| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tanzeel Ur Rehman, Islam Ullah Khan, Muhammad Ashraf, Hamadeh Tarazi, Sadaf Riaz, Muhammad Ya. An Efficient Synthesis of bi-Aryl Pyrimidine Heterocycles: Potential New Drug Candidates to Treat Alzheimer's Disease. Archiv der Pharmazie. vol 350. issue 3-4. 2017-05-15. PMID:28220522. |
the enzyme inhibitory potential of these compounds was investigated against acetylcholinesterase (ache) and butyrylcholinesterase (bche) because these enzymes play a crucial role in the treatment of alzheimer's disease. |
2017-05-15 |
2023-08-13 |
Not clear |
| Malavalli Madaiah, Bidarur K Jayanna, Arakere S Manu, Maralekere K Prashanth, Hosakere D Revanasiddappa, Bantal Veeres. Synthesis, Characterization, and Evaluation of Difluoropyrido[4,3-b]indoles as Potential Agents for Acetylcholinesterase and Antiamnesic Activity. Archiv der Pharmazie. vol 350. issue 3-4. 2017-05-15. PMID:28326602. |
acetylcholinesterase (ache) inhibitors are currently the most widely prescribed drugs for alzheimer's disease. |
2017-05-15 |
2023-08-13 |
rat |
| Dorothea Kaufmann, Anudeep Kaur Dogra, Ahmad Tahrani, Florian Herrmann, Michael Win. Extracts from Traditional Chinese Medicinal Plants Inhibit Acetylcholinesterase, a Known Alzheimer's Disease Target. Molecules (Basel, Switzerland). vol 21. issue 9. 2017-04-17. PMID:27589716. |
inhibition of acetylcholinesterase (ache) is a common treatment for early stages of the most general form of dementia, alzheimer's disease (ad). |
2017-04-17 |
2023-08-13 |
Not clear |
| Kyung Hoan Im, Trung Kien Nguyen, Jaehyuk Choi, Tae Soo Le. In Vitro Antioxidant, Anti-Diabetes, Anti-Dementia, and Inflammation Inhibitory Effect of Trametes pubescens Fruiting Body Extracts. Molecules (Basel, Switzerland). vol 21. issue 5. 2017-04-13. PMID:27196881. |
the acetylcholinesterase (ache) and butyrylcholinesterase (bche) inhibitory effects of me and hwe were moderate and comparable with galanthamine, the standard drug to treat early stages of alzheimer's disease (ad). |
2017-04-13 |
2023-08-13 |
rat |
| Eun Bi Kuk, A Ra Jo, Seo In Oh, Hee Sook Sohn, Su Hui Seong, Anupom Roy, Jae Sue Choi, Hyun Ah Jun. Anti-Alzheimer's disease activity of compounds from the root bark of Morus alba L. Archives of pharmacal research. vol 40. issue 3. 2017-04-04. PMID:28093699. |
anti-alzheimer's disease activity of compounds from the root bark of morus alba l. the inhibition of acetylcholinesterase (ache), butyrylcholinesterase (bche), and β-site amyloid precursor protein cleaving enzyme 1 (bace1) plays important roles in prevention and treatment of alzheimer's disease (ad). |
2017-04-04 |
2023-08-13 |
Not clear |
| Stanton F McHardy, Hua-Yu Leo Wang, Shelby V McCowen, Matthew C Valde. Recent advances in acetylcholinesterase Inhibitors and Reactivators: an update on the patent literature (2012-2015). Expert opinion on therapeutic patents. vol 27. issue 4. 2017-03-22. PMID:27967267. |
mild inhibition of ache has been shown to have therapeutic relevance in alzheimer's disease (ad), myasthenia gravis, and glaucoma among others. |
2017-03-22 |
2023-08-13 |
Not clear |
| Qiong Xie, Zhaoxi Zheng, Biyun Shao, Wei Fu, Zheng Xia, Wei Li, Jian Sun, Wei Zheng, Weiwei Zhang, Wei Sheng, Qihong Zhang, Hongzhuan Chen, Hao Wang, Zhuibai Qi. Pharmacophore-based design and discovery of (-)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis. Journal of enzyme inhibition and medicinal chemistry. vol 32. issue 1. 2017-03-17. PMID:28274151. |
