| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Bi, Y Zhang, J Wu, D Wang, Q Zha. Association between low-density lipoprotein receptor-related protein gene, butyrylcholinesterase gene and Alzheimer' s disease in Chinese. Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih. vol 16. issue 2. 2003-12-12. PMID:12901493. |
to research the relations between low-density lipoprotein receptor-related protein gene (lrp) polymorphism, butyrylcholinesterase gene (bche) polymorphism and alzheimer's disease (ad) in chinese. |
2003-12-12 |
2023-08-12 |
Not clear |
| K W Kim, J H Jhoo, J H Lee, K U Lee, D Y Lee, J C Youn, J Y Youn, J I Wo. Neither the butyrylcholinesterase K variant nor transferrin C2 variant confers a risk for Alzheimer's disease in Koreans. Journal of neural transmission (Vienna, Austria : 1996). vol 108. issue 10. 2002-04-16. PMID:11725818. |
to investigate the possible involvement of the butyrylcholinesterase (bche) k variant and transferrin (tf) c2 variant in the manifestation of alzheimer's disease (ad), we analyzed the bche, tf and apolipoprotein e (apoe) genotypes of 164 sporadic ad patients and 239 normal elderly controls. |
2002-04-16 |
2023-08-12 |
Not clear |
| Y Hashim, D Shepherd, S Wiltshire, R R Holman, J C Levy, A Clark, C A Cul. Butyrylcholinesterase K variant on chromosome 3 q is associated with Type II diabetes in white Caucasian subjects. Diabetologia. vol 44. issue 12. 2002-04-01. PMID:11793025. |
to determine the association of three genes associated with alzheimer's disease--butyrylcholinesterase (bche) on chromosome 3 q, alpha2 macroglobulin (alpha2m) on chromosome 12 p and apolipoprotein e (apoe) on chromosome 19 q--with type ii (non-insulin-dependent) diabetes mellitus. |
2002-04-01 |
2023-08-12 |
human |
| A S Balasubramania. Amyloid beta peptide processing, insulin degrading enzyme, and butyrylcholinesterase. Neurochemical research. vol 26. issue 4. 2002-01-02. PMID:11495357. |
abnormal cholinesterases similar to butyrylcholinesterase (bche) are found in alzheimer brain. |
2002-01-02 |
2023-08-12 |
Not clear |
| N H Greig, E De Micheli, H W Holloway, Q S Yu, T Utsuki, T A Perry, A Brossi, D K Ingram, J Deutsch, D K Lahiri, T T Soncran. The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. Acta neurologica Scandinavica. Supplementum. vol 176. 2001-05-17. PMID:11261809. |
phenserine, a phenylcarbamate of physostigmine, is a new potent and highly selective acetylcholinesterase (ache) inhibitor, with a > 50-fold activity versus butyrylcholinesterase (bche), in clinical trials for the treatment of alzheimer's disease (ad). |
2001-05-17 |
2023-08-12 |
rat |
| A Alvarez-Arcaya, O Combarros, J Llorca, M Sánchez-Guerra, J Berciano, C Fernández-Viadero, N Peñ. The butyrylcholinesterase K variant is a protective factor for sporadic Alzheimer's disease in women. Acta neurologica Scandinavica. vol 102. issue 6. 2001-02-15. PMID:11125748. |
recent reports indicate that the k variant of the butyrylcholinesterase (bche) gene may act in synergism with the epsilon4 allele of apolipoprotein e (apoe) to increase the risk of alzheimer's disease (ad), but this is controversial. |
2001-02-15 |
2023-08-12 |
Not clear |
| K M Mattila, J O Rinne, M Röyttä, P Laippala, T Pietilä, H Kalimo, T Koivula, H Frey, T Lehtimäk. Dipeptidyl carboxypeptidase 1 (DCP1) and butyrylcholinesterase (BCHE) gene interactions with the apolipoprotein E epsilon4 allele as risk factors in Alzheimer's disease and in Parkinson's disease with coexisting Alzheimer pathology. Journal of medical genetics. vol 37. issue 10. 2001-02-01. PMID:11015454. |
