| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Cho Rong Kim, Soo Jung Choi, Yoon Kyung Kwon, Jae Kyeom Kim, Youn-Jung Kim, Gwi Gun Park, Dong-Hoon Shi. Cinnamomum loureirii Extract Inhibits Acetylcholinesterase Activity and Ameliorates Trimethyltin-Induced Cognitive Dysfunction in Mice. Biological & pharmaceutical bulletin. vol 39. issue 7. 2017-01-27. PMID:27374288. |
the pathogenesis of alzheimer's disease (ad) has been linked to the deficiency of neurotransmitter acetylcholine (ach) in the brain, and the main treatment strategy for improving ad symptoms is the inhibition of acetylcholinesterase (ache) activity. |
2017-01-27 |
2023-08-13 |
mouse |
| Katsuyoshi Mizukami, Hiroyasu Akatsu, Eric E Abrahamson, Zhiping Mi, Milos D Ikonomovi. Immunohistochemical analysis of hippocampal butyrylcholinesterase: Implications for regional vulnerability in Alzheimer's disease. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 36. issue 2. 2017-01-09. PMID:26293308. |
studies of acetylcholine degrading enzymes acetylcholinesterase (ache) and butyrylcholinesterase (bche) in alzheimer's disease (ad) have suggested their potential role in the development of fibrillar amyloid-β (aβ) plaques (amyloid plaques). |
2017-01-09 |
2023-08-13 |
Not clear |
| Mina Saeedi, Maedeh Golipoor, Mohammad Mahdavi, Alireza Moradi, Hamid Nadri, Saeed Emami, Alireza Foroumadi, Abbas Shafie. Phthalimide-Derived N-Benzylpyridinium Halides Targeting Cholinesterases: Synthesis and Bioactivity of New Potential Anti-Alzheimer's Disease Agents. Archiv der Pharmazie. vol 349. issue 4. 2017-01-09. PMID:26898241. |
in order to develop potent dual-binding cholinesterase inhibitors as potential drugs for the treatment of alzheimer's disease, we designed and synthesized phthalimide-based acetylcholinesterase (ache) inhibitors (7) containing a substituted n-benzylpyridinium residue. |
2017-01-09 |
2023-08-13 |
Not clear |
| Yu Wang, Hao Wang, Hong-zhuan Che. AChE Inhibition-based Multi-target-directed Ligands, a Novel Pharmacological Approach for the Symptomatic and Disease-modifying Therapy of Alzheimer's Disease. Current neuropharmacology. vol 14. issue 4. 2016-12-30. PMID:26786145. |
ache inhibition-based multi-target-directed ligands, a novel pharmacological approach for the symptomatic and disease-modifying therapy of alzheimer's disease. |
2016-12-30 |
2023-08-13 |
Not clear |
| Jiajia Lin, Ling Huang, Jie Yu, Siying Xiang, Jialing Wang, Jinrong Zhang, Xiaojun Yan, Wei Cui, Shan He, Qinwen Wan. Fucoxanthin, a Marine Carotenoid, Reverses Scopolamine-Induced Cognitive Impairments in Mice and Inhibits Acetylcholinesterase in Vitro. Marine drugs. vol 14. issue 4. 2016-12-19. PMID:27023569. |
based on our current findings, we anticipate that fucoxanthin might exhibit great therapeutic efficacy for the treatment of alzheimer's disease by acting on multiple targets, including inhibiting ache and increasing bdnf expression. |
2016-12-19 |
2023-08-13 |
mouse |
| Shahid A Khan, Sher B Khan, Zarbad Shah, Abdullah M Asir. Withanolides: Biologically Active Constituents in the Treatment of Alzheimer's Disease. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 12. issue 3. 2016-12-13. PMID:26527154. |
acetyl cholinesterase (ache) and butyrylcholinesterase (bche) are two types of cholinesterase enzymes that have been identified in vertebrates that are responsible for alzheimer's disease and related dementia. |
2016-12-13 |
2023-08-13 |
Not clear |
