| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ahsan Raza, Aamer Saeed, Aliya Ibrar, Muhammad Muddassar, Aftab Ahmed Khan, Jamshed Iqba. Pharmacological Evaluation and Docking Studies of 3-Thiadiazolyl- and Thioxo-1,2,4-triazolylcoumarin Derivatives as Cholinesterase Inhibitors. ISRN pharmacology. vol 2012. 2012-09-12. PMID:22966467. |
inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche) is considered a promising strategy for the treatment of alzheimer's disease (ad). |
2012-09-12 |
2023-08-12 |
rabbit |
| Jung Keun Cho, Young Bae Ryu, Marcus J Curtis-Long, Hyung Won Ryu, Heung Joo Yuk, Dae Wook Kim, Hye Jin Kim, Woo Song Lee, Ki Hun Par. Cholinestrase inhibitory effects of geranylated flavonoids from Paulownia tomentosa fruits. Bioorganic & medicinal chemistry. vol 20. issue 8. 2012-09-04. PMID:22445674. |
inhibition of human acetylcholinestrase (hache) and butyrylcholinestrase (bche) has been linked to amelioration of alzheimer's symptoms and research into inhibitors is of critical importance. |
2012-09-04 |
2023-08-12 |
human |
| Cecilia Bartolucci, Jure Stojan, Qian-sheng Yu, Nigel H Greig, Doriano Lamb. Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group. The Biochemical journal. vol 444. issue 2. 2012-07-13. PMID:22390827. |
natural and synthetic carbamates act as pseudo-irreversible inhibitors of ache (acetylcholinesterase) as well as bche (butyrylcholinesterase), two enzymes involved in neuronal function as well as in the development and progression of ad (alzheimer's disease). |
2012-07-13 |
2023-08-12 |
Not clear |
| Ilkay Erdogan Orhan, Ipek Pesin Suntar, Esra Kupeli Akko. In vitro neuroprotective effects of the leaf and fruit extracts of Juglans regia L. (walnut) through enzymes linked to Alzheimer's disease and antioxidant activity. International journal of food sciences and nutrition. vol 62. issue 8. 2012-05-22. PMID:21627404. |
anticholinesterase activity was determined against acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes vital for alzheimer's disease, at 50, 100 and 200 μg ml(-1). |
2012-05-22 |
2023-08-12 |
Not clear |
| I Erdogan Orhan, G Orhan, E Gurka. An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production. Mini reviews in medicinal chemistry. vol 11. issue 10. 2012-02-15. PMID:21762104. |
cholinesterase enzyme family consisting of acetylcholinesterase (ache) and butrylcholinesterase (bche) is important in pathogenesis of alzheimer's disease (ad), explained by "cholinergic hypothesis". |
2012-02-15 |
2023-08-12 |
Not clear |
| Caterina Chianella, Daniela Gragnaniello, Pierpaolo Maisano Delser, Maria Francesca Visentini, Elisabetta Sette, Maria Rosaria Tola, Guido Barbujani, Silvia Fusell. BCHE and CYP2D6 genetic variation in Alzheimer's disease patients treated with cholinesterase inhibitors. European journal of clinical pharmacology. vol 67. issue 11. 2012-02-13. PMID:21630031. |
bche and cyp2d6 genetic variation in alzheimer's disease patients treated with cholinesterase inhibitors. |
2012-02-13 |
2023-08-12 |
Not clear |
| Rita Romani, Roberta Galeazzi, Gabriella Rosi, Rosamaria Fiorini, Irene Pirisinu, Annarina Ambrosini, Giovanna Zoles. Anandamide and its congeners inhibit human plasma butyrylcholinesterase. Possible new roles for these endocannabinoids? Biochimie. vol 93. issue 9. 2012-02-03. PMID:21664223. |
furthermore, recent studies suggest that brain bche can have a role in alzheimer's disease (ad). |
2012-02-03 |
2023-08-12 |
human |
