| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Stane Pajk, Damijan Knez, Urban Košak, Maja Zorović, Xavier Brazzolotto, Nicolas Coquelle, Florian Nachon, Jacques-Philippe Colletier, Marko Živin, Jure Stojan, Stanislav Gobe. Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes. Journal of enzyme inhibition and medicinal chemistry. vol 35. issue 1. 2020-02-05. PMID:31914836. |
brain butyrylcholinesterase (bche) is an attractive target for drugs designed for the treatment of alzheimer's disease (ad) in its advanced stages. |
2020-02-05 |
2023-08-13 |
human |
| b' Kre\\xc5\\xa1imir Baumann, Lorena Kordi\\xc4\\x87, Marko Mo\\xc4\\x8dibob, Goran \\xc5\\xa0inko, Sr\\xc4\\x91anka Tomi\\xc4\\x8. Synthesis and In Vitro Screening of Novel Heterocyclic \\xce\\xb2-d-Gluco- and \\xce\\xb2-d-Galactoconjugates as Butyrylcholinesterase Inhibitors. Molecules (Basel, Switzerland). vol 24. issue 15. 2020-01-14. PMID:31382668.' |
the development of selective butyrylcholinesterase (bche) inhibitors may improve the treatment of alzheimer's disease by increasing lower synaptic levels of the neurotransmitter acetylcholine, which is hydrolysed by acetylcholinesterase, as well as by overexpressed bche. |
2020-01-14 |
2023-08-13 |
Not clear |
| Ilkay Erdogan Orhan, F Sezer Senol Deniz, Ramin Ekhteiari Salmas, Serdar Durdagi, Francesco Epifano, Salvatore Genovese, Serena Fiorit. Combined molecular modeling and cholinesterase inhibition studies on some natural and semisynthetic O-alkylcoumarin derivatives. Bioorganic chemistry. vol 84. 2020-01-13. PMID:30530106. |
in the present study, 26 novel o-alkylcoumarin derivatives were synthesized and have been tested at 100 µm for their in vitro inhibitory potential against acetylcholinesterase (ache) and butyrlcholinesterase (bche) targets which are the key enzymes playing role in the pathogenesis of alzheimer's disease. |
2020-01-13 |
2023-08-13 |
Not clear |
| Esengul Karahisar, Osman Tugay, Ilkay Erdogan Orhan, Fatma Sezer Senol Deniz, Simon Vlad Luca, Krystyna Skalicka-Wozniak, Mustafa Sahi. Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC-DAD-ESI-Q-TOF-MS/MS) and Neurobiological Potential of Haplophyllum sahinii and H. vulcanicum Extracts. Chemistry & biodiversity. vol 16. issue 9. 2019-12-09. PMID:31365785. |
& heldr., were screened against acetylcholinesterase (ache) and butyrylcholinesterase (bche) associated with alzheimer's disease as well as tyrosinase (tyr) linked to parkinson's disease using elisa microplate assay at 200 μg/ml. |
2019-12-09 |
2023-08-13 |
Not clear |
| Grażyna Budryn, Joanna Grzelczyk, Andrzej Jaśkiewicz, Dorota Żyżelewicz, Horacio Pérez-Sánchez, José P Cerón-Carrasc. Evaluation of butyrylcholinesterase inhibitory activity by chlorogenic acids and coffee extracts assed in ITC and docking simulation models. Food research international (Ottawa, Ont.). vol 109. 2019-11-07. PMID:29803450. |
in patients with alzheimer's disease (ad), elevated levels of butyrylcholinesterase (bche) are observed. |
2019-11-07 |
2023-08-13 |
Not clear |
| Grażyna Budryn, Joanna Grzelczyk, Andrzej Jaśkiewicz, Dorota Żyżelewicz, Horacio Pérez-Sánchez, José P Cerón-Carrasc. Evaluation of butyrylcholinesterase inhibitory activity by chlorogenic acids and coffee extracts assed in ITC and docking simulation models. Food research international (Ottawa, Ont.). vol 109. 2019-11-07. PMID:29803450. |
therefore, bche inhibitors are used in the treatment of alzheimer's disease, especially synthetic ones, showing side effects with long-term intake. |
2019-11-07 |
2023-08-13 |
Not clear |
| Shi-Yu Liu, Hao Xiong, Jia-Qian Yang, Shu-Hou Yang, Yingfu Li, Wen-Chao Yang, Guang-Fu Yan. Discovery of Butyrylcholinesterase-Activated Near-Infrared Fluorogenic Probe for Live-Cell and In Vivo Imaging. ACS sensors. vol 3. issue 10. 2019-09-18. PMID:30203965. |
butyrylcholinesterase (bche) is widely distributed in various tissues and highly implicated in several important human diseases, especially alzheimer's disease (ad). |
