| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brianna E Glynn-Servedio, Trisha Seys Ranol. AChE Inhibitors and NMDA Receptor Antagonists in Advanced Alzheimer's Disease. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists. vol 32. issue 9. 2017-11-07. PMID:28855009. |
ache inhibitors and nmda receptor antagonists in advanced alzheimer's disease. |
2017-11-07 |
2023-08-13 |
Not clear |
| Ling Huang, Jiajia Lin, Siying Xiang, Kangrong Zhao, Jie Yu, Jiacheng Zheng, Daping Xu, Shinghung Mak, Shengquan Hu, Shehani Nirasha, Chuang Wang, Xiaowei Chen, Junfang Zhang, Shujun Xu, Xiaofei Wei, Zaijun Zhang, Dongsheng Zhou, Wenhua Zhou, Wei Cui, Yifan Han, Zhenyu Hu, Qinwen Wan. Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice. ACS chemical neuroscience. vol 7. issue 8. 2017-10-30. PMID:27046396. |
surprisingly, sunitinib could attenuate cognitive impairments to a similar extent as donepezil, a marketed ache inhibitor used for the treatment of alzheimer's disease. |
2017-10-30 |
2023-08-13 |
mouse |
| Leili Jalili-Baleh, Hamid Nadri, Alireza Moradi, Syed Nasir Abbas Bukhari, Mojtaba Shakibaie, Mandana Jafari, Mostafa Golshani, Farshad Homayouni Moghadam, Loghman Firoozpour, Ali Asadipour, Saeed Emami, Mehdi Khoobi, Alireza Foroumad. New racemic annulated pyrazolo[1,2-b]phthalazines as tacrine-like AChE inhibitors with potential use in Alzheimer's disease. European journal of medicinal chemistry. vol 139. 2017-10-18. PMID:28803044. |
new racemic annulated pyrazolo[1,2-b]phthalazines as tacrine-like ache inhibitors with potential use in alzheimer's disease. |
2017-10-18 |
2023-08-13 |
Not clear |
| Liang Peng, Zhengxing Rong, Hao Wang, Biyun Shao, Lei Kang, Hong Qi, Hongzhuan Che. A novel assay to determine acetylcholinesterase activity: The application potential for screening of drugs against Alzheimer's disease. Biomedical chromatography : BMC. vol 31. issue 10. 2017-10-09. PMID:28295437. |
acetycholinesterase (ache) that regulates hydrolysis of acetylcholine (ach) in the brain, is an important target for treatment of alzheimer's disease (ad), a feature of which is ach deficiency. |
2017-10-09 |
2023-08-13 |
Not clear |
| Leonardo Pisani, Marco Catto, Annalisa De Palma, Roberta Farina, Saverio Cellamare, Cosimo D Altomar. Discovery of Potent Dual Binding Site Acetylcholinesterase Inhibitors via Homo- and Heterodimerization of Coumarin-Based Moieties. ChemMedChem. vol 12. issue 16. 2017-10-09. PMID:28570763. |
acetylcholinesterase (ache) inhibitors still comprise the majority of the marketed drugs for alzheimer's disease (ad). |
2017-10-09 |
2023-08-13 |
Not clear |
| Babar Ali, Qazi M S Jamal, Saiba Shams, Naser A Al-Wabel, Mughees U Siddiqui, Mohammad A Alzohairy, Mohammed A Al Karaawi, Kavindra Kumar Kesari, Gohar Mushtaq, Mohammad A Kama. In Silico Analysis of Green Tea Polyphenols as Inhibitors of AChE and BChE Enzymes in Alzheimer's Disease Treatment. CNS & neurological disorders drug targets. vol 15. issue 5. 2017-10-04. PMID:26996169. |
in silico analysis of green tea polyphenols as inhibitors of ache and bche enzymes in alzheimer's disease treatment. |
2017-10-04 |
2023-08-13 |
Not clear |
| Pavan Kumar Chintamaneni, Praveen T Krishnamurthy, Pachava Vengal Rao, SaiKiran S S Pindiprol. Surface modified nano-lipid drug conjugates of positive allosteric modulators of M1 muscarinic acetylcholine receptor for the treatment of Alzheimer's disease. Medical hypotheses. vol 101. 2017-10-03. PMID:28351483. |
