| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Akinori Akaike, Yuki Takada-Takatori, Toshiaki Kume, Yasuhiko Izum. Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection. Journal of molecular neuroscience : MN. vol 40. issue 1-2. 2010-04-21. PMID:19714494. |
donepezil, galanatamine and tacrine, therapeutic acetylcholinesterase (ache) inhibitors currently being used for treatment of alzheimer's disease also protected neuronal cells from glutamate neurotoxicity. |
2010-04-21 |
2023-08-12 |
rat |
| Wolfgang Härtig, Johannes Kacza, Bernd-Reiner Paulke, Jens Grosche, Ute Bauer, Anke Hoffmann, Paul W Elsinghorst, Michael Gütscho. In vivo labelling of hippocampal beta-amyloid in triple-transgenic mice with a fluorescent acetylcholinesterase inhibitor released from nanoparticles. The European journal of neuroscience. vol 31. issue 1. 2010-04-16. PMID:20092557. |
the drastic loss of cholinergic projection neurons in the basal forebrain is a hallmark of alzheimer's disease (ad), and drugs most frequently applied for the treatment of dementia include inhibitors of the acetylcholine-degrading enzyme acetylcholinesterase (ache). |
2010-04-16 |
2023-08-12 |
mouse |
| Hongjun Fu, Juan Dou, Wenming Li, Wei Cui, Shinghung Mak, Qiansheng Hu, Jialie Luo, Colin S C Lam, Yuanping Pang, Moussa B H Youdim, Yifan Ha. Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently. European journal of pharmacology. vol 623. issue 1-3. 2010-02-22. PMID:19765582. |
combined with previous findings of direct inhibition of ache and bace-1 by this dimer, this work indicates that strategy may have potential to provide new insights into designing novel drugs that target multiple steps of aberrant app processing to treat alzheimer's disease. |
2010-02-22 |
2023-08-12 |
human |
| Pattara Sawasdee, Chalisa Sabphon, Duangporn Sitthiwongwanit, Udom Kokpo. Anticholinesterase activity of 7-methoxyflavones isolated from Kaempferia parviflora. Phytotherapy research : PTR. vol 23. issue 12. 2010-01-25. PMID:19548291. |
interestingly, 5,7-dimethoxyflavone (7) exhibited strong selectivity for bche over ache which may be of great interest to modify as a treatment agent for alzheimer's disease. |
2010-01-25 |
2023-08-12 |
Not clear |
| Ondrej Soukup, Jan Proska, Jiri Binder, Jana Zdarova Karasova, Gunnar Tobin, Daniel Jun, Jan Marek, Kamil Musílek, Josef Fusek, Kamil Kuc. Methylacridinium and its cholinergic properties. Neurotoxicity research. vol 16. issue 4. 2010-01-22. PMID:19565307. |
inhibitors of acetylcholinesterase (ache) are used in the treatment of myasthenia gravis, alzheimer's disease, and in the prophylaxis of poisoning with organophosphates. |
2010-01-22 |
2023-08-12 |
human |
| Bin Guo, Lingling Xu, Yahui Wei, Chunzhao Li. [Research advances of Huperzia serrata (Thunb.) Trev]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 34. issue 16. 2010-01-04. PMID:19938535. |
it has become known worldwide as a medicinal plant since chinese scientists discovered huperzine a from it in the 1980s, which is reversible, potent and selective acetylcholine esterase (ache) inhibitors by in vitro and in vivo pharmacological, and produce definite effects in the treatment of alzheimer's disease. |
2010-01-04 |
2023-08-12 |
Not clear |
| Mireille Basselin, Henry N Nguyen, Lisa Chang, Jane M Bell, Stanley I Rapopor. Acute but not chronic donepezil increases muscarinic receptor-mediated signaling via arachidonic acid in unanesthetized rats. Journal of Alzheimer's disease : JAD. vol 17. issue 2. 2009-12-16. PMID:19363262. |
