| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| H Shimada, S Hirano, H Sinotoh, T Ota, N Tanaka, K Sato, M Yamada, K Fukushi, T Irie, M R Zhang, M Higuchi, S Kuwabara, T Suhar. Dementia with Lewy bodies can be well-differentiated from Alzheimer's disease by measurement of brain acetylcholinesterase activity-a [11C]MP4A PET study. International journal of geriatric psychiatry. vol 30. issue 11. 2016-07-01. PMID:26280153. |
to investigate the diagnostic performance of brain acetylcholinesterase (ache) activity measurement using n-[(11) c]-methyl-4-piperidyl acetate (mp4a) and pet in patients with dementia with lewy bodies (dlb) and alzheimer's disease (ad). |
2016-07-01 |
2023-08-13 |
Not clear |
| Hammad Saleem, Irshad Ahmad, Muhammad Nabeel Shahid, Muhammad Shoaib Ali Gill, Muhammad Faisal Nadeem, Waqas Mahmood, Imran Rashi. IN VITRO ACETYLCHOLINESTERASE AND BUTYRYLCHOLINESTERASE INHIBITORY POTENTIALS OF JATROPHA GOSSYPIFOLIA PLANT EXTRACTS. Acta poloniae pharmaceutica. vol 73. issue 2. 2016-06-20. PMID:27180434. |
inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (buche), which breakdown acetylcholine and butyrylcholine, are considered as a promising strategy in the management of alzheimer's disease (ad). |
2016-06-20 |
2023-08-13 |
Not clear |
| Piotr Draczkowski, Anna Tomaszuk, Pawel Halczuk, Maciej Strzemski, Dariusz Matosiuk, Krzysztof Jozwia. Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry. Biochimica et biophysica acta. vol 1860. issue 5. 2016-06-09. PMID:26586471. |
acetylcholinesterase (ache), an enzyme rapidly terminating nerve signals at synapses of cholinergic neurons is an important drug target in treatment of alzheimer's disease and related memory loss conditions. |
2016-06-09 |
2023-08-13 |
Not clear |
| Yao Chen, Zong-liang Liu, Ting-ming Fu, Wei Li, Xiao-li Xu, Hao-peng Su. Discovery of new acetylcholinesterase inhibitors with small core structures through shape-based virtual screening. Bioorganic & medicinal chemistry letters. vol 25. issue 17. 2016-05-18. PMID:26212777. |
targeting acetylcholinesterase (ache) using small molecule inhibitors is considered to be the most successful therapeutic strategy in the treatment of alzheimer's disease (ad). |
2016-05-18 |
2023-08-13 |
Not clear |
| Vyacheslav E Semenov, Irina V Zueva, Marat A Mukhamedyarov, Sofya V Lushchekina, Alexandra D Kharlamova, Elena O Petukhova, Anatoly S Mikhailov, Sergey N Podyachev, Lilya F Saifina, Konstantin A Petrov, Oksana A Minnekhanova, Vladimir V Zobov, Evgeny E Nikolsky, Patrick Masson, Vladimir S Rezni. 6-Methyluracil Derivatives as Bifunctional Acetylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. ChemMedChem. vol 10. issue 11. 2016-05-10. PMID:26412714. |
the most potent ache inhibitor, 3 d (1,3-bis[5-(o-nitrobenzylethylamino)pentyl]-6-methyluracil), was found to improve working memory in scopolamine and transgenic app/ps1 murine models of alzheimer's disease, and to significantly decrease the number and area of β-amyloid peptide plaques in the brain. |
2016-05-10 |
2023-08-13 |
human |
| Jin Bae Weon, Youn Sik Jung, Choong Je M. Cognitive-Enhancing Effect of Dianthus superbus var. Longicalycinus on Scopolamine-Induced Memory Impairment in Mice. Biomolecules & therapeutics. vol 24. issue 3. 2016-05-02. PMID:27133261. |
these results indicated that d. superbus improved memory functioning accompanied by inhibition of ache and upregulation of bdnf, suggesting that d. superbus may be a useful therapeutic agent for the prevention or treatment of alzheimer's disease. |
2016-05-02 |
2023-08-13 |
mouse |
| Abdulilah Ece, Boris Peji. A computational insight into acetylcholinesterase inhibitory activity of a new lichen depsidone. Journal of enzyme inhibition and medicinal chemistry. vol 30. issue 4. 2016-04-25. PMID:25198888. |