acetyl cholinesterase (ache) inhibitors such as donepezil, rivastigmine and galantamine are approved by us-fda as first line drugs to treat the cognitive symptoms of alzheimer's disease (ad). |
2017-10-03 |
2023-08-13 |
Not clear |
| Xiong-Jie Zhao, Da-Min Gong, Yu-Ren Jiang, Dong Guo, Yao Zhu, You-Chao Den. Multipotent AChE and BACE-1 inhibitors for the treatment of Alzheimer's disease: Design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2H-isoquilin-3-one derivates. European journal of medicinal chemistry. vol 138. 2017-10-02. PMID:28728106. |
multipotent ache and bace-1 inhibitors for the treatment of alzheimer's disease: design, synthesis and bio-analysis of 7-amino-1,4-dihydro-2h-isoquilin-3-one derivates. |
2017-10-02 |
2023-08-13 |
Not clear |
| Siddappa A Patil, Renukadevi Patil, Shivaputra A Pati. Recent developments in biological activities of indanones. European journal of medicinal chemistry. vol 138. 2017-09-20. PMID:28667874. |
among the medicinally important indanones, the most significant drug probably is donepezil (iv), an acetylcholinesterase (ache) inhibitor, which has been approved by the us food and drug administration for the treatment of alzheimer's disease (ad). |
2017-09-20 |
2023-08-13 |
Not clear |
| Soledad Fernández, Javier Giglio, Ana Laura Reyes, Andrés Damián, Concepción Pérez, Daniel I Pérez, Mercedes González, Patricia Oliver, Ana Rey, Henry Engler, Hugo Cerecett. 3-(Benzyloxy)-1-(5-[ Future medicinal chemistry. vol 9. issue 10. 2017-09-12. PMID:28632402. |
3-(benzyloxy)-1-(5-[ noninvasive studies of the acetylcholinesterase (ache) level in alzheimer's disease (ad) patients can contribute to a better understanding of the disease and its therapeutic. |
2017-09-12 |
2023-08-13 |
Not clear |
| Alon Simchovitz, Michael T Heneka, Hermona Sore. Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28326544. |
notably, ache inhibitors are the only currently approved line of treatment for alzheimer's disease patients. |
2017-09-07 |
2023-08-13 |
Not clear |
| Alon Simchovitz, Michael T Heneka, Hermona Sore. Personalized genetics of the cholinergic blockade of neuroinflammation. Journal of neurochemistry. vol 142 Suppl 2. 2017-09-07. PMID:28326544. |
since cholinergic signaling blocks neuroinflammation which is inherent to alzheimer's disease, genomic changes modifying ache's properties and its susceptibility to inhibitors and/or to cholinomirs regulation may affect the levels and properties of inflammasome components such as nlrp3. |
2017-09-07 |
2023-08-13 |
Not clear |
| Anuttama Kulkarni, Yasmin Khan, Krishanu Ra. Heterotrimeric kinesin-2, together with kinesin-1, steers vesicular acetylcholinesterase movements toward the synapse. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 31. issue 3. 2017-09-06. PMID:27920150. |
aberrant ache activity and ectopic axonal accumulation of the enzyme are associated with neurodegenerative disorders, such as alzheimer's disease. |
2017-09-06 |
2023-08-13 |
Not clear |
| Jin Wang, Zhi-Min Wang, Xue-Mei Li, Fan Li, Jia-Jia Wu, Ling-Yi Kong, Xiao-Bing Wan. Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin. Bioorganic & medicinal chemistry. vol 24. issue 18. 2017-07-26. PMID:27460699. |
a novel series of compounds obtained by fusing the acetylcholinesterase (ache) inhibitor donepezil and the antioxidant melatonin were designed as multi-target-directed ligands for the treatment of alzheimer's disease (ad). |
2017-07-26 |
2023-08-13 |
Not clear |
