| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hafiz Muhammad Abdullah Asif, Shagufta Kamal, Aziz-Ur Rehman, Shahid Rasool, Muhammad Sajid Hamid Akas. Synthesis, Characterization, and Enzyme Inhibition Properties of 1,2,4-Triazole Bearing Azinane Analogues. ACS omega. vol 7. issue 36. 2022-09-19. PMID:36119993. |
considering the importance of acetylcholine esterase (ache, bche) and α-glucosidase in the treatment of alzheimer's disease and diabetes mellitus, the synthesis of novel azinane triazole-based derivatives as effective acetylcholinesterase (ache), α-glucosidase, urease, lipoxygenase (lox), and butyrylcholinesterase (bche) inhibitors is described. |
2022-09-19 |
2023-08-14 |
Not clear |
| Philipp Spatz, Thomas Zimmermann, Sophie Steinmüller, Julian Hofmann, Tangui Maurice, Michael Decke. Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model. RSC medicinal chemistry. vol 13. issue 8. 2022-09-12. PMID:36092149. |
as levels of acetylcholinesterase (ache) decrease while levels of butyrylcholinesterase (bche) increase in later stages of alzheimer's disease (ad), bche stands out as a promising target for treatment of ad. |
2022-09-12 |
2023-08-14 |
mouse |
| Xin Lu, Nan Qin, Yijun Liu, Chenxi Du, Feng Feng, Wenyuan Liu, Yao Chen, Haopeng Su. Design, synthesis, and biological evaluation of aromatic tertiary amine derivatives as selective butyrylcholinesterase inhibitors for the treatment of Alzheimer's disease. European journal of medicinal chemistry. vol 243. 2022-09-09. PMID:36084535. |
butyrylcholinesterase (bche) is recently regarded as a biomarker in progressed alzheimer's disease (ad), the development of selective bche inhibitors has attracted a great deal of interest and may be a viable therapeutic strategy for ad. |
2022-09-09 |
2023-08-14 |
Not clear |
| Marco Paolino, Mariagrazia Rullo, Samuele Maramai, Modesto de Candia, Leonardo Pisani, Marco Catto, Claudia Mugnaini, Antonella Brizzi, Andrea Cappelli, Massimo Olivucci, Federico Corelli, Cosimo D Altomar. Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors. RSC medicinal chemistry. vol 13. issue 7. 2022-08-04. PMID:35923722. |
to this aim, we designed and synthesized a small library of cinnamic acid-inspired isomeric compounds with light modulated activity able to inhibit acetylcholinesterase (ache) and monoamine oxidase b (mao-b), with remarkable selectivity over butyrylcholinesterase (bche) and mao-a, which have been investigated as the enzyme targets related to alzheimer's disease (ad). |
2022-08-04 |
2023-08-14 |
Not clear |
| Selena P Maxwell, Meghan K Cash, Sultan Darves. Neuropathology and cholinesterase expression in the brains of octogenarians and older. Chemico-biological interactions. 2022-07-25. PMID:35872043. |
tissues from age- and sex-matched cnoo and alzheimer's disease (ad) rpfc and hippocampal formation were stained for β-amyloid (aβ), tau, α-synuclein, phosphorylated tar dna-binding protein 43 (ptdp-43), acetylcholinesterase (ache), and butyrylcholinesterase (bche). |
2022-07-25 |
2023-08-14 |
Not clear |
| Ozum Ozturk, Fathima Manaal Farouk, Luyi Ooi, Christine Shing Wei Law, Muhammed Tilahun Muhammed, Esin Aki-Yalcin, Keng Yoon Yeon. Synthesis of novel carboxamide- and carbohydrazide-benzimidazoles as selective butyrylcholinesterase inhibitors. Molecular diversity. 2022-07-02. PMID:35780204. |
selectively inhibiting butyrylcholinesterase (bche) is hypothesized to help in the management of alzheimer's disease (ad). |
2022-07-02 |
2023-08-14 |
Not clear |
| Ozum Ozturk, Fathima Manaal Farouk, Luyi Ooi, Christine Shing Wei Law, Muhammed Tilahun Muhammed, Esin Aki-Yalcin, Keng Yoon Yeon. Synthesis of novel carboxamide- and carbohydrazide-benzimidazoles as selective butyrylcholinesterase inhibitors. Molecular diversity. 2022-07-02. PMID:35780204. |
