| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marta Goschorska, Izabela Gutowska, Irena Baranowska-Bosiacka, Katarzyna Piotrowska, Emilia Metryka, Krzysztof Safranow, Dariusz Chlube. Influence of Acetylcholinesterase Inhibitors Used in Alzheimer's Disease Treatment on the Activity of Antioxidant Enzymes and the Concentration of Glutathione in International journal of environmental research and public health. vol 16. issue 1. 2019-05-28. PMID:30577562. |
influence of acetylcholinesterase inhibitors used in alzheimer's disease treatment on the activity of antioxidant enzymes and the concentration of glutathione in it has been reported that donepezil and rivastigmine, the acetylcholinesterase (ache) inhibitors commonly used in the treatment of alzheimer's disease (ad), do not only inhibit ache but also have antioxidant properties. |
2019-05-28 |
2023-08-13 |
cat |
| Kazuki Terada, Keisuke Migita, Yukari Matsushima, Yumi Sugimoto, Chiaki Kamei, Taichi Matsumoto, Masayoshi Mori, Kazuhisa Matsunaga, Jiro Takata, Yoshiharu Karub. Cholinesterase inhibitor rivastigmine enhances nerve growth factor-induced neurite outgrowth in PC12 cells via sigma-1 and sigma-2 receptors. PloS one. vol 13. issue 12. 2019-05-21. PMID:30557385. |
rivastigmine (riv) is a potent and selective cholinesterase (acetylcholinesterase, ache and butyrylcholinesterase, buche) inhibitor developed for the treatment of alzheimer's disease (ad). |
2019-05-21 |
2023-08-13 |
Not clear |
| H Saleh, L Sadegh. Investigation of THDOC effects on pathophysiological signs of Alzheimer's disease as an endogenous neurosteroid: inhibition of acetylcholinesterase and plaque deposition. Bratislavske lekarske listy. vol 120. issue 2. 2019-05-15. PMID:30793620. |
alzheimer's disease (ad) is an advanced neurodegenerative disorder greatly accompanied by acetylcholinesterase (ache) activation and amyloid plaque deposition. |
2019-05-15 |
2023-08-13 |
rat |
| Lu Kang, Xiao-Hui Gao, Hao-Ran Liu, Xue Men, Hong-Nian Wu, Pei-Wu Cui, Eric Oldfield, Jian-Ye Ya. Structure-activity relationship investigation of coumarin-chalcone hybrids with diverse side-chains as acetylcholinesterase and butyrylcholinesterase inhibitors. Molecular diversity. vol 22. issue 4. 2019-05-08. PMID:29934672. |
overall, the results show that coumarin-chalcone hybrids with choline-like side-chains have promising activity and selectivity against ache and be promising therapeutic leads for alzheimer's disease. |
2019-05-08 |
2023-08-13 |
Not clear |
| Killian Oukoloff, Nicolas Coquelle, Manuela Bartolini, Marina Naldi, Rémy Le Guevel, Stéphane Bach, Béatrice Josselin, Sandrine Ruchaud, Marco Catto, Leonardo Pisani, Nunzio Denora, Rosa Maria Iacobazzi, Israel Silman, Joel L Sussman, Frédéric Buron, Jacques-Philippe Colletier, Ludovic Jean, Sylvain Routier, Pierre-Yves Renar. Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3. European journal of medicinal chemistry. vol 168. 2019-04-22. PMID:30798053. |
both cholinesterases (ache and bche) and kinases, such as gsk-3α/β, are associated with the pathology of alzheimer's disease. |
2019-04-22 |
2023-08-13 |
human |
| Qi He, Jing Liu, Jin-Shuai Lan, Jiaoli Ding, Yongbing Sun, Yuanying Fang, Neng Jiang, Zunhua Yang, Liyuan Sun, Yi Jin, Sai-Sai Xi. Coumarin-dithiocarbamate hybrids as novel multitarget AChE and MAO-B inhibitors against Alzheimer's disease: Design, synthesis and biological evaluation. Bioorganic chemistry. vol 81. 2019-04-15. PMID:30245233. |
coumarin-dithiocarbamate hybrids as novel multitarget ache and mao-b inhibitors against alzheimer's disease: design, synthesis and biological evaluation. |
2019-04-15 |
2023-08-13 |
Not clear |
| Huseyin Cavdar, Murat Senturk, Murat Guney, Serdar Durdagi, Gulru Kayik, Claudiu T Supuran, Deniz Ekinc. Inhibition of acetylcholinesterase and butyrylcholinesterase with uracil derivatives: kinetic and computational studies. Journal of enzyme inhibition and medicinal chemistry. vol 34. issue 1. 2019-03-14. PMID:30734597. |
acetylcholinesterase (ache) and butyrylcholinesterase (buche) inhibitors are interesting compounds for different therapeutic applications, among which alzheimer's disease. |
2019-03-14 |
2023-08-13 |
Not clear |
