| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Himmatrao Saluba Bawaskar, Parag Himmatrao Bawaskar, Pramodini Himmatrao Bawaska. RBC acetyl cholinesterase: A poor man's early diagnostic biomarker for familial alzheimer's and Parkinson's disease dementia. Journal of neurosciences in rural practice. vol 6. issue 1. 2015-01-01. PMID:25552849. |
analysis of red blood cell acetyl cholinesterase (ache) in a familial alzheimer's diseases (ad) parkinson's disease dementia (pdd) and their first generation. |
2015-01-01 |
2023-08-13 |
Not clear |
| Aamer Saeed, Parvez Ali Mahesar, Sumera Zaib, Muhammad Siraj Khan, Abdul Matin, Mohammad Shahid, Jamshed Iqba. Synthesis, cytotoxicity and molecular modelling studies of new phenylcinnamide derivatives as potent inhibitors of cholinesterases. European journal of medicinal chemistry. vol 78. 2014-12-24. PMID:24675179. |
controlled inhibition of brain acetylcholinesterase (ache) and butyrylcholinesterase (bche) may slow neurodegeneration in alzheimer's diseases (ad). |
2014-12-24 |
2023-08-12 |
Not clear |
| Maryam Farrokhnia, Iraj Nabipou. Marine natural products as acetylcholinesterase inhibitor: comparative quantum mechanics and molecular docking study. Current computer-aided drug design. vol 10. issue 1. 2014-12-22. PMID:24712383. |
three of the investigated molecules correlate better to well-known ad drugs such as huperzine a, galanthamine and donepezil which represent possible ache inhibitors against alzheimer disease. |
2014-12-22 |
2023-08-13 |
aplysia |
| Ganiyu Oboh, Ayodele J Akinyemi, Olasunkanmi S Omojokun, Idowu S Oyeley. Anticholinesterase and Antioxidative Properties of Aqueous Extract of Cola acuminata Seed In Vitro. International journal of Alzheimer's disease. vol 2014. 2014-12-16. PMID:25506036. |
inhibition of ache and bche activities has been the primary treatment method for mild alzheimer's disease (ad). |
2014-12-16 |
2023-08-13 |
rat |
| Fouad H Darras, Steffen Pockes, Guozheng Huang, Sarah Wehle, Andrea Strasser, Hans-Joachim Wittmann, Martin Nimczick, Christoph A Sotriffer, Michael Decke. Synthesis, biological evaluation, and computational studies of Tri- and tetracyclic nitrogen-bridgehead compounds as potent dual-acting AChE inhibitors and hH3 receptor antagonists. ACS chemical neuroscience. vol 5. issue 3. 2014-12-03. PMID:24422467. |
combination of ache inhibiting and histamine h3 receptor antagonizing properties in a single molecule might show synergistic effects to improve cognitive deficits in alzheimer's disease, since both pharmacological actions are able to enhance cholinergic neurotransmission in the cortex. |
2014-12-03 |
2023-08-12 |
Not clear |
| Raju Suresh Kumar, Abdulrahman I Almansour, Natarajan Arumugam, Hasnah Osman, Mohamed Ashraf Ali, Alireza Basiri, Yalda Ki. An expedient synthesis and screening for antiacetylcholinesterase activity of piperidine embedded novel pentacyclic cage compounds. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 10. issue 2. 2014-11-24. PMID:23627271. |
most of the compounds exhibited moderate to good ache inhibitory activity, compound 5i showed potent inhibitory activity with ic50 1.12 ± 0.01 µm and this may provide a new lead for developing potential inhibitors for alzheimer's disease. |
2014-11-24 |
2023-08-12 |
Not clear |