| Ya Wang, Zheng Lai, Xi-Xi Li, Ri-Ming Yan, Zhi-Bin Zhang, Hui-Lin Yang, Du Zh. Isolation, diversity and acetylcholinesterase inhibitory activity of the culturable endophytic fungi harboured in Huperzia serrata from Jinggang Mountain, China. World journal of microbiology & biotechnology. vol 32. issue 2. 2016-11-03. PMID:26745980. |
our findings highlight that h. serrata grown in jinggang mountain harbors a rich and fascinating endophytic fungus community with potential ache inhibitory activity, which could further broaden the natural acetylcholinesterase inhibitors resources used for alzheimer's disease treatment. |
2016-11-03 |
2023-08-13 |
Not clear |
| Laís Flávia Nunes Lemes, Giselle de Andrade Ramos, Andressa Souza de Oliveira, Fernanda Motta R da Silva, Gina de Castro Couto, Marina da Silva Boni, Marcos Jorge R Guimarães, Isis Nem O Souza, Manuela Bartolini, Vincenza Andrisano, Patrícia Coelho do Nascimento Nogueira, Edilberto Rocha Silveira, Guilherme D Brand, Ondřej Soukup, Jan Korábečný, Nelilma C Romeiro, Newton G Castro, Maria Laura Bolognesi, Luiz Antonio Soares Romeir. Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease. European journal of medicinal chemistry. vol 108. 2016-10-17. PMID:26735910. |
cardanol-derived ache inhibitors: towards the development of dual binding derivatives for alzheimer's disease. |
2016-10-17 |
2023-08-13 |
human |
| Manuela E García, José L Borioni, Valeria Cavallaro, Marcelo Puiatti, Adriana B Pierini, Ana P Murray, Alicia B Peñéñor. Solanocapsine derivatives as potential inhibitors of acetylcholinesterase: Synthesis, molecular docking and biological studies. Steroids. vol 104. 2016-10-05. PMID:26362598. |
in this context, acetylcholinesterase (ache) inhibitors comprise one type of the compounds most actively studied in the search for an effective treatment of symptoms of alzheimer's disease. |
2016-10-05 |
2023-08-13 |
Not clear |
| Kadir Ozden Yerdelen, Mehmet Koca, Baris Anil, Handan Sevindik, Zeynep Kasap, Zekai Halici, Kubra Turkaydin, Gulsen Gunesaca. Synthesis of donepezil-based multifunctional agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry letters. vol 25. issue 23. 2016-10-05. PMID:26514744. |
amyloid beta (aβ) and cholinesterase enzymes (ache, buche) are important biological targets for the effective treatment of alzheimer's disease. |
2016-10-05 |
2023-08-13 |
Not clear |
| Nadia Khan, Ali Saad, Syed M Nurulain, Fouad H Darras, Michael Decker, Bassem Sade. The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats. Behavioural brain research. vol 297. 2016-09-20. PMID:26467607. |
therefore, dual-active h3r antagonists and ache inhibitors (acheis) have shown in several studies to hold promise to treat cognitive disorders like alzheimer's disease (ad). |
2016-09-20 |
2023-08-13 |
rat |
| Sudhakar Manda, Sadhana Sharma, Abubakar Wani, Prashant Joshi, Vikas Kumar, Santosh K Guru, Sonali S Bharate, Shashi Bhushan, Ram A Vishwakarma, Ajay Kumar, Sandip B Bharat. Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship. European journal of medicinal chemistry. vol 107. 2016-09-20. PMID:26560048. |
additionally, compounds 6a and 6f also showed inhibition of acetylcholinestease (ache), an enzyme responsible for neuronal loss in alzheimer's disease. |
2016-09-20 |
2023-08-13 |
human |
| Michael F Santillo, Yitong Li. A fluorescence assay for measuring acetylcholinesterase activity in rat blood and a human neuroblastoma cell line (SH-SY5Y). Journal of pharmacological and toxicological methods. vol 76. 2016-09-12. PMID:26165232. |
acetylcholinesterase (ache) is an enzyme responsible for metabolism of the neurotransmitter acetylcholine, and inhibition of ache can have therapeutic applications (e.g., drugs for alzheimer's disease) or neurotoxic consequences (e.g., pesticides). |