multifunctional carbamate-type acetylcholinesterase (ache) inhibitors with anti-amyloidogenic properties like phenserine are potential therapeutic agents for alzheimer's disease (ad). |
2017-03-17 |
2023-08-13 |
Not clear |
| Dan Zhou, Wei Zhou, Jun-Ke Song, Zhang-Ying Feng, Ran-Yao Yang, Song Wu, Lin Wang, Ai-Lin Liu, Guan-Hua D. DL0410, a novel dual cholinesterase inhibitor, protects mouse brains against Aβ-induced neuronal damage via the Akt/JNK signaling pathway. Acta pharmacologica Sinica. vol 37. issue 11. 2017-03-15. PMID:27498773. |
1,1'-([1,1'-biphenyl]-4,4'-diyl)bis(3-(piperidin-1-yl)propan-1-one)dihydrochloride (dl0410) is a novel synthetic dual acetylcholinesterase (ache)/butyrocholinesterase (buche) inhibitor, which has shown a potential therapeutic effect on alzheimer's disease (ad). |
2017-03-15 |
2023-08-13 |
mouse |
| Jeelan Basha Shaik, Bhagath Kumar Palaka, Mohan Penumala, Siddhartha Eadlapalli, Manidhar Darla Mark, Dinakara Rao Ampasala, Ramakrishna Vadde, Damu Amooru Gangaia. Synthesis, Biological Evaluation, and Molecular Docking of 8-imino-2-oxo-2H,8H-pyrano[2,3-f]chromene Analogs: New Dual AChE Inhibitors as Potential Drugs for the Treatment of Alzheimer's Disease. Chemical biology & drug design. vol 88. issue 1. 2017-03-01. PMID:26833890. |
synthesis, biological evaluation, and molecular docking of 8-imino-2-oxo-2h,8h-pyrano[2,3-f]chromene analogs: new dual ache inhibitors as potential drugs for the treatment of alzheimer's disease. |
2017-03-01 |
2023-08-13 |
Not clear |
| Begüm Nurpelin Sağlık, Sinem Ilgın, Yusuf Özka. Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes. European journal of medicinal chemistry. vol 124. 2017-02-28. PMID:27783974. |
donepezil (dnp), an acetylcholinesterase (ache) inhibitor, is one of the most preferred choices in alzheimer diseases (ad) therapy. |
2017-02-28 |
2023-08-13 |
Not clear |
| Giuseppina Tommonaro, Nuria García-Font, Rosa Maria Vitale, Boris Pejin, Carmine Iodice, Sixta Cañadas, José Marco-Contelles, María Jesús Oset-Gasqu. Avarol derivatives as competitive AChE inhibitors, non hepatotoxic and neuroprotective agents for Alzheimer's disease. European journal of medicinal chemistry. vol 122. 2017-02-16. PMID:27376495. |
avarol derivatives as competitive ache inhibitors, non hepatotoxic and neuroprotective agents for alzheimer's disease. |
2017-02-16 |
2023-08-13 |
human |
| Zhi-Min Wang, Pei Cai, Qiao-Hong Liu, Ding-Qiao Xu, Xue-Lian Yang, Jia-Jia Wu, Ling-Yi Kong, Xiao-Bing Wan. Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease. European journal of medicinal chemistry. vol 123. 2017-02-13. PMID:27484514. |
a series of novel donepezil derivatives was designed, synthesized and evaluated as multifunctional acetylcholinesterase (ache) inhibitors for the treatment of alzheimer's disease (ad). |
2017-02-13 |
2023-08-13 |
mouse |
| Ladan Pourabdi, Mehdi Khoobi, Hamid Nadri, Alireza Moradi, Farshad Homayouni Moghadam, Saeed Emami, Mohammad M Mojtahedi, Ismaeil Haririan, Hamid Forootanfar, Alieh Ameri, Alireza Foroumadi, Abbas Shafie. Synthesis and structure-activity relationship study of tacrine-based pyrano[2,3-c]pyrazoles targeting AChE/BuChE and 15-LOX. European journal of medicinal chemistry. vol 123. 2017-02-13. PMID:27484515. |
a series of tacrine-based pyrazolo[4',3':5,6]pyrano[2,3-b]quinolines and related compounds were designed and synthesized for targeting ache, buche and 15-lox enzymes in the field of alzheimer's disease therapy. |
2017-02-13 |
2023-08-13 |
Not clear |
