| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mohan Gupta, Avinash Kumar, Chakrawarti Prasun, Maya S Nair, Suvarna G Kini, Divya Yadav, Sumitra Nai. Design, synthesis, extra-precision docking, and molecular dynamics simulation studies of pyrrolidin-2-one derivatives as potential acetylcholinesterase inhibitors. Journal of biomolecular structure & dynamics. 2022-08-03. PMID:35921217. |
inhibition of acetylcholinesterase (ache) has been widely explored to develop novel molecules for management of alzheimer's disease. |
2022-08-03 |
2023-08-14 |
Not clear |
| Yichuang Wu, Xiangdong Su, Jielang Lu, Meifang Wu, Seo Young Yang, Yang Mai, Wenbin Deng, Yongbo Xu. Frontiers in pharmacology. vol 13. 2022-07-28. PMID:35899116. |
current studies have found that butyrylcholinesterase (buche) replaces the biological function of acetylcholinesterase (ache) in the late stage of alzheimer's disease. |
2022-07-28 |
2023-08-14 |
Not clear |
| Selena P Maxwell, Meghan K Cash, Sultan Darves. Neuropathology and cholinesterase expression in the brains of octogenarians and older. Chemico-biological interactions. 2022-07-25. PMID:35872043. |
tissues from age- and sex-matched cnoo and alzheimer's disease (ad) rpfc and hippocampal formation were stained for β-amyloid (aβ), tau, α-synuclein, phosphorylated tar dna-binding protein 43 (ptdp-43), acetylcholinesterase (ache), and butyrylcholinesterase (bche). |
2022-07-25 |
2023-08-14 |
Not clear |
| Jing-Ling Tan, Yun-Ling Xu, Yi-Qin Fei, Guo-Hua Zheng, Xiao-Ping Din. Simultaneous screening, identification, quantitation, and activity evaluation of six acetylcholinesterase (AChE) inhibitors in Coptidis Rhizoma by online UPLC-DAD coupled with AChE biochemical detection. Journal of pharmaceutical and biomedical analysis. vol 219. 2022-07-03. PMID:35780528. |
acetylcholinesterase (ache) inhibition is a common treatment in the early stages of dementia and neurodegenerative diseases, including alzheimer's disease (ad). |
2022-07-03 |
2023-08-14 |
Not clear |
| Sidrah Tariq, Sadaf Mutahir, Muhammad Asim Khan, Zeeshan Mutahir, Safdar Hussain, Muhammad Ashraf, Xiaofang Bao, Baojing Zhou, Christian Bw Stark, Islam Ullah Kha. Synthesis, in vitro cholinesterase inhibition, molecular docking, DFT and ADME studies of novel 1,3,4-oxadiazole 2-thiol derivatives. Chemistry & biodiversity. 2022-06-29. PMID:35767725. |
a sequence of 1,3,4-oxadiazole 2-thiol derivatives bearing various alkyl or aryl moieties was designed, synthesized, and characterized by modern spectroscopic methods to yield 17 compounds ( 6a - 6q ) which were screened for acetylcholinesterase (ache) and butyrylcholinesterase (bche) enzymes in search of 'lead' compounds for the treatment of alzheimer disease (ad). |
2022-06-29 |
2023-08-14 |
Not clear |
| Trung Hai Nguyen, Phuong-Thao Tran, Ngoc Quynh Anh Pham, Van-Hai Hoang, Dinh Minh Hiep, Son Tung Ng. Identifying Possible AChE Inhibitors from Drug-like Molecules via Machine Learning and Experimental Studies. ACS omega. vol 7. issue 24. 2022-06-27. PMID:35755364. |
acetylcholinesterase (ache) is one of the most important drug targets for alzheimer's disease (ad) treatment. |
2022-06-27 |
2023-08-14 |
Not clear |
| Nancy D Asen, Rotimi E Aluk. Acetylcholinesterase and butyrylcholinesterase inhibitory activities of antioxidant peptides obtained from enzymatic pea protein hydrolysates and their ultrafiltration peptide fractions. Journal of food biochemistry. 2022-06-27. PMID:35758753. |
