| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Rumyana Simeonova, Dimitrina Zheleva, Iva Valkova, Georgi Stavrakov, Irena Philipova, Mariyana Atanasova, Irini Doytchinov. A Novel Galantamine-Curcumin Hybrid as a Potential Multi-Target Agent against Neurodegenerative Disorders. Molecules (Basel, Switzerland). vol 26. issue 7. 2021-05-12. PMID:33806197. |
the acetylcholinesterase (ache) inhibitors are the main drugs for symptomatic treatment of neurodegenerative disorders like alzheimer's disease. |
2021-05-12 |
2023-08-13 |
mouse |
| Cüneyt Türkeş, Suleyman Akocak, Mesut Işık, Nebih Lolak, Parham Taslimi, Mustafa Durgun, İlhami Gülçin, Yakup Budak, Şükrü Beydemi. Novel inhibitors with sulfamethazine backbone: synthesis and biological study of multi-target cholinesterases and α-glucosidase inhibitors. Journal of biomolecular structure & dynamics. 2021-05-05. PMID:33950796. |
inhibition of metabolic enzymes such as cholinesterases (ches; acetylcholinesterase, ache and butyrylcholinesterase, bche) and α-glucosidase (α-gly) is one of the accepted approaches in the treatment of alzheimer's disease (ad) and diabetes mellitus (dm). |
2021-05-05 |
2023-08-13 |
Not clear |
| Yu Zhou, Yan Fu, Wanchao Yin, Jian Li, Wei Wang, Fang Bai, Shengtao Xu, Qi Gong, Tao Peng, Yu Hong, Dong Zhang, Dan Zhang, Qiufeng Liu, Yechun Xu, H Eric Xu, Haiyan Zhang, Hualiang Jiang, Hong Li. Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate. Journal of medicinal chemistry. vol 64. issue 4. 2021-05-04. PMID:33570950. |
the acetylcholinesterase (ache) inhibitors remain key therapeutic drugs for the treatment of alzheimer's disease (ad). |
2021-05-04 |
2023-08-13 |
Not clear |
| Eman Shawky, Samah M El Sohafy, Jean Paulo de Andrade, Warley de Souza Borge. Profiling of acetylcholinesterase inhibitory alkaloids from some Natural product research. vol 35. issue 5. 2021-05-03. PMID:30990078. |
profiling of acetylcholinesterase inhibitory alkaloids from some acetylcholinesterase (ache) inhibitors remain the class of drugs used for the treatment of alzheimer disease (ad). |
2021-05-03 |
2023-08-13 |
Not clear |
| Rongtian Lin, Shuwen Rao, Yanbing Li, Lei Zhang, Liyu Xu, Yepu He, Zhijun Liu, Heru Che. Conjugation of tacrine with genipin derivative not only enhances effects on AChE but also leads to autophagy against Alzheimer's disease. European journal of medicinal chemistry. vol 211. 2021-04-30. PMID:33338868. |
conjugation of tacrine with genipin derivative not only enhances effects on ache but also leads to autophagy against alzheimer's disease. |
2021-04-30 |
2023-08-13 |
Not clear |
| Jie Wu, Marco Pistolozzi, Siyu Liu, Wen Ta. Design, synthesis and biological evaluation of novel carbamates as potential inhibitors of acetylcholinesterase and butyrylcholinesterase. Bioorganic & medicinal chemistry. vol 28. issue 5. 2021-04-27. PMID:32008882. |
rivastigmine, a dual inhibitor of acetylcholinesterase (ache) and butyrylcholinesterase (bche), has been approved by u.s. food and drug administration to treat alzheimer's disease (ad) and parkinson's disease (pd) dementia. |
2021-04-27 |
2023-08-13 |
Not clear |
| Samaneh Zarei, Mohammad Shafiei, Maryam Firouzi, Loghman Firoozpour, Kouros Divsalar, Ali Asadipour, Tahmineh Akbarzadeh, Alireza Foroumad. Design, synthesis and biological assessment of new 1-benzyl-4-((4-oxoquinazolin-3(4 Heliyon. vol 7. issue 4. 2021-04-21. PMID:33869871. |
