| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| P K Mukherjee, N Satheeshkumar, P Venkatesh, M Venkates. Lead finding for acetyl cholinesterase inhibitors from natural origin: structure activity relationship and scope. Mini reviews in medicinal chemistry. vol 11. issue 3. 2011-08-23. PMID:21222577. |
acetylcholinesterase (ache) inhibitors are considered as promising therapeutic agents for the treatment of several neurological disorders such as alzheimer's disease (ad), senile dementia, ataxia and myasthenia gravis. |
2011-08-23 |
2023-08-12 |
Not clear |
| Dong Hyun Kim, Yearn Seong Choe, Joon Young Choi, Kyung-Han Lee, Byung-Tae Ki. Binding of 2-[18F]fluoro-CP-118,954 to mouse acetylcholinesterase: microPET and ex vivo Cerenkov luminescence imaging studies. Nuclear medicine and biology. vol 38. issue 4. 2011-08-23. PMID:21531291. |
acetylcholinesterase (ache) has been an important cholinergic factor for the diagnosis of alzheimer's disease (ad), because of reduced ache activity in the postmortem brains of ad patients. |
2011-08-23 |
2023-08-12 |
mouse |
| Wontae Kim, Daeweon Lee, Jinkyu Choi, Ayoung Kim, Sangmi Han, Kwanho Park, Jiyoung Choi, Jonggil Kim, Youngcheol Choi, Si Hyeock Lee, Young Ho Ko. Pharmacogenetic regulation of acetylcholinesterase activity in Drosophila reveals the regulatory mechanisms of AChE inhibitors in synaptic plasticity. Neurochemical research. vol 36. issue 5. 2011-08-16. PMID:21305389. |
because ache inhibitors are utilized for medications for alzheimer's disease, we investigated whether pharmacological inhibition of ache activity induced any synaptic defects. |
2011-08-16 |
2023-08-12 |
human |
| Wontae Kim, Daeweon Lee, Jinkyu Choi, Ayoung Kim, Sangmi Han, Kwanho Park, Jiyoung Choi, Jonggil Kim, Youngcheol Choi, Si Hyeock Lee, Young Ho Ko. Pharmacogenetic regulation of acetylcholinesterase activity in Drosophila reveals the regulatory mechanisms of AChE inhibitors in synaptic plasticity. Neurochemical research. vol 36. issue 5. 2011-08-16. PMID:21305389. |
our study suggests that exposure to ache inhibitors for 6-12 months may induce altered synaptic architectures in human brains with alzheimer's diseases, similar to those reported here. |
2011-08-16 |
2023-08-12 |
human |
| Chun-Yan Wang, Wei Zheng, Tao Wang, Jing-Wei Xie, Si-Ling Wang, Bao-Lu Zhao, Wei-Ping Teng, Zhan-You Wan. Huperzine A activates Wnt/β-catenin signaling and enhances the nonamyloidogenic pathway in an Alzheimer transgenic mouse model. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 5. 2011-07-13. PMID:21289607. |
huperzine a (hupa) is a reversible and selective inhibitor of acetylcholinesterase (ache), and it has multiple targets when used for alzheimer's disease (ad) therapy. |
2011-07-13 |
2023-08-12 |
mouse |
| Shikhar Gupta, Adyary Fallarero, Päivi Järvinen, Daniela Karlsson, Mark S Johnson, Pia M Vuorela, C Gopi Moha. Discovery of dual binding site acetylcholinesterase inhibitors identified by pharmacophore modeling and sequential virtual screening techniques. Bioorganic & medicinal chemistry letters. vol 21. issue 4. 2011-05-23. PMID:21273074. |
dual binding site acetylcholinesterase (ache) inhibitors are promising for the treatment of alzheimer's disease (ad). |
2011-05-23 |
2023-08-12 |
Not clear |
| Lygia Azevedo Marques, Martin Giera, Henk Lingeman, Wilfried Ma Niesse. Analysis of acetylcholinesterase inhibitors: bioanalysis, degradation and metabolism. Biomedical chromatography : BMC. vol 25. issue 1-2. 2011-04-28. PMID:21154892. |
the drugs of choice for the treatment of alzheimer's disease are acetylcholinesterase (ache) inhibitors. |
2011-04-28 |
2023-08-12 |
Not clear |
