| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anika Varma, Hawi B Gemeda, Matthew J McNulty, Karen A McDonald, Somen Nandi, Jennifer M Knip. Immobilization of transgenic plant cells towards bioprinting for production of a recombinant biodefense agent. Biotechnology journal. vol 16. issue 10. 2021-10-12. PMID:34347377. |
transgenic rice cells (oryza sativa) producing recombinant butyrylcholinesterase (bche) as a prophylactic/therapeutic against organophosphate nerve agent poisoning, cocaine toxicity, and neurodegenerative diseases like alzheimer's were immobilized in a polyethylene glycol-based hydrogel. |
2021-10-12 |
2023-08-13 |
Not clear |
| Rosa Purgatorio, Larisa N Kulikova, Leonardo Pisani, Marco Catto, Modesto de Candia, Antonio Carrieri, Saverio Cellamare, Annalisa De Palma, Andrey A Beloglazkin, Ghulam Reza Raesi, Leonid G Voskressensky, Cosimo D Altomar. Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets. ChemMedChem. vol 15. issue 20. 2021-09-20. PMID:32716595. |
a number of 1,2,3,4-tetrahydrochromeno[3,2-c]pyridin-10-one derivatives have been synthesized and screened against different targets involved in the onset and progression of alzheimer's disease (ad), such as acetyl- and butyrylcholinesterase (ache and bche), monoamine oxidases a and b (mao a and b), aggregation of β-amyloid (aβ) and reactive oxygen species (ros) production. |
2021-09-20 |
2023-08-13 |
human |
| Saravanan Kandasamy, Chitra Loganathan, Penislusshiyan Sakayanathan, Subramani Karthikeyan, Arputharaj David Stephen, Dinesh Kumar Marimuthu, Saravanan Ravichandran, Vignesh Sivalingam, Palvannan Thayumanava. In silico, theoretical biointerface analysis and in vitro kinetic analysis of amine compounds interaction with acetylcholinesterase and butyrylcholinesterase. International journal of biological macromolecules. vol 185. 2021-08-16. PMID:34216669. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are considered important target for drug design against alzheimer's disease. |
2021-08-16 |
2023-08-13 |
Not clear |
| Suleyman Akocak, Parham Taslimi, Nebih Lolak, Mesut Işık, Mustafa Durgun, Yakup Budak, Cüneyt Türkeş, İlhami Gülçin, Şükrü Beydemi. Synthesis, Characterization, and Inhibition Study of Novel Substituted Phenylureido Sulfaguanidine Derivatives as α-Glycosidase and Cholinesterase Inhibitors. Chemistry & biodiversity. vol 18. issue 4. 2021-07-26. PMID:33620128. |
in vitro and in silico inhibitory effects of the novel ureido-substituted sulfaguanidine derivatives were investigated by spectrophotometric methods for α-glycosidase (α-gly), acetylcholinesterase (ache), and butyrylcholinesterase (bche) enzymes associated with diabetes mellitus (dm) and alzheimer's disease (ad). |
2021-07-26 |
2023-08-13 |
Not clear |
| Stephen A Adefegha, Bathlomew M Okeke, Ganiyu Obo. Antioxidant properties of eugenol, butylated hydroxylanisole, and butylated hydroxyl toluene with key biomolecules relevant to Alzheimer's diseases-In vitro. Journal of food biochemistry. vol 45. issue 3. 2021-07-08. PMID:32458455. |
this research work examined and likened effect of eugenol a natural phenolic compound with butylated hydroxylanisole (bha) and butylated hydroxyl toluene (bht) synthetic phenolic compounds with key biomolecules [acetylcholinesterase (ache), butyrylcholinesterase (bche), and monoamine oxidase (mao)] relevant to alzheimer's diseases (ad) in vitro. |
2021-07-08 |
2023-08-13 |
Not clear |
| Qi Li, Ying Chen, Shuaishuai Xing, Qinghong Liao, Baichen Xiong, Yuanyuan Wang, Weixuan Lu, Siyu He, Feng Feng, Wenyuan Liu, Yao Chen, Haopeng Su. Highly Potent and Selective Butyrylcholinesterase Inhibitors for Cognitive Improvement and Neuroprotection. Journal of medicinal chemistry. vol 64. issue 10. 2021-06-21. PMID:33973470. |
butyrylcholinesterase (bche) has been considered as a potential therapeutic target for alzheimer's disease (ad) because of its compensation capacity to hydrolyze acetylcholine (ach) and its close association with aβ deposit. |
