| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Söderberg, C Edlund, I Alafuzoff, K Kristensson, G Dallne. Lipid composition in different regions of the brain in Alzheimer's disease/senile dementia of Alzheimer's type. Journal of neurochemistry. vol 59. issue 5. 1992-11-20. PMID:1402910. |
the cortical areas that are morphologically affected by alzheimer's disease, i.e., frontal and temporal cortex and the hippocampus, showed elevated contents of lipid solvent-extractable phosphatidylinositol. |
1992-11-20 |
2023-08-11 |
Not clear |
| C F Lippa, T W Smit. The indusium griseum in Alzheimer's disease: an immunocytochemical study. Journal of the neurological sciences. vol 111. issue 1. 1992-11-12. PMID:1328542. |
the immunocytochemical features of the indusium griseum (ig) were compared with the corresponding hippocampus in 5 patients with alzheimer's disease (ad) and 5 age-matched nondemented individuals using antibodies against beta-amyloid, the a68 protein (alz-50 antibody), tau, ubiquitin and synapsin i. beta-amyloid-positive plaques were prominent in the ad hippocampus but were not present in the ig. |
1992-11-12 |
2023-08-11 |
Not clear |
| Z Ali-Khan, J Normand, K Alizadeh-Khiavi, Y Robitaille, S Chronopoulo. Ubiquitin profile and amyloid enhancing factor activity in Alzheimer and 'normal' human brain extracts. Neuroscience letters. vol 139. issue 1. 1992-11-06. PMID:1328964. |
tris-hcl or laemmli sample buffer extracted frontal lobe and hippocampal samples from normal aged and alzheimer's disease (ad) subjects were used to determine total ubiquitin (ub), distribution of monomeric ub and ub-protein conjugates and amyloid enhancing factor (aef) activity using the dot-blot, western blot and mouse aef bioassay techniques, respectively. |
1992-11-06 |
2023-08-11 |
mouse |
| J Ułas, L C Brunner, J W Geddes, W Choe, C W Cotma. N-methyl-D-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with Alzheimer's disease. Neuroscience. vol 49. issue 1. 1992-11-06. PMID:1407551. |
n-methyl-d-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with alzheimer's disease. |
1992-11-06 |
2023-08-11 |
Not clear |
| J Ułas, L C Brunner, J W Geddes, W Choe, C W Cotma. N-methyl-D-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with Alzheimer's disease. Neuroscience. vol 49. issue 1. 1992-11-06. PMID:1407551. |
the binding of [3h]mk-801 to channel-associated phencyclidine sites appeared to be most severely impaired in alzheimer's disease, especially at the anterior hippocampal level. |
1992-11-06 |
2023-08-11 |
Not clear |
| J Pascual, B Grijalba, J A García-Sevilla, J J Zarranz, A Pazo. Loss of high-affinity alpha 2-adrenoceptors in Alzheimer's disease: an autoradiographic study in frontal cortex and hippocampus. Neuroscience letters. vol 142. issue 1. 1992-11-04. PMID:1357610. |
loss of high-affinity alpha 2-adrenoceptors in alzheimer's disease: an autoradiographic study in frontal cortex and hippocampus. |
1992-11-04 |
2023-08-11 |
Not clear |
| J Pascual, B Grijalba, J A García-Sevilla, J J Zarranz, A Pazo. Loss of high-affinity alpha 2-adrenoceptors in Alzheimer's disease: an autoradiographic study in frontal cortex and hippocampus. Neuroscience letters. vol 142. issue 1. 1992-11-04. PMID:1357610. |
we assessed, by quantitative autoradiography, the density of high-affinity alpha 2-adrenoceptors in hippocampus and frontal cortex sections from 18 patients dying with alzheimer's disease (ad) in comparison with a control group of 13 matched cases. |
1992-11-04 |
2023-08-11 |
Not clear |
| b' J J Barski, J Lewin-Kowalik, A L Siero\\xc5\\x8. [Current views on the structure and function of the hippocampus]. Neurologia i neurochirurgia polska. vol 26. issue 2. 1992-10-22. PMID:1326724.' |
we also present recent view points on the relationships between changes in hippocampal structure and alzheimer disease. |
1992-10-22 |
2023-08-11 |
Not clear |
| M K Sutherland, L Wong, M J Somerville, P Handley, L Yoong, C Bergeron, D R McLachla. Reduction of thyroid hormone receptor c-ERB A alpha mRNA levels in the hippocampus of Alzheimer as compared to Huntington brain. Neurobiology of aging. vol 13. issue 2. 1992-10-13. PMID:1387923. |
reduction of thyroid hormone receptor c-erb a alpha mrna levels in the hippocampus of alzheimer as compared to huntington brain. |
1992-10-13 |
2023-08-11 |
Not clear |
| M K Sutherland, L Wong, M J Somerville, P Handley, L Yoong, C Bergeron, D R McLachla. Reduction of thyroid hormone receptor c-ERB A alpha mRNA levels in the hippocampus of Alzheimer as compared to Huntington brain. Neurobiology of aging. vol 13. issue 2. 1992-10-13. PMID:1387923. |
message levels for a thyroid hormone receptor highly expressed in brain (c-erb a alpha) was reduced by 52% in ca1 and 43% in ca2 in alzheimer hippocampus as compared to huntington controls. |