emerging of the dual acetylcholinesterase (ache)/butyrylcholinesterase (buche) inhibitors has increased for treating alzheimer disease. |
2021-04-21 |
2023-08-13 |
Not clear |
| Anas Shamsi, Saleha Anwar, Taj Mohammad, Mohamed F Alajmi, Afzal Hussain, Md Tabish Rehman, Gulam Mustafa Hasan, Asimul Islam, Md Imtaiyaz Hassa. MARK4 Inhibited by AChE Inhibitors, Donepezil and Rivastigmine Tartrate: Insights into Alzheimer's Disease Therapy. Biomolecules. vol 10. issue 5. 2021-04-02. PMID:32443670. |
mark4 inhibited by ache inhibitors, donepezil and rivastigmine tartrate: insights into alzheimer's disease therapy. |
2021-04-02 |
2023-08-13 |
Not clear |
| Soomaayeh Heysieattalab, Leila Sadegh. Effects of Delphinidin on Pathophysiological Signs of Nucleus Basalis of Meynert Lesioned Rats as Animal Model of Alzheimer Disease. Neurochemical research. vol 45. issue 7. 2021-03-29. PMID:32297026. |
alzheimer's disease (ad) is an advanced neurodegenerative disorder greatly accompanied by cognitive deficits, oxidative stress, inflammation, amyloid plaques deposition, and acetylcholinesterase (ache) hyper-activation. |
2021-03-29 |
2023-08-13 |
rat |
| Mary Nokuthula Sibanyoni, Sushil Kumar Chaudhary, Weiyang Chen, Hamid-Reza Adhami, Sandra Combrinck, Vinesh Maharaj, Daniela Schuster, Alvaro Viljoe. Isolation, in vitro evaluation and molecular docking of acetylcholinesterase inhibitors from South African Amaryllidaceae. Fitoterapia. vol 146. 2021-03-22. PMID:32479767. |
inhibition of acetylcholinesterase (ache) is considered a promising strategy for the treatment of alzheimer's disease (ad) and dementia. |
2021-03-22 |
2023-08-13 |
Not clear |
| Shu Liu, Minyan Dang, Yan Lei, Syed S Ahmad, Mohammad Khalid, Mohammad A Kamal, Li Che. Ajmalicine and its Analogues Against AChE and BuChE for the Management of Alzheimer's Disease: An Current pharmaceutical design. vol 26. issue 37. 2021-03-19. PMID:32264807. |
ajmalicine and its analogues against ache and buche for the management of alzheimer's disease: an alzheimer's disease (ad) is the most well-known reason for disability in persons aged greater than 65 years worldwide. |
2021-03-19 |
2023-08-13 |
Not clear |
| Samir F de A Cavalcante, Alessandro B C Simas, Marcos C Barcellos, Victor G M de Oliveira, Roberto B Sousa, Paulo A de M Cabral, Kamil Kuča, Tanos C C Franç. Acetylcholinesterase: The "Hub" for Neurodegenerative Diseases and Chemical Weapons Convention. Biomolecules. vol 10. issue 3. 2021-03-18. PMID:32155996. |
this article describes acetylcholinesterase (ache), an enzyme involved in parasympathetic neurotransmission, its activity, and how its inhibition can be pharmacologically useful for treating dementia, caused by alzheimer's disease, or as a warfare method due to the action of nerve agents. |
2021-03-18 |
2023-08-13 |
Not clear |
| Reza Yekta, Leila Sadeghi, Gholamreza Dehgha. The inefficacy of donepezil on glycated-AChE inhibition: Binding affinity, complex stability and mechanism. International journal of biological macromolecules. vol 160. 2021-03-17. PMID:32454110. |
donepezil (dpz) is a well-known drug for alzheimer's disease that inhibits acetylcholinesterase activity (ache). |
2021-03-17 |
2023-08-13 |
Not clear |
