| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bruk Getachew, Tamaro Hudson, Thomas Heinbockel, Antonei B Csoka, Yousef Tizab. Protective Effects of Donepezil Against Alcohol-Induced Toxicity in Cell Culture: Role of Caspase-3. Neurotoxicity research. vol 34. issue 3. 2018-11-06. PMID:29804239. |
donepezil (don), a centrally acting, reversible and non-competitive acetylcholinesterase (ache) inhibitor, approved for use in alzheimer's disease (ad), may also attenuate etoh-induced cognitive impairment. |
2018-11-06 |
2023-08-13 |
human |
| Sita Sharan Patel, Ramsaneh Raghuwanshi, Misha Masood, Ashish Acharya, Surendra Kumar Jai. Medicinal plants with acetylcholinesterase inhibitory activity. Reviews in the neurosciences. vol 29. issue 5. 2018-10-23. PMID:29303784. |
acetylcholinesterase (ache) is an enzyme that metabolises the ach at synaptic cleft resulting in alzheimer's disease. |
2018-10-23 |
2023-08-13 |
human |
| Xia-Min Hu, Wei Dong, Zhi-Wen Cui, Cheng-Zhi Gao, Zhi-Jun Yu, Qiong Yuan, Zhen-Li Mi. In silico identification of AChE and PARP-1 dual-targeted inhibitors of Alzheimer's disease. Journal of molecular modeling. vol 24. issue 7. 2018-10-18. PMID:29869722. |
in silico identification of ache and parp-1 dual-targeted inhibitors of alzheimer's disease. |
2018-10-18 |
2023-08-13 |
Not clear |
| Xiaocong Pang, Hui Fu, Shilun Yang, Lin Wang, Ai-Lin Liu, Song Wu, Guan-Hua D. Evaluation of Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors as Potential Anti-Alzheimer's Disease Agents Using Pharmacophore, 3D-QSAR, and Molecular Docking Approaches. Molecules (Basel, Switzerland). vol 22. issue 8. 2018-10-04. PMID:28933746. |
dl0410, containing biphenyl and piperidine skeletons, was identified as an acetylcholinesterase (ache) and butyrylcholinesterase (buche) inhibitor through high-throughput screening assays, and further studies affirmed its efficacy and safety for alzheimer's disease treatment. |
2018-10-04 |
2023-08-13 |
Not clear |
| Gustavo Roberto Thomé, Vitor Antunes Oliveira, Maria Rosa Chitolina Schetinger, Rogério Aquino Saraiva, Diego Souza, Oscar Endrigo Dorneles Rodrigues, João Batista Teixeira Rocha, Rafael Porto Ineu, Maria Ester Pereir. Selenothymidine protects against biochemical and behavioral alterations induced by ICV-STZ model of dementia in mice. Chemico-biological interactions. vol 294. 2018-09-14. PMID:30120923. |
all these findings support the neuroprotective role of s1073 in mice model of alzheimer's dementia-type induced by icv-stz, which may be associated with its antioxidant activity and/or with its inhibitory effect in brain ache. |
2018-09-14 |
2023-08-13 |
mouse |
| María Figueiredo-González, Patricia Reboredo-Rodríguez, Carmen González-Barreiro, Alegría Carrasco-Pancorbo, Jesús Simal-Gándara, Beatriz Cancho-Grand. Nutraceutical Potential of Phenolics from 'Brava' and 'Mansa' Extra-Virgin Olive Oils on the Inhibition of Enzymes Associated to Neurodegenerative Disorders in Comparison with Those of 'Picual' and 'Cornicabra'. Molecules (Basel, Switzerland). vol 23. issue 4. 2018-09-03. PMID:29561824. |
extra-virgin olive oils (evoos) obtained from 'brava' and 'mansa', varieties recently identified from galicia (northwestern spain), were selected for in vitro screening to evaluate their capacity to inhibit key enzymes involved in alzheimer's disease (ad) (acetylcholinesterase (ache), butyrylcholinesterase (buche) and 5-lipoxygenase (5-lox)), major depressive disorder (mdd) and parkinson's disease (pd) (monoamine oxidases: |
2018-09-03 |
2023-08-13 |
Not clear |
| Fei Mao, Huan Wang, Wei Ni, Xinyu Zheng, Manjiong Wang, Keting Bao, Dazheng Ling, Xiaokang Li, Yixiang Xu, Haiyan Zhang, Jian L. Design, Synthesis, and Biological Evaluation of Orally Available First-Generation Dual-Target Selective Inhibitors of Acetylcholinesterase (AChE) and Phosphodiesterase 5 (PDE5) for the Treatment of Alzheimer's Disease. ACS chemical neuroscience. vol 9. issue 2. 2018-08-17. PMID:29068218. |
