimer's disease. |
1993-12-08 |
2023-08-12 |
Not clear |