| Myriam Ouberai, Kristoffer Brannstrom, Monika Vestling, Anders Olofsson, Pascal Dumy, Sabine Chierici, Julian Garci. Clicked tacrine conjugates as acetylcholinesterase and β-amyloid directed compounds. Organic & biomolecular chemistry. vol 9. issue 4. 2011-04-19. PMID:21152577. |
the multifaceted nature of alzheimer's disease (ad) has led to the development of multi-targeted compounds based on the classical ad drug, tacrine, first known to inhibit the acetylcholine-degrading enzyme acetylcholinesterase (ache). |
2011-04-19 |
2023-08-12 |
Not clear |
| David Hicks, Danielle John, Natalia Z Makova, Zaineb Henderson, Natalia N Nalivaeva, Anthony J Turne. Membrane targeting, shedding and protein interactions of brain acetylcholinesterase. Journal of neurochemistry. vol 116. issue 5. 2011-03-30. PMID:21214569. |
we are currently probing the mechanism(s) of ache shedding, and whether this process and its apparent association with α7 nicotinic acetylcholine receptors and metabolism of the alzheimer's amyloid precursor protein is determined by its association with lipid raft domains either in normal or pathological situations. |
2011-03-30 |
2023-08-12 |
rat |
| Stefano Dall'Acqua, Filippo Maggi, Paola Minesso, Marina Salvagno, Fabrizio Papa, Sauro Vittori, Gabbriella Innocent. Identification of non-alkaloid acetylcholinesterase inhibitors from Ferulago campestris (Besser) Grecescu (Apiaceae). Fitoterapia. vol 81. issue 8. 2011-03-29. PMID:20713133. |
inhibition of acetylcholinesterase (ache) is still considered as a strategy for the treatment of neurological disorders such as alzheimer's disease. |
2011-03-29 |
2023-08-12 |
Not clear |
| Yukihiro Noda, Akihiro Mouri, Yu Ando, Yukari Waki, Shin-Nosuke Yamada, Akira Yoshimi, Kiyofumi Yamada, Norio Ozaki, Dayong Wang, Toshitaka Nabeshim. Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems. The international journal of neuropsychopharmacology. vol 13. issue 10. 2011-03-18. PMID:20219155. |
galantamine, a drug used to treat alzheimer's disease, inhibits acetylcholinesterase (ache) and allosterically modulates nicotinic acetylcholine receptors (nachrs) resulting in stimulation of catecholamine neurotransmission. |
2011-03-18 |
2023-08-12 |
mouse |
| Zhe Jin, Liu Yang, Si-Jie Liu, Jian Wang, Shuo Li, Huang-Quan Lin, David Chi Cheong Wan, Chun H. Synthesis and biological evaluation of 3,6-diaryl-7H-thiazolo[3,2-b] [1,2,4]triazin-7-one derivatives as acetylcholinesterase inhibitors. Archives of pharmacal research. vol 33. issue 10. 2011-03-07. PMID:21052939. |
acetylcholinesterase (ache) inhibitors played an important role in developing a cure for alzheimer' s disease. |
2011-03-07 |
2023-08-12 |
Not clear |
| Eftim Milkani, Christopher R Lambert, W Grant McGimpse. Direct detection of acetylcholinesterase inhibitor binding with an enzyme-based surface plasmon resonance sensor. Analytical biochemistry. vol 408. issue 2. 2011-03-01. PMID:20849808. |
acetylcholinesterase (ache) inhibitors are potentially lethal but also have applications as therapeutic drugs for neurodegenerative diseases such as alzheimer's. |
2011-03-01 |
2023-08-12 |
Not clear |
| Monika M Hedberg, M Victoria Clos, Miriam Ratia, Daniel Gonzalez, Christina Unger Lithner, Pelayo Camps, Diego Muñoz-Torrero, Albert Badia, Lydia Giménez-Llort, Agneta Nordber. Effect of huprine X on β-amyloid, synaptophysin and α7 neuronal nicotinic acetylcholine receptors in the brain of 3xTg-AD and APPswe transgenic mice. Neuro-degenerative diseases. vol 7. issue 6. 2011-02-17. PMID:20689242. |
several studies implicate acetylcholinesterase (ache) in the pathogenesis of alzheimer's disease (ad), raising the question of whether inhibitors of ache also might act in a disease-modifying manner. |
