| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Homa Hajimehdipoor, Mahmoud Mosaddegh, Farzaneh Naghibi, Ali Haeri, Maryam Hamzeloo-Moghada. Natural sesquiterpen lactones as acetylcholinesterase inhibitors. Anais da Academia Brasileira de Ciencias. vol 86. issue 2. 2019-11-20. PMID:24838542. |
conclusion: among the three sesquiterpene lactones, gaillardin with 67% inhibition of ache could be considered a good candidate for future alzheimer studies. |
2019-11-20 |
2023-08-13 |
Not clear |
| Cheng-Han Tsai, Yue-Horng Yen, John Po-Wen Yan. Finding of polysaccharide-peptide complexes in Cordyceps militaris and evaluation of its acetylcholinesterase inhibition activity. Journal of food and drug analysis. vol 23. issue 1. 2019-11-20. PMID:28911447. |
acetylcholinesterase (ache) inhibition enhances learning and cognitive ability for treatment of alzheimer's disease. |
2019-11-20 |
2023-08-13 |
Not clear |
| Mesut Işık, Şükrü Beydemi. AChE mRNA expression as a possible novel biomarker for the diagnosis of coronary artery disease and Alzheimer's disease, and its association with oxidative stress. Archives of physiology and biochemistry. 2019-11-15. PMID:31726885. |
ache mrna expression as a possible novel biomarker for the diagnosis of coronary artery disease and alzheimer's disease, and its association with oxidative stress. |
2019-11-15 |
2023-08-13 |
Not clear |
| Mesut Işık, Şükrü Beydemi. AChE mRNA expression as a possible novel biomarker for the diagnosis of coronary artery disease and Alzheimer's disease, and its association with oxidative stress. Archives of physiology and biochemistry. 2019-11-15. PMID:31726885. |
thus, alzheimer's and coronary artery patients were observed that the protein carbonyl levels and mrna expression of ache were increased ( |
2019-11-15 |
2023-08-13 |
Not clear |
| Amira G Zaki, Einas H El-Shatoury, Ashraf S Ahmed, Ola E A Al-Haga. Production and enhancement of the acetylcholinesterase inhibitor, huperzine A, from an endophytic Alternaria brassicae AGF041. Applied microbiology and biotechnology. vol 103. issue 14. 2019-11-12. PMID:31119352. |
huperzine a (hupa) is a potent acetylcholinesterase (ache) inhibitor of a great consideration as a prospective drug candidate for alzheimer's disease treatment. |
2019-11-12 |
2023-08-13 |
Not clear |
| Md Junaid, Nazrul Islam, Md Kamal Hossain, M Obayed Ullah, Mohammad A Hali. Metal based donepezil analogues designed to inhibit human acetylcholinesterase for Alzheimer's disease. PloS one. vol 14. issue 2. 2019-11-04. PMID:30785927. |
these results further confirm the ability of metal-directed drugs to bind simultaneously to the active sites of ache and support them as potential candidates for the future treatment of alzheimer's disease. |
2019-11-04 |
2023-08-13 |
human |
| C David Andersson, Nicolas Martinez, Dominik Zeller, Anders Allgardsson, Michael M Koza, Bernhard Frick, Fredrik Ekström, Judith Peters, Anna Linusso. Influence of Enantiomeric Inhibitors on the Dynamics of Acetylcholinesterase Measured by Elastic Incoherent Neutron Scattering. The journal of physical chemistry. B. vol 122. issue 36. 2019-10-11. PMID:30110543. |
small molecules that inhibit the function of ache are important for their use as drugs in the, for example, symptomatic treatment of alzheimer's disease. |
2019-10-11 |
2023-08-13 |
Not clear |
| Nermin Eissa, Sheikh Azimullah, Petrilla Jayaprakash, Richard L Jayaraj, David Reiner, Shreesh K Ojha, Rami Beiram, Holger Stark, Dorota Łażewska, Katarzyna Kieć-Kononowicz, Bassem Sade. The dual-active histamine H3 receptor antagonist and acetylcholine esterase inhibitor E100 ameliorates stereotyped repetitive behavior and neuroinflammmation in sodium valproate induced autism in mice. Chemico-biological interactions. vol 312. 2019-10-07. PMID:31369746. |