2021-06-21 |
2023-08-13 |
Not clear |
| Weiwei Liu, Yan Cao, Yue Lin, Keai Sinn Tan, Haishan Zhao, Haihua Guo, Wen Ta. Enhancement of Fear Extinction Memory and Resistance to Age-Related Cognitive Decline in Butyrylcholinesterase Knockout Mice and ( Biology. vol 10. issue 5. 2021-06-15. PMID:34062954. |
enhancement of fear extinction memory and resistance to age-related cognitive decline in butyrylcholinesterase knockout mice and ( butyrylcholinesterase (bche) is detected in plaques preferentially in alzheimer's disease (ad) and may be associated with stress disorders. |
2021-06-15 |
2023-08-13 |
mouse |
| Zhipeng Yu, Huizhuo Ji, Juntong Shen, Ruotong Kan, Wenzhu Zhao, Jianrong Li, Long Ding, Jingbo Li. Identification and molecular docking study of fish roe-derived peptides as potent BACE 1, AChE, and BChE inhibitors. Food & function. vol 11. issue 7. 2021-06-03. PMID:32656560. |
acetylcholinesterase (ache), butyrylcholinesterase (bche), and beta-secretase 1 (bace 1) play vital roles in the development and progression of alzheimer's disease (ad). |
2021-06-03 |
2023-08-13 |
Not clear |
| F Sezer Senol Deniz, Gokcen Eren, Ilkay Erdogan Orhan, Bilge Sener, Ufuk Ozgen, Randa Aldaba, Ihsan Cali. Outlining In Vitro and In Silico Cholinesterase Inhibitory Activity of Twenty-Four Natural Products of Various Chemical Classes: Smilagenin, Kokusaginine, and Methyl Rosmarinate as Emboldening Inhibitors. Molecules (Basel, Switzerland). vol 26. issue 7. 2021-05-24. PMID:33916300. |
cholinesterase (che) inhibition is an important treatment strategy for alzheimer's disease (ad) as acetylcholinesterase (ache) and butyrylcholinesterase (bche) are involved in the pathology of ad. |
2021-05-24 |
2023-08-13 |
Not clear |
| Qian Zhang, Caixia Fu, Xinjie Guo, Jian Gao, Peng Zhang, Caifeng Din. Fluorescent Determination of Butyrylcholinesterase Activity and Its Application in Biological Imaging and Pesticide Residue Detection. ACS sensors. vol 6. issue 3. 2021-05-14. PMID:33503372. |
the bio-investigation ranged from cells to an organism, declaring a noteworthy prospect in disease diagnosis, especially for alzheimer's disease (ad), a common neurodegenerative disease with over-expressed bche. |
2021-05-14 |
2023-08-13 |
human |
| Cüneyt Türkeş, Suleyman Akocak, Mesut Işık, Nebih Lolak, Parham Taslimi, Mustafa Durgun, İlhami Gülçin, Yakup Budak, Şükrü Beydemi. Novel inhibitors with sulfamethazine backbone: synthesis and biological study of multi-target cholinesterases and α-glucosidase inhibitors. Journal of biomolecular structure & dynamics. 2021-05-05. PMID:33950796. |
inhibition of metabolic enzymes such as cholinesterases (ches; acetylcholinesterase, ache and butyrylcholinesterase, bche) and α-glucosidase (α-gly) is one of the accepted approaches in the treatment of alzheimer's disease (ad) and diabetes mellitus (dm). |
2021-05-05 |
2023-08-13 |
Not clear |
| Jie Wu, Marco Pistolozzi, Siyu Liu, Wen Ta. Design, synthesis and biological evaluation of novel carbamates as potential inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorganic & medicinal chemistry. vol 28. issue 5. 2021-04-27. PMID:32008882. |
rivastigmine, a dual inhibitor of acetylcholinesterase (ache) and butyrylcholinesterase (bche), has been approved by u.s. food and drug administration to treat alzheimer's disease (ad) and parkinson's disease (pd) dementia. |
2021-04-27 |
2023-08-13 |
Not clear |
| Shuaishuai Xing, Ying Chen, Baichen Xiong, Weixuan Lu, Qi Li, Yuanyuan Wang, Mengxia Jiao, Feng Feng, Yao Chen, Wenyuan Liu, Haopeng Su. Synthesis and bio-evaluation of a novel selective butyrylcholinesterase inhibitor discovered through structure-based virtual screening. International journal of biological macromolecules. vol 166. 2021-04-09. PMID:33161083. |
