| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Motahareh Hassanzadeh, Farshid Hassanzadeh, Ghadam Ali Khodarahmi, Mahbobe Rostami, Fateme Azimi, Hamid Nadri, Farshad Homayouni Moghada. Design, synthesis, and bio-evaluation of new isoindoline-1,3-dione derivatives as possible inhibitors of acetylcholinesterase. Research in pharmaceutical sciences. vol 16. issue 5. 2021-09-16. PMID:34522196. |
a significant decrease in acetylcholine level in the brain is common in most patients with alzheimer's disease, therefore acetylcholinesterase (ache) inhibitors such as donepezil and rivastigmine are widely used for patients with limited therapeutic results and major side effects. |
2021-09-16 |
2023-08-13 |
Not clear |
| Boris Nemzer, Diganta Kalita, Nebiyu Abshir. Quantification of Major Bioactive Constituents, Antioxidant Activity, and Enzyme Inhibitory Effects of Whole Coffee Cherries ( Molecules (Basel, Switzerland). vol 26. issue 14. 2021-09-15. PMID:34299581. |
in this study we examined the potential antioxidant activity and enzyme inhibitory effects of whole coffee cherries (wcc) and their two extracts on α-amylase, α-glucosidase and acetylcholinesterase (ache) activities, which are targets for the control of diabetes and alzheimer's diseases. |
2021-09-15 |
2023-08-13 |
Not clear |
| Erma Fatiha Muhammad, Ashutosh Kumar, Habibah A Wahab, Kam Y J Zhan. Identification of 1,2,4-Triazolylthioethanone Scaffold for the Design of New Acetylcholinesterase Inhibitors. Molecular informatics. vol 40. issue 8. 2021-08-26. PMID:34060234. |
acetylcholinesterase (ache) inhibitors are the most effective drugs for alzheimer's disease treatment. |
2021-08-26 |
2023-08-13 |
Not clear |
| María-Ángeles Cortés-Gómez, Esther Llorens-Álvarez, Jordi Alom, Teodoro Del Ser, Jesús Avila, Javier Sáez-Valero, María-Salud García-Aylló. Tau phosphorylation by glycogen synthase kinase 3β modulates enzyme acetylcholinesterase expression. Journal of neurochemistry. vol 157. issue 6. 2021-08-24. PMID:32955735. |
in alzheimer's disease (ad), the enzyme acetylcholinesterase (ache) co-localizes with hyperphosphorylated tau (p-tau) within neurofibrillary tangles. |
2021-08-24 |
2023-08-13 |
mouse |
| Saravanan Kandasamy, Chitra Loganathan, Penislusshiyan Sakayanathan, Subramani Karthikeyan, Arputharaj David Stephen, Dinesh Kumar Marimuthu, Saravanan Ravichandran, Vignesh Sivalingam, Palvannan Thayumanava. In silico, theoretical biointerface analysis and in vitro kinetic analysis of amine compounds interaction with acetylcholinesterase and butyrylcholinesterase. International journal of biological macromolecules. vol 185. 2021-08-16. PMID:34216669. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) are considered important target for drug design against alzheimer's disease. |
2021-08-16 |
2023-08-13 |
Not clear |
| Mark J Millan, Anne Dekeyne, Alain Gobert, Mauricette Brocco, Clotilde Mannoury la Cour, Jean-Claude Ortuno, David Watson, Kevin C F Fon. Dual-acting agents for improving cognition and real-world function in Alzheimer's disease: Focus on 5-HT6 and D3 receptors as hubs. Neuropharmacology. vol 177. 2021-08-12. PMID:32525060. |
to date, there are no interventions that impede the inexorable progression of alzheimer's disease (ad), and currently-available drugs cholinesterase (ache) inhibitors and the n-methyl-d-aspartate receptor antagonist, memantine, offer only modest symptomatic benefit. |
2021-08-12 |
2023-08-13 |
Not clear |
| Fatima Y Adeowo, Murtala A Ejalonibu, Ahmed A Elrashedy, Monsurat M Lawal, Hezekiel M Kumal. Multi-target approach for Alzheimer's disease treatment: computational biomolecular modeling of cholinesterase enzymes with a novel 4- Journal of biomolecular structure & dynamics. vol 39. issue 11. 2021-08-11. PMID:33030113. |
