| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Houria Berhail Boudouda, Assia Zeghib, Anastazia Karioti, Anna Rita Bilia, Mehmet Öztürk, Mahjoub Aouni, Ahmed Kabouche, Zahia Kabouch. Antibacterial, antioxidant, anti-cholinesterase potential and flavonol glycosides of Biscutella raphanifolia (Brassicaceae). Pakistan journal of pharmaceutical sciences. vol 28. issue 1. 2015-04-20. PMID:25553679. |
since there is a relationship between antioxidants and cholinesterase enzyme inhibitors, we used two methods to determine the in vitro anti-cholinesterase activity by the use of the basic enzymes that occur in causing alzheimer's disease: acetylcholinesterase (ache) and butyrylcholinesterase (bche). |
2015-04-20 |
2023-08-13 |
human |
| Adriana Ferreira Lopes Vilela, Joyce Izidoro da Silva, Lucas Campos Curcino Vieira, Gilberto C R Bernasconi, Arlene Gonçalves Corrêa, Quezia Bezerra Cass, Carmen Lúcia Cardos. Immobilized cholinesterases capillary reactors on-flow screening of selective inhibitors. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. vol 968. 2015-03-31. PMID:24321276. |
the discovery of selective inhibitors for acetylcholinesterase (ache) or butyrylcholinesterase (bche) is extremely important for the development of drugs that can be used in the treatment of patients diagnosed with the alzheimer's disease (ad). |
2015-03-31 |
2023-08-12 |
Not clear |
| Aziz-ur Rehman, Muhammad Athar Abbasi, Shahid Rasool, Muhammad Ashraf, Syeda Abida Ejaz, Rabia Hassan, Noreen Khali. Synthesis, spectral characterization and enzyme inhibition studies of different chlorinated sulfonamides. Pakistan journal of pharmaceutical sciences. vol 27. issue 6. 2015-01-22. PMID:25362587. |
all the compounds exhibited good inhibitory activities against these enzymes but the strong activity was shown against bche and hence can be employed for discovery of 'lead' compounds against alzheimer's disease (ad). |
2015-01-22 |
2023-08-13 |
Not clear |
| Aamer Saeed, Parvez Ali Mahesar, Sumera Zaib, Muhammad Siraj Khan, Abdul Matin, Mohammad Shahid, Jamshed Iqba. Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases. European journal of medicinal chemistry. vol 78. 2014-12-24. PMID:24675179. |
controlled inhibition of brain acetylcholinesterase (ache) and butyrylcholinesterase (bche) may slow neurodegeneration in alzheimer's diseases (ad). |
2014-12-24 |
2023-08-12 |
Not clear |
| Boris Brus, Urban Košak, Samo Turk, Anja Pišlar, Nicolas Coquelle, Janko Kos, Jure Stojan, Jacques-Philippe Colletier, Stanislav Gobe. Discovery, biological evaluation, and crystal structure of a novel nanomolar selective butyrylcholinesterase inhibitor. Journal of medicinal chemistry. vol 57. issue 19. 2014-12-18. PMID:25226236. |
butyrylcholinesterase (bche) is regarded as a promising drug target as its levels and activity significantly increase in the late stages of alzheimer's disease. |
2014-12-18 |
2023-08-13 |
human |
| Ganiyu Oboh, Ayodele J Akinyemi, Olasunkanmi S Omojokun, Idowu S Oyeley. Anticholinesterase and Antioxidative Properties of Aqueous Extract of Cola acuminata Seed In Vitro. International journal of Alzheimer's disease. vol 2014. 2014-12-16. PMID:25506036. |
inhibition of ache and bche activities has been the primary treatment method for mild alzheimer's disease (ad). |
2014-12-16 |
2023-08-13 |
rat |
| Hye B Yoo, Hae W Lee, Sue Shin, Sun-Won Park, Jung S Choi, Hee Y Jung, Jungho Cha, Jong-Min Lee, Jun-Young Le. Butyrylcholinesterase K and apolipoprotein ε4 affect cortical thickness and neuropsychiatric symptoms in Alzheimer's disease. Current Alzheimer research. vol 11. issue 2. 2014-11-24. PMID:24479631. |
two major genotypes are known to affect the development and progression of alzheimer's disease (ad) and its response to cholinesterase inhibitors: the apolipoprotein e (apoe) and butyrylcholinesterase genes (bche). |
2014-11-24 |
2023-08-12 |
Not clear |
| Wei Liu, Yadi Yang, Xuemei Cheng, Can Gong, Shuping Li, Dandan He, Li Yang, Zhengtao Wang, Changhong Wan. Rapid and sensitive detection of the inhibitive activities of acetyl- and butyryl-cholinesterases inhibitors by UPLC-ESI-MS/MS. Journal of pharmaceutical and biomedical analysis. vol 94. 2014-11-17. PMID:24631841. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are legitimate therapeutic targets for alzheimer's disease. |
2014-11-17 |
2023-08-12 |
Not clear |
| Fang Zheng, Max Zhan, Xiaoqin Huang, Mohamed Diwan M Abdul Hameed, Chang-Guo Zha. Modeling in vitro inhibition of butyrylcholinesterase using molecular docking, multi-linear regression and artificial neural network approaches. Bioorganic & medicinal chemistry. vol 22. issue 1. 2014-11-06. PMID:24290065. |
as bche is also an established drug target to develop new treatment for alzheimer's disease (ad). |
2014-11-06 |
2023-08-12 |
Not clear |
| S Schwarz, R Csuk, A P Raute. Microwave-assisted synthesis of novel purine nucleosides as selective cholinesterase inhibitors. Organic & biomolecular chemistry. vol 12. issue 15. 2014-11-06. PMID:24604285. |