donepezil, an acetylcholinesterase (ache) inhibitor used for treating alzheimer's disease patients, is thought to act by increasing brain extracellular acetylcholine (ach), and ach binding to cholinergic receptors. |
2009-12-16 |
2023-08-12 |
rat |
| Dmitriy Chekmarev, Vladyslav Kholodovych, Sandhya Kortagere, William J Welsh, Sean Ekin. Predicting inhibitors of acetylcholinesterase by regression and classification machine learning approaches with combinations of molecular descriptors. Pharmaceutical research. vol 26. issue 9. 2009-11-02. PMID:19603258. |
acetylcholinesterase (ache) is both a therapeutic target for alzheimer's disease and a target for organophosphorus, carbamates and chemical warfare agents. |
2009-11-02 |
2023-08-12 |
Not clear |
| Yu-fang Shi, Hai-yan Zhang, Wei Wang, Yan Fu, Yu Xia, Xi-can Tang, Dong-lu Bai, Xu-chang H. Novel 16-substituted bifunctional derivatives of huperzine B: multifunctional cholinesterase inhibitors. Acta pharmacologica Sinica. vol 30. issue 8. 2009-10-22. PMID:19578388. |
to design novel bifunctional derivatives of huperzine b (hupb) based on the concept of dual binding site of acetylcholinesterase (ache) and evaluate their pharmacological activities for seeking new drug candidates against alzheimer's disease (ad). |
2009-10-22 |
2023-08-12 |
Not clear |
| A A N de Paula, J B L Martins, M L dos Santos, L de C Nascente, L A S Romeiro, T F M A Areas, K S T Vieira, N F Gambôa, N G Castro, R Gargan. New potential AChE inhibitor candidates. European journal of medicinal chemistry. vol 44. issue 9. 2009-10-14. PMID:19446931. |
among the proposed compounds we identified that the structures with substitution by n,n-dimethycarbamoyl, n,n-dimethylamine, and pyrrolidine groups were better correlated to rivastigmine, and represent possible ache inhibitors against alzheimer disease. |
2009-10-14 |
2023-08-12 |
Not clear |
| H R Girisha, J N Narendra Sharath Chandra, Sriramamurthy Boppana, Manish Malviya, C T Sadashiva, Kanchugarakoppal S Rangapp. Active site directed docking studies: synthesis and pharmacological evaluation of cis-2,6-dimethyl piperidine sulfonamides as inhibitors of acetylcholinesterase. European journal of medicinal chemistry. vol 44. issue 10. 2009-10-14. PMID:19493592. |
hypocholinergic function associated with alzheimer's disease (ad) is well-accepted hypothesis, in this regard, many research attempts have been made to elevate the reduced cholinergic neurotransmission, among them two main treatment strategies were widely explored, namely stimulation of muscarinic receptor 1 and/or reversible inhibition of acetylcholinesterase (ache) enzyme. |
2009-10-14 |
2023-08-12 |
rat |
| Ramanna V Rajesh, Loganathan Chitra, Paul G Layer, Rathanam Boopath. The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain. Biochimie. vol 91. issue 9. 2009-10-14. PMID:19607873. |
remarkably, the major alzheimer drugs- huperzine and donepezil, much more strongly inhibited aaa activity of ache at younger developmental stages whose ic50 values are 0.01 mum and 0.1 mum respectively. |
2009-10-14 |
2023-08-12 |
chicken |
| Ramanna V Rajesh, Loganathan Chitra, Paul G Layer, Rathanam Boopath. The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain. Biochimie. vol 91. issue 9. 2009-10-14. PMID:19607873. |
since in alzheimer's disease (ad), embryonic forms of ache have been reported to reappear, a possible role of aaa activity in the pathogenesis of ad should be considered. |