multi-target approach for alzheimer's disease treatment: computational biomolecular modeling of cholinesterase enzymes with a novel 4- the identification of dual inhibitors targeting the active sites of the cholinesterase enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (buche), have lately surfaced as a multi-approach towards alzheimer treatment. |
2021-08-11 |
2023-08-13 |
Not clear |
| Giselle de Andrade Ramos, Andressa Souza de Oliveira, Manuela Bartolini, Marina Naldi, Irene Liparulo, Christian Bergamini, Elisa Uliassi, Ling Wu, Paul E Fraser, Monica Abreu, Alessandra Sofia Kiametis, Ricardo Gargano, Edilberto Rocha Silveira, Guilherme D Brand, Lukas Prchal, Ondřej Soukup, Jan Korábečný, Maria Laura Bolognesi, Luiz Antonio Soares Romeir. Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties. RSC medicinal chemistry. vol 12. issue 7. 2021-08-07. PMID:34355181. |
as part of our efforts to develop sustainable drugs for alzheimer's disease (ad), we have been focusing on the inexpensive and largely available cashew nut shell liquid (cnsl) as a starting material for the identification of new acetylcholinesterase (ache) inhibitors. |
2021-08-07 |
2023-08-13 |
Not clear |
| João P S Ferreira, Hélio M T Albuquerque, Susana M Cardoso, Artur M S Silva, Vera L M Silv. Dual-target compounds for Alzheimer's disease: Natural and synthetic AChE and BACE-1 dual-inhibitors and their structure-activity relationship (SAR). European journal of medicinal chemistry. vol 221. 2021-08-06. PMID:33984802. |
dual-target compounds for alzheimer's disease: natural and synthetic ache and bace-1 dual-inhibitors and their structure-activity relationship (sar). |
2021-08-06 |
2023-08-13 |
Not clear |
| Md Sahab Uddin, Abdullah Al Mamun, Md Tanvir Kabir, Ghulam Md Ashraf, May N Bin-Jumah, Mohamed M Abdel-Dai. Multi-Target Drug Candidates for Multifactorial Alzheimer's Disease: AChE and NMDAR as Molecular Targets. Molecular neurobiology. vol 58. issue 1. 2021-08-04. PMID:32935230. |
multi-target drug candidates for multifactorial alzheimer's disease: ache and nmdar as molecular targets. |
2021-08-04 |
2023-08-13 |
Not clear |
| Behnaz Moghadam, Mitra Ashouri, Hossein Roohi, Mohammad Hosein Karimi-Jafar. Computational evidence of new putative allosteric sites in the acetylcholinesterase receptor. Journal of molecular graphics & modelling. vol 107. 2021-08-03. PMID:34246109. |
acetylcholinesterase (ache), with a rigid structure and buried active site at the end of a deep narrow gorge, is interesting enough to solve the paradox between high catalytic activity and unavailability of the active site in treatment of alzheimer's disease (ad). |
2021-08-03 |
2023-08-13 |
Not clear |
| G Dhamodharan, C Gopi Moha. Machine learning models for predicting the activity of AChE and BACE1 dual inhibitors for the treatment of Alzheimer's disease. Molecular diversity. 2021-07-30. PMID:34327619. |
machine learning models for predicting the activity of ache and bace1 dual inhibitors for the treatment of alzheimer's disease. |
2021-07-30 |
2023-08-13 |
Not clear |
| Suleyman Akocak, Parham Taslimi, Nebih Lolak, Mesut Işık, Mustafa Durgun, Yakup Budak, Cüneyt Türkeş, İlhami Gülçin, Şükrü Beydemi. Synthesis, Characterization, and Inhibition Study of Novel Substituted Phenylureido Sulfaguanidine Derivatives as α-Glycosidase and Cholinesterase Inhibitors. Chemistry & biodiversity. vol 18. issue 4. 2021-07-26. PMID:33620128. |
in vitro and in silico inhibitory effects of the novel ureido-substituted sulfaguanidine derivatives were investigated by spectrophotometric methods for α-glycosidase (α-gly), acetylcholinesterase (ache), and butyrylcholinesterase (bche) enzymes associated with diabetes mellitus (dm) and alzheimer's disease (ad). |
2021-07-26 |
2023-08-13 |
