| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M E Harris, K Hensley, D A Butterfield, R A Leedle, J M Carne. Direct evidence of oxidative injury produced by the Alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons. Experimental neurology. vol 131. issue 2. 1995-04-27. PMID:7895820. |
direct evidence of oxidative injury produced by the alzheimer's beta-amyloid peptide (1-40) in cultured hippocampal neurons. |
1995-04-27 |
2023-08-12 |
Not clear |
| S S Sisodia, D L Pric. Role of the beta-amyloid protein in Alzheimer's disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 9. issue 5. 1995-04-27. PMID:7896005. |
a major histopathological hallmark of alzheimer's disease (ad) is the presence of amyloid deposits in the parenchyma of the amygdala, hippocampus, and neocortex. |
1995-04-27 |
2023-08-12 |
Not clear |
| H Hörtnag. AF64A-induced brain damage and its relation to dementia. Journal of neural transmission. Supplementum. vol 44. 1995-04-27. PMID:7897396. |
the af64a-induced withdrawal of cholinergic function in the rat hippocampus was associated with reversible functional changes in other neurotransmitters, including noradrenaline, serotonin, somatostatin and glutamate, thereby mimicking changes in alzheimer's disease. |
1995-04-27 |
2023-08-12 |
rat |
| T M Westlake, A C Howlett, T I Bonner, L A Matsuda, M Herkenha. Cannabinoid receptor binding and messenger RNA expression in human brain: an in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains. Neuroscience. vol 63. issue 3. 1995-04-26. PMID:7898667. |
levels of messenger rna expression did not differ between alzheimer's and control brains, but there were regionally discrete statistically significant losses of the intensely expressing cells in the hippocampus. |
1995-04-26 |
2023-08-12 |
human |
| R Cutler, J A Joseph, K Yamagami, R Villalobos-Molina, G S Rot. Area specific alterations in muscarinic stimulated low Km GTPase activity in aging and Alzheimer's disease: implications for altered signal transduction. Brain research. vol 664. issue 1-2. 1995-04-24. PMID:7895046. |
carbachol-stimulated low km gtpase activity (an index of muscarinic receptor-g protein coupling) was examined in hippocampus, basal ganglia, orbital frontal gyrus and superior frontal gyrus obtained from mature, aged and alzheimer's disease (ad) groups. |
1995-04-24 |
2023-08-12 |
rat |
| P E Gottschall, X Y. Cytokines regulate gelatinase A and B (matrix metalloproteinase 2 and 9) activity in cultured rat astrocytes. Journal of neurochemistry. vol 64. issue 4. 1995-04-18. PMID:7891077. |
little is known about the function of matrix metalloproteinases or agents that regulate their production in adult brain; however, it has been shown that the activity of a calcium-dependent metalloproteinase is elevated in alzheimer's hippocampus. |
1995-04-18 |
2023-08-12 |
rat |
| N Lexow, J N Joyce, S J Kim, J Phillips, M F Casanova, E D Bird, J E Kleinman, A Winoku. Alterations in TRH receptors in temporal lobe of schizophrenics: a quantitative autoradiographic study. Synapse (New York, N.Y.). vol 18. issue 4. 1995-04-10. PMID:7886624. |
no significant differences from non-neuropsychiatric controls were noted within the hippocampus in any of these disease states; however, slight alterations were noted in the central and medial basal amygdala in huntington's disease and in the cortical amygdala in alzheimer's disease. |
1995-04-10 |
2023-08-12 |
human |
| J L Yau, P A Kelly, J R Seck. Increased glucocorticoid receptor gene expression in the rat hippocampus following combined serotonergic and medial septal cholinergic lesions. Brain research. Molecular brain research. vol 27. issue 1. 1995-04-06. PMID:7877448. |
degeneration of both cholinergic and serotonergic (5-ht) hippocampal afferents is prominent in aged rats and alzheimer's disease. |
1995-04-06 |
2023-08-12 |
rat |
| C Bancher, K A Jellinge. Neurofibrillary tangle predominant form of senile dementia of Alzheimer type: a rare subtype in very old subjects. Acta neuropathologica. vol 88. issue 6. 1995-03-31. PMID:7879604. |
in a consecutive autopsy series of 580 demented elderly subjects, 256 with the clinical diagnosis of probable/possible alzheimer's disease (ad), there were 10 cases aged between 80 and 99 years with moderate to severe dementia or confusional state in which neuropathological studies revealed abundant neurofibrillary tangles with predominant involvement of the allocortex (entorhinal region, subiculum, ca 1 sector of hippocampus, amygdala) but no or only very few senile plaques. |
1995-03-31 |
2023-08-12 |
human |
| H Schägger, T G Oh. Human diseases with defects in oxidative phosphorylation. 2. F1F0 ATP-synthase defects in Alzheimer disease revealed by blue native polyacrylamide gel electrophoresis. European journal of biochemistry. vol 227. issue 3. 1995-03-28. PMID:7867655. |