| Francesca Trampetti, Catarina Pereira, Maria João Rodrigues, Odeta Celaj, Brigida D'Abrosca, Gokhan Zengin, Adriano Mollica, Azzurra Stefanucci, Luísa Custódi. Exploring the halophyte Cistanche phelypaea (L.) Cout as a source of health promoting products: In vitro antioxidant and enzyme inhibitory properties, metabolomic profile and computational studies. Journal of pharmaceutical and biomedical analysis. vol 165. 2019-03-12. PMID:30529825. |
the water extracts had the highest antioxidant activity, especially those from roots and flowers, and were further appraised for in vitro inhibition of enzymes implicated on the onset of human ailments, namely acetyl- (ache) and butyrylcholinesterase (buche) for alzheimer's disease, α-glucosidase and α-amylase for diabetes, and tyrosinase for skin hyperpigmentation disorders. |
2019-03-12 |
2023-08-13 |
human |
| Mathiyazahan Dhivya Bharathi, Arokiasamy Justin-Thenmozhi, Thamilarasan Manivasagam, Mashoque Ahmad Rather, Chidambaram Saravana Babu, Musthafa Mohamed Essa, Gilles J Guillemi. Amelioration of Aluminum Maltolate-Induced Inflammation and Endoplasmic Reticulum Stress-Mediated Apoptosis by Tannoid Principles of Emblica officinalis in Neuronal Cellular Model. Neurotoxicity research. vol 35. issue 2. 2019-03-11. PMID:30242626. |
the neuroprotective role of tannoid principles of emblica officinalis (eot), an indian and chinese traditional medicinal plant against memory loss in aluminum chloride-induced in vivo model of alzheimer's disease through attenuating ache activity, oxidative stress, amyloid and tau toxicity, and apoptosis, was recently reported in our lab. |
2019-03-11 |
2023-08-13 |
Not clear |
| Yi Guo, Na Zhang, Weiguang Sun, Xueyan Duan, Qing Zhang, Qun Zhou, Chunmei Chen, Hucheng Zhu, Zengwei Luo, Junjun Liu, Xiao-Nian Li, Yongbo Xue, Yonghui Zhan. Bioactive polycyclic polyprenylated acylphloroglucinols from Hypericum perforatum. Organic & biomolecular chemistry. vol 16. issue 43. 2019-03-08. PMID:30334059. |
interestingly, compound 5 showed the most balanced inhibitory activities against both ache and bace1 of all the tested compounds, which means that 5 could serve as the first valuable dual-targeted ppap for the treatment of alzheimer's disease. |
2019-03-08 |
2023-08-13 |
Not clear |
| Lihu Zhang, Dongdong Li, Fuliang Cao, Wei Xiao, Linguo Zhao, Gang Ding, Zhen Zhong Wan. Identification of Human Acetylcholinesterase Inhibitors from the Constituents of EGb761 by Modeling Docking and Molecular Dynamics Simulations. Combinatorial chemistry & high throughput screening. vol 21. issue 1. 2019-01-18. PMID:29173156. |
identification of natural acetylcholinesterase (ache) inhibitors from egb761 would provide a novel therapeutic approach against the alzheimer's disease. |
2019-01-18 |
2023-08-13 |
human |
| Maryam Nazari, Sayyed Abbas Tabatabai, Elham Rezae. 2D & 3D-QSAR Study on Novel Piperidine and Piperazine Derivatives as Acetylcholinesterase Enzyme Inhibitors. Current computer-aided drug design. vol 14. issue 4. 2019-01-11. PMID:30047333. |
acetylcholinesterase enzyme (ache) is the main target in alzheimer's disease therapy and designing of novel ache inhibitors is a great deal of attention. |
2019-01-11 |
2023-08-13 |
Not clear |
| Xiaojuan Yan, Tinggui Chen, Liwei Zhang, Huizhi D. Study of the interactions of forsythiaside and rutin with acetylcholinesterase (AChE). International journal of biological macromolecules. vol 119. 2019-01-02. PMID:30048725. |
acetylcholinesterase (ache) inhibitors have been considered as candidates for the treatment of alzheimer's disease (ad) and have been utilized in clinical trials. |
2019-01-02 |
2023-08-13 |
Not clear |
| Leonardo Pisani, Rosa Maria Iacobazzi, Marco Catto, Mariagrazia Rullo, Roberta Farina, Nunzio Denora, Saverio Cellamare, Cosimo Damiano Altomar. Investigating alkyl nitrates as nitric oxide releasing precursors of multitarget acetylcholinesterase-monoamine oxidase B inhibitors. European journal of medicinal chemistry. vol 161. 2018-12-18. PMID:30366255. |
herein we envisaged the possibility of exploiting alkyl nitrates as precursors of alcohol-bearing dual inhibitors targeting acetylcholinesterase (ache) and monoamine oxidase b (mao b), key enzymes in neurodegenerative syndromes such as alzheimer's disease (ad), through biotransformation unmasking an alcoholic function upon nitric oxide (no) release. |