in recent years, butyrylcholinesterase (bche) has gradually gained worldwide interests as a novel target for treating alzheimer's disease (ad). |
2021-04-09 |
2023-08-13 |
Not clear |
| Mehmet Oguz, Erbay Kalay, Suleyman Akocak, Alessio Nocentini, Nebih Lolak, Mehmet Boga, Mustafa Yilmaz, Claudiu T Supura. Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action. Journal of enzyme inhibition and medicinal chemistry. vol 35. issue 1. 2021-01-25. PMID:32401067. |
the calix[4]azacrown substituted sulphonamide schiff bases were also investigated as inhibitors of acetylcholinesterase (ache), butyrylcholinesterase (bche) and tyrosinase enzymes, associated with several diseases such as alzheimer, parkinson, and pigmentation disorders. |
2021-01-25 |
2023-08-13 |
human |
| Zhiyang Zhang, Fangfang Fan, Wen Luo, Yuan Zhao, Chaojie Wan. Molecular Dynamics Revealing a Detour-Forward Release Mechanism of Tacrine: Implication for the Specific Binding Characteristics in Butyrylcholinesterase. Frontiers in chemistry. vol 8. 2020-11-17. PMID:33195011. |
butyrylcholinesterase (bche) is a non-specific enzyme with clinical pharmacological and toxicological significance, which was a renewed interest as therapeutic target in alzheimer's disease (ad) nowadays. |
2020-11-17 |
2023-08-13 |
Not clear |
| Roshanak Ghobadian, Roghaieh Esfandyari, Hamid Nadri, Alireza Moradi, Mohammad Mahdavi, Tahmineh Akbarzadeh, Hossein Khaleghzadeh-Ahangar, Najmeh Edraki, Mohammad Sharifzadeh, Mohsen Amin. Design, synthesis, in vivo and in vitro studies of 1,2,3,4-tetrahydro-9H-carbazole derivatives, highly selective and potent butyrylcholinesterase inhibitors. Molecular diversity. vol 24. issue 1. 2020-10-13. PMID:30927138. |
inhibition of butyrylcholinesterase (bche) might be a useful therapeutic target for alzheimer's disease (ad). |
2020-10-13 |
2023-08-13 |
Not clear |
| Penislusshiyan Sakayanathan, Chitra Loganathan, Saravanan Kandasamy, Rajesh V Ramanna, Kumaradhas Poomani, Palvannan Thayumanava. In vitro and in silico analysis of novel astaxanthin-s-allyl cysteine as an inhibitor of butyrylcholinesterase and various globular forms of acetylcholinesterases. International journal of biological macromolecules. vol 140. 2020-04-16. PMID:31442505. |
in alzheimer's disease (ad) and diabetes-associated cognitive decline, the acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity is increased. |
2020-04-16 |
2023-08-13 |
human |
| You Zhou, Xin Lu, Hongyu Yang, Yao Chen, Feng Wang, Jifu Li, Zhiran Tang, Xifei Cheng, Yingbin Yang, Li Xu, Qingyou Xi. Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations. Molecules (Basel, Switzerland). vol 24. issue 23. 2020-04-14. PMID:31757047. |
as there are increased levels and activity of butyrylcholiesterase (bche) in the late stage of alzheimer's disease (ad), development of selective bche inhibitors is of vital importance. |
2020-04-14 |
2023-08-13 |
Not clear |
| Nabih Lolak, Mehmet Boga, Muhammed Tuneg, Gulcin Karakoc, Suleyman Akocak, Claudiu T Supura. Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile. Journal of enzyme inhibition and medicinal chemistry. vol 35. issue 1. 2020-03-05. PMID:31899985. |
they were also investigated as inhibitors of acetylcholinesterase (ache), butyrylcholinesterase (bche) and tyrosinase, which are associated with several diseases such as alzheimer, parkinson and pigmentation disorders. |
2020-03-05 |
2023-08-13 |
Not clear |
| Xin Lu, Hongyu Yang, Qihang Li, Yao Chen, Qi Li, You Zhou, Feng Feng, Wenyuan Liu, Qinglong Guo, Haopeng Su. Expansion of the scaffold diversity for the development of highly selective butyrylcholinesterase (BChE) inhibitors: Discovery of new hits through the pharmacophore model generation, virtual screening and molecular dynamics simulation. Bioorganic chemistry. vol 85. 2020-02-11. PMID:30605885. |
butyrylcholinesterase (bche) is recently considered as a new target for the treatment of alzheimer's disease (ad). |
2020-02-11 |
2023-08-13 |
Not clear |