| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Virendra Kumar Meena, Shubhra Chaturvedi, Rakesh Kumar Sharma, Anil Kumar Mishra, Puja Panwar Hazar. Potent Acetylcholinesterase Selective and Reversible Homodimeric Agent Based on Tacrine for Theranostics. Molecular pharmaceutics. vol 16. issue 6. 2020-03-16. PMID:31059278. |
acetylcholinesterase (ache) has been an important biomarker for diagnosing alzheimer's disease (ad), due to reduction in ache activity in post-mortem brains of ad patients. |
2020-03-16 |
2023-08-13 |
Not clear |
| Pablo Zambrano, Mario Suwalsky, Malgorzata Jemiola-Rzeminska, Kazimierz Strzalka, Luis F Aguila. An in vitro study on the interaction of the anti-Alzheimer drug rivastigmine with human erythrocytes. Chemico-biological interactions. vol 319. 2020-03-16. PMID:32092302. |
the inhibition of the enzyme acetylcholinesterase (ache) is a frequently used therapeutic option to treat alzheimer's disease (ad). |
2020-03-16 |
2023-08-13 |
human |
| Nabih Lolak, Mehmet Boga, Muhammed Tuneg, Gulcin Karakoc, Suleyman Akocak, Claudiu T Supura. Sulphonamides incorporating 1,3,5-triazine structural motifs show antioxidant, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory profile. Journal of enzyme inhibition and medicinal chemistry. vol 35. issue 1. 2020-03-05. PMID:31899985. |
they were also investigated as inhibitors of acetylcholinesterase (ache), butyrylcholinesterase (bche) and tyrosinase, which are associated with several diseases such as alzheimer, parkinson and pigmentation disorders. |
2020-03-05 |
2023-08-13 |
Not clear |
| A L Pascoini, L B Federico, A L F Arêas, B A Verde, P G Freitas, I Camp. In silico development of new acetylcholinesterase inhibitors. Journal of biomolecular structure & dynamics. vol 37. issue 4. 2020-03-04. PMID:29607738. |
ache is associated with alzheimer's disease (ad). |
2020-03-04 |
2023-08-13 |
Not clear |
| Irina Zueva, José Dias, Sofya Lushchekina, Vyacheslav Semenov, Marat Mukhamedyarov, Tatiana Pashirova, Vasiliy Babaev, Florian Nachon, Natalia Petrova, Leniz Nurullin, Lucia Zakharova, Victor Ilyin, Patrick Masson, Konstantin Petro. New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease. Neuropharmacology. vol 155. 2020-02-28. PMID:31132435. |
our results provide additional evidence that dual binding site inhibitors of ache have alzheimer's disease-modifying action. |
2020-02-28 |
2023-08-13 |
mouse |
| Ehab Mahran, Gertrud E Morlock, Michael Keusge. Guided isolation of new iridoid glucosides from Anarrhinum pubescens by high-performance thin-layer chromatography-acetylcholinesterase assay. Journal of chromatography. A. vol 1609. 2020-02-28. PMID:31447207. |
this neuroprotective potential of iridoids mediated through ache inhibition promote them to compete as natural curatives for neurodegenerative disorders like alzheimer's disease. |
2020-02-28 |
2023-08-13 |
Not clear |
| Jinhui Hu, Ya-Dan Huang, Tingting Pan, Tianhua Zhang, Tao Su, Xingshu Li, Hai-Bin Luo, Ling Huan. Design, Synthesis, and Biological Evaluation of Dual-Target Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 9A (PDE9A) for the Treatment of Alzheimer's Disease. ACS chemical neuroscience. vol 10. issue 1. 2020-02-18. PMID:30252439. |
design, synthesis, and biological evaluation of dual-target inhibitors of acetylcholinesterase (ache) and phosphodiesterase 9a (pde9a) for the treatment of alzheimer's disease. |
2020-02-18 |
2023-08-13 |
Not clear |
| Oscar Galarce-Bustos, Jessy Pavón, Karem Henríquez-Aedo, Mario Arand. Detection and identification of acetylcholinesterase inhibitors in Annona cherimola Mill. by effect-directed analysis using thin-layer chromatography-bioassay-mass spectrometry. Phytochemical analysis : PCA. vol 30. issue 6. 2020-02-17. PMID:31183917. |