practical applications: alzheimer's disease (ad) has multiple pathological pathways in addition to the loss of acetylcholine (ach) catalyzed by acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2022-06-27 |
2023-08-14 |
Not clear |
| Grażyna Budryn, Iwona Majak, Joanna Grzelczyk, Dominik Szwajgier, Alejandro Rodríguez-Martínez, Horacio Pérez-Sánche. Hydroxybenzoic Acids as Acetylcholinesterase Inhibitors: Calorimetric and Docking Simulation Studies. Nutrients. vol 14. issue 12. 2022-06-24. PMID:35745206. |
one of the symptoms of alzheimer's disease (ad) is low acetylcholine level due to high acetylcholinesterase (ache) activity. |
2022-06-24 |
2023-08-14 |
Not clear |
| Katarina Komatović, Ana Matošević, Nataša Terzić-Jovanović, Suzana Žunec, Sandra Šegan, Mario Zlatović, Nikola Maraković, Anita Bosak, Dejan M Opsenic. 4-Aminoquinoline-Based Adamantanes as Potential Anticholinesterase Agents in Symptomatic Treatment of Alzheimer's Disease. Pharmaceutics. vol 14. issue 6. 2022-06-24. PMID:35745878. |
considering that acetylcholinesterase (ache) inhibition is the most important mode of action expected of a potential drug used for the treatment of symptoms of alzheimer's disease (ad), our previous pilot study of 4-aminoquinolines as potential human cholinesterase inhibitors was extended to twenty-two new structurally distinct 4-aminoquinolines bearing an adamantane moiety. |
2022-06-24 |
2023-08-14 |
human |
| Asaad Khalid, Mohnad Abdalla, Maria Saeed, Muhammad Nabeel Ghayur, Surya Kant Kalauni, Mohammed Albratty, Hassan A Alhazmi, Mohammed Ahmed Mesaik, Anwarul Hassan Gilani, Zaheer Ul-Ha. Sarcorucinine-D Inhibits Cholinesterases and Calcium Channels: Molecular Dynamics Simulation and In Vitro Mechanistic Investigations. Molecules (Basel, Switzerland). vol 27. issue 11. 2022-06-10. PMID:35684298. |
acetylcholinesterase (ache) inhibitors and calcium channel blockers are considered effective therapies for alzheimer's disease. |
2022-06-10 |
2023-08-14 |
Not clear |
| Quynh Mai Thai, T Ngoc Han Pham, Dinh Minh Hiep, Minh Quan Pham, Phuong-Thao Tran, Trung Hai Nguyen, Son Tung Ng. Searching for AChE inhibitors from natural compounds by using machine learning and atomistic simulations. Journal of molecular graphics & modelling. vol 115. 2022-06-06. PMID:35661591. |
acetylcholinesterase (ache) is one of the most important drug targets for alzheimer's disease treatment. |
2022-06-06 |
2023-08-14 |
Not clear |
| Iohanan Daniel García Marín, Raúl Horacio Camarillo López, Oscar Aurelio Martínez, Itzia Irene Padilla-Martínez, José Correa-Basurto, Martha Cecilia Rosales-Hernánde. New compounds from heterocyclic amines scaffold with multitarget inhibitory activity on Aβ aggregation, AChE, and BACE1 in the Alzheimer disease. PloS one. vol 17. issue 6. 2022-06-03. PMID:35657793. |
new compounds from heterocyclic amines scaffold with multitarget inhibitory activity on aβ aggregation, ache, and bace1 in the alzheimer disease. |
2022-06-03 |
2023-08-14 |
Not clear |
| Gabriel Rodrigues Coutinho Pereira, Lucas Machado Gonçalves, Bárbara de Azevedo Abrahim-Vieira, Joelma Freire De Mesquit. In silico analyses of acetylcholinesterase (AChE) and its genetic variants in interaction with the anti-Alzheimer drug Rivastigmine. Journal of cellular biochemistry. 2022-06-01. PMID:35644025. |
however, mutations in ache, which affect approximately 5% of the population, can modify protein structure and function, changing the individual response to alzheimer's treatment. |