| Wei Liu, Yadi Yang, Xuemei Cheng, Can Gong, Shuping Li, Dandan He, Li Yang, Zhengtao Wang, Changhong Wan. Rapid and sensitive detection of the inhibitive activities of acetyl- and butyryl-cholinesterases inhibitors by UPLC-ESI-MS/MS. Journal of pharmaceutical and biomedical analysis. vol 94. 2014-11-17. PMID:24631841. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are legitimate therapeutic targets for alzheimer's disease. |
2014-11-17 |
2023-08-12 |
Not clear |
| J Broad, V W S Kung, G Boundouki, Q Aziz, J H De Maeyer, C H Knowles, G J Sange. Cholinergic interactions between donepezil and prucalopride in human colon: potential to treat severe intestinal dysmotility. British journal of pharmacology. vol 170. issue 6. 2014-11-06. PMID:24032987. |
these include the ache inhibitor donepezil (used for alzheimer's disease, with reduced cardio-bronchial liability) and prucalopride, the first selective, clinically available 5-ht4 receptor agonist. |
2014-11-06 |
2023-08-12 |
human |
| Hiroyuki Kimura, Tomoki Kawai, Yoshio Hamashima, Hidekazu Kawashima, Kenji Miura, Yuta Nakaya, Makoto Hirasawa, Kenji Arimitsu, Tetsuya Kajimoto, Yoshiro Ohmomo, Masahiro Ono, Manabu Node, Hideo Saj. Synthesis and evaluation of (-)- and (+)-[¹¹C]galanthamine as PET tracers for cerebral acetylcholinesterase imaging. Bioorganic & medicinal chemistry. vol 22. issue 1. 2014-11-06. PMID:24315193. |
improved radiopharmaceuticals for imaging cerebral acetylcholinesterase (ache) are needed for the diagnosis of alzheimer's disease (ad). |
2014-11-06 |
2023-08-12 |
mouse |
| Li-Na Hou, Jian-Rong Xu, Qing-Nan Zhao, Xiao-Ling Gao, Yong-Yao Cui, Jun Xu, Hao Wang, Hong-Zhuan Che. A new motif in the N-terminal of acetylcholinesterase triggers amyloid-β aggregation and deposition. CNS neuroscience & therapeutics. vol 20. issue 1. 2014-09-29. PMID:23981668. |
as a molecular chaperone, acetylcholinesterase (ache; ec 3.1.1.7) plays a critical role in the pathogenesis of alzheimer's disease (ad). |
2014-09-29 |
2023-08-12 |
Not clear |
| Maya Mathew, Sarada Subramania. In vitro screening for anti-cholinesterase and antioxidant activity of methanolic extracts of ayurvedic medicinal plants used for cognitive disorders. PloS one. vol 9. issue 1. 2014-09-29. PMID:24466247. |
inhibition of acetylcholinesterase (ache) is still considered as the main therapeutic strategy against alzheimer's disease (ad). |
2014-09-29 |
2023-08-12 |
Not clear |
| Manjinder Singh, Maninder Kaur, Hitesh Kukreja, Rajan Chugh, Om Silakari, Dhandeep Sing. Acetylcholinesterase inhibitors as Alzheimer therapy: from nerve toxins to neuroprotection. European journal of medicinal chemistry. vol 70. 2014-09-19. PMID:24148993. |
this review article gives a spectrum of strategies to design ache inhibitors used in the alzheimer therapy. |
2014-09-19 |
2023-08-12 |
Not clear |
| Sanda Vladimir-Knežević, Biljana Blažeković, Marija Kindl, Jelena Vladić, Agnieszka D Lower-Nedza, Adelheid H Brantne. Acetylcholinesterase inhibitory, antioxidant and phytochemical properties of selected medicinal plants of the Lamiaceae family. Molecules (Basel, Switzerland). vol 19. issue 1. 2014-09-19. PMID:24413832. |
these findings indicate that lamiaceae species are a rich source of various natural ache inhibitors and antioxidants that could be useful in the prevention and treatment of alzheimer's and other related diseases. |
2014-09-19 |
2023-08-12 |
Not clear |
