| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Aleksandra Siwicka, Zuzanna Moleda, Krystyna Wojtasiewicz, Anna Zawadzka, Jan K Maurin, Mirosława Panasiewicz, Tadeusz Pacuszka, Zbigniew Czarnock. The oxidation products of melatonin derivatives exhibit acetylcholinesterase and butyrylcholinesterase inhibitory activity. Journal of pineal research. vol 45. issue 1. 2008-10-28. PMID:18284552. |
the compounds obtained possess the 2,3,8,8a-tetrahydropyrrolo[2,3-b]indole heterocyclic system which is a structural motif characteristic of alkaloids, physostigmine and phenserine, that are potent acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitors used in the alzheimer's disease treatment. |
2008-10-28 |
2023-08-12 |
human |
| Ilkay Orhan, Fatma Tosun, Bilge Sene. Coumarin, anthroquinone and stilbene derivatives with anticholinesterase activity. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 63. issue 5-6. 2008-08-26. PMID:18669022. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are the key enzymes in pathogenesis of alzheimer's disease (ad), which is characterized by a deficit in central cholinergic transmission. |
2008-08-26 |
2023-08-12 |
Not clear |
| Min Wang, Ji-Quan Wang, Mingzhang Gao, Qi-Huang Zhen. Facile synthesis of new carbon-11 labeled conformationally restricted rivastigmine analogues as potential PET agents for imaging AChE and BChE enzymes. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. vol 66. issue 4. 2008-06-10. PMID:18155915. |
rivastigmine is a newer-generation inhibitor with a dual inhibitory action on both acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes, and is used for the treatment of ache- and bche-related diseases such as brain alzheimer's disease and cardiovascular disease. |
2008-06-10 |
2023-08-12 |
Not clear |
| E Podoly, T Bruck, S Diamant, N Melamed-Book, A Weiss, Y Huang, O Livnah, S Langermann, H Wilgus, H Sore. Human recombinant butyrylcholinesterase purified from the milk of transgenic goats interacts with beta-amyloid fibrils and suppresses their formation in vitro. Neuro-degenerative diseases. vol 5. issue 3-4. 2008-05-15. PMID:18322399. |
in alzheimer's disease (ad), brain butyrylcholinesterase (bche) co-localizes with beta-amyloid (abeta) fibrils. |
2008-05-15 |
2023-08-12 |
human |
| Amélia P Rauter, Isabel Branco, Rui G Lopes, Jorge Justino, Filipa V M Silva, João P Noronha, Eurico J Cabrita, Ignacio Brouard, Jaime Bermej. A new lupene triterpenetriol and anticholinesterase activity of Salvia sclareoides. Fitoterapia. vol 78. issue 7-8. 2008-03-06. PMID:17570616. |
the acetone, ethanol, butanol and water extracts of the plant were screened for the in vitro inhibitory activity of acetylcholinesterase (ache) and butyrilcholinesterase (bche), enzymes which play a role in the alzheimer disease. |
2008-03-06 |
2023-08-12 |
Not clear |
| Maria Cándida Déniz-Naranjo, Carmen Muñoz-Fernández, Maria Jesús Alemany-Rodríguez, Maria del Carmen Pérez-Vieitez, Yolanda Aladro-Benito, Juncal Irurita-Latasa, Florentino Sánchez-Garcí. Butyrylcholinesterase, ApoE and Alzheimer's disease in a population from the Canary Islands (Spain). Neuroscience letters. vol 427. issue 1. 2008-01-25. PMID:17923322. |
butyrylcholinesterase (bche) is one of the cholinesterases with increased activity in the brain of alzheimer's patients. |
2008-01-25 |
2023-08-12 |
Not clear |
| Mariapaola Piccardi, Donatella Congiu, Alessio Squassina, Francesca Manconi, Paolo Francesco Putzu, Rosa Maria Mereu, Caterina Chillotti, Maria Del Zomp. Alzheimer's disease: case-control association study of polymorphisms in ACHE, CHAT, and BCHE genes in a Sardinian sample. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 144B. issue 7. 2007-12-06. PMID:17503475. |
alzheimer's disease: case-control association study of polymorphisms in ache, chat, and bche genes in a sardinian sample. |