acetylcholinesterase (ache) inhibitors are yet the best drugs currently available for the management of alzheimer's disease. |
2016-04-25 |
2023-08-13 |
Not clear |
| Tran Manh Hung, Joo Sang Lee, Nguyen Ngoc Chuong, Jeong Ah Kim, Sang Ho Oh, Mi Hee Woo, Jae Sue Choi, Byung Sun Mi. Kinetics and molecular docking studies of cholinesterase inhibitors derived from water layer of Lycopodiella cernua (L.) Pic. Serm. (II). Chemico-biological interactions. vol 240. 2016-03-15. PMID:26297990. |
acetylcholinesterase (ache) inhibitors increase the availability of acetylcholine in central cholinergic synapses and are the most promising drugs currently available for the treatment of alzheimer's disease (ad). |
2016-03-15 |
2023-08-13 |
Not clear |
| K Petro. Macrocyclic derivatives of 6-methyluracil: New ligands of the peripheral anionic site of acetylcholinesterase. The International journal of risk & safety in medicine. vol 27 Suppl 1. 2016-03-15. PMID:26639720. |
acetylcholinesterase (ache) inhibitors are widely used in medicine for pharmacological correction of cholinergic neurotransmission pathologies such as myasthenia gravis (mg) and alzheimer's disease [1, 2]. |
2016-03-15 |
2023-08-13 |
Not clear |
| Pierre Bohn, Fabienne Gourand, Cyril Papamicaël, Méziane Ibazizène, Martine Dhilly, Vincent Gembus, Florent Alix, Mihaela-Liliana Ţînţaş, Francis Marsais, Louisa Barré, Vincent Levache. Dihydroquinoline Carbamate Derivatives as "Bio-oxidizable" Prodrugs for Brain Delivery of Acetylcholinesterase Inhibitors: [¹¹C] Radiosynthesis and Biological Evaluation. ACS chemical neuroscience. vol 6. issue 5. 2016-03-07. PMID:25695305. |
with the aim of improving the efficiency of marketed acetylcholinesterase (ache) inhibitors in the symptomatic treatment of alzheimer's disease, plagued by adverse effects arising from peripheral cholinergic activation, this work reports a biological evaluation of new central ache inhibitors based on an original "bio-oxidizable" prodrug strategy. |
2016-03-07 |
2023-08-13 |
mouse |
| Jaspreet Kaur Dhanjal, Sudhanshu Sharma, Abhinav Grover, Asmita Da. Use of ligand-based pharmacophore modeling and docking approach to find novel acetylcholinesterase inhibitors for treating Alzheimer's. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 71. 2016-02-10. PMID:25960230. |
finally, we have reported two compounds, opa and omt, which possess high affinity for catalytic site of ache enzyme and thus, can be considered as potential ache inhibitors for the symptomatic treatment of alzheimer's. |
2016-02-10 |
2023-08-13 |
Not clear |
| Lütfiye Ömür Demirezer, Perihan Gürbüz, Emine Pelin Kelicen Uğur, Mine Bodur, Nadire Özenver, Ayse Uz, Zühal Güvenal. Molecular docking and ex vivo and in vitro anticholinesterase activity studies of Salvia sp. and highlighted rosmarinic acid. Turkish journal of medical sciences. vol 45. issue 5. 2016-02-09. PMID:26738360. |
to evaluate acetylcholinesterase (ache) inhibitory activity and antioxidant capacity of the major molecule from salvia sp., rosmarinic acid, as a drug candidate molecule for treatment of alzheimer disease (ad). |
2016-02-09 |
2023-08-13 |
Not clear |
| Elvis A F Martis, Rakesh C Chandarana, Mushtaque S Shaikh, Premlata K Ambre, Jacinta S D'Souza, Krishna R Iyer, Evans C Coutinho, Santosh R Nandan, Raghuvir R S Pissurlenka. Quantifying ligand-receptor interactions for gorge-spanning acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. Journal of biomolecular structure & dynamics. vol 33. issue 5. 2016-01-15. PMID:24905476. |
there is a need for continued development of acetylcholinesterase (ache) inhibitors that could prolong the life of acetylcholine in the synaptic cleft and also prevent the aggregation of amyloid peptides associated with alzheimer's disease. |
2016-01-15 |
2023-08-13 |
Not clear |
