| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Benítez-Martínez, E Caballero-Díaz, M Valcárce. Development of a biosensing system for tacrine based on nitrogen-doped graphene quantum dots and acetylcholinesterase. The Analyst. vol 141. issue 9. 2018-07-09. PMID:27055393. |
tacrine was the first drug approved for alzheimer's disease and it is currently being used in several therapeutic treatments given its activity as a reversible inhibitor of ache. |
2018-07-09 |
2023-08-13 |
Not clear |
| Seulah Lee, Dahae Lee, Jiwon Baek, Eun Bee Jung, Ji Yun Baek, Il Kyun Lee, Tae Su Jang, Ki Sung Kang, Ki Hyun Ki. In vitro assessment of selected Korean plants for antioxidant and antiacetylcholinesterase activities. Pharmaceutical biology. vol 55. issue 1. 2018-07-06. PMID:29115888. |
antiacetylcholinesterase (ache) drugs have been a main therapeutic treatment for alzheimer's disease because increased ache levels play a key role in reducing neurotransmission. |
2018-07-06 |
2023-08-13 |
Not clear |
| Carlos Roca, Carlos Requena, Víctor Sebastián-Pérez, Sony Malhotra, Chris Radoux, Concepción Pérez, Ana Martinez, Juan Antonio Páez, Tom L Blundell, Nuria E Campill. Identification of new allosteric sites and modulators of AChE through computational and experimental tools. Journal of enzyme inhibition and medicinal chemistry. vol 33. issue 1. 2018-07-05. PMID:29873262. |
acetylcholinesterase (ache), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for amyloidosis in alzheimer's disease through interaction with amyloid β-peptide. |
2018-07-05 |
2023-08-13 |
Not clear |
| Liao-Bin Dong, Xing-De Wu, Xin Shi, Zhi-Jun Zhang, Jing Yang, Qin-Shi Zha. Phleghenrines A-D and Neophleghenrine A, Bioactive and Structurally Rigid Lycopodium Alkaloids from Phlegmariurus henryi. Organic letters. vol 18. issue 18. 2018-06-07. PMID:27583693. |
compounds 1 and 4 showed potent acetylcholinesterase (ache) inhibitory activities, and 4 is a good lead natural product for the treatment of alzheimer's disease. |
2018-06-07 |
2023-08-13 |
Not clear |
| Ayodele Jacob Akinyemi, Ganiyu Oboh, Adewale Oluwaseun Fadaka, Babawale Peter Olatunji, Seun Akomolaf. Curcumin administration suppress acetylcholinesterase gene expression in cadmium treated rats. Neurotoxicology. vol 62. 2018-05-30. PMID:28527659. |
in conclusion, curcumin exhibit anti-acetylcholinesterase activity and suppressed ache mrna gene expression level in cd exposed rats, thus providing some biochemical and molecular evidence on the therapeutic effect of this turmeric-derived compound in treating neurological disorders including alzheimer's disease. |
2018-05-30 |
2023-08-13 |
rat |
| Adam Kostelnik, Pavel Kopel, Alexander Cegan, Miroslav Pohank. Construction of an Acetylcholinesterase Sensor Based on Synthesized Paramagnetic Nanoparticles, a Simple Tool for Neurotoxic Compounds Assay. Sensors (Basel, Switzerland). vol 17. issue 4. 2018-05-17. PMID:28338634. |
acetylcholinesterase (ache) is an enzyme playing crucial role in neurotransmission and the enzyme is targeted by various molecules like alzheimer's drugs, pesticides and warfare agents. |
2018-05-17 |
2023-08-13 |
Not clear |
| Mu-Han Li, Jing Zhang, Run-Qing Zhao, Xian-Zhe Dong, Yuan Hu, Ting Chen, Jie Li, Li Liu, Ping Li. [Effect of six class of Kaixin San formulas on pharmacological and preliminary mechanism of Alzheimer's disease mice]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 41. issue 7. 2018-05-15. PMID:28879742. |
kunming mice were selected and established a mouse model of alzheimer's by intraperitoneal injection of d-galactose and sodium nitrite, continued intragastric 4 weeks, using the ability of learning and memory in morris water maze test to evaluate the animals in each group; the content of bdnf in the hippocampus of mice with western blotting detected; elisa method for the detection of each group of mice hippocampal tau protein,p-tau protein, aβ,ach,ache and serum nt-probnp levels. |