| L Parnetti, D Chiasserini, U Andreasson, M Ohlson, C Hüls, H Zetterberg, L Minthon, A K Wallin, N Andreasen, V N Talesa, K Blenno. Changes in CSF acetyl- and butyrylcholinesterase activity after long-term treatment with AChE inhibitors in Alzheimer's disease. Acta neurologica Scandinavica. vol 124. issue 2. 2011-11-02. PMID:20880294. |
to measure cerebrospinal fluid (csf) activity of acetylcholinesterase (ache) and butyrylcholinesterase (bche) in patients with alzheimer's disease (ad) participating in randomized clinical trials from three european centers, before and after long-term treatment with different ache inhibitors (acheis). |
2011-11-02 |
2023-08-12 |
Not clear |
| Miguel O Mitchell, Robert W Figliozzi, Mustafa Guze. In silico ligand-receptor docking of potentially selective butyrylcholinesterase inhibitors structurally related to the marine natural product debromoflustramine B. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 6. issue 3. 2011-05-19. PMID:20632975. |
selective human butyrylcholinesterase (bche) inhibitors such as cymserine have shown considerable promise for restoring cognition in alzheimer's disease. |
2011-05-19 |
2023-08-12 |
human |
| Gumpeny R Sridhar, Allam Appa Rao, Kudipudi Srinivas, Gumpeny Nirmala, Gumpeny Lakshmi, Dasika Suryanarayna, Padmanabhuni V Nageswara Rao, Dowluru G S V G L Kaladhar, Sali Veeresh Kumar, Tatavarthi Uma Devi, Turaga Nitesh, Thota Hanuma. Butyrylcholinesterase in metabolic syndrome. Medical hypotheses. vol 75. issue 6. 2011-02-18. PMID:20797821. |
we also demonstrated a possible pathogenic role for bche in the common existence of insulin resistance, type 2 diabetes and alzheimer's disease by in silico method and followed it up with a diabetic mouse study where cognition was slowed along with changes in bche levels. |
2011-02-18 |
2023-08-12 |
mouse |
| Zaheer Ul-Haq, Waqasuddin Khan, Saima Kalsoom, Farzana L Ansar. In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of beta-amyloid plaques associated with Alzheimer's disease. Theoretical biology & medical modelling. vol 7. 2010-09-17. PMID:20550720. |
in silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against bche in the formation of beta-amyloid plaques associated with alzheimer's disease. |
2010-09-17 |
2023-08-12 |
Not clear |
| Nurgun Kucukboyaci, Ilkay Orhan, Bilge Sener, S Ahmad Nawaz, M Iqbal Choudhar. Assessment of enzyme inhibitory and antioxidant activities of lignans from Taxus baccata L. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 65. issue 3-4. 2010-06-03. PMID:20469636. |
compounds 1-5 were evaluated for their acetylcholinesterase (ache), butyrylcholinesterase (bche), and lipoxygenase (lox) inhibitory activities, which play a role in the pathogenesis of alzheimer's disease (ad), by in vitro spectrophotometric methods, while they were also screened for their antioxidant capacity in 2,2-diphenyl-1-picrylhydrazyl (dpph) radical scavenging, ferrous ion-chelating effect, and ferric-reducing antioxidant power (frap) at 125, 250, 500, and 1000 microg ml(-1). |
2010-06-03 |
2023-08-12 |
Not clear |
| F S Senol, I Orhan, G Yilmaz, M Ciçek, B Sene. Acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibition studies and antioxidant activities of 33 Scutellaria L. taxa from Turkey. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 48. issue 3. 2010-06-02. PMID:20026160. |
therefore, we initiated a study to screen the methanol extracts prepared from the aerial parts of 33 turkish scutellaria species for their acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitory activities, which are the key enzymes taking place in pathogenesis of alzheimer's disease. |
2010-06-02 |
2023-08-12 |
Not clear |