dipeptidyl carboxypeptidase 1 (dcp1) and butyrylcholinesterase (bche) gene interactions with the apolipoprotein e epsilon4 allele as risk factors in alzheimer's disease and in parkinson's disease with coexisting alzheimer pathology. |
2001-02-01 |
2023-08-12 |
human |
| K M Mattila, J O Rinne, M Röyttä, P Laippala, T Pietilä, H Kalimo, T Koivula, H Frey, T Lehtimäk. Dipeptidyl carboxypeptidase 1 (DCP1) and butyrylcholinesterase (BCHE) gene interactions with the apolipoprotein E epsilon4 allele as risk factors in Alzheimer's disease and in Parkinson's disease with coexisting Alzheimer pathology. Journal of medical genetics. vol 37. issue 10. 2001-02-01. PMID:11015454. |
we thus conclude that, in finns, interaction between dcp1 *i and epsilon4 increases the risk of ad as well as of pd with coexisting alzheimer pathology, which underlines the importance of the dcp1 i/d polymorphism in the development of alzheimer neuropathology, whereas the wild type bche genotype in combination with epsilon4 had a combined effect with regard to the risk of ad. |
2001-02-01 |
2023-08-12 |
human |
| D W Lee, H C Liu, T Y Liu, C W Chi, C J Hon. No association between butyrylcholinesterase K-variant and Alzheimer disease in Chinese. American journal of medical genetics. vol 96. issue 2. 2000-09-06. PMID:10893490. |
increased butyrylcholinesterase (bche) activity has been reported to be associated with the formation of amyloid plaques and neurofibrillary tangles and may consequently be involved in the pathogenesis of alzheimer disease (ad). |
2000-09-06 |
2023-08-12 |
Not clear |
| C V Altamirano, C F Bartels, O Lockridg. The butyrylcholinesterase K-variant shows similar cellular protein turnover and quaternary interaction to the wild-type enzyme. Journal of neurochemistry. vol 74. issue 2. 2000-02-10. PMID:10646540. |
a recent study has linked the butyrylcholinesterase (bche) k-variant and the apolipoprotein epsilon4 isoform to late-onset alzheimer's disease. |
2000-02-10 |
2023-08-12 |
Not clear |
| J M Grubber, A M Saunders, A R Crane-Gatherum, W K Scott, E R Martin, C S Haynes, P M Conneally, G W Small, A D Roses, J L Haines, M A Pericak-Vanc. Analysis of association between Alzheimer disease and the K variant of butyrylcholinesterase (BCHE-K). Neuroscience letters. vol 269. issue 2. 1999-10-14. PMID:10430518. |
recently, an increased odds of carrying the k variant of bche (bche-k) was reported among alzheimer disease (ad) cases as compared with controls. |
1999-10-14 |
2023-08-12 |
human |
| C S Ki, D L Na, J W Kim, H J Kim, D K Kim, B K Yoo. No association between the genes for butyrylcholinesterase K variant and apolipoprotein E4 in late-onset Alzheimer's disease. American journal of medical genetics. vol 88. issue 2. 1999-06-28. PMID:10206226. |
butyrylcholinesterase (bche) as well as acetylcholinesterase has been suggested to be associated with alzheimer's disease (ad). |
1999-06-28 |
2023-08-12 |
human |
| Q Yu, H W Holloway, T Utsuki, A Brossi, N H Grei. Synthesis of novel phenserine-based-selective inhibitors of butyrylcholinesterase for Alzheimer's disease. Journal of medicinal chemistry. vol 42. issue 10. 1999-06-10. PMID:10346939. |
as our structure-activity studies predicted, these compounds are highly potent and selective inhibitors of human butyrylcholinesterase (bche) and will test the novel hypothesis that bche inhibitors are useful in the treatment of alzheimer's disease. |