in our continuous effort to find potent bche inhibitors for alzheimer's disease, a total of 22 novel benzimidazoles with diversified substitutions were synthesized and evaluated for their anticholinesterase activities in this study. |
2022-07-02 |
2023-08-14 |
Not clear |
| Sidrah Tariq, Sadaf Mutahir, Muhammad Asim Khan, Zeeshan Mutahir, Safdar Hussain, Muhammad Ashraf, Xiaofang Bao, Baojing Zhou, Christian Bw Stark, Islam Ullah Kha. Synthesis, in vitro cholinesterase inhibition, molecular docking, DFT and ADME studies of novel 1,3,4-oxadiazole 2-thiol derivatives. Chemistry & biodiversity. 2022-06-29. PMID:35767725. |
a sequence of 1,3,4-oxadiazole 2-thiol derivatives bearing various alkyl or aryl moieties was designed, synthesized, and characterized by modern spectroscopic methods to yield 17 compounds ( 6a - 6q ) which were screened for acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes in search of 'lead' compounds for the treatment of alzheimer disease (ad). |
2022-06-29 |
2023-08-14 |
Not clear |
| Qi Li, Baichen Xiong, Yuanyuan Wang, Weiping Lyu, Shuaishuai Xing, Ying Chen, Qinghong Liao, Siyu He, Feng Feng, Wenyuan Liu, Yao Chen, Haopeng Su. A highly effective and stable butyrylcholinesterase inhibitor with multi-faceted neuroprotection and cognition improvement. European journal of medicinal chemistry. vol 239. 2022-06-21. PMID:35728508. |
butyrylcholinesterase (bche) has been more and more attractive for treating neurodegenerative diseases, especially alzheimer's disease (ad). |
2022-06-21 |
2023-08-14 |
Not clear |
| Ferah Comert Onder, Kader Sahin, Murat Senturk, Serdar Durdagi, Mehmet A. Identifying highly effective coumarin-based novel cholinesterase inhibitors by in silico and in vitro studies. Journal of molecular graphics & modelling. vol 115. 2022-05-27. PMID:35623143. |
inhibition of high cholinesterase levels including acetylcholinesterase (ache) and butyrylcholinesterase (bche), is one of the most important strategies for the treatment of alzheimer's disease (ad). |
2022-05-27 |
2023-08-13 |
Not clear |
| b' Mehmet Koca, U\\xc4\\x9fur G\\xc3\\xbcller, P\\xc4\\xb1nar G\\xc3\\xbcller, Ziya Da\\xc4\\x9falan, Bilal Ni\\xc5\\x9fanc\\xc4\\xb. Design and Synthesis of Novel Dual Cholinesterase Inhibitors: In Vitro Inhibition Studies Supported with Molecular Docking. Chemistry & biodiversity. 2022-04-26. PMID:35470963.' |
the major cholinesterase enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (bche), are important in the therapy of alzheimer's disease (ad) based on the cholinergic hypothesis. |
2022-04-26 |
2023-08-13 |
human |
| Sihan Chen, Zheng Li, Zhenzhen Huang, Qiong Ji. Construction of a copper nanocluster/MnO Journal of materials chemistry. B. 2022-03-28. PMID:35343562. |
construction of a copper nanocluster/mno an abnormal level of butyrylcholinesterase (bche) activity is highly connected with hepatic damage and alzheimer's disease. |
2022-03-28 |
2023-08-13 |
Not clear |
| Matthias Scheiner, Alexandra Sink, Matthias Hoffmann, Cassandre Vrigneau, Erik Endres, Allison Carles, Christoph Sotriffer, Tangui Maurice, Michael Decke. Photoswitchable Pseudoirreversible Butyrylcholinesterase Inhibitors Allow Optical Control of Inhibition Journal of the American Chemical Society. 2022-02-09. PMID:35138833. |
photoswitchable pseudoirreversible butyrylcholinesterase inhibitors allow optical control of inhibition to develop tools to investigate the biological functions of butyrylcholinesterase (bche) and the mechanisms by which bche affects alzheimer's disease (ad), we synthesized several selective, nanomolar active, pseudoirreversible photoswitchable bche inhibitors. |
