| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalia Wszelaki, Agnieszka Kuciun, Anna Karolina Kis. Screening of traditional European herbal medicines for acetylcholinesterase and butyrylcholinesterase inhibitory activity. Acta pharmaceutica (Zagreb, Croatia). vol 60. issue 1. 2010-09-23. PMID:20228046. |
acetylcholinesterase (ache) inhibitors are widely used for the symptomatic treatment of alzheimer's disease (ad) to enhance central cholinergic transmission. |
2010-09-23 |
2023-08-12 |
Not clear |
| Cláudia Seidl, Beatriz L Correia, Andréa E M Stinghen, Cid A M Santo. Acetylcholinesterase inhibitory activity of uleine from Himatanthus lancifolius. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 65. issue 7-8. 2010-09-21. PMID:20737911. |
application of acetylcholinesterase (ache) inhibitors is the primary treatment for alzheimer's disease. |
2010-09-21 |
2023-08-12 |
Not clear |
| V Tumiatti, A Minarini, M L Bolognesi, A Milelli, M Rosini, C Melchiorr. Tacrine derivatives and Alzheimer's disease. Current medicinal chemistry. vol 17. issue 17. 2010-09-08. PMID:20345341. |
to date, the pharmacotherapy of alzheimer's disease (ad) has relied on acetylcholinesterase (ache) inhibitors (acheis) and, more recently, an n-methyl-d-aspartate receptor (nmdar) antagonist. |
2010-09-08 |
2023-08-12 |
Not clear |
| Amy C Halliday, Oliver Kim, Cherie E Bond, Susan A Greenfiel. Evaluation of a technique to identify acetylcholinesterase C-terminal peptides in human serum samples. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20156431. |
this preliminary study aimed to identify the cleaved ache c-terminal peptide in serum from human alzheimer's disease patients using immunoaffinity purification. |
2010-09-01 |
2023-08-12 |
human |
| Pelayo Camps, Xavier Formosa, Carles Galdeano, Tània Gómez, Diego Muñoz-Torrero, Lorena Ramírez, Elisabet Viayna, Elena Gómez, Nicolás Isambert, Rodolfo Lavilla, Albert Badia, M Victòria Clos, Manuela Bartolini, Francesca Mancini, Vincenza Andrisano, Axel Bidon-Chanal, Oscar Huertas, Thomai Dafni, F Javier Luqu. Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20167211. |
these hybrid compounds are all potent and selective inhibitors of human ache, and more interestingly, are able to interfere in vitro both formation and aggregation of the beta-amyloid peptide, the latter effects endowing these compounds with the potential to modify alzheimer's disease progression. |
2010-09-01 |
2023-08-12 |
human |
| Ava J Y Guo, Heidi Q Xie, Roy C Y Choi, Ken Y Z Zheng, Cathy W C Bi, Sherry L Xu, Tina T X Dong, Karl W K Tsi. Galangin, a flavonol derived from Rhizoma Alpiniae Officinarum, inhibits acetylcholinesterase activity in vitro. Chemico-biological interactions. vol 187. issue 1-3. 2010-09-01. PMID:20452337. |
acetylcholinesterase (ache) inhibitors are widely used for the treatment of alzheimer's disease (ad). |
2010-09-01 |
2023-08-12 |
Not clear |
| Zaheer-ul-Haq, Sobia Ahsan Halim, Reaz Uddin, Jeffry D Madur. Benchmarking docking and scoring protocol for the identification of potential acetylcholinesterase inhibitors. Journal of molecular graphics & modelling. vol 28. issue 8. 2010-08-12. PMID:20447848. |
ache has become an important drug target because partial inhibition of ache results in modest increase in ach levels that can have therapeutic benefits, thus ache inhibitors have proved useful in the symptomatic treatment of alzheimer's disease. |
2010-08-12 |
2023-08-12 |
Not clear |