histamine h3 receptor (h3r) and acetylcholine esterase (ache) are involved in several cognitive disorders such as alzheimer's disease, schizophrenia, anxiety, and narcolepsy, all of which are comorbid with asd. |
2019-10-07 |
2023-08-13 |
mouse |
| M Figueiredo-González, P Reboredo-Rodríguez, C González-Barreiro, J Simal-Gándara, P Valentão, A Carrasco-Pancorbo, P B Andrade, B Cancho-Grand. Evaluation of the neuroprotective and antidiabetic potential of phenol-rich extracts from virgin olive oils by in vitro assays. Food research international (Ottawa, Ont.). vol 106. 2019-09-30. PMID:29579961. |
in this work, phenol-rich extracts from 'cornicabra' and 'picual' virgin-olive oils (evoos) were examined, for the first time, to establish their capacity to inhibit key enzymes involved in alzheimer's disease (ad) (acetylcholinesterase (ache), butyrylcholinesterase (buche) and 5-lipoxygenase (lox)), major depressive disorder (mdd) and parkinson's disease (pd) (monoamine oxidases: hmao-a and hmao-b respectively), and diabetes mellitus (dm) (α-glucosidase and α-amylase). |
2019-09-30 |
2023-08-13 |
Not clear |
| Wei Ni, Huan Wang, Xiaokang Li, Xinyu Zheng, Manjiong Wang, Jian Zhang, Qi Gong, Dazheng Ling, Fei Mao, Haiyan Zhang, Jian L. Novel Tadalafil Derivatives Ameliorates Scopolamine-Induced Cognitive Impairment in Mice via Inhibition of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5). ACS chemical neuroscience. vol 9. issue 7. 2019-09-30. PMID:29616790. |
on the basis of the drug-repositioning and redeveloping strategy, first-generation dual-target inhibitors of acetylcholinesterase (ache) and phosphodiesterase 5 (pde5) have been recently reported as a potentially novel therapeutic method for the treatment of alzheimer's disease (ad), and the lead compound 2 has proven this method was feasible in ad mouse models. |
2019-09-30 |
2023-08-13 |
mouse |
| Hong-Lin Li, Wei Gao, Kun-Peng Xia, Qi-Yue Sun, Xiao-Wei Tong, Kai-di Luan, Hong-Qi Zhu, Hui-Min Qi, Bin Zhu, Fei X. [Effects of cluster needling at the scalp points on the expression of ChAT and AchE of hippocampus in rats with Alzheimer's disease]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 39. issue 4. 2019-08-20. PMID:30957452. |
[effects of cluster needling at the scalp points on the expression of chat and ache of hippocampus in rats with alzheimer's disease]. |
2019-08-20 |
2023-08-13 |
rat |
| Elham Manouchehrizadeh, Azar Mostoufi, Elham Tahanpesar, Masood Fereidoonnezha. Alignment-independent 3D-QSAR and molecular docking studies of tacrine-4-oxo-4H-Chromene hybrids as anti-Alzheimer's agents. Computational biology and chemistry. vol 80. 2019-08-05. PMID:31170562. |
a series of novel tacrine derivatives as multifunctional agents with potential inhibitory effects on both acetylcholinesterase(ache) and butyrylcholinesterase (buche) enzymes for the treatment of alzheimer's disease(ad), were applied to alignment independent 3d-qsar methods using pentacle software. |
2019-08-05 |
2023-08-13 |
Not clear |
| Rosa Purgatorio, Modesto de Candia, Marco Catto, Antonio Carrieri, Leonardo Pisani, Annalisa De Palma, Maddalena Toma, Olga A Ivanova, Leonid G Voskressensky, Cosimo D Altomar. Investigating 1,2,3,4,5,6-hexahydroazepino[4,3-b]indole as scaffold of butyrylcholinesterase-selective inhibitors with additional neuroprotective activities for Alzheimer's disease. European journal of medicinal chemistry. vol 177. 2019-07-25. PMID:31158754. |
due to the role of butyrylcholinesterase (bche) in acetylcholine hydrolysis in the late stages of the alzheimer's disease (ad), inhibitors of butyrylcholinesterase (bche) have been recently envisaged, besides acetylcholinesterase (ache) inhibitors, as candidates for treating mild-to-moderate ad. |
2019-07-25 |
2023-08-13 |
Not clear |
