| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Chen, J S Richardson, J E Caldwell, L C An. Regional brain activity of free radical defense enzymes in autopsy samples from patients with Alzheimer's disease and from nondemented controls. The International journal of neuroscience. vol 75. issue 1-2. 1994-09-08. PMID:8050854. |
in alzheimer's brains, superoxide dismutase activity is not statistically different among the various brain regions studied, but it is significantly lower than control in the cerebellum (-27%), frontal cortex (-27%) and hippocampus (-35%). |
1994-09-08 |
2023-08-12 |
Not clear |
| L Chen, J S Richardson, J E Caldwell, L C An. Regional brain activity of free radical defense enzymes in autopsy samples from patients with Alzheimer's disease and from nondemented controls. The International journal of neuroscience. vol 75. issue 1-2. 1994-09-08. PMID:8050854. |
catalase is significantly higher in alzheimer's cerebellum, frontal cortex and temporal cortex than in alzheimer's hippocampus, parietal cortex and entorhinal cortex. |
1994-09-08 |
2023-08-12 |
Not clear |
| K D Murray, C M Gall, E G Jones, P J Isackso. Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease. Neuroscience. vol 60. issue 1. 1994-09-08. PMID:8052419. |
the relative levels of messenger rna for brain-derived neurotrophic factor and the alpha subunit of calcium/calmodulin-dependent protein kinase type ii were examined in hippocampal sections from alzheimer's diseased and age matched non-diseased brains by in situ hybridization histochemistry. |
1994-09-08 |
2023-08-12 |
monkey |
| K D Murray, C M Gall, E G Jones, P J Isackso. Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease. Neuroscience. vol 60. issue 1. 1994-09-08. PMID:8052419. |
within the hippocampus of alzheimer's diseased brains, levels of calcium/calmodulin-dependent protein kinase ii messenger rna were increased and levels of brain-derived neurotrophic factor messenger rna were decreased in comparison with matched controls. |
1994-09-08 |
2023-08-12 |
monkey |
| K D Murray, C M Gall, E G Jones, P J Isackso. Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease. Neuroscience. vol 60. issue 1. 1994-09-08. PMID:8052419. |
these results suggest that within the alzheimer's hippocampus an altered program of gene expression is occurring leading to aberrant levels of both calcium/calmodulin-dependent protein kinase ii and brain-derived neurotrophic factor messenger rna. |
1994-09-08 |
2023-08-12 |
monkey |
| K D Murray, C M Gall, E G Jones, P J Isackso. Differential regulation of brain-derived neurotrophic factor and type II calcium/calmodulin-dependent protein kinase messenger RNA expression in Alzheimer's disease. Neuroscience. vol 60. issue 1. 1994-09-08. PMID:8052419. |
previous studies of the activity-dependent regulation of these messenger rna species suggest these results are consistent with a decrease in afferent activity within the alzheimer's hippocampus. |
1994-09-08 |
2023-08-12 |
monkey |
| R A Armstron. Differences in beta-amyloid (beta/A4) deposition in human patients with Down's syndrome and sporadic Alzheimer's disease. Neuroscience letters. vol 169. issue 1-2. 1994-09-01. PMID:8047269. |
the density of diffuse, primitive, classic and compact beta-amyloid (beta/a4) deposits was estimated in the hippocampus and adjacent gyri in human patients with down's syndrome (ds) and sporadic alzheimer's disease (ad). |
1994-09-01 |
2023-08-12 |
human |
| C Bouras, P R Hof, P Giannakopoulos, J P Michel, J H Morriso. Regional distribution of neurofibrillary tangles and senile plaques in the cerebral cortex of elderly patients: a quantitative evaluation of a one-year autopsy population from a geriatric hospital. Cerebral cortex (New York, N.Y. : 1991). vol 4. issue 2. 1994-08-25. PMID:8038565. |
detailed analyses of the neuropathologic changes in the cerebral cortex of elderly individuals and alzheimer's disease patients have demonstrated that certain components of the neocortical and hippocampal circuits are likely to be selectively vulnerable. |
1994-08-25 |
2023-08-12 |
Not clear |
| J Löffler, D Langui, A Probst, G Hube. Accumulation of a 50 kDa N-terminal fragment of beta-APP695 in Alzheimer's disease hippocampus and neocortex. Neurochemistry international. vol 24. issue 3. 1994-08-10. PMID:8025536. |
accumulation of a 50 kda n-terminal fragment of beta-app695 in alzheimer's disease hippocampus and neocortex. |
1994-08-10 |
2023-08-12 |
Not clear |
| I Ceballos-Pico. [Transgenic mice overexpressing copper-zinc superoxide dismutase: a model for the study of radical mechanisms and aging]. Comptes rendus des seances de la Societe de biologie et de ses filiales. vol 187. issue 3. 1994-08-03. PMID:8019910. |
moreover, the level of cuznsod protein and mrna is particularly high in pyramidal hippocampal neurons susceptible to degenerative processes in alzheimer's disease, and in dopaminergic melanized-neurons vulnerable in parkinson's disease. |
1994-08-03 |
2023-08-12 |
mouse |