1992-10-13 |
2023-08-11 |
Not clear |
| M K Sutherland, L Wong, M J Somerville, P Handley, L Yoong, C Bergeron, D R McLachla. Reduction of thyroid hormone receptor c-ERB A alpha mRNA levels in the hippocampus of Alzheimer as compared to Huntington brain. Neurobiology of aging. vol 13. issue 2. 1992-10-13. PMID:1387923. |
in contrast, message levels for another form of thyroid hormone receptor (c-erb a beta 1) in alzheimer hippocampus were not significantly different from huntington controls. |
1992-10-13 |
2023-08-11 |
Not clear |
| J L Yau, R C Dow, G Fink, J R Seck. Medial septal cholinergic lesions increase hippocampal mineralocorticoid and glucocorticoid receptor messenger RNA expression. Brain research. vol 577. issue 1. 1992-10-09. PMID:1325858. |
loss of the cholinergic innervation of the hippocampus and failure of central (presumably hippocampal) suppressive control of hypothalamic-pituitary-adrenal axis activity are important features of alzheimer's dementia. |
1992-10-09 |
2023-08-11 |
rat |
| J L Yau, R C Dow, G Fink, J R Seck. Medial septal cholinergic lesions increase hippocampal mineralocorticoid and glucocorticoid receptor messenger RNA expression. Brain research. vol 577. issue 1. 1992-10-09. PMID:1325858. |
since glucocorticoids potentiate the effects of neurotoxins in the hippocampus, the increased expression of receptors following loss of cholinergic inputs in alzheimer's disease may increase hippocampal neuronal vulnerability. |
1992-10-09 |
2023-08-11 |
rat |
| P R Hof, L M Bierer, D P Perl, A Delacourte, L Buée, C Bouras, J H Morriso. Evidence for early vulnerability of the medial and inferior aspects of the temporal lobe in an 82-year-old patient with preclinical signs of dementia. Regional and laminar distribution of neurofibrillary tangles and senile plaques. Archives of neurology. vol 49. issue 9. 1992-10-02. PMID:1520086. |
detailed neuropathologic studies of neurofibrillary tangle and senile plaque distribution have shown that key elements of certain neocortical and hippocampal circuits are either compromised or lost in alzheimer's disease. |
1992-10-02 |
2023-08-11 |
Not clear |
| C Watson, F Andermann, P Gloor, M Jones-Gotman, T Peters, A Evans, A Olivier, D Melanson, G Lerou. Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging. Neurology. vol 42. issue 9. 1992-10-01. PMID:1513464. |
both the amygdala and the hippocampus are involved in the pathogenesis of a number of neurologic conditions, including temporal lobe epilepsy, postanoxic amnesia, and alzheimer's disease. |
1992-10-01 |
2023-08-11 |
human |
| R N Kalaria, S M Sromek, I Grahovac, S I Hari. Transferrin receptors of rat and human brain and cerebral microvessels and their status in Alzheimer's disease. Brain research. vol 585. issue 1-2. 1992-09-29. PMID:1511337. |
in alzheimer's disease, transferrin receptor densities were significantly reduced in the hippocampus and the temporal and occipital cortex but were unchanged in the frontal and parietal cortex and the cerebellum. |
1992-09-29 |
2023-08-11 |
human |
| R N Kalaria, S M Sromek, I Grahovac, S I Hari. Transferrin receptors of rat and human brain and cerebral microvessels and their status in Alzheimer's disease. Brain research. vol 585. issue 1-2. 1992-09-29. PMID:1511337. |
these results suggest that transferrin receptor density was decreased in some cortical areas including the hippocampus in alzheimer's disease but relatively unchanged in cerebral microvessels. |
1992-09-29 |
2023-08-11 |
human |
| M Goedert, S S Sisodia, D L Pric. Neurofibrillary tangles and beta-amyloid deposits in Alzheimer's disease. Current opinion in neurobiology. vol 1. issue 3. 1992-08-26. PMID:1821689. |
alzheimer's disease is characterized by the presence of abundant neurofibrillary tangles and beta-amyloid deposits in neocortex, hippocampus and amygdala. |
1992-08-26 |
2023-08-11 |
Not clear |
| P F Good, D P Perl, L M Bierer, J Schmeidle. Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer's disease: a laser microprobe (LAMMA) study. Annals of neurology. vol 31. issue 3. 1992-08-25. PMID:1637136. |
we report the results of an examination of the elemental content of neurofibrillary tangle-bearing and neurofibrillary tangle-free neurons identified within the hippocampus of 10 subjects with alzheimer's disease and 4 neuropathologically intact age-matched control subjects. |
1992-08-25 |
2023-08-11 |
human |
| K A Jellinger, W Paulu. Clinico-pathological correlations in Parkinson's disease. Clinical neurology and neurosurgery. vol 94 Suppl. 1992-08-12. PMID:1320531. |
demented pd subjects showed higher cell loss in snm than non-demented ones indicating dysfunction of the mesocortical dopamine system, and significantly more severe alzheimer lesions in isocortex and hippocampus. |
1992-08-12 |
2023-08-11 |
human |