| Elena Soriano, Abdelouahid Samadi, Mourad Chioua, Cristóbal de los Ríos, José Marco-Contelle. Molecular modelling, synthesis and acetylcholinesterase inhibition of ethyl 5-amino-2-methyl-6,7,8,9-tetrahydrobenzo[b][1,8]naphthyridine-3-carboxylate. Bioorganic & medicinal chemistry letters. vol 20. issue 9. 2010-07-27. PMID:20350807. |
the synthesis and the ache/buche inhibition studies are reported, confirming that compound 2 is a potent and selective ache inhibitor, and consequently, a new lead compound for further development into new dual cas/pas cholinergic agents for the treatment of alzheimer's disease. |
2010-07-27 |
2023-08-12 |
Not clear |
| Wei Lv, Ying Xu. Prediction of acetylcholinesterase inhibitors and characterization of correlative molecular descriptors by machine learning methods. European journal of medicinal chemistry. vol 45. issue 3. 2010-07-22. PMID:20053484. |
acetylcholinesterase (ache) has become an important drug target and its inhibitors have proved useful in the symptomatic treatment of alzheimer's disease. |
2010-07-22 |
2023-08-12 |
Not clear |
| Sang-Hoon Lee, Jin-Sook Park, Se-Kwon Kim, Chang-Bum Ahn, Jae-Young J. Chitooligosaccharides suppress the level of protein expression and acetylcholinesterase activity induced by Abeta25-35 in PC12 cells. Bioorganic & medicinal chemistry letters. vol 19. issue 3. 2010-07-06. PMID:19097785. |
clinical applications of acetylcholinesterase (ache) inhibitors are widespread in alzheimer's sufferers in order to activate central cholinergic system and alleviate cognitive deficits by inhibiting the hydrolysis of acetylcholine. |
2010-07-06 |
2023-08-12 |
Not clear |
| Torsten Geissler, Wolfgang Brandt, Andrea Porzel, Dagmar Schlenzig, Astrid Kehlen, Ludger Wessjohann, Norbert Arnol. Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus. Bioorganic & medicinal chemistry. vol 18. issue 6. 2010-07-06. PMID:20176490. |
inhibition of acetylcholinesterase (ache) and therefore prevention of acetylcholine degradation is one of the most accepted therapy opportunities for alzheimer s disease (ad), today. |
2010-07-06 |
2023-08-12 |
Not clear |
| Thomas Leyhe, Nadine Hoffmann, Elke Stransky, Christoph Lask. Increase of SCF plasma concentration during donepezil treatment of patients with early Alzheimer's disease. The international journal of neuropsychopharmacology. vol 12. issue 10. 2010-06-29. PMID:19580698. |
alzheimer's disease (ad) can be treated with inhibitors of the enzyme acetylcholinesterase (ache). |
2010-06-29 |
2023-08-12 |
Not clear |
| Vildan Alptüzün, Michaela Prinz, Verena Hörr, Josef Scheiber, Krzysztof Radacki, Adyary Fallarero, Pia Vuorela, Bernd Engels, Holger Braunschweig, Ercin Erciyas, Ulrike Holzgrab. Interaction of (benzylidene-hydrazono)-1,4-dihydropyridines with beta-amyloid, acetylcholine, and butyrylcholine esterases. Bioorganic & medicinal chemistry. vol 18. issue 5. 2010-06-15. PMID:20149667. |
approved drugs for the treatment of alzheimer's disease belong to the group of inhibitors of the acetylcholinesterase (ache) and nmda receptor inhibitors. |
2010-06-15 |
2023-08-12 |
Not clear |
| Narihiro Toda, Tsugio Kaneko, Hiroshi Koge. Development of an efficient therapeutic agent for Alzheimer's disease: design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter. Chemical & pharmaceutical bulletin. vol 58. issue 3. 2010-06-15. PMID:20190429. |
to date, acetylcholinesterase (ache) inhibitors have been clinically effective drugs for the palliative treatment of alzheimer's disease, but their clinical efficacy is limited, mainly due to their adverse effects on peripheral organs. |
2010-06-15 |
2023-08-12 |
mouse |