alzheimer's disease (ad), the most common form of senile dementia, is characterized by high butyrylcholinesterase (bche) levels in the brain in later ad stages, for which no treatment is available. |
2014-11-06 |
2023-08-12 |
Not clear |
| Yee-Hui Koay, Alireza Basiri, Vikneswaran Murugaiyah, Kit-Lam Cha. Isocorilagin, a cholinesterase inhibitor from Phyllanthus niruri. Natural product communications. vol 9. issue 4. 2014-06-26. PMID:24868872. |
drugs that have dual inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche) produce better clinical efficacy against alzheimer's disease (ad) than those that selectively inhibit one enzyme. |
2014-06-26 |
2023-08-13 |
Not clear |
| Monica Rosa Loizzo, Mariem Ben Jemia, Felice Senatore, Maurizio Bruno, Francesco Menichini, Rosa Tundi. Chemistry and functional properties in prevention of neurodegenerative disorders of five Cistus species essential oils. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 59. 2014-03-28. PMID:23831310. |
essential oils were screened also for their potential antioxidant effects (by dpph, abts, frap and β-carotene bleaching test) and their acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitory activity, useful for prevention and treatment of alzheimer's disease. |
2014-03-28 |
2023-08-12 |
Not clear |
| Zongtao Lin, Hong Wang, Qingrong Fu, Haijuan An, Yi Liang, Baobao Zhang, Yuki Hashi, Shizhong Che. Simultaneous separation, identification and activity evaluation of three butyrylcholinesterase inhibitors from Plumula nelumbinis using on-line HPLC-UV coupled with ESI-IT-TOF-MS and BChE biochemical detection. Talanta. vol 110. 2013-10-28. PMID:23618192. |
the proposed on-line method has been validated as having good precision and reproducibility, and could be used to rapidly identify bche inhibitors and to screen potential drugs for the treatment of alzheimer's disease in complicated samples. |
2013-10-28 |
2023-08-12 |
Not clear |
| Francesca Lak. BCHE reported to be associated with plaque level in Alzheimer's disease. Biomarkers in medicine. vol 7. issue 2. 2013-09-17. PMID:23547813. |
bche reported to be associated with plaque level in alzheimer's disease. |
2013-09-17 |
2023-08-12 |
Not clear |
| Dowluru Svgk Kaladhar, Nagendra Sastry Yarla, N Anush. Functional Analysis and Molecular Docking studies of Medicinal Compounds for AChE and BChE in Alzheimer's Disease and Type 2 Diabetes Mellitus. Aging and disease. vol 4. issue 4. 2013-08-12. PMID:23936743. |
functional analysis and molecular docking studies of medicinal compounds for ache and bche in alzheimer's disease and type 2 diabetes mellitus. |
2013-08-12 |
2023-08-12 |
Not clear |
| Dowluru Svgk Kaladhar, Nagendra Sastry Yarla, N Anush. Functional Analysis and Molecular Docking studies of Medicinal Compounds for AChE and BChE in Alzheimer's Disease and Type 2 Diabetes Mellitus. Aging and disease. vol 4. issue 4. 2013-08-12. PMID:23936743. |
phylogenetic tree was constructed to these proteins usinf upgma and maximum likelihood methods in mega software has shown interaction of ache and bche with ageing diseases like alzheimer's disease and diabetes. |
2013-08-12 |
2023-08-12 |
Not clear |
| Dowluru Svgk Kaladhar, Nagendra Sastry Yarla, N Anush. Functional Analysis and Molecular Docking studies of Medicinal Compounds for AChE and BChE in Alzheimer's Disease and Type 2 Diabetes Mellitus. Aging and disease. vol 4. issue 4. 2013-08-12. PMID:23936743. |
the present studies is also accomplished that ache, bche, colq, hand1, app, nlgn2 and ngf proteins has interactions with diseases such as alzheimer's and d2m using pathwaylinker and string. |
2013-08-12 |
2023-08-12 |
Not clear |
| Daiane Priscila Simão-Silva, Paulo Henrique Ferreira Bertolucci, Roger William de Labio, Spencer Luiz Marques Payão, Lupe Furtado-Alle, Ricardo Lehtonen Rodrigues Souz. Association analysis between K and -116A variants of butyrylcholinesterase and Alzheimer's disease in a Brazilian population. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23022600. |
in alzheimer's disease (ad) a reduction in acetylcholinesterase (ache) and an increase in butyrylcholinesterase (bche) activity are observed. |
2013-05-28 |
2023-08-12 |
human |
| Daniela Karlsson, Adyary Fallarero, Gerda Brunhofer, Claudia Mayer, Ohm Prakash, C Gopi Mohan, Pia Vuorela, Thomas Erke. The exploration of thienothiazines as selective butyrylcholinesterase inhibitors. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 47. issue 1. 2013-03-08. PMID:22683890. |
the role of butyrylcholinesterase (bche) in the progression of alzheimer's disease (ad) has recently become more crucial. |
2013-03-08 |
2023-08-12 |
human |
| Santanu Bhadra, Pulok K Mukherjee, A Bandyopadhya. Cholinesterase inhibition activity of Marsilea quadrifolia Linn. an edible leafy vegetable from West Bengal, India. Natural product research. vol 26. issue 16. 2012-12-14. PMID:21978132. |
these findings suggest that m. quadrifolia is a potential lead as an ache and bche inhibitor, which may be useful in the management of alzheimer's disease. |
2012-12-14 |
2023-08-12 |
Not clear |