2007-12-06 |
2023-08-12 |
human |
| Efrat Groner, Yacov Ashani, Donna Schorer-Apelbaum, Jeffrey Sterling, Yaacov Herzig, Marta Weinstoc. The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates. Molecular pharmacology. vol 71. issue 6. 2007-07-18. PMID:17347320. |
controlled inhibition of brain acetyl- and butyrylcholinesterases (ache and bche, respectively) and of monoamine oxidase-b (mao-b) may slow neurodegeneration in alzheimer's and parkinson's diseases. |
2007-07-18 |
2023-08-12 |
human |
| Carlos H T P da Silva, Vanessa Leiria Campo, Ivone Carvalho, Carlton A Taf. Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease. Journal of molecular graphics & modelling. vol 25. issue 2. 2007-01-08. PMID:16413803. |
molecular modeling techniques were of utmost importance to design a new pharmaceutical against alzheimer's disease, with potential inhibitory activity over ache, since the inhibition of human plasma butyrylcholinesterase (bche) may cause side effects. |
2007-01-08 |
2023-08-12 |
human |
| Yvonne Schott, Michael Decker, Hans Rommelspacher, Jochen Lehman. 6-Hydroxy- and 6-methoxy-beta-carbolines as acetyl- and butyrylcholinesterase inhibitors. Bioorganic & medicinal chemistry letters. vol 16. issue 22. 2007-01-03. PMID:16945529. |
in the course of studies directed toward the discovery of novel acetyl- and butyrylcholinesterase (ache and bche) inhibitors for the treatment of alzheimer's disease, we focused on beta-carbolines (bcs). |
2007-01-03 |
2023-08-12 |
Not clear |
| Sophia Diamant, Erez Podoly, Assaf Friedler, Hagai Ligumsky, Oded Livnah, Hermona Sore. Butyrylcholinesterase attenuates amyloid fibril formation in vitro. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 23. 2006-07-19. PMID:16731619. |
in alzheimer's disease, both acetylcholinesterase (ache) and butyrylcholinesterase (bche) colocalize with brain fibrils of amyloid-beta (abeta) peptides, and synaptic ache-s facilitates fibril formation by association with insoluble abeta fibrils. |
2006-07-19 |
2023-08-12 |
human |
| Sophia Diamant, Erez Podoly, Assaf Friedler, Hagai Ligumsky, Oded Livnah, Hermona Sore. Butyrylcholinesterase attenuates amyloid fibril formation in vitro. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 23. 2006-07-19. PMID:16731619. |
in alzheimer's disease, bche may have thus acquired an inverse role to that of ache by adopting imperfect amphipathic characteristics of its c terminus. |
2006-07-19 |
2023-08-12 |
human |
| Richard K Gordon, Julian R Haigh, Gregory E Garcia, Shawn R Feaster, Michael A Riel, David E Lenz, Paul S Aisen, Bhupendra P Docto. Oral administration of pyridostigmine bromide and huperzine A protects human whole blood cholinesterases from ex vivo exposure to soman. Chemico-biological interactions. vol 157-158. 2006-02-24. PMID:16256090. |
in the second fda human study for the treatment of alzheimer's disease, the wrair che wb assay was used to determine the rbc-ache and serum bche profile of healthy elderly volunteers receiving huperzine a. huperzine a is a plant-derived reversible and selective ache inhibitor compared to bche, and is a more potent inhibitor of ache than pb. |
2006-02-24 |
2023-08-12 |
human |
| Nigel H Greig, Tadanobu Utsuki, Donald K Ingram, Yue Wang, Giancarlo Pepeu, Carla Scali, Qian-Sheng Yu, Jacek Mamczarz, Harold W Holloway, Tony Giordano, DeMao Chen, Katsutoshi Furukawa, Kumar Sambamurti, Arnold Brossi, Debomoy K Lahir. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 47. 2006-01-12. PMID:16275899. |
like acetylcholinesterase, butyrylcholinesterase (bche) inactivates the neurotransmitter acetylcholine (ach) and is hence a viable therapeutic target in alzheimer's disease, which is characterized by a cholinergic deficit. |
2006-01-12 |
2023-08-12 |
mouse |