design, synthesis, and biological evaluation of orally available first-generation dual-target selective inhibitors of acetylcholinesterase (ache) and phosphodiesterase 5 (pde5) for the treatment of alzheimer's disease. |
2018-08-17 |
2023-08-13 |
mouse |
| Natalie Cortes, Karina Sierra, Fernando Alzate, Edison H Osorio, Edison Osori. Alkaloids of Amaryllidaceae as Inhibitors of Cholinesterases (AChEs and BChEs): An Integrated Bioguided Study. Phytochemical analysis : PCA. vol 29. issue 2. 2018-08-16. PMID:29044771. |
enzymatic inhibition of acetylcholinesterase (ache) is an essential therapeutic target for the treatment of alzheimer's disease (ad) and ache inhibitors are the first-line drugs for it treatment. |
2018-08-16 |
2023-08-13 |
Not clear |
| Ilkay Erdogan Orhan, Dariusz Jedrejek, F Sezer Senol, Ramin Ekhteiari Salmas, Serdar Durdagi, Iwona Kowalska, Lukasz Pecio, Wieslaw Olesze. Molecular modeling and in vitro approaches towards cholinesterase inhibitory effect of some natural xanthohumol, naringenin, and acyl phloroglucinol derivatives. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 42. 2018-08-13. PMID:29655693. |
many natural products, particularly phenolic compounds, have been reported to have a strong inhibition against acetylcholinesterase (ache) and butyrylcholinesterase (bche), the key enzymes in the pathology of alzheimer's disease (ad). |
2018-08-13 |
2023-08-13 |
Not clear |
| Bui Thanh Tung, Dang Kim Thu, Nguyen Thi Kim Thu, Nguyen Thanh Ha. Antioxidant and acetylcholinesterase inhibitory activities of ginger root (Zingiber officinale Roscoe) extract. Journal of complementary & integrative medicine. vol 14. issue 4. 2018-08-10. PMID:29345437. |
conclusions our results suggest that the etoac fraction of z. officinale may be a promising source of ache inhibitors for alzheimer's disease. |
2018-08-10 |
2023-08-13 |
Not clear |
| Tae Woog Kang, Su-Ji Jeon, Hye-In Kim, Jung Hyun Park, DaBin Yim, Hye-Rim Lee, Jong-Min Ju, Man-Jin Kim, Jong-Ho Ki. Optical Detection of Enzymatic Activity and Inhibitors on Non-Covalently Functionalized Fluorescent Graphene Oxide. ACS nano. vol 10. issue 5. 2018-07-27. PMID:27136042. |
it has been of great interest to measure the activity of acetylcholinesterase (ache) and its inhibitor, as ache is known to accelerate the aggregation of the amyloid beta peptides that underlie alzheimer's disease. |
2018-07-27 |
2023-08-13 |
Not clear |
| Ümide Demir Özkay, Özgür Devrim Can, Begüm Nurpelin Sağlık, Nazlı Tura. A benzothiazole/piperazine derivative with acetylcholinesterase inhibitory activity: Improvement in streptozotocin-induced cognitive deficits in rats. Pharmacological reports : PR. vol 69. issue 6. 2018-07-27. PMID:29132093. |
acetylcholinesterase (ache) inhibitors are frequently prescribed to mitigate the cognitive decline in alzheimer's disease. |
2018-07-27 |
2023-08-13 |
rat |
| Ümide Demir Özkay, Özgür Devrim Can, Begüm Nurpelin Sağlık, Nazlı Tura. A benzothiazole/piperazine derivative with acetylcholinesterase inhibitory activity: Improvement in streptozotocin-induced cognitive deficits in rats. Pharmacological reports : PR. vol 69. issue 6. 2018-07-27. PMID:29132093. |
thus, we investigated the possible efficacy of the ache inhibitor 2-[(6-nitro-2-benzothiazolyl)amino]-2-oxoethyl4-[2-(n,n-dimethylamino)ethyl] piperazine-1 carbodithioate (bpct) in a streptozotocin (stz)-induced alzheimer's disease model (sadm). |
2018-07-27 |
2023-08-13 |
rat |