Not clear |
| Toshiro Noshita, Kentaro Fujita, Takeru Koga, Hidekazu Ouchi, Akihiro Ta. Synthesis and biological activity of (±)-7,3',4'-trihydroxyhomoisoflavan and its analogs. Bioorganic & medicinal chemistry letters. vol 31. 2021-07-22. PMID:33161123. |
acetylcholinesterase (ache) inhibitors and neurite outgrowth promoters are thought to alleviate the symptoms of degenerative brain disorders, such as alzheimer's disease. |
2021-07-22 |
2023-08-13 |
Not clear |
| Nae-Won Kang, So-Yeon Yoon, Sungho Kim, Na-Young Yu, Ju-Hwan Park, Jae-Young Lee, Hyun-Jong Cho, Dae-Duk Ki. Subcutaneously Injectable Hyaluronic Acid Hydrogel for Sustained Release of Donepezil with Reduced Initial Burst Release: Effect of Hybridization of Microstructured Lipid Carriers and Albumin. Pharmaceutics. vol 13. issue 6. 2021-07-14. PMID:34208289. |
the daily oral administration of acetylcholinesterase (ache) inhibitors for alzheimer's disease features low patient compliance and can lead to low efficacy or high toxicity owing to irregular intake. |
2021-07-14 |
2023-08-13 |
human |
| Wansiri Innok, Asadhawut Hiranrat, Netnapa Chana, Thanyada Rungrotmongkol, Panita Kongsun. In silico and in vitro anti-AChE activity investigations of constituents from Mytragyna speciosa for Alzheimer's disease treatment. Journal of computer-aided molecular design. vol 35. issue 3. 2021-07-13. PMID:33439402. |
acetylcholinesterase (ache), one of the major therapeutic strategies for the treatment of alzheimer's disease (ad) is to increase the acetylcholine (ach) level in the brain by inhibiting the biological activity of ache. |
2021-07-13 |
2023-08-13 |
Not clear |
| Stephen A Adefegha, Bathlomew M Okeke, Ganiyu Obo. Antioxidant properties of eugenol, butylated hydroxylanisole, and butylated hydroxyl toluene with key biomolecules relevant to Alzheimer's diseases-In vitro. Journal of food biochemistry. vol 45. issue 3. 2021-07-08. PMID:32458455. |
this research work examined and likened effect of eugenol a natural phenolic compound with butylated hydroxylanisole (bha) and butylated hydroxyl toluene (bht) synthetic phenolic compounds with key biomolecules [acetylcholinesterase (ache), butyrylcholinesterase (bche), and monoamine oxidase (mao)] relevant to alzheimer's diseases (ad) in vitro. |
2021-07-08 |
2023-08-13 |
Not clear |
| Yanyu Wang, Yanping Zhao, Chaochun Wei, Nana Tian, Hong Ya. 4D-QSAR Molecular Modeling and Analysis of Flavonoid Derivatives as Acetylcholinesterase Inhibitors. Biological & pharmaceutical bulletin. vol 44. issue 7. 2021-07-01. PMID:34193695. |
flavonoids are potential strikingly natural compounds with antioxidant activity and acetylcholinesterase (ache) inhibitory activity for treating alzheimer's disease (ad). |
2021-07-01 |
2023-08-13 |
Not clear |
| Hongtao Du, Xinyu Jiang, Meng Ma, Huili Xu, Shuang Liu, Fang M. Novel deoxyvasicinone and tetrahydro-beta-carboline hybrids as inhibitors of acetylcholinesterase and amyloid beta aggregation. Bioorganic & medicinal chemistry letters. vol 30. issue 24. 2021-06-25. PMID:33137375. |
a novel series of deoxyvasicinone-tetrahydro-beta-carboline hybrids were synthesized and evaluated as acetylcholinesterase (ache) and β-amyloid peptide (aβ) aggregation inhibitors for the treatment of alzheimer's disease. |
2021-06-25 |
2023-08-13 |
Not clear |
| Phujinn Honorio, Supawadee Sainimnuan, Supa Hannongbua, Patchreenart Saparpakor. Binding interaction of protoberberine alkaloids against acetylcholinesterase (AChE) using molecular dynamics simulations and QM/MM calculations. Chemico-biological interactions. vol 344. 2021-06-25. PMID:34033838. |
acetylcholinesterase (ache) plays a vital role in alzheimer's disease (ad), which is one of the most common causes of dementia. |
2021-06-25 |
2023-08-13 |
Not clear |