| C O'Neill, B Wiehager, C J Fowler, R Ravid, B Winblad, R F Cowbur. Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain. Brain research. vol 636. issue 2. 1994-07-26. PMID:8012802. |
in the present study the relative densities of a number of g protein subunits were quantified in membranes prepared from the hippocampus, temporal cortex and angular gyrus of alzheimer's disease and control post-mortem brain by immunoblotting with specific polyclonal antisera against gs alpha, gi alpha, gi alpha-1, g(o) alpha and g beta protein subunits. |
1994-07-26 |
2023-08-12 |
Not clear |
| C O'Neill, B Wiehager, C J Fowler, R Ravid, B Winblad, R F Cowbur. Regionally selective alterations in G protein subunit levels in the Alzheimer's disease brain. Brain research. vol 636. issue 2. 1994-07-26. PMID:8012802. |
the ratio of large to small molecular weight isoforms of the gs alpha subunit was significantly increased in both the hippocampus and the angular gyrus of the alzheimer's disease samples when compared to control values, although the difference in individual gs alpha isoform levels did not attain statistical significance when comparing groups. |
1994-07-26 |
2023-08-12 |
Not clear |
| F Dehaut, K Haddad, G Alhayek, A Pouplard-Barthelai. Autoantibodies against H- and M-subunits of neurofilaments are induced by PC12 cell grafts or lesions into different sites of rat brain. Neuroscience letters. vol 165. issue 1-2. 1994-07-26. PMID:8015739. |
we have thus either grafted pc12 cells or injected culture medium alone into three sites of rat central nervous system (cns): olfactory bulb (ob), olfactory anterior nucleus (oan) and hippocampus (hc), all three sites being impaired in alzheimer's disease. |
1994-07-26 |
2023-08-12 |
rat |
| A M Cataldo, D J Hamilton, R A Nixo. Lysosomal abnormalities in degenerating neurons link neuronal compromise to senile plaque development in Alzheimer disease. Brain research. vol 640. issue 1-2. 1994-07-21. PMID:8004466. |
at the earliest stages of cell atrophy, hydrolase-positive lysosomes accumulated at the basal pole and then massively throughout the perikarya and proximal and proximal dendrites of affected pyramidal neurons in alzheimer prefrontal cortex and hippocampus, far exceeding the changes of normal aging. |
1994-07-21 |
2023-08-12 |
Not clear |
| D W Dickson, M L Schmidt, V M Lee, M L Zhao, S H Yen, J Q Trojanowsk. Immunoreactivity profile of hippocampal CA2/3 neurites in diffuse Lewy body disease. Acta neuropathologica. vol 87. issue 3. 1994-07-20. PMID:7912027. |
to examine the molecular composition of these lesions, hippocampal sections were obtained at postmortem from cases of dlbd, parkinson's disease and alzheimer's disease. |
1994-07-20 |
2023-08-12 |
Not clear |
| C R Jac. MRI-based hippocampal volume measurements in epilepsy. Epilepsia. vol 35 Suppl 6. 1994-07-14. PMID:8206012. |
abnormalities in hippocampal morphology, including unilateral or bilateral volume loss, are known to occur in epilepsy, alzheimer's disease, and in certain amnestic syndromes. |
1994-07-14 |
2023-08-12 |
Not clear |
| W W Zhang, T Badonic, A Höög, M H Jiang, K C Ma, X J Nie, Y Olsso. Astrocytes in Alzheimer's disease express immunoreactivity to the vaso-constrictor endothelin-1. Journal of the neurological sciences. vol 122. issue 1. 1994-06-24. PMID:8195809. |
many nerve cells in the cerebral neocortex, hippocampus, cerebellum and pons of alzheimer cases and controls exhibited endothelin-1-like immunoreactivity. |
1994-06-24 |
2023-08-12 |
Not clear |
| E Masliah, W G Honer, M Mallory, M Voigt, P Kushner, L Hansen, R Terr. Topographical distribution of synaptic-associated proteins in the neuritic plaques of Alzheimer's disease hippocampus. Acta neuropathologica. vol 87. issue 2. 1994-06-01. PMID:8171963. |
topographical distribution of synaptic-associated proteins in the neuritic plaques of alzheimer's disease hippocampus. |
1994-06-01 |
2023-08-12 |
Not clear |
| F J García-Ladona, J M Palacios, A Probst, H G Wieser, G Mengo. Excitatory amino acid AMPA receptor mRNA localization in several regions of normal and neurological disease affected human brain. An in situ hybridization histochemistry study. Brain research. Molecular brain research. vol 21. issue 1-2. 1994-05-23. PMID:8164524. |
in situ hybridization in the hippocampus of patients affected by alzheimer's disease (age range 77-82 years, postmortem delay 19-25.5 h) revealed a decrease on the content of the mrnas coding for these excitatory amino acid receptors, while an increase was detected in surgically dissected epileptic human hippocampi. |
1994-05-23 |
2023-08-12 |
human |
| Y Nakamura, M Takeda, K Yoshimi, H Hattori, S Hariguchi, S Kitajima, S Hashimoto, T Nishimur. Involvement of clathrin light chains in the pathology of Alzheimer's disease. Acta neuropathologica. vol 87. issue 1. 1994-04-22. PMID:8140893. |
in alzheimer brains, granular staining of lcb.2 around neurons in the hippocampus was weaker or patchily defected in comparison with control brains. |
1994-04-22 |
2023-08-12 |
Not clear |