| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hai-Yan Zhan. New insights into huperzine A for the treatment of Alzheimer's disease. Acta pharmacologica Sinica. vol 33. issue 9. 2013-01-29. PMID:22941287. |
huperzine a, an active lycopodium alkaloid extracted from traditional chinese herb, is a potent, selective and reversible acetylcholinesterase (ache) inhibitor and has been widely used in china for the treatment of alzheimer's disease (ad). |
2013-01-29 |
2023-08-12 |
Not clear |
| Gabrielle L Haddad, Sherri C Young, Ned D Heindel, Darryl J Bornhop, Robert A Flower. Back-scattering interferometry: an ultrasensitive method for the unperturbed detection of acetylcholinesterase-inhibitor interactions. Angewandte Chemie (International ed. in English). vol 51. issue 44. 2013-01-22. PMID:23037915. |
this method can be used to screen for mixed ache inhibitors, agents that have shown high efficacy against alzheimer's disease, by detecting dual-binding interactions. |
2013-01-22 |
2023-08-12 |
Not clear |
| Faviola Alcántara-González, Claudia Rebeca Mendoza-Perez, Néstor Zaragoza, Ismael Juarez, Luis Enrique Arroyo-García, Citlalli Gamboa, Fidel De La Cruz, Sergio Zamudio, Fernando Garcia-Dolores, Gonzalo Flore. Combined administration of cerebrolysin and donepezil induces plastic changes in prefrontal cortex in aged mice. Synapse (New York, N.Y.). vol 66. issue 11. 2013-01-09. PMID:22826038. |
cerebrolysin (cbl) shows neurotrophic and neuroprotective properties while donepezil (dnp) is a potent acetylcholinesterase (ache) inhibitor, both drugs are prescribed for alzheimer's disease (ad) treatment. |
2013-01-09 |
2023-08-12 |
mouse |
| Dingbin Liu, Wenwen Chen, Yue Tian, Sha He, Wenfu Zheng, Jiashu Sun, Zhuo Wang, Xingyu Jian. A highly sensitive gold-nanoparticle-based assay for acetylcholinesterase in cerebrospinal fluid of transgenic mice with Alzheimer's disease. Advanced healthcare materials. vol 1. issue 1. 2013-01-03. PMID:23184691. |
due to its good sensitivity and selectivity, the assay can be used for monitoring ache levels in the cerebrospinal fluid of transgenic mice with alzheimer's disease. |
2013-01-03 |
2023-08-12 |
mouse |
| Santanu Bhadra, Pulok K Mukherjee, A Bandyopadhya. Cholinesterase inhibition activity of Marsilea quadrifolia Linn. an edible leafy vegetable from West Bengal, India. Natural product research. vol 26. issue 16. 2012-12-14. PMID:21978132. |
these findings suggest that m. quadrifolia is a potential lead as an ache and bche inhibitor, which may be useful in the management of alzheimer's disease. |
2012-12-14 |
2023-08-12 |
Not clear |
| Hailin Zheng, Mati Fridkin, Moussa B H Youdi. Novel chelators targeting cell cycle arrest, acetylcholinesterase, and monoamine oxidase for Alzheimer's therapy. Current drug targets. vol 13. issue 8. 2012-12-10. PMID:22676912. |
the recent finding that acetylcholinesterase (ache) colocalizes with β-amyloid (aβ), promotes and accelerates aβ aggregation has renewed an intense interest in developing new multitarget ache inhibitors as potential disease-modifying drugs for alzheimer's therapy. |
2012-12-10 |
2023-08-12 |
Not clear |
| Wei Zheng, Juan Li, Zhuibai Qiu, Zheng Xia, Wei Li, Lining Yu, Hailin Chen, Jianxing Chen, Yan Chen, Zhuqin Hu, Wei Zhou, Biyun Shao, Yongyao Cui, Qiong Xie, Hongzhuan Che. Novel bis-(-)-nor-meptazinol derivatives act as dual binding site AChE inhibitors with metal-complexing property. Toxicology and applied pharmacology. vol 264. issue 1. 2012-11-19. PMID:22842334. |