2018-05-15 |
2023-08-13 |
mouse |
| Shifu Xiao, Tao Wang, Xiuqiang Ma, Yingyi Qin, Xia Li, Zhongxin Zhao, Xueyuan Liu, Xiaoping Wang, Hengge Xie, Qinpu Jiang, Li Sun, Benyan Luo, Lan Shang, Weixian Chen, Yan Bai, Muni Tang, Maolin He, Lan Wu, Qilin Ma, Deren Hou, Jia H. Efficacy and safety of a novel acetylcholinesterase inhibitor octohydroaminoacridine in mild-to-moderate Alzheimer's disease: a Phase II multicenter randomised controlled trial. Age and ageing. vol 46. issue 5. 2018-05-14. PMID:28419192. |
inhibition of acetylcholinesterase (ache) has been a effective treatment for alzheimer's disease (ad). |
2018-05-14 |
2023-08-13 |
Not clear |
| Anders Allgardsson, C David Andersson, Christine Akfur, Franz Worek, Anna Linusson, Fredrik Ekströ. An Unusual Dimeric Inhibitor of Acetylcholinesterase: Cooperative Binding of Crystal Violet. Molecules (Basel, Switzerland). vol 22. issue 9. 2018-05-08. PMID:28867801. |
ache is an important target for treatment of various cholinergic deficiencies, including alzheimer's disease and myasthenia gravis. |
2018-05-08 |
2023-08-13 |
Not clear |
| M Rejwan Ali, Mostafa Sadoqi, Simon G Møller, Allal Boutajangout, Mihaly Meze. Assessing the binding of cholinesterase inhibitors by docking and molecular dynamics studies. Journal of molecular graphics & modelling. vol 76. 2018-05-02. PMID:28711758. |
in this report we assessed by docking and molecular dynamics the binding mechanisms of three fda-approved alzheimer drugs, inhibitors of the enzyme acetylcholinesterase (ache): donepezil, galantamine and rivastigmine. |
2018-05-02 |
2023-08-13 |
Not clear |
| R-J Wen, D Huang, Y Zhang, Y-W Li. Bis(3)-tacrine inhibits the sustained potassium current in cultured rat hippocampal neurons. Physiological research. vol 66. issue 3. 2018-04-23. PMID:28248535. |
bis(3)-tacrine is a dimeric ache inhibitor derived from tacrine with a potential to treat alzheimer's disease. |
2018-04-23 |
2023-08-13 |
rat |
| Eva Mezeiova, Jan Korabecny, Vendula Sepsova, Martina Hrabinova, Petr Jost, Lubica Muckova, Tomas Kucera, Rafael Dolezal, Jan Misik, Katarina Spilovska, Ngoc Lam Pham, Lucia Pokrievkova, Jaroslav Roh, Daniel Jun, Ondrej Soukup, Daniel Kaping, Kamil Kuc. Development of 2-Methoxyhuprine as Novel Lead for Alzheimer's Disease Therapy. Molecules (Basel, Switzerland). vol 22. issue 8. 2018-04-23. PMID:28788095. |
tacrine (tha), the first clinically effective acetylcholinesterase (ache) inhibitor and the first approved drug for the treatment of alzheimer's disease (ad), was withdrawn from the market due to its side effects, particularly its hepatotoxicity. |
2018-04-23 |
2023-08-13 |
human |
| Ilkay Erdogan Orhan, Fatma Sezer Senol, Suhaib Shekfeh, Krystyna Skalicka-Wozniak, Erden Banogl. Pteryxin - A promising butyrylcholinesterase-inhibiting coumarin derivative from Mutellina purpurea. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. vol 109. issue Pt 2. 2018-03-12. PMID:28286309. |
in this study, pteryxin, which was previously isolated from the fruits of mutellina purpurea, was investigated for its inhibitory potential against acetylcholinesterase (ache) and butyrylcholinesterase (bche), which are the key enzymes in the pathology of alzheimer's disease (ad). |
2018-03-12 |
2023-08-13 |
Not clear |
| Pinar Atukeren, Mahir Cengiz, Hakan Yavuzer, Remise Gelisgen, Esma Altunoglu, Sena Oner, Fusun Erdenen, Damla Yuceakın, Himmet Derici, Ufuk Cakatay, Hafize Uzu. The efficacy of donepezil administration on acetylcholinesterase activity and altered redox homeostasis in Alzheimer's disease. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 90. 2018-02-16. PMID:28427041. |