2016-09-12 |
2023-08-13 |
human |
| I Ayelen Ramallo, Mario O Salazar, Ricardo L E Furla. Thin Layer Chromatography-Autography-High Resolution Mass Spectrometry Analysis: Accelerating the Identification of Acetylcholinesterase Inhibitors. Phytochemical analysis : PCA. vol 26. issue 6. 2016-08-22. PMID:26102595. |
the prevailing treatment for alzheimer's disease is the use of acetylcholinesterase (ache) inhibitors. |
2016-08-22 |
2023-08-13 |
Not clear |
| Abdul Hameed, Syeda T Zehra, Syed J A Shah, Khalid M Khan, Rima D Alharthy, Norbert Furtmann, Jürgen Bajorath, Muhammad N Tahir, Jamshed Iqba. Syntheses, cholinesterases inhibition, and molecular docking studies of pyrido[2,3-b]pyrazine derivatives. Chemical biology & drug design. vol 86. issue 5. 2016-08-01. PMID:25951978. |
cholinesterases, acetylcholinesterase (ache) and butyrylcholinesterase (bche), have a role in cholinergic deficit which evidently leads to alzheimer's disease (ad). |
2016-08-01 |
2023-08-13 |
Not clear |
| Yao Chen, Yaoyao Bian, Yuan Sun, Chen Kang, Sheng Yu, Tingming Fu, Wei Li, Yuqiong Pei, Haopeng Su. Identification of 4-aminoquinoline core for the design of new cholinesterase inhibitors. PeerJ. vol 4. 2016-07-21. PMID:27441112. |
inhibition of acetylcholinesterase (ache) using small molecules is still one of the most successful therapeutic strategies in the treatment of alzheimer's disease (ad). |
2016-07-21 |
2023-08-13 |
Not clear |
| Tsuyoshi Sato, Yuichiro Enoki, Yasushi Sakamoto, Kazuhiro Yokota, Masahiko Okubo, Masahito Matsumoto, Naoki Hayashi, Michihiko Usui, Shoichiro Kokabu, Toshihide Mimura, Yoshihiko Nakazato, Nobuo Araki, Toru Fukuda, Yasushi Okazaki, Tatsuo Suda, Shu Takeda, Tetsuya Yod. Donepezil prevents RANK-induced bone loss via inhibition of osteoclast differentiation by downregulating acetylcholinesterase. Heliyon. vol 1. issue 1. 2016-07-21. PMID:27441211. |
donepezil, an inhibitor of acetylcholinesterase (ache) targeting the brain, is a common medication for alzheimer's disease. |
2016-07-21 |
2023-08-13 |
Not clear |
| Yong Li, Xiao-Xiao Zhang, Li-Juan Jiang, Li Yuan, Ting-Ting Cao, Xia Li, Lin Dong, Ying Li, Shu-Fan Yi. Inhibition of Acetylcholinesterase (AChE): A Potential Therapeutic Target to Treat Alzheimer's Disease. Chemical biology & drug design. vol 86. issue 4. 2016-07-20. PMID:25736722. |
inhibition of acetylcholinesterase (ache): a potential therapeutic target to treat alzheimer's disease. |
2016-07-20 |
2023-08-13 |
Not clear |
| An Zhou, Jianping Hu, Lirong Wang, Guochen Zhong, Jian Pan, Zeyu Wu, Ailing Hu. Combined 3D-QSAR, molecular docking, and molecular dynamics study of tacrine derivatives as potential acetylcholinesterase (AChE) inhibitors of Alzheimer's disease. Journal of molecular modeling. vol 21. issue 10. 2016-07-11. PMID:26438408. |
combined 3d-qsar, molecular docking, and molecular dynamics study of tacrine derivatives as potential acetylcholinesterase (ache) inhibitors of alzheimer's disease. |
2016-07-11 |
2023-08-13 |
Not clear |
| An Zhou, Jianping Hu, Lirong Wang, Guochen Zhong, Jian Pan, Zeyu Wu, Ailing Hu. Combined 3D-QSAR, molecular docking, and molecular dynamics study of tacrine derivatives as potential acetylcholinesterase (AChE) inhibitors of Alzheimer's disease. Journal of molecular modeling. vol 21. issue 10. 2016-07-11. PMID:26438408. |
acetylcholinesterase (ache) is one of the key targets of drugs for treating alzheimer's disease (ad). |
2016-07-11 |
2023-08-13 |
Not clear |