1999-06-10 |
2023-08-12 |
human |
| P G Kehoe, H Williams, P Holmans, G Wilcock, N J Cairns, J Neal, M J Owe. The butyrylcholinesterase K variant and susceptibility to Alzheimer's disease. Journal of medical genetics. vol 35. issue 12. 1999-03-22. PMID:9863603. |
previous work has shown an association between the k variant of the butyrylcholinesterase (bche) gene and alzheimer's disease (ad) in patients carrying the epsilon4 allele of apoe. |
1999-03-22 |
2023-08-12 |
Not clear |
| F Crawford, D Fallin, Z Suo, L Abdullah, M Gold, A Gauntlett, R Duara, M Mulla. The butyrylcholinesterase gene is neither independently nor synergistically associated with late-onset AD in clinic- and community-based populations. Neuroscience letters. vol 249. issue 2-3. 1998-09-30. PMID:9682830. |
the k variant of the butyrylcholinesterase gene (bche) was recently found to occur at an increased frequency in a late onset alzheimer's disease (ad) population, specifically in individuals carrying the epsilon4 allele of the apolipoprotein e (apoe) gene. |
1998-09-30 |
2023-08-12 |
Not clear |
| D H Small, S Michaelson, G Sbern. Non-classical actions of cholinesterases: role in cellular differentiation, tumorigenesis and Alzheimer's disease. Neurochemistry international. vol 28. issue 5-6. 1996-12-30. PMID:8792327. |
abnormal expression of ache and bche has been detected around the amyloid plaques and neurofibrillary tangles in the brains of patients with alzheimer's disease. |
1996-12-30 |
2023-08-12 |
Not clear |
| P G Laye. Nonclassical roles of cholinesterases in the embryonic brain and possible links to Alzheimer disease. Alzheimer disease and associated disorders. vol 9 Suppl 2. 1996-02-07. PMID:8534420. |
evidence about nonclassic functions of acetyl- (ache) and butyryl-cholinesterase (bche) during embryonic development of vertebrate brains is compared with evidence of their expression in alzheimer disease (ad). |
1996-02-07 |
2023-08-12 |
Not clear |
| C I Wright, C Geula, M M Mesula. Protease inhibitors and indolamines selectively inhibit cholinesterases in the histopathologic structures of Alzheimer's disease. Annals of the New York Academy of Sciences. vol 695. 1993-12-10. PMID:8239315. |
neurofibrillary tangles and amyloid plaques express acetylcholinesterase (ache) and butyrylcholinesterase (bche) activity in alzheimer's disease. |
1993-12-10 |
2023-08-12 |
Not clear |
| C I Wright, C Geula, M M Mesula. Neurological cholinesterases in the normal brain and in Alzheimer's disease: relationship to plaques, tangles, and patterns of selective vulnerability. Annals of neurology. vol 34. issue 3. 1993-09-30. PMID:8363355. |
butyrylcholinesterase (bche) and an altered form of acetylcholinesterase (ache) accumulate in the plaques and tangles of alzheimer's disease (ad). |
1993-09-30 |
2023-08-12 |
Not clear |
| T Arendt, M K Brückner, M Lange, V Big. Changes in acetylcholinesterase and butyrylcholinesterase in Alzheimer's disease resemble embryonic development--a study of molecular forms. Neurochemistry international. vol 21. issue 3. 1993-06-24. PMID:1303164. |
the pattern of molecular forms of acetylcholinesterase (ache, ec 3.1.1.7) and butyrylcholinesterase (bche, ec 3.1.1.8) separated by density gradient centrifugation was investigated in the brain and cerebrospinal fluid in alzheimer's disease (ad), in human embryonic brain and in rat brain after experimental cholinergic deafferentation of the cerebral cortex. |
1993-06-24 |
2023-08-11 |
human |