we intended to investigate the effects of acetylcholinesterase inhibition via donepezil on protein carbonyl (pco), advanced protein oxidation products (aopp) and ischemia modified albumin (ima) as protein oxidation markers and ferric reducing antioxidant power (frap), prooxidant-antioxidant balance (pab), total thiol (t-sh), protein thiol (p-sh) as antioxidant status markers and also kynurenine (kyn), n-formyl kynurenine (n-fkyn) and protein bound dityrosine (dt) levels all in one demonstrating the redox homeostasis in alzheimer patients also correlated with ache activity. |
2018-02-16 |
2023-08-13 |
human |
| Amit Kumar, Taher Darreh-Shor. DMSO: A Mixed-Competitive Inhibitor of Human Acetylcholinesterase. ACS chemical neuroscience. vol 8. issue 12. 2018-01-30. PMID:29017007. |
here, we report the detailed biochemical analysis of the effects of dmso on the human acetylcholine-degrading enzyme, acetylcholinesterase (ache), the primary target of current alzheimer's therapeutics. |
2018-01-30 |
2023-08-13 |
human |
| Maria-Letizia Campanari, Francisco Navarrete, Stephen D Ginsberg, Jorge Manzanares, Javier Sáez-Valero, María-Salud García-Aylló. Increased Expression of Readthrough Acetylcholinesterase Variants in the Brains of Alzheimer's Disease Patients. Journal of Alzheimer's disease : JAD. vol 53. issue 3. 2018-01-26. PMID:27258420. |
alzheimer's disease (ad) is characterized by a decrease in the enzymatic activity of the enzyme acetylcholinesterase (ache). |
2018-01-26 |
2023-08-13 |
human |
| Ganiyu Oboh, Opeyemi Babatunde Ogunsuyi, Oluwaseyi Emmanuel Olonisol. Does caffeine influence the anticholinesterase and antioxidant properties of donepezil? Evidence from in vitro and in vivo studies. Metabolic brain disease. vol 32. issue 2. 2018-01-12. PMID:28091956. |
with reports of the potential cognitive enhancing properties of caffeine, we sought to investigate if caffeine can influence the anticholinesterase and antioxidant properties of donepezil-a selective acetylcholinesterase (ache) inhibitor used in the management of alzheimer's disease (ad). |
2018-01-12 |
2023-08-13 |
human |
| Lydia Giménez-Llort, Miriam Ratia, Belén Pérez, Pelayo Camps, Diego Muñoz-Torrero, Albert Badia, M Victoria Clo. Behavioural effects of novel multitarget anticholinesterasic derivatives in Alzheimer's disease. Behavioural pharmacology. vol 28. issue 2 and 3-Spec Issue. 2018-01-11. PMID:28125507. |
the current pharmacological approach to alzheimer's disease (ad) treatment, mostly based on acetylcholinesterase inhibitors (acheis), is being revisited, especially in terms of the temporal frames and the potential benefits of their noncanonic actions, raising the question of whether inhibitors of ache might also act in a disease-modifying manner. |
2018-01-11 |
2023-08-13 |
mouse |
| Renata P Sakata, Micheli Figueiro, Daniel F Kawano, Wanda P Almeid. Effect on Acetylcholinesterase and Anti-oxidant Activity of Synthetic Chalcones having a Good Predicted Pharmacokinetic Profile. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 13. issue 7. 2017-12-05. PMID:28545385. |
acetylcholinesterase (ache) is an important target in the development of drug to treat alzheimer's disease (ad). |
2017-12-05 |
2023-08-13 |
Not clear |
| Jeannette Gonzalez, Jennifer Ramirez, Jason P Schwan. Evaluating Fmoc-amino acids as selective inhibitors of butyrylcholinesterase. Amino acids. vol 48. issue 12. 2017-12-04. PMID:27522651. |
for the two major classes of cholinesterases, such as acetylcholinesterase (ache) and butyrylcholinesterase (bche), previous studies reported bche activity is elevated in patients with alzheimer's disease, while ache levels remain the same or decrease. |
2017-12-04 |
2023-08-13 |
Not clear |