2018-12-18 |
2023-08-13 |
human |
| Cheng-Zhi Gao, Wei Dong, Zhi-Wen Cui, Qiong Yuan, Xia-Min Hu, Qing-Ming Wu, Xianlin Han, Yao Xu, Zhen-Li Mi. Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors. Journal of enzyme inhibition and medicinal chemistry. vol 34. issue 1. 2018-12-18. PMID:30427217. |
as a parp-1 inhibitor had been reported to be viable to neuroprotection, in order to search for new multitarget-directed ligands (mtdls) for the treatment of alzheimer's disease (ad), the inhibitory activities of the synthesized compounds against the enzymes ache (from electric eel) and bche (from equine serum) were also tested. |
2018-12-18 |
2023-08-13 |
Not clear |
| Cheng-Zhi Gao, Wei Dong, Zhi-Wen Cui, Qiong Yuan, Xia-Min Hu, Qing-Ming Wu, Xianlin Han, Yao Xu, Zhen-Li Mi. Synthesis, preliminarily biological evaluation and molecular docking study of new Olaparib analogues as multifunctional PARP-1 and cholinesterase inhibitors. Journal of enzyme inhibition and medicinal chemistry. vol 34. issue 1. 2018-12-18. PMID:30427217. |
our research gave a clue to search for new agents based on ache and parp-1 dual-inhibited activities to treat alzheimer's disease. |
2018-12-18 |
2023-08-13 |
Not clear |
| Esra Ucar, Nuraniye Eruygur, Mehmet Atas, Merve Ergul, Mustafa Ergul, Fazli Sozme. Determination of inhibitory activities of enzymes, related to Alzheimer's disease and diabetes mellitus of plane tree (Platanus orientalis L.) extracts and their antioxidant, antimicrobial and anticancer activities. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 11. 2018-12-11. PMID:30213283. |
the aim of the study was to evaluate the inhibitory effects against alzheimer's disease-related enzymes acetylcholinesterase (ache) and butyrylcholinesterase (buche), diabetes mellitus related enzymes α-glucosidase and α-amylase. |
2018-12-11 |
2023-08-13 |
Not clear |
| Vivitri Prasasty, Muhammad Radifar, Enade Istyaston. Natural Peptides in Drug Discovery Targeting Acetylcholinesterase. Molecules (Basel, Switzerland). vol 23. issue 9. 2018-12-11. PMID:30217053. |
acetylcholinesterase-inhibitory peptide has gained much importance since it can inhibit acetylcholinesterase (ache) and increase the availability of acetylcholine in cholinergic synapses, enhancing cholinergic transmission in pharmacological treatment of alzheimer's disease (ad). |
2018-12-11 |
2023-08-13 |
Not clear |
| Mahdi Abbas-Mohammadi, Mahdi Moridi Farimani, Peyman Salehi, Samad Nejad Ebrahimi, Ali Sonboli, Celine Kelso, Danielle Skropet. Acetylcholinesterase-inhibitory activity of Iranian plants: Combined HPLC/bioassay-guided fractionation, molecular networking and docking strategies for the dereplication of active compounds. Journal of pharmaceutical and biomedical analysis. vol 158. 2018-11-08. PMID:29960238. |
in order to search for discovery of acetylcholinesterase (ache) inhibitors, as a therapeutic strategy for treatment of the alzheimer's disease, twenty-five iranian plants have been evaluated by an in vitro enzymatic ellman method and molecular docking study. |
2018-11-08 |
2023-08-13 |
Not clear |
| Stephen Adeniyi Adefegh. Functional Foods and Nutraceuticals as Dietary Intervention in Chronic Diseases; Novel Perspectives for Health Promotion and Disease Prevention. Journal of dietary supplements. vol 15. issue 6. 2018-11-07. PMID:29281341. |
this review explains the interaction of functional food bioactive compounds including polyphenols (phenolic acids [hydroxybenzoic acids and hydroxycinnamic acids], flavonoids [flavonols, flavones, flavanols, flavanones, isoflavones, proanthocyanidins], stilbenes, and lignans), terpenoids, carotenoids, alkaloids, omega-3 and polyunsaturated fatty acids, among others with critical enzymes (α- amylase, α- glucosidase, angiotensin-i converting enzyme [ace], acetylcholinesterase [ache], and arginase) linked to some degenerative diseases (type-2 diabetes, cardiovascular diseases [hypertension], neurodegenerative diseases [alzheimer's disease] and erectile dysfunction). |
2018-11-07 |
2023-08-13 |
Not clear |