2019-09-18 |
2023-08-13 |
mouse |
| Noor Atatreh, Sara Al Rawashdah, Shaikha S Al Neyadi, Sawsan M Abuhamdah, Mohammad A Ghatta. Discovery of new butyrylcholinesterase inhibitors via structure-based virtual screening. Journal of enzyme inhibition and medicinal chemistry. vol 34. issue 1. 2019-08-12. PMID:31347933. |
butyrylcholinesterase (bche) plays an important role in the progression of the alzheimer's disease. |
2019-08-12 |
2023-08-13 |
Not clear |
| Lanlan Jing, Gaochan Wu, Dongwei Kang, Zhongxia Zhou, Yuning Song, Xinyong Liu, Peng Zha. Contemporary medicinal-chemistry strategies for the discovery of selective butyrylcholinesterase inhibitors. Drug discovery today. vol 24. issue 2. 2019-07-31. PMID:30503804. |
butyrylcholinesterase (bche) is considered a promising drug target for the treatment of moderate to severe alzheimer's disease (ad). |
2019-07-31 |
2023-08-13 |
Not clear |
| Rosa Purgatorio, Modesto de Candia, Marco Catto, Antonio Carrieri, Leonardo Pisani, Annalisa De Palma, Maddalena Toma, Olga A Ivanova, Leonid G Voskressensky, Cosimo D Altomar. Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease. European journal of medicinal chemistry. vol 177. 2019-07-25. PMID:31158754. |
due to the role of butyrylcholinesterase (bche) in acetylcholine hydrolysis in the late stages of the alzheimer's disease (ad), inhibitors of butyrylcholinesterase (bche) have been recently envisaged, besides acetylcholinesterase (ache) inhibitors, as candidates for treating mild-to-moderate ad. |
2019-07-25 |
2023-08-13 |
Not clear |
| Shuo Zhou, Yaxia Yuan, Fang Zheng, Chang-Guo Zha. Structure-based virtual screening leading to discovery of highly selective butyrylcholinesterase inhibitors with solanaceous alkaloid scaffolds. Chemico-biological interactions. vol 308. 2019-07-22. PMID:31152736. |
according to recent research advance, it is interesting to identify new, potent and selective inhibitors of human butyrylcholinesterase (bche) for therapeutic treatment of both the alzheimer's disease (ad) and heroin abuse. |
2019-07-22 |
2023-08-13 |
human |
| Catarina Oliveira, Donatella Bagetta, Fernando Cagide, José Teixeira, Ricardo Amorim, Tiago Silva, Jorge Garrido, Fernando Remião, Eugenio Uriarte, Paulo J Oliveira, Stefano Alcaro, Francesco Ortuso, Fernanda Borge. Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents. European journal of medicinal chemistry. vol 174. 2019-06-17. PMID:31029943. |
the discovery of new chemical entities endowed with potent and selective acetylcholinesterase (ache) and/or butyrylcholinesterase (bche) inhibitory activity is still a relevant subject for alzheimer's disease therapy. |
2019-06-17 |
2023-08-13 |
human |
| Tonino G Adessi, José L Borioni, Natalia B Pigni, Jaume Bastida, Valeria Cavallaro, Ana P Murray, Marcelo Puiatti, Juan C Oberti, Segundo Leiva, Viviana E Nicotra, Manuela E Garci. Clinanthus microstephium, an Amaryllidaceae Species with Cholinesterase Inhibitor Alkaloids: Structure-Activity Analysis of Haemanthamine Skeleton Derivatives. Chemistry & biodiversity. vol 16. issue 5. 2019-05-31. PMID:30801949. |
an epimeric mixture of a haemanthamine-type compound (6-hydroxymaritidine) was tested as an inhibitor against acetyl- and butyrylcholinesterase enzymes (ache and bche, respectively), two enzymes relevant in the treatment of alzheimer's disease, with good results. |
2019-05-31 |
2023-08-13 |
Not clear |
| Killian Oukoloff, Nicolas Coquelle, Manuela Bartolini, Marina Naldi, Rémy Le Guevel, Stéphane Bach, Béatrice Josselin, Sandrine Ruchaud, Marco Catto, Leonardo Pisani, Nunzio Denora, Rosa Maria Iacobazzi, Israel Silman, Joel L Sussman, Frédéric Buron, Jacques-Philippe Colletier, Ludovic Jean, Sylvain Routier, Pierre-Yves Renar. Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. European journal of medicinal chemistry. vol 168. 2019-04-22. PMID:30798053. |