| Jovana Mišković, Maja Karaman, Milena Rašeta, Nenad Krsmanović, Sanja Berežni, Dragica Jakovljević, Federica Piattoni, Alessandra Zambonelli, Maria Letizia Gargano, Giuseppe Venturell. Comparison of Two Journal of fungi (Basel, Switzerland). vol 7. issue 2. 2021-03-16. PMID:33557141. |
comparison of two in recent years, fungi have been recognized as producers of acetylcholinesterase (ache) inhibitors, agents important for the prevention of alzheimer's disease (ad). |
2021-03-16 |
2023-08-13 |
Not clear |
| Thai-Son Tran, Minh-Tri Le, Thi-Cam-Vi Nguyen, The-Huan Tran, Thanh-Dao Tran, Khac-Minh Tha. Synthesis, In Silico and In Vitro Evaluation for Acetylcholinesterase and BACE-1 Inhibitory Activity of Some Molecules (Basel, Switzerland). vol 25. issue 17. 2021-03-12. PMID:32867308. |
synthesis, in silico and in vitro evaluation for acetylcholinesterase and bace-1 inhibitory activity of some acetylcholinesterase (ache) and beta-secretase (bace-1) are two attractive targets in the discovery of novel substances that could control multiple aspects of alzheimer's disease (ad). |
2021-03-12 |
2023-08-13 |
Not clear |
| Thai-Son Tran, Thanh-Dao Tran, The-Huan Tran, Thanh-Tan Mai, Ngoc-Le Nguyen, Khac-Minh Thai, Minh-Tri L. Synthesis, In Silico and In Vitro Evaluation of Some Flavone Derivatives for Acetylcholinesterase and BACE-1 Inhibitory Activity. Molecules (Basel, Switzerland). vol 25. issue 18. 2021-03-11. PMID:32899576. |
acetylcholinesterase (ache) and β-secretase (bace-1) have become attractive therapeutic targets for alzheimer's disease (ad). |
2021-03-11 |
2023-08-13 |
Not clear |
| Thai-Son Tran, Minh-Tri Le, Thanh-Dao Tran, The-Huan Tran, Khac-Minh Tha. Design of Curcumin and Flavonoid Derivatives with Acetylcholinesterase and Beta-Secretase Inhibitory Activities Using in Silico Approaches. Molecules (Basel, Switzerland). vol 25. issue 16. 2021-03-04. PMID:32785161. |
acetylcholinesterase (ache) and beta-secretase (bace-1) are the two crucial enzymes involved in the pathology of alzheimer's disease. |
2021-03-04 |
2023-08-13 |
Not clear |
| Fareeha Anwar, Uzma Saleem, Bashir Ahmad, Muhammad Ashraf, Atta Ur Rehman, Matheus Froeyen, Lee Yean Kee, Iskandar Abdullah, Muhammad Usman Mirza, Sarfraz Ahma. New naphthalene derivative for cost-effective AChE inhibitors for Alzheimer's treatment: In silico identification, in vitro and in vivo validation. Computational biology and chemistry. vol 89. 2021-02-08. PMID:33002716. |
new naphthalene derivative for cost-effective ache inhibitors for alzheimer's treatment: in silico identification, in vitro and in vivo validation. |
2021-02-08 |
2023-08-13 |
Not clear |
| Amira G Zaki, El-Sayed R El-Sayed, M Abd Elkodous, Gharieb S El-Sayya. Microbial acetylcholinesterase inhibitors for Alzheimer's therapy: recent trends on extraction, detection, irradiation-assisted production improvement and nano-structured drug delivery. Applied microbiology and biotechnology. vol 104. issue 11. 2021-02-01. PMID:32285176. |
key points: • ache inhibitors are potential therapies for alzheimer's disease. |
2021-02-01 |
2023-08-13 |
Not clear |
| Hiroshi Aoyama, Tomohiro Dour. Selective acetylcholinesterase inhibitors derived from muscle relaxant dantrolene. Bioorganic & medicinal chemistry letters. vol 30. issue 4. 2021-01-28. PMID:31901380. |
recently, it has been reported that dantrolene has a weak inhibitory effect on acetylcholinesterase (ache), which is a therapeutic drug target for alzheimer's disease. |
2021-01-28 |
2023-08-13 |
Not clear |