| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yee-Hui Koay, Alireza Basiri, Vikneswaran Murugaiyah, Kit-Lam Cha. Isocorilagin, a cholinesterase inhibitor from Phyllanthus niruri. Natural product communications. vol 9. issue 4. 2014-06-26. PMID:24868872. |
drugs that have dual inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche) produce better clinical efficacy against alzheimer's disease (ad) than those that selectively inhibit one enzyme. |
2014-06-26 |
2023-08-13 |
Not clear |
| George T Grossber. Cholinesterase inhibitors for the treatment of Alzheimer's disease:: getting on and staying on. Current therapeutic research, clinical and experimental. vol 64. issue 4. 2014-06-19. PMID:24944370. |
cholinesterase (che) inhibitors currently used in the treatment of alzheimer's disease (ad) are the acetylcholinesterase (ache)-selective inhibitors, donepezil and galantamine, and the dual ache and butyrylcholinesterase (buche) inhibitor, rivastigmine. |
2014-06-19 |
2023-08-13 |
Not clear |
| Kenia Lourenço Vanzolini, Zhengjin Jiang, Xiaoqi Zhang, Lucas Campos Curcino Vieira, Arlene Gonçalvez Corrêa, Carmen Lucia Cardoso, Quezia Bezerra Cass, Ruin Moadde. Acetylcholinesterase immobilized capillary reactors coupled to protein coated magnetic beads: a new tool for plant extract ligand screening. Talanta. vol 116. 2014-06-03. PMID:24148457. |
in this work the selected target was the enzyme acetylcholinesterase (ache), which acts on the central nervous system and is a validated target for the treatment of alzheimer's disease, as well as for new insecticides. |
2014-06-03 |
2023-08-12 |
Not clear |
| José C J M D S Menezes, José A S Cavaleiro, M Rosário M Domingue. Structural analysis of 2-arylidene-1-indanone derivatives by electrospray ionization tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. vol 27. issue 21. 2014-05-06. PMID:24097403. |
2-arylidene-4-methoxy (or hydroxy)-7-methyl-1-indanone derivatives inspired from donepezil, the current drug used for the treatment of alzheimer's disease as inhibitor of acetylcholinesterase (ache), were studied for the first time by electrospray ionization mass spectrometry (esi-ms) and tandem mass spectrometry (ms/ms). |
2014-05-06 |
2023-08-12 |
Not clear |
| Miroslav Pohanka, Oto Pavlis, Jiri Pikul. Tacrine alters antibodies level in Francisella tularensis-infected mice. Neuro endocrinology letters. vol 34 Suppl 2. 2014-05-05. PMID:24362106. |
tacrine is an inhibitor of acetylcholinestrase (ache) formerly used to treat cognitive impairment of alzheimer disease. |
2014-05-05 |
2023-08-12 |
mouse |
| Abdelouahid Samadi, Mario de la Fuente Revenga, Concepción Pérez, Isabel Iriepa, Ignacio Moraleda, María Isabel Rodríguez-Franco, José Marco-Contelle. Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease. European journal of medicinal chemistry. vol 67. 2014-04-04. PMID:23838422. |
synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: new dual ache inhibitors as potential drugs for the treatment of alzheimer's disease. |
2014-04-04 |
2023-08-12 |
Not clear |
| Monica Rosa Loizzo, Mariem Ben Jemia, Felice Senatore, Maurizio Bruno, Francesco Menichini, Rosa Tundi. Chemistry and functional properties in prevention of neurodegenerative disorders of five Cistus species essential oils. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 59. 2014-03-28. PMID:23831310. |
essential oils were screened also for their potential antioxidant effects (by dpph, abts, frap and β-carotene bleaching test) and their acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitory activity, useful for prevention and treatment of alzheimer's disease. |
2014-03-28 |
2023-08-12 |
Not clear |
| Sibelle Feitosa da Cunha Xavier Soares, Andréia Aguiar Vieira, Reinaldo Teixeira Delfino, José Daniel Figueroa-Villa. NMR determination of Electrophorus electricus acetylcholinesterase inhibition and reactivation by neutral oximes. Bioorganic & medicinal chemistry. vol 21. issue 18. 2014-03-26. PMID:23916150. |
the results confirmed that nmr is a very efficient method for monitoring the action of ache, showing that neutral oximes, which display a significant ache inhibition activity, are potential drugs for alzheimer disease. |
2014-03-26 |
2023-08-12 |
Not clear |
| Koteswara Rao Valasani, Michael O Chaney, Victor W Day, Shirley Shidu Ya. Acetylcholinesterase inhibitors: structure based design, synthesis, pharmacophore modeling, and virtual screening. Journal of chemical information and modeling. vol 53. issue 8. 2014-03-21. PMID:23777291. |
acetylcholinesterase (ache) is a main drug target, and its inhibitors have demonstrated functionality in the symptomatic treatment of alzheimer's disease (ad). |
2014-03-21 |
2023-08-12 |
human |
| Cho Rong Kim, Soo Jung Choi, Seung Sang Oh, Yoon Kyung Kwon, Na Young Lee, Gwi Gun Park, Youn-Jung Kim, Ho Jin Heo, Woo Jin Jun, Cheung-Seog Park, Dong-Hoon Shi. Rubus coreanus Miquel inhibits acetylcholinesterase activity and prevents cognitive impairment in a mouse model of dementia. Journal of medicinal food. vol 16. issue 9. 2014-03-21. PMID:24044488. |
to find acetylcholinesterase (ache) inhibitors for the prevention of neurological disorders, such as alzheimer's disease, ethanol extracts of promising traditional edible korean plants were tested. |