tissue specimens from the hippocampus of brains from patients with alzheimer's disease were screened by blue native electrophoresis for alterations of the proteins of oxidative phosphorylation. |
1995-03-28 |
2023-08-12 |
human |
| A Furuta, D L Price, C A Pardo, J C Troncoso, Z S Xu, N Taniguchi, L J Marti. Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus. The American journal of pathology. vol 146. issue 2. 1995-03-16. PMID:7856748. |
localization of superoxide dismutases in alzheimer's disease and down's syndrome neocortex and hippocampus. |
1995-03-16 |
2023-08-12 |
human |
| A Furuta, D L Price, C A Pardo, J C Troncoso, Z S Xu, N Taniguchi, L J Marti. Localization of superoxide dismutases in Alzheimer's disease and Down's syndrome neocortex and hippocampus. The American journal of pathology. vol 146. issue 2. 1995-03-16. PMID:7856748. |
the observed changes in the cellular localization of superoxide dismutases in neocortex and hippocampus in cases of alzheimer's disease and down's syndrome support a role for oxidative injury in neuronal degeneration and senile plaque formation. |
1995-03-16 |
2023-08-12 |
human |
| C M Morris, J M Kerwin, J A Edwardso. Non-haem iron histochemistry of the normal and Alzheimer's disease hippocampus. Neurodegeneration : a journal for neurodegenerative disorders, neuroprotection, and neuroregeneration. vol 3. issue 4. 1995-03-09. PMID:7842297. |
non-haem iron histochemistry of the normal and alzheimer's disease hippocampus. |
1995-03-09 |
2023-08-12 |
Not clear |
| P Giannakopoulos, P R Hof, C Boura. Alzheimer's disease with asymmetric atrophy of the cerebral hemispheres: morphometric analysis of four cases. Acta neuropathologica. vol 88. issue 5. 1995-03-09. PMID:7847073. |
moreover, the relative sparing of the hippocampus, comparable to that found in cases with focal progressive dementia, suggests that the dementing process may involve different cortical structures in cases with asymmetric cerebral atrophy than in typical alzheimer's disease cases. |
1995-03-09 |
2023-08-12 |
Not clear |
| C M Morris, J M Candy, J M Kerwin, J A Edwardso. Transferrin receptors in the normal human hippocampus and in Alzheimer's disease. Neuropathology and applied neurobiology. vol 20. issue 5. 1995-03-08. PMID:7845533. |
transferrin receptors in the normal human hippocampus and in alzheimer's disease. |
1995-03-08 |
2023-08-12 |
human |
| L J Houenou, P L Turner, L Li, R W Oppenheim, B W Festof. A serine protease inhibitor, protease nexin I, rescues motoneurons from naturally occurring and axotomy-induced cell death. Proceedings of the National Academy of Sciences of the United States of America. vol 92. issue 3. 1995-03-03. PMID:7846074. |
free pni protein is markedly decreased in various anatomical brain regions, including hippocampus, of patients with alzheimer disease. |
1995-03-03 |
2023-08-12 |
mouse |
| P Dournaud, P Cervera-Pierot, E Hirsch, F Javoy-Agid, C Kordon, Y Agid, J Epelbau. Somatostatin messenger RNA-containing neurons in Alzheimer's disease: an in situ hybridization study in hippocampus, parahippocampal cortex and frontal cortex. Neuroscience. vol 61. issue 4. 1995-03-02. PMID:7838375. |
somatostatin messenger rna-containing neurons in alzheimer's disease: an in situ hybridization study in hippocampus, parahippocampal cortex and frontal cortex. |
1995-03-02 |
2023-08-12 |
human |
| P Dournaud, P Cervera-Pierot, E Hirsch, F Javoy-Agid, C Kordon, Y Agid, J Epelbau. Somatostatin messenger RNA-containing neurons in Alzheimer's disease: an in situ hybridization study in hippocampus, parahippocampal cortex and frontal cortex. Neuroscience. vol 61. issue 4. 1995-03-02. PMID:7838375. |
the analysis was carried out in the frontal and parahippocampal cortices and hippocampus of six age- and post mortem delay-matched alzheimer's disease and control brains. |
1995-03-02 |
2023-08-12 |
human |
| P Dournaud, P Cervera-Pierot, E Hirsch, F Javoy-Agid, C Kordon, Y Agid, J Epelbau. Somatostatin messenger RNA-containing neurons in Alzheimer's disease: an in situ hybridization study in hippocampus, parahippocampal cortex and frontal cortex. Neuroscience. vol 61. issue 4. 1995-03-02. PMID:7838375. |
somatostatin messenger rna-containing neurons displayed a similar regional and subregional distribution in control subjects and patients with alzheimer's disease, being more abundant in the frontal cortex, followed by the hippocampus and the parahippocampal cortex. |
1995-03-02 |
2023-08-12 |
human |
| P Dournaud, P Cervera-Pierot, E Hirsch, F Javoy-Agid, C Kordon, Y Agid, J Epelbau. Somatostatin messenger RNA-containing neurons in Alzheimer's disease: an in situ hybridization study in hippocampus, parahippocampal cortex and frontal cortex. Neuroscience. vol 61. issue 4. 1995-03-02. PMID:7838375. |
an overall reduction of labelled cell density was observed in patients with alzheimer's disease (frontal cortex gray matter:--41%; white matter:--66%; hippocampus:--44%; parahippocampal cortex white matter:--40%). |
1995-03-02 |
2023-08-12 |
human |