2022-06-01 |
2023-08-13 |
Not clear |
| Mariyana Atanasova, Ivan Dimitrov, Stefan Ivanov, Borislav Georgiev, Strahil Berkov, Dimitrina Zheleva-Dimitrova, Irini Doytchinov. Virtual Screening and Hit Selection of Natural Compounds as Acetylcholinesterase Inhibitors. Molecules (Basel, Switzerland). vol 27. issue 10. 2022-05-28. PMID:35630613. |
acetylcholinesterase (ache) is one of the classical targets in the treatment of alzheimer's disease (ad). |
2022-05-28 |
2023-08-13 |
Not clear |
| Bui Thanh Tung, Ta Thi Thu Hang, Nguyen Bao Kim, Nguyen Hong Nhung, Vu Khanh Linh, Dang Kim Th. Molecular docking and molecular dynamics approach to identify potential compounds in Journal of complementary & integrative medicine. 2022-05-27. PMID:35621378. |
the enzyme acetylcholinesterase (ache), butyrylcholinesterase (buche), monoamine oxidase a (mao a), beta-secretase cleavage enzyme (bace 1) and n-methyl-d-aspartate (nmda) receptors play an important role in the pathogenesis of alzheimer's disease. |
2022-05-27 |
2023-08-13 |
Not clear |
| Ferah Comert Onder, Kader Sahin, Murat Senturk, Serdar Durdagi, Mehmet A. Identifying highly effective coumarin-based novel cholinesterase inhibitors by in silico and in vitro studies. Journal of molecular graphics & modelling. vol 115. 2022-05-27. PMID:35623143. |
inhibition of high cholinesterase levels including acetylcholinesterase (ache) and butyrylcholinesterase (bche), is one of the most important strategies for the treatment of alzheimer's disease (ad). |
2022-05-27 |
2023-08-13 |
Not clear |
| Ante Miličević, Goran Šink. Use of connectivity index and simple topological parameters for estimating the inhibition potency of acetylcholinesterase. Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society. vol 30. issue 4. 2022-05-09. PMID:35527825. |
acetylcholinesterase (ache) has proven to be an effective drug target in the treatment of neurodegenerative diseases such as alzheimer's, parkinson's and dementia. |
2022-05-09 |
2023-08-13 |
Not clear |
| b' Mehmet Koca, U\\xc4\\x9fur G\\xc3\\xbcller, P\\xc4\\xb1nar G\\xc3\\xbcller, Ziya Da\\xc4\\x9falan, Bilal Ni\\xc5\\x9fanc\\xc4\\xb. Design and Synthesis of Novel Dual Cholinesterase Inhibitors: In Vitro Inhibition Studies Supported with Molecular Docking. Chemistry & biodiversity. 2022-04-26. PMID:35470963.' |
the major cholinesterase enzymes, acetylcholinesterase (ache) and butyrylcholinesterase (bche), are important in the therapy of alzheimer's disease (ad) based on the cholinergic hypothesis. |
2022-04-26 |
2023-08-13 |
human |
| Pavan Kumar Chintamaneni, Praveen Thaggikuppe Krishnamurthy, Sai Kiran S S Pindiprol. Polysorbate-80 surface modified nano-stearylamine BQCA conjugate for the management of Alzheimer's disease. RSC advances. vol 11. issue 10. 2022-04-15. PMID:35423107. |
acetylcholinesterase (ache) inhibitors such as donepezil, galantamine and rivastigmine are used for the management of dementia in alzheimer's disease (ad). |
2022-04-15 |
2023-08-13 |
Not clear |
| Cai-Hong Li, Wei-Feng Wang, Nsanzamahoro Stanislas, Jun-Li Yan. Facile preparation of fluorescent water-soluble non-conjugated polymer dots and fabricating an acetylcholinesterase biosensor. RSC advances. vol 12. issue 13. 2022-04-15. PMID:35424765. |
acetylcholinesterase (ache) has been demonstrated as a crucial enzyme in the development and treatment of alzheimer's disease (ad). |
2022-04-15 |
2023-08-13 |
Not clear |