| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| F E Murray, J P Landsberg, R J Williams, M M Esiri, F Wat. Elemental analysis of neurofibrillary tangles in Alzheimer's disease using proton-induced X-ray analysis. Ciba Foundation symposium. vol 169. 1993-02-26. PMID:1490423. |
we have investigated the elemental content of hippocampal slices from normal human brain and from brains of alzheimer's disease patients by x-ray fluorescence using both electron and proton beam microprobes. |
1993-02-26 |
2023-08-11 |
human |
| K M Schegg, L S Harrington, S Neilsen, R M Zweig, J H Peacoc. Soluble and membrane-bound forms of brain acetylcholinesterase in Alzheimer's disease. Neurobiology of aging. vol 13. issue 6. 1993-02-26. PMID:1491735. |
in order to determine the effect of alzheimer's disease on the relative distribution of soluble and membrane-bound molecular forms of acetylcholinesterase (ache) in the brain, postmortem samples (delay interval less than 12 h) were obtained from parietal cortex (brodmann area 40) and hippocampus as well as the areas containing their respective projection nuclei, i.e., substantia innominata and septal nucleus, in 9 patients with alzheimer's disease (ad) and 4 normal controls. |
1993-02-26 |
2023-08-11 |
Not clear |
| C T Huesgen, P C Burger, B J Crain, G A Johnso. In vitro MR microscopy of the hippocampus in Alzheimer's disease. Neurology. vol 43. issue 1. 1993-02-23. PMID:8423879. |
in vitro mr microscopy of the hippocampus in alzheimer's disease. |
1993-02-23 |
2023-08-12 |
Not clear |
| C T Huesgen, P C Burger, B J Crain, G A Johnso. In vitro MR microscopy of the hippocampus in Alzheimer's disease. Neurology. vol 43. issue 1. 1993-02-23. PMID:8423879. |
we used mr microscopy at 7 tesla to identify the anatomy of the degenerating hippocampus in alzheimer's disease (ad), which we then correlated with the histopathologic findings in the same specimens. |
1993-02-23 |
2023-08-12 |
Not clear |
| P W Landfield, O Thibault, M L Mazzanti, N M Porter, D S Ker. Mechanisms of neuronal death in brain aging and Alzheimer's disease: role of endocrine-mediated calcium dyshomeostasis. Journal of neurobiology. vol 23. issue 9. 1993-01-28. PMID:1469387. |
this paper reviews evidence that brain aging and alzheimer's disease (ad) are somehow closely related and that the hippocampus (ca1) is highly vulnerable to cell loss under both conditions. |
1993-01-28 |
2023-08-11 |
Not clear |
| A B Youn. Role of excitotoxins in heredito-degenerative neurologic diseases. Research publications - Association for Research in Nervous and Mental Disease. vol 71. 1993-01-26. PMID:8093331. |
in alzheimer's disease, the cerebral cortex and hippocampus are dependent on eaaergic neurotransmission for normal function. |
1993-01-26 |
2023-08-12 |
Not clear |
| G J Brewer, J W Ashfor. Human serum stimulates Alzheimer markers in cultured hippocampal neurons. Journal of neuroscience research. vol 33. issue 3. 1993-01-25. PMID:1335088. |
human serum stimulates alzheimer markers in cultured hippocampal neurons. |
1993-01-25 |
2023-08-11 |
human |
| A Sato, Y Sat. Regulation of regional cerebral blood flow by cholinergic fibers originating in the basal forebrain. Neuroscience research. vol 14. issue 4. 1993-01-14. PMID:1334245. |
we propose through this review that although studies investigating neural regulation of cortical and hippocampal blood flow by cholinergic fibers originating in the basal forebrain have added much to the understanding of regulation of regional cerebral blood flow further studies are needed to determine the physiological relevance of regional cerebral blood flow in relation to higher nervous functions such as memory, learning, and personality, and changes in these cognitive functions with aging and pathology such as alzheimer's disease. |
1993-01-14 |
2023-08-11 |
Not clear |
| J M Kerwin, C M Morris, R H Perry, E K Perr. Hippocampal nerve growth factor receptor immunoreactivity in patients with Alzheimer's and Parkinson's disease. Neuroscience letters. vol 143. issue 1-2. 1992-12-23. PMID:1436650. |
hippocampal nerve growth factor receptor immunoreactivity in patients with alzheimer's and parkinson's disease. |
1992-12-23 |
2023-08-11 |
human |
| J M Kerwin, C M Morris, R H Perry, E K Perr. Hippocampal nerve growth factor receptor immunoreactivity in patients with Alzheimer's and Parkinson's disease. Neuroscience letters. vol 143. issue 1-2. 1992-12-23. PMID:1436650. |
using the monoclonal antibody, me 20.4, against the p75 nerve growth factor (ngf) receptor, ngf receptor-like immunoreactivity has been identified in axonal processes innervating the human hippocampus, where previously a loss of reactivity has been reported in a preliminary study of alzheimer's disease [10]. |
1992-12-23 |