| Narihiro Toda, Tsugio Kaneko, Hiroshi Koge. Development of an efficient therapeutic agent for Alzheimer's disease: design and synthesis of dual inhibitors of acetylcholinesterase and serotonin transporter. Chemical & pharmaceutical bulletin. vol 58. issue 3. 2010-06-15. PMID:20190429. |
since patients of alzheimer's disease often exhibit depression as well as memory impairment, dual inhibitors of ache and serotonin transporter (sert) would be a better therapeutic method. |
2010-06-15 |
2023-08-12 |
mouse |
| H Sore. Cholinergic mechanisms--tenth international symposium. 1-5 September 1998, Arcachon, France. IDrugs : the investigational drugs journal. vol 1. issue 7. 2010-06-09. PMID:18465647. |
cholinergic drugs are currently in use, or in advanced stages of development, for the chronic treatment of alzheimer's disease (ad) and myasthenia gravis, as well as for the treatment of acute intoxication with organophosphate or carbamate inhibitors of the ach hydrolyzing enzyme acetyl-cholinesterase (ache). |
2010-06-09 |
2023-08-12 |
Not clear |
| Nurgun Kucukboyaci, Ilkay Orhan, Bilge Sener, S Ahmad Nawaz, M Iqbal Choudhar. Assessment of enzyme inhibitory and antioxidant activities of lignans from Taxus baccata L. Zeitschrift fur Naturforschung. C, Journal of biosciences. vol 65. issue 3-4. 2010-06-03. PMID:20469636. |
compounds 1-5 were evaluated for their acetylcholinesterase (ache), butyrylcholinesterase (bche), and lipoxygenase (lox) inhibitory activities, which play a role in the pathogenesis of alzheimer's disease (ad), by in vitro spectrophotometric methods, while they were also screened for their antioxidant capacity in 2,2-diphenyl-1-picrylhydrazyl (dpph) radical scavenging, ferrous ion-chelating effect, and ferric-reducing antioxidant power (frap) at 125, 250, 500, and 1000 microg ml(-1). |
2010-06-03 |
2023-08-12 |
Not clear |
| F S Senol, I Orhan, G Yilmaz, M Ciçek, B Sene. Acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibition studies and antioxidant activities of 33 Scutellaria L. taxa from Turkey. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 48. issue 3. 2010-06-02. PMID:20026160. |
therefore, we initiated a study to screen the methanol extracts prepared from the aerial parts of 33 turkish scutellaria species for their acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitory activities, which are the key enzymes taking place in pathogenesis of alzheimer's disease. |
2010-06-02 |
2023-08-12 |
Not clear |
| Xiang-Yuan Li, Jian Zhang, Jia-Pei Dai, Xiang-Ming Liu, Zhi-Wang L. Actions of bis(7)-tacrine and tacrine on transient potassium current in rat DRG neurons and potassium current mediated by K(V)4.2 expressed in Xenopus oocyte. Brain research. vol 1318. 2010-05-20. PMID:20043893. |
bis(7)-tacrine [bis(7)-tetrahydroaminacrine] is a dimeric ache inhibitor derived from tacrine with a potential to treat alzheimer's disease. |
2010-05-20 |
2023-08-12 |
rat |
| Ramanna V Rajesh, Paul G Layer, Rathanam Boopath. High aryl acylamidase activity associated with cobra venom acetylcholinesterase: biological significance. Biochimie. vol 91. issue 11-12. 2010-04-23. PMID:19695303. |
the study becomes interesting because of i) the cobra venom ache exists in monomeric globular forms; ii) in alzheimer's disease too the most abundant forms of cholinesterases are monomeric globular forms, thought to be involved in the pathogenesis of alzheimer's disease; iii) the effect of alzheimer's disease drugs on the aaa activity of cobra venom, indicated that aaa activity of cobra venom was more sensitive than ache and iv) huperzine and tacrine showed more pronounced effect on aaa. |
2010-04-23 |
2023-08-12 |
human |