| Yunqin Zhang, Shuqun Zhang, Guowei Xu, Hui Yan, Yinglan Pu, Zhili Zu. The discovery of new acetylcholinesterase inhibitors derived from pharmacophore modeling, virtual screening, docking simulation and bioassays. Molecular bioSystems. vol 12. issue 12. 2017-07-24. PMID:27801451. |
hyperactivity of acetylcholinesterase (ache) in the brain is the immediate cause of alzheimer's disease (ad), which is one of the most prevalent fatal diseases afflicting numerous older people. |
2017-07-24 |
2023-08-13 |
Not clear |
| Bassem Sadek, Nadia Khan, Fouad H Darras, Steffen Pockes, Michael Decke. The dual-acting AChE inhibitor and H3 receptor antagonist UW-MD-72 reverses amnesia induced by scopolamine or dizocilpine in passive avoidance paradigm in rats. Physiology & behavior. vol 165. 2017-07-11. PMID:27568232. |
hence, dual-active ache inhibitors (acheis) and h3r antagonists hold potential to treat cognitive disorders like alzheimer's disease (ad). |
2017-07-11 |
2023-08-13 |
rat |
| Dahong Yao, Jing Wang, Guan Wang, Yingnan Jiang, Lei Shang, Yuqian Zhao, Jian Huang, Shilin Yang, Jinhui Wang, Yamei Y. Design, synthesis and biological evaluation of coumarin derivatives as novel acetylcholinesterase inhibitors that attenuate H2O2-induced apoptosis in SH-SY5Y cells. Bioorganic chemistry. vol 68. 2017-06-29. PMID:27479541. |
these findings highlight a new approach for the development of a novel potential neuroprotective compound targeting ache with autophagy-inducing activity in future alzheimer's disease (ad) therapy. |
2017-06-29 |
2023-08-13 |
human |
| Leonardo Pisani, Roberta Farina, Marco Catto, Rosa Maria Iacobazzi, Orazio Nicolotti, Saverio Cellamare, Giuseppe Felice Mangiatordi, Nunzio Denora, Ramon Soto-Otero, Lydia Siragusa, Cosimo Damiano Altomare, Angelo Carott. Exploring Basic Tail Modifications of Coumarin-Based Dual Acetylcholinesterase-Monoamine Oxidase B Inhibitors: Identification of Water-Soluble, Brain-Permeant Neuroprotective Multitarget Agents. Journal of medicinal chemistry. vol 59. issue 14. 2017-06-09. PMID:27347731. |
aiming at modulating two key enzymatic targets for alzheimer's disease (ad), i.e., acetylcholinesterase (ache) and monoamine oxidase b (mao b), a series of multitarget ligands was properly designed by linking the 3,4-dimethylcoumarin scaffold to 1,3- and 1,4-substituted piperidine moieties, thus modulating the basicity to improve the hydrophilic/lipophilic balance. |
2017-06-09 |
2023-08-13 |
human |
| Xia Yang, Xiaoming Qiang, Yan Li, Li Luo, Rui Xu, Yunxiaozhu Zheng, Zhongcheng Cao, Zhenghuai Tan, Yong Den. Pyridoxine-resveratrol hybrids Mannich base derivatives as novel dual inhibitors of AChE and MAO-B with antioxidant and metal-chelating properties for the treatment of Alzheimer's disease. Bioorganic chemistry. vol 71. 2017-06-06. PMID:28267984. |
pyridoxine-resveratrol hybrids mannich base derivatives as novel dual inhibitors of ache and mao-b with antioxidant and metal-chelating properties for the treatment of alzheimer's disease. |
2017-06-06 |
2023-08-13 |
Not clear |
| Muhammad Shakil Shah, Shafi Ullah Khan, Syeda Abida Ejaz, Saifullah Afridi, Syed Umar Farooq Rizvi, Muhammad Najam-Ul-Haq, Jamshed Iqba. Cholinesterases inhibition and molecular modeling studies of piperidyl-thienyl and 2-pyrazoline derivatives of chalcones. Biochemical and biophysical research communications. vol 482. issue 4. 2017-05-29. PMID:27865835. |
therefore, cholinesterases (ache & bche) inhibition are considered as a promising strategy for the treatment of alzheimer's disease. |
2017-05-29 |
2023-08-13 |
Not clear |