the strategy of dual binding site acetylcholinesterase (ache) inhibition along with metal chelation may represent a promising direction for multi-targeted interventions in the pathophysiological processes of alzheimer's disease (ad). |
2012-11-19 |
2023-08-12 |
human |
| Yao Chen, Lei Fang, Sixun Peng, Hong Liao, Jochen Lehmann, Yihua Zhan. Discovery of a novel acetylcholinesterase inhibitor by structure-based virtual screening techniques. Bioorganic & medicinal chemistry letters. vol 22. issue 9. 2012-10-11. PMID:22472693. |
acetylcholinesterase (ache) is considered to be one of the most important targets for the treatment of alzheimer's disease (ad). |
2012-10-11 |
2023-08-12 |
Not clear |
| George D Geromichalos, Fotini N Lamari, Magdalini A Papandreou, Dimitrios T Trafalis, Marigoula Margarity, Athanasios Papageorgiou, Zacharias Sinako. Saffron as a source of novel acetylcholinesterase inhibitors: molecular docking and in vitro enzymatic studies. Journal of agricultural and food chemistry. vol 60. issue 24. 2012-10-10. PMID:22655699. |
inhibitors of acetylcholine breakdown by acetylcholinesterase (ache) constitute the main therapeutic modality for alzheimer's disease. |
2012-10-10 |
2023-08-12 |
Not clear |
| J R Atack, C May, J A Kaye, S I Rapopor. Cerebrospinal fluid gradients of acetylcholinesterase and butyrylcholinesterase activity in healthy aging. Neurochemistry international. vol 16. issue 4. 2012-10-02. PMID:20504592. |
brain and spinal cord) origin of ache in lumbar csf would explain the relatively modest changes in lumbar csf ache activity in diseases involving certain central cholinergic systems, most notably alzheimer's disease. |
2012-10-02 |
2023-08-12 |
human |
| Eleonora Alfinito, Cecilia Pennetta, Lino Reggian. A network model to correlate conformational change and the impedance spectrum of single proteins. Nanotechnology. vol 19. issue 6. 2012-10-02. PMID:21730695. |
here we focus on two relevant kinds of protein: bovine rhodopsin, prototype of g-protein-coupled-receptor (gpcr) proteins, and the enzyme acetylcholinesterase (ache), whose inhibition is one of the most qualified treatments of alzheimer's disease. |
2012-10-02 |
2023-08-12 |
cattle |
| Jerald J Nair, Johannes van Stade. Acetylcholinesterase inhibition within the lycorine series of Amaryllidaceae alkaloids. Natural product communications. vol 7. issue 7. 2012-09-20. PMID:22908593. |
in this regard, the alzheimer's drug galanthamine has gained much prominence due to its selective and reversible inhibitory interaction with the enzyme acetylcholinesterase (ache), of significance in the progression of neurodegeneration associated with alzheimer's disease (ad). |
2012-09-20 |
2023-08-12 |
Not clear |
| Vikas Kotagal, Martijn L T M Müller, Daniel I Kaufer, Robert A Koeppe, Nicolaas I Bohne. Thalamic cholinergic innervation is spared in Alzheimer disease compared to parkinsonian disorders. Neuroscience letters. vol 514. issue 2. 2012-09-14. PMID:22414859. |
we investigated thalamic cholinergic afferent integrity by measuring ppn-thalamic (ppn-thal) acetylcholinesterase (ache) activity via pet imaging in alzheimer (ad), parkinson disease without dementia (pd), parkinson disease with dementia (pdd) and dementia with lewy bodies (dlb). |
2012-09-14 |
2023-08-12 |
human |