| Pattara Sawasdee, Chalisa Sabphon, Duangporn Sitthiwongwanit, Udom Kokpo. Anticholinesterase activity of 7-methoxyflavones isolated from Kaempferia parviflora. Phytotherapy research : PTR. vol 23. issue 12. 2010-01-25. PMID:19548291. |
interestingly, 5,7-dimethoxyflavone (7) exhibited strong selectivity for bche over ache which may be of great interest to modify as a treatment agent for alzheimer's disease. |
2010-01-25 |
2023-08-12 |
Not clear |
| Walter Maetzler, Stefanie Keller, Joan Michelis, Niklas Koehler, Elke Stransky, Clemens Becker, Claudia Schulte, Arthur Melms, Thomas Gasser, Daniela Ber. No differences of butyrylcholinesterase protein activity and allele frequency in Lewy body diseases. Neurobiology of disease. vol 35. issue 2. 2009-09-21. PMID:19481150. |
butyrylcholinesterase (bche) genotypes and protein (buche) activity, especially in combination with apolipoprotein e4 (apoe4), have been investigated as risk factors for developing alzheimer disease (ad) and may be associated with the rate of progression of cognitive decline. |
2009-09-21 |
2023-08-12 |
human |
| Renato Scacchi, Giuseppe Gambina, Giuseppe Moretto, Rosa Maria Corb. Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 4. 2009-07-30. PMID:18780301. |
variability of ache, bche, and chat genes in the late-onset form of alzheimer's disease and relationships with response to treatment with donepezil and rivastigmine. |
2009-07-30 |
2023-08-12 |
human |
| Ellen G Duysen, Bin Li, Oksana Lockridg. The butyrylcholinesterase knockout mouse a research tool in the study of drug sensitivity, bio-distribution, obesity and Alzheimer's disease. Expert opinion on drug metabolism & toxicology. vol 5. issue 5. 2009-07-08. PMID:19416087. |
the bche ko mouse cannot tolerate standard doses of the muscle relaxant succinylcholine or the alzheimer's disease drugs huperzine a and donepezil. |
2009-07-08 |
2023-08-12 |
mouse |
| Kamalakaran Anand Solomon, Srinivasan Sundararajan, Veluchamy Abiram. QSAR studies on N-aryl derivative activity towards Alzheimer's disease. Molecules (Basel, Switzerland). vol 14. issue 4. 2009-06-05. PMID:19384276. |
a quantitative structure activity relationship (qsar) study has been an attempted on a series of 88 n-aryl derivatives which display varied inhibitory activity towards both acetylcholinesterase (ache) and butyrylcholinesterase (bche), targets in alzheimer's drug discovery. |
2009-06-05 |
2023-08-12 |
Not clear |
| Manuela Bartolini, Nigel H Greig, Qian-Sheng Yu, Vincenza Andrisan. Immobilized butyrylcholinesterase in the characterization of new inhibitors that could ease Alzheimer's disease. Journal of chromatography. A. vol 1216. issue 13. 2009-05-12. PMID:18950780. |
focus of this work was the development and characterization of a new immobilized enzyme reactor (imer) containing human recombinant butyrylcholinesterase (rbche) for the on-line kinetic characterization of specific, pseudo-irreversible and brain-targeted bche inhibitors as potential drug candidates for alzheimer's disease (ad). |
2009-05-12 |
2023-08-12 |
human |
| Christian Fleck, Dorothea Appenroth, Michael Decker, Jochen Lehman. A new way of data interpretation for cognition tests in rats used to characterise six choline esterase inhibitors with heterocyclic nitrogen bridgehead structure. Application in Alzheimer therapy. Arzneimittel-Forschung. vol 58. issue 11. 2009-02-23. PMID:19137904. |
six new tri- and tetracyclic nitrogen bridgehead compounds known to be moderate to potent inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (bche) in vitro were tested in vivo as experimental therapeutics for treatment of alzheimer's disease. |
2009-02-23 |
2023-08-12 |
rat |