| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sophie Sokolow, Xiaohui Li, Lucia Chen, Kent D Taylor, Jerome I Rotter, Robert A Rissman, Paul S Aisen, Liana G Apostolov. Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment. Journal of Alzheimer's disease : JAD. vol 56. issue 1. 2018-02-21. PMID:27911294. |
in alzheimer's disease, butyrylcholinesterase (bche) activity increases with disease progression and may replace acetylcholinesterase function. |
2018-02-21 |
2023-08-13 |
Not clear |
| Louis De Beaumont, Sandra Pelleieux, Louise Lamarre-Théroux, Doris Dea, Judes Poirie. Butyrylcholinesterase K and Apolipoprotein E-ɛ4 Reduce the Age of Onset of Alzheimer's Disease, Accelerate Cognitive Decline, and Modulate Donepezil Response in Mild Cognitively Impaired Subjects. Journal of Alzheimer's disease : JAD. vol 54. issue 3. 2018-01-26. PMID:27567841. |
together with the apolipoprotein e4 (apoe-ɛ4) gene, butyrylcholinesterase (bche) has become recently one of the few alzheimer's disease (ad) susceptibility genes with distinct pharmacogenomic properties. |
2018-01-26 |
2023-08-13 |
human |
| Jeannette Gonzalez, Jennifer Ramirez, Jason P Schwan. Evaluating Fmoc-amino acids as selective inhibitors of butyrylcholinesterase. Amino acids. vol 48. issue 12. 2017-12-04. PMID:27522651. |
for the two major classes of cholinesterases, such as acetylcholinesterase (ache) and butyrylcholinesterase (bche), previous studies reported bche activity is elevated in patients with alzheimer's disease, while ache levels remain the same or decrease. |
2017-12-04 |
2023-08-13 |
Not clear |
| Babar Ali, Qazi M S Jamal, Saiba Shams, Naser A Al-Wabel, Mughees U Siddiqui, Mohammad A Alzohairy, Mohammed A Al Karaawi, Kavindra Kumar Kesari, Gohar Mushtaq, Mohammad A Kama. In Silico Analysis of Green Tea Polyphenols as Inhibitors of AChE and BChE Enzymes in Alzheimer's Disease Treatment. CNS & neurological disorders drug targets. vol 15. issue 5. 2017-10-04. PMID:26996169. |
in silico analysis of green tea polyphenols as inhibitors of ache and bche enzymes in alzheimer's disease treatment. |
2017-10-04 |
2023-08-13 |
Not clear |
| Sultan Darves. Butyrylcholinesterase as a Diagnostic and Therapeutic Target for Alzheimer's Disease. Current Alzheimer research. vol 13. issue 10. 2017-10-02. PMID:27040140. |
in the human brain bche is mainly expressed in white matter and glia and in distinct populations of neurons in regions that are important in cognition and behavior, functions compromised in alzheimer's disease (ad). |
2017-10-02 |
2023-08-13 |
mouse |
| Urban Košak, Damijan Knez, Nicolas Coquelle, Boris Brus, Anja Pišlar, Florian Nachon, Xavier Brazzolotto, Janko Kos, Jacques-Philippe Colletier, Stanislav Gobe. N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents. Bioorganic & medicinal chemistry. vol 25. issue 2. 2017-08-14. PMID:27908752. |
in the brains of patients with alzheimer's disease, the enzymatic activities of butyrylcholinesterase (bche) and monoamine oxidase b (mao-b) are increased. |
2017-08-14 |
2023-08-13 |
human |
| Urban Košak, Damijan Knez, Nicolas Coquelle, Boris Brus, Anja Pišlar, Florian Nachon, Xavier Brazzolotto, Janko Kos, Jacques-Philippe Colletier, Stanislav Gobe. N-Propargylpiperidines with naphthalene-2-carboxamide or naphthalene-2-sulfonamide moieties: Potential multifunctional anti-Alzheimer's agents. Bioorganic & medicinal chemistry. vol 25. issue 2. 2017-08-14. PMID:27908752. |