2022-02-09 |
2023-08-13 |
Not clear |
| G A Reid, S Darves. Interaction of Exogenous Butyrylcholinesterase with β-Amyloid Plaques in 5XFAD/Butyrylcholinesterase-Knockout Mouse Brain. Current Alzheimer research. vol 18. issue 6. 2021-12-09. PMID:34455970. |
in alzheimer's disease (ad), and amyloid models such as the 5xfad mouse, butyrylcholinesterase (bche) is associated with β-amyloid (aβ) plaques and has unique biochemical features which distinguish it from that found in neurons. |
2021-12-09 |
2023-08-13 |
mouse |
| Christian Gentzsch, Matthias Hoffmann, Yasuhiro Ohshima, Naoko Nose, Xinyu Chen, Takahiro Higuchi, Michael Decke. Synthesis and Initial Characterization of a Selective, Pseudo-irreversible Inhibitor of Human Butyrylcholinesterase as PET Tracer. ChemMedChem. vol 16. issue 9. 2021-12-07. PMID:33645891. |
the enzyme butyrylcholinesterase (bche) represents a promising target for imaging probes to potentially enable early diagnosis of neurodegenerative diseases like alzheimer's disease (ad) and to monitor disease progression in some forms of cancer. |
2021-12-07 |
2023-08-13 |
human |
| Shuaizhang Li, Andrew J Li, Jameson Travers, Tuan Xu, Srilatha Sakamuru, Carleen Klumpp-Thomas, Ruili Huang, Menghang Xi. Identification of Compounds for Butyrylcholinesterase Inhibition. SLAS discovery : advancing life sciences R & D. vol 26. issue 10. 2021-12-04. PMID:34269114. |
selective bche inhibition has been regarded as a viable therapeutic approach in alzheimer's disease. |
2021-12-04 |
2023-08-13 |
Not clear |
| Muhammad Shahid Nadeem, Jalaluddin Azam Khan, Umer Rashi. Fluoxetine and sertraline based multitarget inhibitors of cholinesterases and monoamine oxidase-A/B for the treatment of Alzheimer's disease: Synthesis, pharmacology and molecular modeling studies. International journal of biological macromolecules. vol 193. issue Pt A. 2021-11-24. PMID:34687762. |
for the potential therapy of alzheimer's disease (ad), cholinesterases (che) and monoamine oxidase (mao) are key enzymes that regulate the level of acetylcholinesterase (ache)/butyrylcholinesterase (bche) and monoamines. |
2021-11-24 |
2023-08-13 |
mouse |
| Hongwei Gao, Yingying Jiang, Jiuyu Zhan, Yingni Su. Pharmacophore-based drug design of AChE and BChE dual inhibitors as potential anti-Alzheimer's disease agents. Bioorganic chemistry. vol 114. 2021-11-09. PMID:34252860. |
the result of best compound zinc08751495 with ache estimate activity (0.028), bche estimate activity (1.55), ache fit value (9.369), bche fit value (8.415), ache -cdocker energy (30.22), bche -cdocker energy (33.13) has the potential for further development as a supplement to treat alzheimer's disease. |
2021-11-09 |
2023-08-13 |
Not clear |
| Shuaishuai Xing, Qi Li, Baichen Xiong, Yao Chen, Feng Feng, Wenyuan Liu, Haopeng Su. Structure and therapeutic uses of butyrylcholinesterase: Application in detoxification, Alzheimer's disease, and fat metabolism. Medicinal research reviews. vol 41. issue 2. 2021-10-28. PMID:33103262. |
the increased level of bche in progressed alzheimer's disease patients made it a promising target to elevate acetylcholine level and attenuate cognitive status. |
2021-10-28 |
2023-08-13 |
mouse |
| Noopur Khare, Sanjiv Kumar Maheshwari, Abhimanyu Kumar Jh. Screening and identification of secondary metabolites in the bark of Journal of biomolecular structure & dynamics. vol 39. issue 16. 2021-10-21. PMID:32720564. |
screening and identification of secondary metabolites in the bark of acetylcholinesterase (ache) and butyrylcholinesterase (bche) acts as a promising protein targets for which drug as an inhibitor can be designed to treat alzheimer's disease. |
2021-10-21 |
2023-08-13 |
Not clear |