2023-08-11 |
human |
| A Kammesheidt, F M Boyce, A F Spanoyannis, B J Cummings, M Ortegón, C Cotman, J L Vaught, R L Nev. Deposition of beta/A4 immunoreactivity and neuronal pathology in transgenic mice expressing the carboxyl-terminal fragment of the Alzheimer amyloid precursor in the brain. Proceedings of the National Academy of Sciences of the United States of America. vol 89. issue 22. 1992-12-23. PMID:1438289. |
in addition, immunocytochemical analysis of the brains with an antibody to the carboxyl terminus of beta app revealed abnormal aggregation of this epitope of beta app within vesicular structures in the cytoplasm and in abnormal-appearing neurites in the ca2/3 region of the hippocampus in transgenic mice, similar to its aggregation in the cells of alzheimer disease brains. |
1992-12-23 |
2023-08-11 |
mouse |
| P Scheltens, D Leys, F Barkhof, D Huglo, H C Weinstein, P Vermersch, M Kuiper, M Steinling, E C Wolters, J Val. Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal ageing: diagnostic value and neuropsychological correlates. Journal of neurology, neurosurgery, and psychiatry. vol 55. issue 10. 1992-12-04. PMID:1431963. |
magnetic resonance imaging (mri) has shown a great reduction in medial temporal lobe and hippocampal volume of patients with alzheimer's disease as compared to controls. |
1992-12-04 |
2023-08-11 |
Not clear |
| J S Davidson, R L West, P Kotikalapudi, L E Marou. Sequence and methylation in the beta/A4 region of the rabbit amyloid precursor protein gene. Biochemical and biophysical research communications. vol 188. issue 2. 1992-12-04. PMID:1445331. |
alzheimer's disease is characterized by the accumulation of the beta/a4 fragment of the amyloid precursor protein in the hippocampal regions of the brain. |
1992-12-04 |
2023-08-11 |
human |
| J P Landsberg, B McDonald, F Wat. Absence of aluminium in neuritic plaque cores in Alzheimer's disease. Nature. vol 360. issue 6399. 1992-12-01. PMID:1436075. |
alzheimer's disease is neuropathologically characterized by the occurrence of a minimum density of neurofibrillary tangles and neuritic plaques in the hippocampus and the association cortex of the brain. |
1992-12-01 |
2023-08-11 |
Not clear |
| M Ikeda, D Dewar, J McCulloc. A correlative study of calcium channel antagonist binding and local neuropathological features in the hippocampus in Alzheimer's disease. Brain research. vol 589. issue 2. 1992-11-25. PMID:1327415. |
a correlative study of calcium channel antagonist binding and local neuropathological features in the hippocampus in alzheimer's disease. |
1992-11-25 |
2023-08-11 |
human |
| M Ikeda, D Dewar, J McCulloc. A correlative study of calcium channel antagonist binding and local neuropathological features in the hippocampus in Alzheimer's disease. Brain research. vol 589. issue 2. 1992-11-25. PMID:1327415. |
[3h]pn200-110 binding sites were studied by means of quantitative autoradiography in hippocampal sections of patients with alzheimer's disease and age-matched control subjects. |
1992-11-25 |
2023-08-11 |
human |
| M Ikeda, D Dewar, J McCulloc. A correlative study of calcium channel antagonist binding and local neuropathological features in the hippocampus in Alzheimer's disease. Brain research. vol 589. issue 2. 1992-11-25. PMID:1327415. |
the activity of choline acetyltransferase in the hippocampus was markedly reduced in alzheimer's disease (controls 6.9 +/- 1.0; alzheimer 2.7 +/- 0.9 nmol/h/mg protein, mean +/- s.e.m., p less than 0.01). |
1992-11-25 |
2023-08-11 |
human |
| M Ikeda, D Dewar, J McCulloc. A correlative study of calcium channel antagonist binding and local neuropathological features in the hippocampus in Alzheimer's disease. Brain research. vol 589. issue 2. 1992-11-25. PMID:1327415. |
the discrete reduction and preservation of [3h]pn200-110 binding in the present study is consistent with the pattern of selective cellular vulnerability in the hippocampal region in alzheimer's disease. |
1992-11-25 |
2023-08-11 |
human |
| J W Geddes, J Ułas, L C Brunner, W Choe, C W Cotma. Hippocampal excitatory amino acid receptors in elderly, normal individuals and those with Alzheimer's disease: non-N-methyl-D-aspartate receptors. Neuroscience. vol 50. issue 1. 1992-11-23. PMID:1328933. |
hippocampal excitatory amino acid receptors in elderly, normal individuals and those with alzheimer's disease: non-n-methyl-d-aspartate receptors. |
1992-11-23 |
2023-08-11 |
human |
| T Bartfai, G Fisone, U Lange. Galanin and galanin antagonists: molecular and biochemical perspectives. Trends in pharmacological sciences. vol 13. issue 8. 1992-11-20. PMID:1384214. |
the enhancing effect of such agents on hippocampal cholinergic function would be useful in treatment of alzheimer's disease. |
1992-11-20 |
2023-08-11 |
Not clear |