while bche is a viable therapeutic target for alleviation of symptoms caused by cholinergic hypofunction, mao-b is a potential therapeutic target for prevention of neurodegeneration in alzheimer's disease. |
2017-08-14 |
2023-08-13 |
human |
| Muhammad Shakil Shah, Shafi Ullah Khan, Syeda Abida Ejaz, Saifullah Afridi, Syed Umar Farooq Rizvi, Muhammad Najam-Ul-Haq, Jamshed Iqba. Cholinesterases inhibition and molecular modeling studies of piperidyl-thienyl and 2-pyrazoline derivatives of chalcones. Biochemical and biophysical research communications. vol 482. issue 4. 2017-05-29. PMID:27865835. |
therefore, cholinesterases (ache & bche) inhibition are considered as a promising strategy for the treatment of alzheimer's disease. |
2017-05-29 |
2023-08-13 |
Not clear |
| Tanzeel Ur Rehman, Islam Ullah Khan, Muhammad Ashraf, Hamadeh Tarazi, Sadaf Riaz, Muhammad Ya. An Efficient Synthesis of bi-Aryl Pyrimidine Heterocycles: Potential New Drug Candidates to Treat Alzheimer's Disease. Archiv der Pharmazie. vol 350. issue 3-4. 2017-05-15. PMID:28220522. |
the enzyme inhibitory potential of these compounds was investigated against acetylcholinesterase (ache) and butyrylcholinesterase (bche) because these enzymes play a crucial role in the treatment of alzheimer's disease. |
2017-05-15 |
2023-08-13 |
Not clear |
| Kyung Hoan Im, Trung Kien Nguyen, Jaehyuk Choi, Tae Soo Le. In Vitro Antioxidant, Anti-Diabetes, Anti-Dementia, and Inflammation Inhibitory Effect of Trametes pubescens Fruiting Body Extracts. Molecules (Basel, Switzerland). vol 21. issue 5. 2017-04-13. PMID:27196881. |
the acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitory effects of me and hwe were moderate and comparable with galanthamine, the standard drug to treat early stages of alzheimer's disease (ad). |
2017-04-13 |
2023-08-13 |
rat |
| Eun Bi Kuk, A Ra Jo, Seo In Oh, Hee Sook Sohn, Su Hui Seong, Anupom Roy, Jae Sue Choi, Hyun Ah Jun. Anti-Alzheimer's disease activity of compounds from the root bark of Morus alba L. Archives of pharmacal research. vol 40. issue 3. 2017-04-04. PMID:28093699. |
anti-alzheimer's disease activity of compounds from the root bark of morus alba l. the inhibition of acetylcholinesterase (ache), butyrylcholinesterase (bche), and β-site amyloid precursor protein cleaving enzyme 1 (bace1) plays important roles in prevention and treatment of alzheimer's disease (ad). |
2017-04-04 |
2023-08-13 |
Not clear |
| Himanshu Kumar Bhakta, Chan Hum Park, Takako Yokozawa, Byung-Sun Min, Hyun Ah Jung, Jae Sue Cho. Kinetics and molecular docking studies of loganin, morroniside and 7-O-galloyl-D-sedoheptulose derived from Corni fructus as cholinesterase and β-secretase 1 inhibitors. Archives of pharmacal research. vol 39. issue 6. 2017-02-07. PMID:27106028. |
we evaluated the major active components isolated from corni fructus: loganin, morroniside, and 7-o-galloyl-d-sedoheptulose as inhibitors of acetylcholinesterase (ache), butyrylcholinesterase (bche), and β-site amyloid precursor protein (app) cleaving enzyme 1 (bace1) for use in alzheimer's disease treatment. |
2017-02-07 |
2023-08-13 |
Not clear |
| Himanshu Kumar Bhakta, Chan Hum Park, Takako Yokozawa, Byung-Sun Min, Hyun Ah Jung, Jae Sue Cho. Kinetics and molecular docking studies of loganin, morroniside and 7-O-galloyl-D-sedoheptulose derived from Corni fructus as cholinesterase and β-secretase 1 inhibitors. Archives of pharmacal research. vol 39. issue 6. 2017-02-07. PMID:27106028. |
