| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ana Paula Murray, María Belén Faraoni, María Julia Castro, Natalia Paola Alza, Valeria Cavallar. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy. Current neuropharmacology. vol 11. issue 4. 2014-01-01. PMID:24381530. |
the fact that naturally-occurring compounds from plants are considered to be a potential source of new inhibitors has led to the discovery of an important number of secondary metabolites and plant extracts with the ability of inhibiting the enzyme ache, which, according to the cholinergic hypothesis, increases the levels of the neurotransmitter acetylcholine in the brain, thus improving cholinergic functions in patients with alzheimer's disease and alleviating the symptoms of this neurological disorder. |
2014-01-01 |
2023-08-12 |
Not clear |
| Filipa Marcelo, Catarina Dias, Alice Martins, Paulo J Madeira, Tiago Jorge, M Helena Florêncio, F Javier Cañada, Eurico J Cabrita, Jesús Jiménez-Barbero, Amélia P Raute. Molecular recognition of rosmarinic acid from Salvia sclareoides extracts by acetylcholinesterase: a new binding site detected by NMR spectroscopy. Chemistry (Weinheim an der Bergstrasse, Germany). vol 19. issue 21. 2013-12-24. PMID:23536497. |
acetylcholinesterase (ache) inhibition is one of the most currently available therapies for the management of alzheimer's disease (ad) symptoms. |
2013-12-24 |
2023-08-12 |
Not clear |
| Kaitlyn E Shaw, Corina O Bondi, Samuel H Light, Lire A Massimino, Rose L McAloon, Christina M Monaco, Anthony E Klin. Donepezil is ineffective in promoting motor and cognitive benefits after controlled cortical impact injury in male rats. Journal of neurotrauma. vol 30. issue 7. 2013-11-26. PMID:23227953. |
the acetylcholinesterase (ache) inhibitor donepezil is used as a therapy for alzheimer's disease and has been recommended as a treatment for enhancing attention and memory after traumatic brain injury (tbi). |
2013-11-26 |
2023-08-12 |
rat |
| Najoua Mejri, Nadia Malek Said, Sihem Guizani, Imen Essouissi, Mouldi Said. Preliminary studies of acetylcholinesterase activity in the rat brain using N-phenylferrocenecarboxamide labelled by the technetium-99m. Nuclear medicine and biology. vol 40. issue 4. 2013-11-26. PMID:23465564. |
the reduction of acetylcholinesterase (ache) activity in the brain has been measured in dementia disorders such as alzheimer's disease and dementia with lewy bodies using (11)c and (18)f-labeled acetylcholine analogues. |
2013-11-26 |
2023-08-12 |
rat |
| Ren-Shi Li, Xiao-Bing Wang, Xiao-Jun Hu, Ling-Yi Kon. Design, synthesis and evaluation of flavonoid derivatives as potential multifunctional acetylcholinesterase inhibitors against Alzheimer's disease. Bioorganic & medicinal chemistry letters. vol 23. issue 9. 2013-11-08. PMID:23511019. |
a new series of flavonoid derivatives were designed, synthesized and evaluated as potential multifunctional ache inhibitors against alzheimer's disease. |
2013-11-08 |
2023-08-12 |
Not clear |
| Seyyede Faeze Razavi, Mehdi Khoobi, Hamid Nadri, Amirhossein Sakhteman, Alireza Moradi, Saeed Emami, Alireza Foroumadi, Abbas Shafie. Synthesis and evaluation of 4-substituted coumarins as novel acetylcholinesterase inhibitors. European journal of medicinal chemistry. vol 64. 2013-11-05. PMID:23644208. |
a series of 4-hydroxycoumarin derivatives were designed and synthesized as new acetylcholinesterase (ache) inhibitors which could be considered for alzheimer's disease therapeutics. |