both cholinesterases (ache and bche) and kinases, such as gsk-3α/β, are associated with the pathology of alzheimer's disease. |
2019-04-22 |
2023-08-13 |
human |
| Urban Košak, Boris Brus, Damijan Knez, Simon Žakelj, Jurij Trontelj, Anja Pišlar, Roman Šink, Marko Jukič, Marko Živin, Adrian Podkowa, Florian Nachon, Xavier Brazzolotto, Jure Stojan, Janko Kos, Nicolas Coquelle, Kinga Sałat, Jacques-Philippe Colletier, Stanislav Gobe. The Magic of Crystal Structure-Based Inhibitor Optimization: Development of a Butyrylcholinesterase Inhibitor with Picomolar Affinity and in Vivo Activity. Journal of medicinal chemistry. vol 61. issue 1. 2019-02-25. PMID:29227101. |
the enzymatic activity of butyrylcholinesterase (bche) in the brain increases with the progression of alzheimer's disease, thus classifying bche as a promising drug target in advanced alzheimer's disease. |
2019-02-25 |
2023-08-13 |
mouse |
| Cheng-Zhi Gao, Wei Dong, Zhi-Wen Cui, Qiong Yuan, Xia-Min Hu, Qing-Ming Wu, Xianlin Han, Yao Xu, Zhen-Li Mi. Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors. Journal of enzyme inhibition and medicinal chemistry. vol 34. issue 1. 2018-12-18. PMID:30427217. |
as a parp-1 inhibitor had been reported to be viable to neuroprotection, in order to search for new multitarget-directed ligands (mtdls) for the treatment of alzheimer's disease (ad), the inhibitory activities of the synthesized compounds against the enzymes ache (from electric eel) and bche (from equine serum) were also tested. |
2018-12-18 |
2023-08-13 |
Not clear |
| Ilkay Erdogan Orhan, Dariusz Jedrejek, F Sezer Senol, Ramin Ekhteiari Salmas, Serdar Durdagi, Iwona Kowalska, Lukasz Pecio, Wieslaw Olesze. Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 42. 2018-08-13. PMID:29655693. |
many natural products, particularly phenolic compounds, have been reported to have a strong inhibition against acetylcholinesterase (ache) and butyrylcholinesterase (bche), the key enzymes in the pathology of alzheimer's disease (ad). |
2018-08-13 |
2023-08-13 |
Not clear |
| Syed Haris Omar, Christopher J Scott, Adam S Hamlin, Hassan K Obie. Biophenols: Enzymes (β-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.). Fitoterapia. vol 128. 2018-07-20. PMID:29772299. |
the focus of this study was on inhibition of enzymes involved in the pathogenesis alzheimer's disease (ad) including prime amyloid beta (aβ) producing enzyme (β-secretase: bace-1) and disease progression enzymes including acetylcholinesterase (ache), butyrylcholinesterase (bche), histone deacetylase (hdac), and tyrosinase along with the catecholamine l-dopa, by using olive biophenols. |
2018-07-20 |
2023-08-13 |
Not clear |
| N D Josviak, M S Batistela, R K M Souza, N R Wegner, G F Bono, C D Sulzbach, D P Simão-Silva, M R Piovezan, R L R Souza, L Furtado-All. Plasma butyrylcholinesterase activity: a possible biomarker for differential diagnosis between Alzheimer's disease and dementia with Lewy bodies? The International journal of neuroscience. vol 127. issue 12. 2018-06-04. PMID:28504037. |
k and -116a bche variants were associated with decrease in plasma bche activity, and their influence has been investigated in diseases with a cholinergic deficit such as alzheimer's disease (ad) and dementia with lewy bodies (dlb). |
2018-06-04 |
2023-08-13 |
Not clear |
| Ilkay Erdogan Orhan, Fatma Sezer Senol, Suhaib Shekfeh, Krystyna Skalicka-Wozniak, Erden Banogl. Pteryxin - A promising butyrylcholinesterase-inhibiting coumarin derivative from Mutellina purpurea. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 109. issue Pt 2. 2018-03-12. PMID:28286309. |
in this study, pteryxin, which was previously isolated from the fruits of mutellina purpurea, was investigated for its inhibitory potential against acetylcholinesterase (ache) and butyrylcholinesterase (bche), which are the key enzymes in the pathology of alzheimer's disease (ad). |
2018-03-12 |
2023-08-13 |
Not clear |