| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Julio Rodríguez-Lavado, Carlos Gallardo-Garrido, Michael Mallea, Victor Bustos, Rodrigo Osorio, Martín Hödar-Salazar, Hery Chung, Ramiro Araya-Maturana, Marcos Lorca, C David Pessoa-Mahana, Jaime Mella-Raipán, Claudio Saitz, Pablo Jaque, Miguel Reyes-Parada, Patricio Iturriaga-Vásquez, Hernán Pessoa-Mahan. Synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual AChE and SERT ligands for Alzheimer's disease. European journal of medicinal chemistry. vol 198. 2021-01-26. PMID:32388114. |
synthesis, in vitro evaluation and molecular docking of a new class of indolylpropyl benzamidopiperazines as dual ache and sert ligands for alzheimer's disease. |
2021-01-26 |
2023-08-13 |
Not clear |
| Kader Şahİn, Serdar DurdaĞ. Combined ligand and structure-based virtual screening approaches for identification of novel AChE inhibitors. Turkish journal of chemistry. vol 44. issue 3. 2021-01-26. PMID:33488178. |
food and drug administration (fda) approved drugs donepezil, rivastigmine, tacrine and galantamine are ache inhibitors and in the treatment of alzheimer's disease (ad) these drugs are currently prescribed. |
2021-01-26 |
2023-08-13 |
Not clear |
| Sai Vamshi R Jonnalagadda, Andrew James Gerace, Kathleen Thai, Jonathan Johnson, Kostas Tsimenidis, Joseph M Jakubowski, Christina Shen, Kendal J Henderson, Phanourios Tamamis, Manos Gkika. Amyloid Peptide Scaffolds Coordinate with Alzheimer's Disease Drugs. The journal of physical chemistry. B. vol 124. issue 3. 2021-01-25. PMID:31881810. |
herein, we report the first to our knowledge amyloid materials, encompassing a gaiig amyloidogenic core, which bind to alzheimer's disease (ad) drugs, by mimicking the mechanism by which the same ad drugs bind to enzymes according to experimentally resolved structures, including the target enzyme acetylcholinesterase (ache). |
2021-01-25 |
2023-08-13 |
Not clear |
| Mehmet Oguz, Erbay Kalay, Suleyman Akocak, Alessio Nocentini, Nebih Lolak, Mehmet Boga, Mustafa Yilmaz, Claudiu T Supura. Synthesis of calix[4]azacrown substituted sulphonamides with antioxidant, acetylcholinesterase, butyrylcholinesterase, tyrosinase and carbonic anhydrase inhibitory action. Journal of enzyme inhibition and medicinal chemistry. vol 35. issue 1. 2021-01-25. PMID:32401067. |
the calix[4]azacrown substituted sulphonamide schiff bases were also investigated as inhibitors of acetylcholinesterase (ache), butyrylcholinesterase (bche) and tyrosinase enzymes, associated with several diseases such as alzheimer, parkinson, and pigmentation disorders. |
2021-01-25 |
2023-08-13 |
human |
| Larisa Ivanova, Mati Karelson, Dimitar A Dobche. Multitarget Approach to Drug Candidates against Alzheimer's Disease Related to AChE, SERT, BACE1 and GSK3β Protein Targets. Molecules (Basel, Switzerland). vol 25. issue 8. 2021-01-22. PMID:32316402. |
multitarget approach to drug candidates against alzheimer's disease related to ache, sert, bace1 and gsk3β protein targets. |
2021-01-22 |
2023-08-13 |
human |
| Malcolm Lane, D'Arice Carter, Joseph D Pescrille, Yasco Aracava, William P Fawcett, G William Basinger, Edna F R Pereira, Edson X Albuquerqu. Oral Pretreatment with Galantamine Effectively Mitigates the Acute Toxicity of a Supralethal Dose of Soman in Cynomolgus Monkeys Posttreated with Conventional Antidotes. The Journal of pharmacology and experimental therapeutics. vol 375. issue 1. 2020-12-14. PMID:32759369. |
earlier reports suggested that galantamine, a drug approved to treat mild-to-moderate alzheimer's disease (ad), and other centrally acting reversible acetylcholinesterase (ache) inhibitors can serve as adjunct pretreatments against poisoning by organophosphorus compounds, including the nerve agent soman. |