2013-11-05 |
2023-08-12 |
Not clear |
| Franziska Mohr, Martina Zimmermann, Jochen Klei. Mice heterozygous for AChE are more sensitive to AChE inhibitors but do not respond to BuChE inhibition. Neuropharmacology. vol 67. 2013-11-04. PMID:23147415. |
an impaired central cholinergic system is at least partly involved in alzheimer's disease (ad) pathogenesis, with cholinergic markers such as acetylcholinesterase (ache) activity and protein levels decreasing as cognitive decline progresses. |
2013-11-04 |
2023-08-12 |
mouse |
| Yueqing Hu, Jun Zhang, Oormila Chandrashankra, Fanny C F Ip, Nancy Y I. Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors. Bioorganic & medicinal chemistry. vol 21. issue 3. 2013-11-04. PMID:23273608. |
four series of novel heterodimers comprised of donepezil and huperzine a (hupa) fragments were designed, synthesized, and evaluated in search of potent acetylcholinesterase (ache) inhibitors as potential therapeutic treatment for alzheimer's disease. |
2013-11-04 |
2023-08-12 |
Not clear |
| Yao-Dong Zhang, Ya-Nan Cai, Qi Zhang, Zong-Li Qi, Qun-Qun Ga. [Inhibitory effect of icariin on acetylcholinesterase]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 47. issue 9. 2013-10-21. PMID:23227542. |
acetylcholinesterase (ache) inhibitors are mainly used in the treatment of alzheimer's disease (ad). |
2013-10-21 |
2023-08-12 |
Not clear |
| Fakhra Amin, Bilqees Ban. Studies on interaction of buffalo brain cystatin with donepezil: an Alzheimer's drug. International journal of Alzheimer's disease. vol 2013. 2013-09-24. PMID:24062965. |
donepezil, an acetyl cholinesterase inhibitor (ache), is commonly prescribed to patients with alzheimer's disease (ad) to enhance cholinergic neurotransmission. |
2013-09-24 |
2023-08-12 |
Not clear |
| M Kannan, P Manivel, K Geetha, J Muthukumaran, H Surya Prakash Rao, R Krishn. Synthesis and in silico evaluation of 1N-methyl-1S-methyl-2-nitroethylene (NMSM) derivatives against Alzheimer disease: to understand their interacting mechanism with acetylcholinesterase. Journal of chemical biology. vol 5. issue 4. 2013-09-20. PMID:24052808. |
anomalous action of human acetylcholinesterase (hache) in alzheimer's disease (ad) was restrained by various ache inhibitors, of which the specific and potent lead candidate donepezil is used for treating the disease ad. |
2013-09-20 |
2023-08-12 |
human |
| Anthony J Veloso, Paul M Nagy, Biao Zhang, Devjani Dhar, Anqi Liang, Tarek Ibrahim, Svetlana Mikhaylichenko, Isabelle Aubert, Kagan Kerma. Miniaturized electrochemical system for cholinesterase inhibitor detection. Analytica chimica acta. vol 774. 2013-09-18. PMID:23567119. |
the utility of a simple, low-cost detection platform for label-free electrochemical characterization of acetylcholinesterase (ache) inhibition is demonstrated as a potential tool for screening of small-molecule therapeutic agents for alzheimer's disease (ad). |
2013-09-18 |
2023-08-12 |
mouse |
| P Russo, A Frustaci, A Del Bufalo, M Fini, A Cesari. From traditional European medicine to discovery of new drug candidates for the treatment of dementia and Alzheimer's disease: acetylcholinesterase inhibitors. Current medicinal chemistry. vol 20. issue 8. 2013-09-13. PMID:23210783. |
the leading alzheimer's disease (ad) therapeutics to date involves inhibitors of acetylcholinesterase (ache), which should, in principle, elevate cholinergic signaling and limit inflammation. |
2013-09-13 |
2023-08-12 |
Not clear |