| Margarita Gutiérrez, María Francisca Matus, Tomas Poblete, Jessica Amigo, Gabriel Vallejos, Luis Astudill. Isoxazoles: synthesis, evaluation and bioinformatic design as acetylcholinesterase inhibitors. The Journal of pharmacy and pharmacology. vol 65. issue 12. 2014-09-05. PMID:24180424. |
inhibition of acetylcholinesterase (ache) is a common treatment for early stages of alzheimer's disease. |
2014-09-05 |
2023-08-12 |
Not clear |
| Eduardo Luis Konrath, Carolina dos Santos Passos, Luiz Carlos Klein, Amélia T Henrique. Alkaloids as a source of potential anticholinesterase inhibitors for the treatment of Alzheimer's disease. The Journal of pharmacy and pharmacology. vol 65. issue 12. 2014-09-05. PMID:24236981. |
the inhibition of acetylcholinesterase (ache), the key enzyme in the breakdown of acetylcholine, is currently the main pharmacological strategy available for alzheimer's disease (ad). |
2014-09-05 |
2023-08-12 |
Not clear |
| Antoine-Scott Badin, John Eraifej, Susan Greenfiel. High-resolution spatio-temporal bioactivity of a novel peptide revealed by optical imaging in rat orbitofrontal cortex in vitro: possible implications for neurodegenerative diseases. Neuropharmacology. vol 73. 2014-08-13. PMID:23711548. |
in conclusion, the t14 peptide derived from ache produced a dose-dependent biphasic modulation of cortical networks activity dependent on the α₇-nachr: these findings should thus provide a more comprehensive insight into the immediate actions of a novel bioactive agent of high potential relevance to neurodegenerative disorders such as alzheimer's disease. |
2014-08-13 |
2023-08-12 |
rat |
| M Zimmerman. Neuronal AChE splice variants and their non-hydrolytic functions: redefining a target of AChE inhibitors? British journal of pharmacology. vol 170. issue 5. 2014-08-08. PMID:23991627. |
ache enzymatic inhibition is a core focus of pharmacological intervention in alzheimer's disease (ad). |
2014-08-08 |
2023-08-12 |
Not clear |
| Per Johansson, Erik G Almqvist, Jan-Ove Johansson, Niklas Mattsson, Ulf Andreasson, Oskar Hansson, Anders Wallin, Kaj Blennow, Henrik Zetterberg, Johan Svensso. Cerebrospinal fluid (CSF) 25-hydroxyvitamin D concentration and CSF acetylcholinesterase activity are reduced in patients with Alzheimer's disease. PloS one. vol 8. issue 11. 2014-08-05. PMID:24312390. |
little is known of vitamin d concentration in cerebrospinal fluid (csf) in alzheimer's disease (ad) and its relation with csf acetylcholinesterase (ache) activity, a marker of cholinergic function. |
2014-08-05 |
2023-08-12 |
Not clear |
| Chandrabhan Seniya, Ghulam Jilani Khan, Kuldeep Uchadi. Identification of potential herbal inhibitor of acetylcholinesterase associated Alzheimer's disorders using molecular docking and molecular dynamics simulation. Biochemistry research international. vol 2014. 2014-07-23. PMID:25054066. |
additionally, acetylcholinesterase (ache) is the target for many alzheimer's dementia drugs which block the function of ache but have some side effects. |
2014-07-23 |
2023-08-13 |
Not clear |
| Ivana Molino, Luisa Colucci, Angiola M Fasanaro, Enea Traini, Francesco Ament. Efficacy of memantine, donepezil, or their association in moderate-severe Alzheimer's disease: a review of clinical trials. TheScientificWorldJournal. vol 2013. 2014-07-17. PMID:24288512. |
acetylcholinesterase (ache)/cholinesterase (che) inhibitors (is) and memantine are licensed for symptomatic treatment of mild-moderate and moderate-severe forms of alzheimer's disease (ad), respectively. |
2014-07-17 |
2023-08-12 |
Not clear |