| Donald E Moss, Ruth G Perez, Haruo Kobayash. Cholinesterase Inhibitor Therapy in Alzheimer's Disease: The Limits and Tolerability of Irreversible CNS-Selective Acetylcholinesterase Inhibition in Primates. Journal of Alzheimer's disease : JAD. vol 55. issue 3. 2017-02-13. PMID:27858711. |
as expected from this cns selectivity, the irreversible ache inhibitor methanesulfonyl fluoride (msf) produces significant cognitive improvement in alzheimer's disease patients without the gastrointestinal toxicity that plagues other ache inhibitors. |
2017-02-13 |
2023-08-13 |
human |
| Shuqun Zhang, Bo Hou, Huaiyu Yang, Zhili Zu. Design and prediction of new acetylcholinesterase inhibitor via quantitative structure activity relationship of huprines derivatives. Archives of pharmacal research. vol 39. issue 5. 2017-02-07. PMID:26832327. |
acetylcholinesterase (ache) is an important enzyme in the pathogenesis of alzheimer's disease (ad). |
2017-02-07 |
2023-08-13 |
Not clear |
| Himanshu Kumar Bhakta, Chan Hum Park, Takako Yokozawa, Byung-Sun Min, Hyun Ah Jung, Jae Sue Cho. Kinetics and molecular docking studies of loganin, morroniside and 7-O-galloyl-D-sedoheptulose derived from Corni fructus as cholinesterase and β-secretase 1 inhibitors. Archives of pharmacal research. vol 39. issue 6. 2017-02-07. PMID:27106028. |
we evaluated the major active components isolated from corni fructus: loganin, morroniside, and 7-o-galloyl-d-sedoheptulose as inhibitors of acetylcholinesterase (ache), butyrylcholinesterase (bche), and β-site amyloid precursor protein (app) cleaving enzyme 1 (bace1) for use in alzheimer's disease treatment. |
2017-02-07 |
2023-08-13 |
Not clear |
| Himanshu Kumar Bhakta, Chan Hum Park, Takako Yokozawa, Byung-Sun Min, Hyun Ah Jung, Jae Sue Cho. Kinetics and molecular docking studies of loganin, morroniside and 7-O-galloyl-D-sedoheptulose derived from Corni fructus as cholinesterase and β-secretase 1 inhibitors. Archives of pharmacal research. vol 39. issue 6. 2017-02-07. PMID:27106028. |
the data suggest that these compounds together can act as a triple inhibitor of ache, bche, and bace1, providing a preventive and therapeutic strategy for alzheimer's disease treatment. |
2017-02-07 |
2023-08-13 |
Not clear |
| Terrone L Rosenberry, Patricia K Martin, A Jeremy Nix, Scott A Wildman, Jonah Cheung, Scott A Snyder, Ren Xiang Ta. Hopeahainol A binds reversibly at the acetylcholinesterase (AChE) peripheral site and inhibits enzyme activity with a novel higher order concentration dependence. Chemico-biological interactions. vol 259. issue Pt B. 2017-02-01. PMID:27297626. |
natural product inhibitors of ache are of interest both because they offer promise as inexpensive drugs for symptomatic relief in alzheimer's disease and because they may provide insights into the structural features of the ache catalytic site. |
2017-02-01 |
2023-08-13 |
Not clear |
| Natalia N Nalivaeva, Anthony J Turne. AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27062894. |
ache and the amyloid precursor protein (app) - cross-talk in alzheimer's disease. |
2017-01-30 |
2023-08-13 |
Not clear |
| Natalia N Nalivaeva, Anthony J Turne. AChE and the amyloid precursor protein (APP) - Cross-talk in Alzheimer's disease. Chemico-biological interactions. vol 259. issue Pt B. 2017-01-30. PMID:27062894. |
the amyloid precursor protein (app) and acetylcholinesterase (ache) are multi-faceted proteins with a wide range of vital functions, both crucially linked with the pathogenesis of alzheimer's disease (ad). |
2017-01-30 |
2023-08-13 |
Not clear |