2020-12-14 |
2023-08-13 |
monkey |
| Luca Piemontese, Roberta Sergio, Federica Rinaldo, Leonardo Brunetti, Filippo M Perna, M Amélia Santos, Vito Capriat. Deep Eutectic Solvents as Effective Reaction Media for the Synthesis of 2-Hydroxyphenylbenzimidazole-based Scaffolds en Route to Donepezil-Like Compounds. Molecules (Basel, Switzerland). vol 25. issue 3. 2020-11-09. PMID:32013037. |
an unsubstituted 2-hydroxyphenylbenzimidazole has recently been included as a scaffold in a series of hybrids (including the hit compound pz1) based on the framework of the acetylcholinesterase (ache) inhibitor donepezil, which is a new promising multi-target ligand in alzheimer's disease (ad) treatment. |
2020-11-09 |
2023-08-13 |
human |
| Donald E Mos. Is Combining an Anticholinergic with a Cholinesterase Inhibitor a Good Strategy for High-Level CNS Cholinesterase Inhibition? Journal of Alzheimer's disease : JAD. vol 71. issue 4. 2020-11-06. PMID:31476160. |
a recent strategy for producing high-level cns acetylcholinesterase (ache) inhibition (50% or higher) is to co-administer a muscarinic anticholinergic with the ache inhibitor to block the dose-limiting cholinergic overstimulation of the gastrointestinal system, allow more robust ache inhibition in the cns, and improve efficacy in the treatment of alzheimer's disease. |
2020-11-06 |
2023-08-13 |
Not clear |
| Donald E Mos. Is Combining an Anticholinergic with a Cholinesterase Inhibitor a Good Strategy for High-Level CNS Cholinesterase Inhibition? Journal of Alzheimer's disease : JAD. vol 71. issue 4. 2020-11-06. PMID:31476160. |
for long-term safety against accelerating the underlying disease processes in alzheimer's disease, anticholinergics used to increase the tolerability of ache inhibitors should not penetrate, or have very limited penetration, of the blood-brain barrier. |
2020-11-06 |
2023-08-13 |
Not clear |
| Sinan Bayindir, Cuneyt Caglayan, Muhammet Karaman, İlhami Gülci. The green synthesis and molecular docking of novel N-substituted rhodanines as effective inhibitors for carbonic anhydrase and acetylcholinesterase enzymes. Bioorganic chemistry. vol 90. 2020-10-14. PMID:31284100. |
recently, inhibition effects of enzymes such as acetylcholinesterase (ache) and carbonic anhydrase (ca) has appeared as a promising approach for pharmacological intervention in a variety of disorders such as epilepsy, alzheimer's disease and obesity. |
2020-10-14 |
2023-08-13 |
Not clear |
| Nur Adalier, Heath Parke. Vitamin E, Turmeric and Saffron in Treatment of Alzheimer's Disease. Antioxidants (Basel, Switzerland). vol 5. issue 4. 2020-10-01. PMID:27792130. |
clinical studies report their therapeutic abilities as protective agents for nerve cells against free radical damage, moderating acetylcholinesterase (ache) activity and reducing neurodegeneration, which are found as key factors in alzheimer's. |
2020-10-01 |
2023-08-13 |
Not clear |
| Suman Chowdhury, Shivani, Suresh Kuma. In vitro anti-acetylcholinesterase activity of an aqueous extract of Unicaria tomentosa and in silico study of its active constituents. Bioinformation. vol 12. issue 3. 2020-10-01. PMID:28149044. |
many herbal plant extracts have been investigated for their potential use in the treatment of alzheimer's disease (ad) by inhibiting ache and upregulating the levels of ach. |
2020-10-01 |
2023-08-13 |
Not clear |
| Shu-Ping Li, Yu-Wen Wang, Sheng-Lan Qi, Yun-Peng Zhang, Gang Deng, Wen-Zheng Ding, Chao Ma, Qi-Yan Lin, Hui-Da Guan, Wei Liu, Xue-Mei Cheng, Chang-Hong Wan. Analogous β-Carboline Alkaloids Harmaline and Harmine Ameliorate Scopolamine-Induced Cognition Dysfunction by Attenuating Acetylcholinesterase Activity, Oxidative Stress, and Inflammation in Mice. Frontiers in pharmacology. vol 9. 2020-10-01. PMID:29755345. |