the data suggest that these compounds together can act as a triple inhibitor of ache, bche, and bace1, providing a preventive and therapeutic strategy for alzheimer's disease treatment. |
2017-02-07 |
2023-08-13 |
Not clear |
| S Darvesh, G A Rei. Reduced fibrillar β-amyloid in subcortical structures in a butyrylcholinesterase-knockout Alzheimer disease mouse model. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27091549. |
in alzheimer's disease (ad), many β-amyloid (aβ) plaques become associated with bche activity, the significance of which is unclear. |
2017-01-30 |
2023-08-13 |
mouse |
| Katsuyoshi Mizukami, Hiroyasu Akatsu, Eric E Abrahamson, Zhiping Mi, Milos D Ikonomovi. Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 2. 2017-01-09. PMID:26293308. |
studies of acetylcholine degrading enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) in alzheimer's disease (ad) have suggested their potential role in the development of fibrillar amyloid-β (aβ) plaques (amyloid plaques). |
2017-01-09 |
2023-08-13 |
Not clear |
| Shahid A Khan, Sher B Khan, Zarbad Shah, Abdullah M Asir. Withanolides: Biologically Active Constituents in the Treatment of Alzheimer's Disease. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 12. issue 3. 2016-12-13. PMID:26527154. |
acetyl cholinesterase (ache) and butyrylcholinesterase (bche) are two types of cholinesterase enzymes that have been identified in vertebrates that are responsible for alzheimer's disease and related dementia. |
2016-12-13 |
2023-08-13 |
Not clear |
| Edgar Sawatzky, Sarah Wehle, Beata Kling, Jan Wendrich, Gerhard Bringmann, Christoph A Sotriffer, Jörg Heilmann, Michael Decke. Discovery of Highly Selective and Nanomolar Carbamate-Based Butyrylcholinesterase Inhibitors by Rational Investigation into Their Inhibition Mode. Journal of medicinal chemistry. vol 59. issue 5. 2016-08-16. PMID:26886849. |
butyrylcholinesterase (bche) is a promising target for the treatment of later stage cognitive decline in alzheimer's disease. |
2016-08-16 |
2023-08-13 |
Not clear |
| Abdul Hameed, Syeda T Zehra, Syed J A Shah, Khalid M Khan, Rima D Alharthy, Norbert Furtmann, Jürgen Bajorath, Muhammad N Tahir, Jamshed Iqba. Syntheses, cholinesterases inhibition, and molecular docking studies of pyrido[2,3-b]pyrazine derivatives. Chemical biology & drug design. vol 86. issue 5. 2016-08-01. PMID:25951978. |
cholinesterases, acetylcholinesterase (ache) and butyrylcholinesterase (bche), have a role in cholinergic deficit which evidently leads to alzheimer's disease (ad). |
2016-08-01 |
2023-08-13 |
Not clear |
| G Andrew Reid, Sultan Darves. Butyrylcholinesterase-knockout reduces brain deposition of fibrillar β-amyloid in an Alzheimer mouse model. Neuroscience. vol 298. 2016-03-21. PMID:25931333. |
in alzheimer's disease (ad), numerous β-amyloid (aβ) plaques are associated with butyrylcholinesterase (bche) activity, the significance of which is unclear. |
2016-03-21 |
2023-08-13 |
mouse |
| Zongcheng Wang, Yuren Jiang, Xi Wang, Yangsen Du, Dandan Xiao, Youchao Deng, Jinlian Wan. Butyrylcholinesterase K variant and Alzheimer's disease risk: a meta-analysis. Medical science monitor : international medical journal of experimental and clinical research. vol 21. 2015-12-28. PMID:25978873. |
although many studies have estimated the association between the butyrylcholinesterase (bche) k variant and alzheimer's disease (ad) risk, the results are still controversial. |
2015-12-28 |
2023-08-13 |
Not clear |