acetylcholinesterase (ache) inhibitors are considered an important strategy in the treatment of neurological disorders such as alzheimer's disease. |
2020-02-17 |
2023-08-13 |
Not clear |
| Mesut Işı. The Binding Mechanisms and Inhibitory Effect of Intravenous Anesthetics on AChE In Vitro and In Vivo: Kinetic Analysis and Molecular Docking. Neurochemical research. vol 44. issue 9. 2020-01-20. PMID:31385137. |
inhibitors of acetylcholinesterase (ache), which have an important role in the prevention of excessive ache activity and β-amyloid (aβ) formation are widely used in the symptomatic treatment of alzheimer's disease (ad). |
2020-01-20 |
2023-08-13 |
Not clear |
| Peterson de Andrade, Susimaire P Mantoani, Paulo Sérgio Gonçalves Nunes, Carlos Roca Magadán, Concepción Pérez, Danilo Jordão Xavier, Elza Tiemi Sakamoto Hojo, Nuria E Campillo, Ana Martínez, Ivone Carvalh. Highly potent and selective aryl-1,2,3-triazolyl benzylpiperidine inhibitors toward butyrylcholinesterase in Alzheimer's disease. Bioorganic & medicinal chemistry. vol 27. issue 6. 2020-01-15. PMID:30765302. |
acetylcholinesterase (ache) is the key enzyme targeted in alzheimer's disease (ad) therapy, nevertheless butyrylcholinesterase (buche) has been drawing attention due to its role in the disease progression. |
2020-01-15 |
2023-08-13 |
Not clear |
| Ilkay Erdogan Orhan, F Sezer Senol Deniz, Ramin Ekhteiari Salmas, Serdar Durdagi, Francesco Epifano, Salvatore Genovese, Serena Fiorit. Combined molecular modeling and cholinesterase inhibition studies on some natural and semisynthetic O-alkylcoumarin derivatives. Bioorganic chemistry. vol 84. 2020-01-13. PMID:30530106. |
in the present study, 26 novel o-alkylcoumarin derivatives were synthesized and have been tested at 100 µm for their in vitro inhibitory potential against acetylcholinesterase (ache) and butyrlcholinesterase (bche) targets which are the key enzymes playing role in the pathogenesis of alzheimer's disease. |
2020-01-13 |
2023-08-13 |
Not clear |
| Ya-Jen Chiu, Yu-Hsuan Hsieh, Te-Hsien Lin, Guan-Chiun Lee, Hsiu Mei Hsieh-Li, Ying-Chieh Sun, Chiung-Mei Chen, Kuo-Hsuan Chang, Guey-Jen Lee-Che. Novel compound VB-037 inhibits Aβ aggregation and promotes neurite outgrowth through enhancement of HSP27 and reduction of P38 and JNK-mediated inflammation in cell models for Alzheimer's disease. Neurochemistry international. vol 125. 2020-01-03. PMID:30707915. |
the pathogenesis of alzheimer's disease (ad) is involved in the aggregation of misfolded amyloid β (aβ), which upregulates the activity of acetylcholinesterase (ache), increases the production of reactive oxygen species (ros), enhances neuroinflammation, and eventually leads to neuronal death. |
2020-01-03 |
2023-08-13 |
Not clear |
| Yaghoub Pourshojaei, Khalil Eskandari, Ali Asadipou. Highly Significant Scaffolds to Design and Synthesis Cholinesterase Inhibitors as Anti-Alzheimer Agents. Mini reviews in medicinal chemistry. vol 19. issue 19. 2019-12-26. PMID:31538893. |
based on the cholinergic hypothesis, and xray crystallographic determination of the structure of acetylcholinesterase (ache) enzyme, the level of acetylcholine (ach, an important neurotransmitter associated with memory) in the hippocampus and cortex area of the brain has a direct effect on alzheimer. |
2019-12-26 |
2023-08-13 |
Not clear |