| Robert Alan Mans, Brian A Warmus, Caroline C Smith, Lori L McMaho. An acetylcholinesterase inhibitor, eserine, induces long-term depression at CA3-CA1 synapses in the hippocampus of adult rats. Journal of neurophysiology. vol 112. issue 10. 2015-10-19. PMID:25143547. |
acetylcholinesterase (ache) inhibitors are commonly prescribed to enhance cholinergic signaling in alzheimer's disease in hopes of rescuing cognitive function, caused, in part, by degeneration of cholinergic innervation to the hippocampus and cortex. |
2015-10-19 |
2023-08-13 |
rat |
| Christina E Turi, Katarina E Axwik, Anderson Smith, A Maxwell P Jones, Praveen K Saxena, Susan J Murc. Galanthamine, an anti-cholinesterase drug, effects plant growth and development in Artemisia tridentata Nutt. via modulation of auxin and neurotransmitter signaling. Plant signaling & behavior. vol 9. issue 4. 2015-10-19. PMID:25764435. |
galanthamine is a naturally occurring acetylcholinesterase (ache) inhibitor that has been well established as a drug for treatment of mild to moderate alzheimer disease, but the role of the compound in plant metabolism is not known. |
2015-10-19 |
2023-08-13 |
Not clear |
| Jun Chen, Hongna Pan, Cynthia Chen, Wei Wu, Kevin Iskandar, Jeffrey He, Tetsade Piermartiri, David M Jacobowitz, Qian-Sheng Yu, John H McDonough, Nigel H Greig, Ann M Marin. (-)-Phenserine attenuates soman-induced neuropathology. PloS one. vol 9. issue 6. 2015-10-13. PMID:24955574. |
(-)-phenserine is a reversible ache inhibitor possessing neuroprotective and amyloid precursor protein lowering actions that reached phase iii clinical trials for alzheimer's disease where it exhibited a wide safety margin. |
2015-10-13 |
2023-08-13 |
rat |
| Li Tao, Jianmei Xie, Yuting Wang, Shi Wang, Shuangchan Wu, Qiman Wang, Hong Din. Protective effects of aloe-emodin on scopolamine-induced memory impairment in mice and H₂O₂-induced cytotoxicity in PC12 cells. Bioorganic & medicinal chemistry letters. vol 24. issue 23. 2015-10-06. PMID:25453793. |
the study indicated that ae could have neuroprotective effects against alzheimer's disease (ad) via inhibiting the activity of ache and modulating oxidative stress. |
2015-10-06 |
2023-08-13 |
mouse |
| Natalie Cortes, Rafael Alvarez, Edison H Osorio, Fernando Alzate, Strahil Berkov, Edison Osori. Alkaloid metabolite profiles by GC/MS and acetylcholinesterase inhibitory activities with binding-mode predictions of five Amaryllidaceae plants. Journal of pharmaceutical and biomedical analysis. vol 102. 2015-09-25. PMID:25305596. |
acetylcholinesterase (ache) enzymatic inhibition is an important target for the management of alzheimer disease (ad) and ache inhibitors are the mainstay drugs for its treatment. |
2015-09-25 |
2023-08-13 |
Not clear |
| Franciele Martini, César Augusto Bruning, Suelen Mendonca Soares, Cristina Wayne Nogueira, Gilson Zen. Inhibitory effect of ebselen on cerebral acetylcholinesterase activity in vitro: kinetics and reversibility of inhibition. Current pharmaceutical design. vol 21. issue 7. 2015-09-11. PMID:25312723. |
this system has a well-known relationship with cognitive process, and ache inhibitors, such as donepezil and galantamine, have been used to treat cognitive deficits, mainly in the alzheimer's disease (ad). |
2015-09-11 |
2023-08-13 |
Not clear |
| b' Marija Kindl, Biljana Bla\\xc5\\xbeekovi\\xc4\\x87, Franz Bucar, Sanda Vladimir-Kne\\xc5\\xbeevi\\xc4\\x8. Antioxidant and Anticholinesterase Potential of Six Thymus Species. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-09-09. PMID:26351513.' |
our results highlighted thymus species as a rich source of natural antioxidants and ache inhibitors that could be useful in preventing and treating alzheimer's disease and other neurodegenerative disorders. |
2015-09-09 |
2023-08-13 |
Not clear |