2011-02-17 |
2023-08-12 |
mouse |
| Zha-Jun Zhan, Qi Yu, Zhan-Li Wang, Wei-Guang Sha. Indole alkaloids from Ervatamia hainanensis with potent acetylcholinesterase inhibition activities. Bioorganic & medicinal chemistry letters. vol 20. issue 21. 2011-01-24. PMID:20850311. |
all isolates were evaluated for acetylcholinesterase (ache) inhibition activities, in which compounds 1 and 3 exhibited the same level of activities as galantamine, a marketed cholinesterase inhibitor for the treatment of alzheimer's disease. |
2011-01-24 |
2023-08-12 |
Not clear |
| Yo Sook Ki, Eun Young Park, Heon-Woo Lee, Myung Sook Oh, Young-Wuk Cho, Yunhee Kim Kwon, Ji Hee Moon, Kyung-Tae Le. Donepezil, a potent acetylcholinesterase inhibitor, induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells. Biological & pharmaceutical bulletin. vol 33. issue 6. 2011-01-10. PMID:20522977. |
although donepezil, a potent acetylcholinesterase (ache) inhibitor, has been used to treat alzheimer's disease (ad) due to its neuroprotective effects, its mode of action to inhibit the growth of cancer cells is poorly understood. |
2011-01-10 |
2023-08-12 |
human |
| David M Pereira, Federico Ferreres, Jorge M A Oliveira, Luís Gaspar, Joana Faria, Patrícia Valentão, Mariana Sottomayor, Paula B Andrad. Pharmacological effects of Catharanthus roseus root alkaloids in acetylcholinesterase inhibition and cholinergic neurotransmission. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 8-9. 2010-12-03. PMID:19962870. |
moreover, given serpentine's potent in vitro ache inhibitory activity and low cholinergic receptor affinity, it is conceivable that minor structural modifications may yield a potent and selective ache inhibitor, potentially useful for the pharmacological management of conditions such as alzheimer's disease and/or myasthenia gravis. |
2010-12-03 |
2023-08-12 |
rat |
| L B Pagliosa, S C Monteiro, K B Silva, J P de Andrade, J Dutilh, J Bastida, M Cammarota, J A S Zuanazz. Effect of isoquinoline alkaloids from two Hippeastrum species on in vitro acetylcholinesterase activity. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 17. issue 8-9. 2010-12-03. PMID:19969445. |
galanthamine, an important alkaloid isolated from the amaryllidaceae family, is approved for the pharmacological treatment of alzheimer's disease (ad) and acts by inhibiting the acetylcholinesterase (ache) activity. |
2010-12-03 |
2023-08-12 |
Not clear |
| Guillaume Bastiat, François Plourde, Aude Motulsky, Alexandra Furtos, Yvan Dumont, Rémi Quirion, Gregor Fuhrmann, Jean-Christophe Lerou. Tyrosine-based rivastigmine-loaded organogels in the treatment of Alzheimer's disease. Biomaterials. vol 31. issue 23. 2010-10-21. PMID:20472283. |
in this work, an injectable subcutaneous organogel system based on safflower oil and a modified-tyrosine organogelator was evaluated in vivo for the delivery of rivastigmine, an acetylcholinesterase (ache) inhibitor used in the treatment of alzheimer's disease. |
2010-10-21 |
2023-08-12 |
Not clear |
| Robert A McArthur, Julian Gray, Rudy Schreibe. Cognitive effects of muscarinic M1 functional agonists in non-human primates and clinical trials. Current opinion in investigational drugs (London, England : 2000). vol 11. issue 7. 2010-10-05. PMID:20571970. |
the limited effect of ache inhibitors and nmda receptor antagonists for the treatment of the cognitive symptoms of alzheimer's disease has prompted the search for new drugs that are capable not only of treating behavioral symptoms, but also of modifying the disease process. |
2010-10-05 |
2023-08-12 |
Not clear |