| Desiree Antequera, Marta Bolos, Carlos Spuch, Consuelo Pascual, Isidro Ferrer, María Isabel Fernandez-Bachiller, María Isabel Rodríguez-Franco, Eva Carr. Effects of a tacrine-8-hydroxyquinoline hybrid (IQM-622) on Aβ accumulation and cell death: involvement in hippocampal neuronal loss in Alzheimer's disease. Neurobiology of disease. vol 46. issue 3. 2012-09-14. PMID:22426395. |
several studies have implicated the enzyme acetylcholinesterase (ache) as well as several biometals in the pathogenesis of alzheimer's disease (ad). |
2012-09-14 |
2023-08-12 |
mouse |
| Ahsan Raza, Aamer Saeed, Aliya Ibrar, Muhammad Muddassar, Aftab Ahmed Khan, Jamshed Iqba. Pharmacological Evaluation and Docking Studies of 3-Thiadiazolyl- and Thioxo-1,2,4-triazolylcoumarin Derivatives as Cholinesterase Inhibitors. ISRN pharmacology. vol 2012. 2012-09-12. PMID:22966467. |
inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche) is considered a promising strategy for the treatment of alzheimer's disease (ad). |
2012-09-12 |
2023-08-12 |
rabbit |
| Nadezhda A Kapai, Julia V Bukanova, Elena I Solntseva, Vladimir G Skrebitsk. Donepezil in a narrow concentration range augments control and impaired by beta-amyloid peptide hippocampal LTP in NMDAR-independent manner. Cellular and molecular neurobiology. vol 32. issue 2. 2012-08-29. PMID:21968642. |
acetylcholinesterase (ache) inhibitor donepezil is widely used for the treatment of alzheimer's disease (ad). |
2012-08-29 |
2023-08-12 |
rat |
| Mona Mehta, Abdu Adem, Marwan Sabbag. New acetylcholinesterase inhibitors for Alzheimer's disease. International journal of Alzheimer's disease. vol 2012. 2012-08-23. PMID:22216416. |
acetylcholinesterase (ache) remains a highly viable target for the symptomatic improvement in alzheimer's disease (ad) because cholinergic deficit is a consistent and early finding in ad. |
2012-08-23 |
2023-08-12 |
Not clear |
| Zhong-Duo Yang, Dong-Zhu Duan, Wei-Wei Xue, Xiao-Jun Yao, Shuo L. Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships. Life sciences. vol 90. issue 23-24. 2012-08-16. PMID:22569298. |
inhibition of acetylcholinesterase (ache) is still considered as a strategy for the treatment of neurological disorders such as alzheimer's disease (ad). |
2012-08-16 |
2023-08-12 |
Not clear |
| Janos Kovacs, Magdolna Pakaski, Anna Juhasz, Agnes Feher, Gergely Drotos, Csilla Orsike Fazekas, Tamas Laszlo Horvath, Zoltan Janka, Janos Kalma. [Achetylcholinesterase (AChE) inhibition and serum lipokines in Alzheimer's disease: friend or foe?]. Neuropsychopharmacologia Hungarica : a Magyar Pszichofarmakologiai Egyesulet lapja = official journal of the Hungarian Association of Psychopharmacology. vol 14. issue 1. 2012-07-23. PMID:22427467. |
[achetylcholinesterase (ache) inhibition and serum lipokines in alzheimer's disease: friend or foe?]. |
2012-07-23 |
2023-08-12 |
Not clear |
| Cecilia Bartolucci, Jure Stojan, Qian-sheng Yu, Nigel H Greig, Doriano Lamb. Kinetics of Torpedo californica acetylcholinesterase inhibition by bisnorcymserine and crystal structure of the complex with its leaving group. The Biochemical journal. vol 444. issue 2. 2012-07-13. PMID:22390827. |
natural and synthetic carbamates act as pseudo-irreversible inhibitors of ache (acetylcholinesterase) as well as bche (butyrylcholinesterase), two enzymes involved in neuronal function as well as in the development and progression of ad (alzheimer's disease). |
2012-07-13 |
2023-08-12 |
Not clear |