| Nigel H Greig, Tadanobu Utsuki, Donald K Ingram, Yue Wang, Giancarlo Pepeu, Carla Scali, Qian-Sheng Yu, Jacek Mamczarz, Harold W Holloway, Tony Giordano, DeMao Chen, Katsutoshi Furukawa, Kumar Sambamurti, Arnold Brossi, Debomoy K Lahir. Selective butyrylcholinesterase inhibition elevates brain acetylcholine, augments learning and lowers Alzheimer beta-amyloid peptide in rodent. Proceedings of the National Academy of Sciences of the United States of America. vol 102. issue 47. 2006-01-12. PMID:16275899. |
selective, reversible inhibition of brain bche may represent a treatment for alzheimer's disease, improving cognition and modulating neuropathological markers of the disease. |
2006-01-12 |
2023-08-12 |
mouse |
| Onofre Combarros, José A Riancho, Jon Infante, Carolina Sañudo, Javier Llorca, María T Zarrabeitia, José Bercian. Interaction between CYP19 aromatase and butyrylcholinesterase genes increases Alzheimer's disease risk. Dementia and geriatric cognitive disorders. vol 20. issue 2-3. 2005-10-13. PMID:16020944. |
biological evidence supports a role of aromatase and butyrilcholinesterase (bche) enzymes in the disruption of the cholinergic neurotransmission observed in alzheimer's disease (ad). |
2005-10-13 |
2023-08-12 |
human |
| Lynnette J Cook, Luk W Ho, Lin Wang, Edith Terrenoire, Carol Brayne, John Grimley Evans, John Xuereb, Nigel J Cairns, Dragana Turic, Paul Hollingworth, Pamela J Moore, Luke Jehu, Nicola Archer, Sarah Walter, Catherine Foy, Amanda Edmondson, John Powell, Simon Lovestone, Julie Williams, David C Rubinsztei. Candidate gene association studies of genes involved in neuronal cholinergic transmission in Alzheimer's disease suggests choline acetyltransferase as a candidate deserving further study. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 132B. issue 1. 2005-05-12. PMID:15690550. |
consistent deficits in the cholinergic system are evident in the brains of alzheimer's disease (ad) patients, including reductions in the activities of acetylcholine, acetylcholinesterase (ache), and choline acetyltransferase (chat), increased butyrylcholinesterase (bche) activity, and a selective loss of nicotinic acetylcholine receptors (nachrs). |
2005-05-12 |
2023-08-12 |
Not clear |
| A Johansen, E-M D Nielsen, G Andersen, Y H Hamid, D P Jensen, C Glümer, T Drivsholm, K Borch-Johnsen, T Jørgensen, T Hansen, O Pederse. Large-scale studies of the functional K variant of the butyrylcholinesterase gene in relation to Type 2 diabetes and insulin secretion. Diabetologia. vol 47. issue 8. 2005-02-17. PMID:15258737. |
polymorphisms of the butyrylcholinesterase gene (bche) are reported to associate with alzheimer's disease and a recent study found a significant association of the bche k variant (g1615a/ala539thr) with type 2 diabetes. |
2005-02-17 |
2023-08-12 |
Not clear |
| Tatsuya Kikuchi, Ming-Rong Zhang, Nobuo Ikota, Kiyoshi Fukushi, Toshimitsu Okamura, Kazutoshi Suzuki, Yasushi Arano, Toshiaki Iri. N-[18F]fluoroethylpiperidin-4-ylmethyl butyrate: a novel radiotracer for quantifying brain butyrylcholinesterase activity by positron emission tomography. Bioorganic & medicinal chemistry letters. vol 14. issue 8. 2004-11-09. PMID:15050629. |
in alzheimer's disease, cerebral cortical butyrylcholinesterase (bche) activity is reported to be elevated. |
2004-11-09 |
2023-08-12 |
Not clear |
| János Kálmán, Anna Juhász, Zoltán Rakonczay, György Abrahám, Marianna Zana, Krisztina Boda, Tibor Farkas, Botond Penke, Zoltán Jank. Increased serum butyrylcholinesterase activity in type IIb hyperlipidaemic patients. Life sciences. vol 75. issue 10. 2004-07-28. PMID:15219807. |
our results point to a possible association between an abnormal lipid metabolism and the bche activity and might have implications as regards the pathomechanism of both alzheimer's and vascular dementias and the cholinesterase inhibitor therapy of dementing disorders. |
2004-07-28 |
2023-08-12 |
Not clear |