the analogous β-carboline alkaloids, harmaline (hal) and harmine (har), possess a variety of biological properties, including acetylcholinesterase (ache) inhibitory activity, antioxidant, anti-inflammatory, and many others, and have great potential for treating alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
mouse |
| Mohd Babu Khan, Bhagath Kumar Palaka, Tuleshwori Devi Sapam, Naidu Subbarao, Dinakara Rao Ampasal. Screening and analysis of acetyl-cholinesterase (AChE) inhibitors in the context of Alzheimer's disease. Bioinformation. vol 14. issue 8. 2020-10-01. PMID:30310249. |
screening and analysis of acetyl-cholinesterase (ache) inhibitors in the context of alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Mohd Babu Khan, Bhagath Kumar Palaka, Tuleshwori Devi Sapam, Naidu Subbarao, Dinakara Rao Ampasal. Screening and analysis of acetyl-cholinesterase (AChE) inhibitors in the context of Alzheimer's disease. Bioinformation. vol 14. issue 8. 2020-10-01. PMID:30310249. |
acetyl-cholinesterase enzyme (ache) is a known target for identifying potential inhibitors against alzheimer diseases (ad). |
2020-10-01 |
2023-08-13 |
Not clear |
| Mohd Babu Khan, Bhagath Kumar Palaka, Tuleshwori Devi Sapam, Naidu Subbarao, Dinakara Rao Ampasal. Screening and analysis of acetyl-cholinesterase (AChE) inhibitors in the context of Alzheimer's disease. Bioinformation. vol 14. issue 8. 2020-10-01. PMID:30310249. |
thus these molecules can be very novel potential inhibitors against ache involved in alzheimer's disease. |
2020-10-01 |
2023-08-13 |
Not clear |
| Subramaniyan Vijayakumar, Palani Manogar, Srinivasan Prabhu, Ram Avadhar Sanjeevkumar Sing. Novel ligand-based docking; molecular dynamic simulations; and absorption, distribution, metabolism, and excretion approach to analyzing potential acetylcholinesterase inhibitors for Alzheimer's disease. Journal of pharmaceutical analysis. vol 8. issue 6. 2020-10-01. PMID:30595949. |
acetylcholinesterase (ache) plays an important role in alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
Not clear |
| Sandip T Auti, Yogesh A Kulkarn. Neuroprotective Effect of Cardamom Oil Against Aluminum Induced Neurotoxicity in Rats. Frontiers in neurology. vol 10. 2020-10-01. PMID:31114535. |
acetylcholinesterase (ache) is an enzyme involved in the progression of alzheimer's disease (ad). |
2020-10-01 |
2023-08-13 |
rat |
| Rafael Vincent Manalo, Maries Ann Silvestre, Aza Lea Anne Barbosa, Paul Mark Medin. Coconut (Cocos nucifera) Ethanolic Leaf Extract Reduces Amyloid-β (1-42) Aggregation and Paralysis Prevalence in Transgenic Caenorhabditis elegans Independently of Free Radical Scavenging and Acetylcholinesterase Inhibition. Biomedicines. vol 5. issue 2. 2020-09-30. PMID:28536360. |
virgin coconut oil (vco) has been the subject of several studies which have aimed to alleviate alzheimer's disease (ad) pathology, focusing on in vitro antioxidant and acetylcholinesterase (ache) inhibitory activities. |
2020-09-30 |
2023-08-13 |
human |
| Mahmood Rasool, Arif Malik, Sulayman Waquar, Qura Tul-Ain, Tassadaq H Jafar, Rabia Rasool, Aasia Kalsoom, Muhammad A Ghafoor, Sheikh A Sehgal, Kalamegam Gauthaman, Muhammad I Naseer, Mohammed H Al-Qahtani, Peter N Pushpara. Frontiers in pharmacology. vol 9. 2020-09-30. PMID:30123124. |
alzheimer's disease (ad) is a neurodegenerative disorder characterized by dementia, excessive acetylcholinesterase (ache) activity, formation of neurotoxic amyloid plaque, and tau protein aggregation. |
2020-09-30 |
2023-08-13 |
rat |