2009-10-14 |
2023-08-12 |
chicken |
| Runa S Naik, Joachim Hartmann, Cornelia Kiewert, Ellen G Duysen, Oksana Lockridge, Jochen Klei. Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. vol 12. issue 1. 2009-09-25. PMID:19470293. |
alzheimer s disease is characterized by a dysfunction of central cholinergic systems and is treated by inhibitors of acetylcholinesterase (ache). |
2009-09-25 |
2023-08-12 |
mouse |
| Yiping Zhu, Kun Xiao, Lanping Ma, Bin Xiong, Yan Fu, Haiping Yu, Wei Wang, Xin Wang, Dingyu Hu, Hongli Peng, Jingya Li, Qi Gong, Qian Chai, Xican Tang, Haiyan Zhang, Jia Li, Jingkang She. Design, synthesis and biological evaluation of novel dual inhibitors of acetylcholinesterase and beta-secretase. Bioorganic & medicinal chemistry. vol 17. issue 4. 2009-09-16. PMID:19162488. |
to explore novel effective drugs for the treatment of alzheimer's disease (ad), a series of dual inhibitors of acetylcholineterase (ache) and beta-secretase (bace-1) were designed based on the multi-target-directed ligands strategy. |
2009-09-16 |
2023-08-12 |
mouse |
| Jae Kyeom Kim, Heyri Bae, Mi-Jeong Kim, Soo Jung Choi, Hong Yon Cho, Han-Joon Hwang, Young Jun Kim, Seung Taik Lim, Eun Ki Kim, Hye Kyung Kim, Bok Yong Kim, Dong-Hoon Shi. Inhibitory effect of Poncirus trifoliate on acetylcholinesterase and attenuating activity against trimethyltin-induced learning and memory impairment. Bioscience, biotechnology, and biochemistry. vol 73. issue 5. 2009-08-28. PMID:19420715. |
various native korean plants were screened to find an effective acetylcholinesterase (ache) inhibitor for the treatment of alzheimer's disease (ad). |
2009-08-28 |
2023-08-12 |
Not clear |
| Ming Wang, Xinggui Gu, Guanxin Zhang, Deqing Zhang, Daoben Zh. Convenient and continuous fluorometric assay method for acetylcholinesterase and inhibitor screening based on the aggregation-induced emission. Analytical chemistry. vol 81. issue 11. 2009-08-05. PMID:19374428. |
given its simplicity and easy operation, this method may extend to high-throughput screening of ache inhibitors and relevant alzheimer's disease (ad) drug discovery. |
2009-08-05 |
2023-08-12 |
Not clear |
| Renato Scacchi, Giuseppe Gambina, Giuseppe Moretto, Rosa Maria Corb. Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 150B. issue 4. 2009-07-30. PMID:18780301. |
variability of ache, bche, and chat genes in the late-onset form of alzheimer's disease and relationships with response to treatment with donepezil and rivastigmine. |
2009-07-30 |
2023-08-12 |
human |
| Zhi-bin Liu, Wen-min Niu, Xiao-hang Yang, Xiao-mei Niu, Yuan Wan. [Effect of "Xiusanzhen" on learning-memory ability and hippocampal ChAT and AChE activity in Alzheimer disease rats]. Zhen ci yan jiu = Acupuncture research. vol 34. issue 1. 2009-07-09. PMID:19526808. |
[effect of "xiusanzhen" on learning-memory ability and hippocampal chat and ache activity in alzheimer disease rats]. |
2009-07-09 |
2023-08-12 |
rat |
| Zhi-bin Liu, Wen-min Niu, Xiao-hang Yang, Xiao-mei Niu, Yuan Wan. [Effect of "Xiusanzhen" on learning-memory ability and hippocampal ChAT and AChE activity in Alzheimer disease rats]. Zhen ci yan jiu = Acupuncture research. vol 34. issue 1. 2009-07-09. PMID:19526808. |
to explore the effect of "xiusanzhen" [bilateral "yingxiang" (li 20) + "yintang" (ex-hn 3)] on learning-memory ability and choline acetyl transferase (chat) and acetyl cholinesterase (ache) activity of hippocampus tissue in alzheimer disease (ad) rats. |
2009-07-09 |
2023-08-12 |
rat |