| Angela I Calderón, Johayra Simithy-Williams, Rocío Sanchez, Alex Espinosa, Iván Valdespino, Mahabir P Gupt. Lycopodiaceae from Panama: a new source of acetylcholinesterase inhibitors. Natural product research. vol 27. issue 4-5. 2013-09-05. PMID:22746970. |
acetylcholinesterase (ache) inhibitors have been used for the symptomatic treatment of alzheimer's disease. |
2013-09-05 |
2023-08-12 |
Not clear |
| Chandran Remya, Kalarickal Vijayan Dileep, Ignatius Tintu, Elessery Jayadevi Variyar, Chittalakkottu Sadasiva. In vitro inhibitory profile of NDGA against AChE and its in silico structural modifications based on ADME profile. Journal of molecular modeling. vol 19. issue 3. 2013-08-13. PMID:23229229. |
acetylcholinesterase (ache) inhibitors are currently in focus for the pharmacotherapy of alzheimer's disease (ad). |
2013-08-13 |
2023-08-12 |
Not clear |
| Wen-Chao Yang, Qi Sun, Ning-Xi Yu, Xiao-Lei Zhu, Guang-Fu Yan. [Design of acetylcholinesterase inhibitor for Alzheimer's disease therapy: from multi-binding site inhibitors to multi-target directed ligands]. Yao xue xue bao = Acta pharmaceutica Sinica. vol 47. issue 3. 2013-08-12. PMID:22645754. |
drug discovery for alzheimer's disease therapy has been a hot research area and a big challenge, in which development of acetylcholinesterase (ache) inhibitors design was the most active and some ache inhibitors are commercially available for ad medication already. |
2013-08-12 |
2023-08-12 |
Not clear |
| Dowluru Svgk Kaladhar, Nagendra Sastry Yarla, N Anush. Functional Analysis and Molecular Docking studies of Medicinal Compounds for AChE and BChE in Alzheimer's Disease and Type 2 Diabetes Mellitus. Aging and disease. vol 4. issue 4. 2013-08-12. PMID:23936743. |
functional analysis and molecular docking studies of medicinal compounds for ache and bche in alzheimer's disease and type 2 diabetes mellitus. |
2013-08-12 |
2023-08-12 |
Not clear |
| Dowluru Svgk Kaladhar, Nagendra Sastry Yarla, N Anush. Functional Analysis and Molecular Docking studies of Medicinal Compounds for AChE and BChE in Alzheimer's Disease and Type 2 Diabetes Mellitus. Aging and disease. vol 4. issue 4. 2013-08-12. PMID:23936743. |
phylogenetic tree was constructed to these proteins usinf upgma and maximum likelihood methods in mega software has shown interaction of ache and bche with ageing diseases like alzheimer's disease and diabetes. |
2013-08-12 |
2023-08-12 |
Not clear |
| Dowluru Svgk Kaladhar, Nagendra Sastry Yarla, N Anush. Functional Analysis and Molecular Docking studies of Medicinal Compounds for AChE and BChE in Alzheimer's Disease and Type 2 Diabetes Mellitus. Aging and disease. vol 4. issue 4. 2013-08-12. PMID:23936743. |
the present studies is also accomplished that ache, bche, colq, hand1, app, nlgn2 and ngf proteins has interactions with diseases such as alzheimer's and d2m using pathwaylinker and string. |
2013-08-12 |
2023-08-12 |
Not clear |
| Hailin Zheng, Moussa B H Youdim, Mati Fridki. Selective acetylcholinesterase inhibitor activated by acetylcholinesterase releases an active chelator with neurorescuing and anti-amyloid activities. ACS chemical neuroscience. vol 1. issue 11. 2013-08-09. PMID:22778810. |
the finding that acetylcholinesterase (ache) colocalizes with β-amyloid (aβ) and promotes and accelerates aβ aggregation has renewed an intense interest in developing new multifunctional ache inhibitors as potential disease-modifying drugs for alzheimer's therapy. |
2013-08-09 |
2023-08-12 |
human |