| Prasenjit Mondal, Varsha Gupta, Gaurav Das, Krishnangsu Pradhan, Juhee Khan, Prabir Kumar Gharai, Surajit Ghos. Peptide-Based Acetylcholinesterase Inhibitor Crosses the Blood-Brain Barrier and Promotes Neuroprotection. ACS chemical neuroscience. vol 9. issue 11. 2019-12-23. PMID:30015476. |
design and development of acetylcholinesterase (ache) inhibitor has tremendous implications in the treatment of alzheimer's disease (ad). |
2019-12-23 |
2023-08-13 |
Not clear |
| Jianguo Zhang, Chunzhi Tang, Wenyan Liao, Mingmin Zhu, Ming Liu, Ningning Su. The antiapoptotic and antioxidative stress effects of Zhisanzhen in the Alzheimer's disease model rat. Neuroreport. vol 30. issue 9. 2019-12-16. PMID:31095002. |
these results suggest that zhisanzhen can markedly enhance learning and memory and reverse the symptoms of alzheimer's disease in ad model rats, which may be related to the role of zhisanzhen in increasing chat and ache activity, decreasing oxidative stress and inhibiting neuronal apoptosis.video abstract: http://links.lww.com/wnr/a517. |
2019-12-16 |
2023-08-13 |
rat |
| Hongjin Tang, Ping Song, Jun Li, Dongsheng Zha. Effect of Salvia miltiorrhiza on acetylcholinesterase: Enzyme kinetics and interaction mechanism merging with molecular docking analysis. International journal of biological macromolecules. vol 135. 2019-12-16. PMID:31128195. |
acetylcholinesterase (ache) serves as an important target for alzheimer's disease. |
2019-12-16 |
2023-08-13 |
Not clear |
| Hongjin Tang, Ping Song, Jun Li, Dongsheng Zha. Effect of Salvia miltiorrhiza on acetylcholinesterase: Enzyme kinetics and interaction mechanism merging with molecular docking analysis. International journal of biological macromolecules. vol 135. 2019-12-16. PMID:31128195. |
these findings put more insights into understanding the interaction of s. miltiorrhiza chemicals and ache, as well as alzheimer's disease. |
2019-12-16 |
2023-08-13 |
Not clear |
| Esengul Karahisar, Osman Tugay, Ilkay Erdogan Orhan, Fatma Sezer Senol Deniz, Simon Vlad Luca, Krystyna Skalicka-Wozniak, Mustafa Sahi. Metabolite Profiling by Hyphenated Liquid Chromatographic Mass Spectrometric Technique (HPLC-DAD-ESI-Q-TOF-MS/MS) and Neurobiological Potential of Haplophyllum sahinii and H. vulcanicum Extracts. Chemistry & biodiversity. vol 16. issue 9. 2019-12-09. PMID:31365785. |
& heldr., were screened against acetylcholinesterase (ache) and butyrylcholinesterase (bche) associated with alzheimer's disease as well as tyrosinase (tyr) linked to parkinson's disease using elisa microplate assay at 200 μg/ml. |
2019-12-09 |
2023-08-13 |
Not clear |
| Yifan Chen, Gang Cheng, Rongfeng Hu, Shengqi Chen, Wenjie Lu, Song Gao, Hongmei Xia, Bin Wang, Chaojie Sun, Xiangjiang Nie, Qiang Shen, Wenyou Fan. A Nasal Temperature and pH Dual-Responsive In Situ Gel Delivery System Based on Microemulsion of Huperzine A: Formulation, Evaluation, and In Vivo Pharmacokinetic Study. AAPS PharmSciTech. vol 20. issue 7. 2019-12-02. PMID:31485857. |
huperzine a (hup a), extracted from the chinese medicinal plant huperzia serrata, is a reversible and highly selective second-generation acetylcholine esterase (ache) inhibitor for treating alzheimer's disease (ad), but it suffers from low bioavailability in the brain. |
2019-12-02 |
2023-08-13 |
Not clear |
| Jie Fu, Fengqi Bao, Min Gu, Jing Liu, Zhipeng Zhang, Jiaoli Ding, Sai-Sai Xie, Jinsong Din. Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer's disease. Journal of enzyme inhibition and medicinal chemistry. vol 35. issue 1. 2019-12-02. PMID:31694418. |
design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional ache inhibitors for the treatment of alzheimer's disease. |
2019-12-02 |
2023-08-13 |
Not clear |