2014-03-21 |
2023-08-12 |
mouse |
| Anél Petzer, Brian H Harvey, Jacobus P Petze. The interactions of azure B, a metabolite of methylene blue, with acetylcholinesterase and butyrylcholinesterase. Toxicology and applied pharmacology. vol 274. issue 3. 2014-03-21. PMID:24161345. |
although the ache and buche inhibitory activities of azure b are twofold and fivefold, respectively, less potent than those recorded for mb [ic50(ache)=0.214μm; ic50(buche)=0.389μm] under identical conditions, azure b may be a contributor to mb's in vivo activation of the cholinergic system and beneficial effects in alzheimer's disease. |
2014-03-21 |
2023-08-12 |
human |
| Shuqing Gu, Youlan Lu, Yaping Ding, Li Li, Fenfen Zhang, Qingsheng W. Droplet-based microfluidics for dose-response assay of enzyme inhibitors by electrochemical method. Analytica chimica acta. vol 796. 2014-03-19. PMID:24016585. |
this system was validated by measuring dose-response curves of three types of acetylcholinesterase (ache) inhibitors, including carbamate pesticide, organophosphorus pesticide, and therapeutic drugs regulating alzheimer's disease. |
2014-03-19 |
2023-08-12 |
Not clear |
| Marco Sifringer, Ivo Bendix, Clarissa von Haefen, Stefanie Endesfelder, Alexander Kalb, Christoph Bührer, Ursula Felderhoff-Mueser, Claudia D Spie. Oxygen toxicity is reduced by acetylcholinesterase inhibition in the developing rat brain. Developmental neuroscience. vol 35. issue 2-3. 2014-03-05. PMID:23445753. |
our results suggest that a single treatment with ache inhibitors at the beginning of hyperoxia attenuated the detrimental effects of oxygen toxicity in the developing brain and may pave the way for ache inhibitors, which are currently used for the treatment of alzheimer's disease, as potential candidates for adjunctive neuroprotective therapies to the immature brain. |
2014-03-05 |
2023-08-12 |
rat |
| Veronica Tello-Franco, Maria Concepcion Lozada-García, Manuel Soriano-Garcí. Experimental and computational studies on the inhibition of acetylcholinesterase by curcumin and some of its derivatives. Current computer-aided drug design. vol 9. issue 2. 2014-02-26. PMID:23106780. |
recent studies have demonstrated several biological activities of curcumin with therapeutic potential against alzheimer's disease, among them the inhibition of the enzyme acetylcholinesterase (ache). |
2014-02-26 |
2023-08-12 |
Not clear |
| Md Rezaul Islam, Aubhishek Zaman, Iffat Jahan, Rajib Chakravorty, Sajib Chakrabort. In silico QSAR analysis of quercetin reveals its potential as therapeutic drug for Alzheimer's disease. Journal of young pharmacists : JYP. vol 5. issue 4. 2014-02-24. PMID:24563598. |
acetylcholine-esterase (ache) inhibitors are one of the most potent drug molecules against alzheimer's disease (ad). |
2014-02-24 |
2023-08-12 |
Not clear |
| Loganathan Chitra, Chinnadurai Raj Kumar, Haleema M Basha, Saravanaraman Ponne, Rathanam Boopath. Interaction of metal chelators with different molecular forms of acetylcholinesterase and its significance in Alzheimer's disease treatment. Proteins. vol 81. issue 7. 2014-02-21. PMID:23408593. |
the peripheral anionic site (pas) of acetylcholinesterase (ache) is involved in amyloid beta (aβ) peptides aggregation of alzheimer's disease (ad). |
2014-02-21 |
2023-08-12 |
Not clear |
| Gerard Esteban, Irene Bolea, Ping Sun, Montse Solé, Abdelouahid Samadi, José Marco-Contelles, Mercedes Unzet. A therapeutic approach to cerebrovascular diseases based on indole substituted hydrazides and hydrazines able to interact with human vascular adhesion protein-1, monoamine oxidases (A and B), AChE and BuChE. Journal of neural transmission (Vienna, Austria : 1996). vol 120. issue 6. 2014-01-10. PMID:23263540. |
the combined inhibition of ssao/vap-1, mao (a and b), ache and buche appear as an important therapeutic target to be considered in the treatment of cerebrovascular and neurological disorders such as alzheimer's disease. |
2014-01-10 |
2023-08-12 |
human |
| Ilkay Erdogan Orha. Nature: a substantial source of auspicious substances with acetylcholinesterase inhibitory action. Current neuropharmacology. vol 11. issue 4. 2014-01-01. PMID:24381529. |
inhibition of ache is associated with treatment of several diseases such as alzheimer's disease (ad), myasthenia gravis, and glaucoma as well as the mechanisms of insecticide and anthelmintic drugs. |
2014-01-01 |
2023-08-12 |
Not clear |
| Ana Paula Murray, María Belén Faraoni, María Julia Castro, Natalia Paola Alza, Valeria Cavallar. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy. Current neuropharmacology. vol 11. issue 4. 2014-01-01. PMID:24381530. |
natural ache inhibitors from plants and their contribution to alzheimer's disease therapy. |
2014-01-01 |
2023-08-12 |
Not clear |
| Ana Paula Murray, María Belén Faraoni, María Julia Castro, Natalia Paola Alza, Valeria Cavallar. Natural AChE Inhibitors from Plants and their Contribution to Alzheimer's Disease Therapy. Current neuropharmacology. vol 11. issue 4. 2014-01-01. PMID:24381530. |
as acetylcholinesterase (ache) inhibitors are an important therapeutic strategy in alzheimer's disease, efforts are being made in search of new molecules with anti-ache activity. |
2014-01-01 |
2023-08-12 |
Not clear |