| Priyapan Posri, Jittra Suthiwong, Pitchayakarn Takomthong, Chatchawan Wongsa, Chindawadee Chuenban, Chantana Boonyarat, Chavi Yenja. A new flavonoid from the leaves of Atalantia monophylla (L.) DC. Natural product research. vol 33. issue 8. 2019-07-22. PMID:29600742. |
focusing on alzheimer's disease, acetylcholine esterase (ache) inhibition and antioxidant activity were evaluated using the modified ellman's method and the abts scavenging assay, respectively. |
2019-07-22 |
2023-08-13 |
Not clear |
| Claudiane S Marinho, Marcos V F Matias, Iago G F Brandão, Elton L Santos, Sonia S Machado, Carmem L P S Zant. Characterization and kinetic study of the brain and muscle acetylcholinesterase from Danio rerio. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. vol 222. 2019-07-01. PMID:30981910. |
acetylcholinesterase (ache) plays an important role in the therapy of alzheimer's disease and in the detection of pesticides such as organophosphates which are also widely used in chemical warfare. |
2019-07-01 |
2023-08-13 |
zebrafish |
| Levent Cavas, Gamze Topcam, Cevher Gundogdu-Hizliates, Yavuz Ergu. Neural Network Modeling of AChE Inhibition by New Carbazole-Bearing Oxazolones. Interdisciplinary sciences, computational life sciences. vol 11. issue 1. 2019-06-25. PMID:29236214. |
acetylcholine esterase (ache) is one of the targeted enzymes in the therapy of important neurodegenerative diseases such as alzheimer's disease. |
2019-06-25 |
2023-08-13 |
Not clear |
| Catarina Oliveira, Donatella Bagetta, Fernando Cagide, José Teixeira, Ricardo Amorim, Tiago Silva, Jorge Garrido, Fernando Remião, Eugenio Uriarte, Paulo J Oliveira, Stefano Alcaro, Francesco Ortuso, Fernanda Borge. Benzoic acid-derived nitrones: A new class of potential acetylcholinesterase inhibitors and neuroprotective agents. European journal of medicinal chemistry. vol 174. 2019-06-17. PMID:31029943. |
the discovery of new chemical entities endowed with potent and selective acetylcholinesterase (ache) and/or butyrylcholinesterase (bche) inhibitory activity is still a relevant subject for alzheimer's disease therapy. |
2019-06-17 |
2023-08-13 |
human |
| Angela Sin-Yee Law, Margaret Ching-Lam Yeung, Vivian Wing-Wah Ya. A Luminescence Turn-On Assay for Acetylcholinesterase Activity and Inhibitor Screening Based on Supramolecular Self-Assembly of Alkynylplatinum(II) Complexes on Coordination Polymer. ACS applied materials & interfaces. vol 11. issue 5. 2019-06-04. PMID:30694047. |
such a method has been applied to ache inhibitor screening, which is important as the demand for ache inhibitor assays arises along with the drug development for alzheimer's disease. |
2019-06-04 |
2023-08-13 |
Not clear |
| Fatemeh Ahmadi-Motamayel, Mohammad Taghi Goodarzi, Shabnam Tarazi, Mehrangiz Vahabia. Evaluation of salivary acetylcholinesterase and pseudocholinesterase in patients with Alzheimer's disease: A case-control study. Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry. vol 39. issue 1. 2019-05-31. PMID:30536408. |
the aim of this study was to evaluate acetylcholinesterase (ache) and pseudocholinesterase (pche) in whole saliva in patients with alzheimer's disease (ad) and in healthy subjects. |
2019-05-31 |
2023-08-13 |
human |
| Tonino G Adessi, José L Borioni, Natalia B Pigni, Jaume Bastida, Valeria Cavallaro, Ana P Murray, Marcelo Puiatti, Juan C Oberti, Segundo Leiva, Viviana E Nicotra, Manuela E Garci. Clinanthus microstephium, an Amaryllidaceae Species with Cholinesterase Inhibitor Alkaloids: Structure-Activity Analysis of Haemanthamine Skeleton Derivatives. Chemistry & biodiversity. vol 16. issue 5. 2019-05-31. PMID:30801949. |
an epimeric mixture of a haemanthamine-type compound (6-hydroxymaritidine) was tested as an inhibitor against acetyl- and butyrylcholinesterase enzymes (ache and bche, respectively), two enzymes relevant in the treatment of alzheimer's disease, with good results. |
2019-05-31 |
2023-08-13 |
Not clear |