| Gauresh S Somani, Mruniya S Nahire, Aakash D Parikh, Mandar B Mulik, Priya J Ghumatkar, Kirti S Laddha, Sadhana Sathay. Neuroprotective effect of Cubebin: A dibenzylbutyrolactone lignan on scopolamine-induced amnesia in mice. The Indian journal of medical research. vol 146. issue 2. 2018-07-27. PMID:29265027. |
acetylcholinesterase (ache) inhibitors represent a major class of drugs which provide symptomatic relief and improvement in cognitive function in alzheimer's disease (ad). |
2018-07-27 |
2023-08-13 |
mouse |
| Kandasamy Saravanan, Chinnasamy Kalaiarasi, Poomani Kumaradha. Understanding the conformational flexibility and electrostatic properties of curcumin in the active site of rhAChE via molecular docking, molecular dynamics, and charge density analysis. Journal of biomolecular structure & dynamics. vol 35. issue 16. 2018-07-20. PMID:27897077. |
acetylcholinesterase (ache) is an important enzyme responsible for alzheimer's disease, as per report, keto-enol form of curcumin inhibits this enzyme. |
2018-07-20 |
2023-08-13 |
human |
| Syed Haris Omar, Christopher J Scott, Adam S Hamlin, Hassan K Obie. Biophenols: Enzymes (β-secretase, Cholinesterases, histone deacetylase and tyrosinase) inhibitors from olive (Olea europaea L.). Fitoterapia. vol 128. 2018-07-20. PMID:29772299. |
the focus of this study was on inhibition of enzymes involved in the pathogenesis alzheimer's disease (ad) including prime amyloid beta (aβ) producing enzyme (β-secretase: bace-1) and disease progression enzymes including acetylcholinesterase (ache), butyrylcholinesterase (bche), histone deacetylase (hdac), and tyrosinase along with the catecholamine l-dopa, by using olive biophenols. |
2018-07-20 |
2023-08-13 |
Not clear |
| Speranta Avram, Maria Mernea, Eyup Bagci, Lucian Hritcu, Livia-Cristina Borcan, Dan Florin Mihailesc. Advanced Structure-activity Relationships Applied to Mentha spicata L. Subsp. spicata Essential Oil Compounds as AChE and NMDA Ligands, in Comparison with Donepezil, Galantamine and Memantine - New Approach in Brain Disorders Pharmacology. CNS & neurological disorders drug targets. vol 16. issue 7. 2018-07-18. PMID:28088901. |
alzheimer's disease (ad) therapy is based on several natural and synthetic compounds that act as acetylcholinesterase (ache) and n-methyl-d-aspartate receptor (nmda) ligands that have limited efficiency in relieving ad symptoms. |
2018-07-18 |
2023-08-13 |
Not clear |
| Joyshree Biswas, Sonam Gupta, Dinesh Kumar Verma, Parul Gupta, Abhishek Singh, Shubhangini Tiwari, Poonam Goswami, Sharad Sharma, Sarika Sing. Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology. Cellular signalling. vol 42. 2018-07-18. PMID:29126976. |
the alzheimer's related pathological marker like acetylcholinesterase (ache) activity, tau phosphorylation and amyloid aggregation were observed after stz administration. |
2018-07-18 |
2023-08-13 |
rat |
| Babitha Pallikkara Pulikkal, Sahila Mohammed Marunnan, Srinivas Bandaru, Mukesh Yadav, Anuraj Nayarisseri, Sivanpillai Sureshkuma. Common SAR Derived from Linear and Non-linear QSAR Studies on AChE Inhibitors used in the Treatment of Alzheimer's Disease. Current neuropharmacology. vol 15. issue 8. 2018-07-16. PMID:27964704. |
common sar derived from linear and non-linear qsar studies on ache inhibitors used in the treatment of alzheimer's disease. |
2018-07-16 |
2023-08-13 |
Not clear |
| Babitha Pallikkara Pulikkal, Sahila Mohammed Marunnan, Srinivas Bandaru, Mukesh Yadav, Anuraj Nayarisseri, Sivanpillai Sureshkuma. Common SAR Derived from Linear and Non-linear QSAR Studies on AChE Inhibitors used in the Treatment of Alzheimer's Disease. Current neuropharmacology. vol 15. issue 8. 2018-07-16. PMID:27964704. |
targeting acetyl cholinesterase (ache) surfaced as a potential therapeutic target in the treatment of alzheimer's disease. |
2018-07-16 |
2023-08-13 |
Not clear |