| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fatima Javed Mirza, Saadia Zahid, Sanila Amber, Sumera, Hira Jabeen, Noreen Asim, Syed Adnan Ali Sha. Multitargeted Molecular Docking and Dynamic Simulation Studies of Bioactive Compounds from Molecules (Basel, Switzerland). vol 27. issue 21. 2022-11-11. PMID:36364071. |
multitargeted molecular docking and dynamic simulation studies of bioactive compounds from alzheimer's disease (ad) has been associated with the hallmark features of cholinergic dysfunction, amyloid beta (aβ) aggregation and impaired synaptic transmission, which makes the associated proteins, such as β-site amyloid precursor protein cleaving enzyme 1 (bace i), acetylcholine esterase (ache) and synapsin i, ii and iii, major targets for therapeutic intervention. |
2022-11-11 |
2023-08-14 |
Not clear |
| Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Neelam Sharma, Sumeet Gupta, Mohammed Albratty, Asim Najmi, Hassan A Alhazmi, Simona Bunga. AChE as a Spark in the Alzheimer's Blaze - Antagonizing Effect of a Cyclized Variant. Ageing research reviews. 2022-11-11. PMID:36368649. |
ache as a spark in the alzheimer's blaze - antagonizing effect of a cyclized variant. |
2022-11-11 |
2023-08-14 |
Not clear |
| Nancy D Asen, Ogadimma D Okagu, Chibuike C Udenigwe, Rotimi E Aluk. Frontiers in nutrition. vol 9. 2022-11-07. PMID:36337665. |
compounds with structural similarities to the neurotransmitter (acetylcholine) are mostly used to inhibit the activity of acetylcholinesterase (ache) in alzheimer's disease (ad) therapy. |
2022-11-07 |
2023-08-14 |
Not clear |
| Nguyen Huy Hung, Pham Minh Quan, Prabodh Satyal, Do Ngoc Dai, Vo Van Hoa, Ngo Gia Huy, Le Duc Giang, Nguyen Thi Ha, Le Thi Huong, Vu Thi Hien, William N Setze. Acetylcholinesterase Inhibitory Activities of Essential Oils from Vietnamese Traditional Medicinal Plants. Molecules (Basel, Switzerland). vol 27. issue 20. 2022-10-27. PMID:36296686. |
furthermore, they are also of interest as aromatherapeutic agents in the treatment of alzheimer's disease, and inhibition of the enzyme acetylcholinesterase (ache) has been evaluated as an important mechanism. |
2022-10-27 |
2023-08-14 |
human |
| Ana Matošević, Anamarija Knežević, Antonio Zandona, Nikola Maraković, Zrinka Kovarik, Anita Bosa. Design, Synthesis and Biological Evaluation of Biscarbamates as Potential Selective Butyrylcholinesterase Inhibitors for the Treatment of Alzheimer's Disease. Pharmaceuticals (Basel, Switzerland). vol 15. issue 10. 2022-10-27. PMID:36297332. |
as butyrylcholinesterase (bche) plays a role in the progression of symptoms and pathophysiology of alzheimer's disease (ad), selective inhibition of bche over acetylcholinesterase (ache) can represent a promising pathway in treating ad. |
2022-10-27 |
2023-08-14 |
Not clear |
| Phujinn Honorio, Supa Hannongbua, Patchreenart Saparpakor. Roles of hybrid donepezil scaffolds as potent human acetylcholinesterase inhibitors using in silico interaction analysis, drug-likeness, and pharmacokinetics prediction. Chemico-biological interactions. 2022-10-27. PMID:36302488. |
acetylcholinesterase (ache) is currently one of the potent targets for the treatment of alzheimer's disease (ad). |
2022-10-27 |
2023-08-14 |
human |
| Ilkay Erdogan Orhan, F Sezer Senol Deniz, Ramin Ekhteiari Salmas, Sule Irmak, Ozden Ozgun Acar, Gurbet Celik Turgut, Alaattin Sen, Ana-Maria Zbancioc, Simon Vlad Luca, Adrianna Skiba, Krystyna Skalicka Wozniak, Gabriela Tataring. Evaluation of anti-Alzheimer activity of synthetic coumarins by combination of in vitro and in silico approaches. Chemistry & biodiversity. 2022-10-25. PMID:36282001. |
series of synthetic coumarin derivatives (1-16) were tested against acetylcholinesterase (ache) and butyrylcholinesterase (bche), two enzymes linked to the pathology of alzheimer's disease (ad). |
2022-10-25 |
2023-08-14 |
human |
| Mohammad Golam Sabbir, Robert C Speth, Benedict C Albens. Loss of Cholinergic Receptor Muscarinic 1 (CHRM1) Protein in the Hippocampus and Temporal Cortex of a Subset of Individuals with Alzheimer's Disease, Parkinson's Disease, or Frontotemporal Dementia: Implications for Patient Survival. Journal of Alzheimer's disease : JAD. 2022-09-26. PMID:36155524. |
dysfunction of cholinergic neurotransmission is a hallmark of alzheimer's disease (ad); forming the basis for using acetylcholine (ach) esterase (ache) inhibitors to mitigate symptoms of ach deficiency in ad. |
2022-09-26 |
2023-08-14 |
Not clear |
| Nebih Lolak, Süleyman Akocak, Mustafa Durgun, Hatice Esra Duran, Adem Necip, Cüneyt Türkeş, Mesut Işık, Şükrü Beydemi. Novel bis-ureido-substituted sulfaguanidines and sulfisoxazoles as carbonic anhydrase and acetylcholinesterase inhibitors. Molecular diversity. 2022-09-22. PMID:36136229. |
to discover alternative substances to compounds used to treat many diseases, especially treating alzheimer's disease (ad) and parkinson's disease targeting carbonic anhydrase (hca) and acetylcholinesterase (ache) enzymes, is important. |
2022-09-22 |
2023-08-14 |
Not clear |
| Muslum Gok, Nimrod Madrer, Tamara Zorbaz, Estelle R Bennett, David Greenberg, David A Bennett, Hermona Sore. Altered levels of variant cholinesterase transcripts contribute to the imbalanced cholinergic signaling in Alzheimer's and Parkinson's disease. Frontiers in molecular neuroscience. vol 15. 2022-09-19. PMID:36117917. |
acetylcholinesterase and butyrylcholinesterase (ache and bche) are involved in modulating cholinergic signaling, but their roles in alzheimer's and parkinson's diseases (ad and pd) remain unclear. |
2022-09-19 |
2023-08-14 |
Not clear |
| Hafiz Muhammad Abdullah Asif, Shagufta Kamal, Aziz-Ur Rehman, Shahid Rasool, Muhammad Sajid Hamid Akas. Synthesis, Characterization, and Enzyme Inhibition Properties of 1,2,4-Triazole Bearing Azinane Analogues. ACS omega. vol 7. issue 36. 2022-09-19. PMID:36119993. |
considering the importance of acetylcholine esterase (ache, bche) and α-glucosidase in the treatment of alzheimer's disease and diabetes mellitus, the synthesis of novel azinane triazole-based derivatives as effective acetylcholinesterase (ache), α-glucosidase, urease, lipoxygenase (lox), and butyrylcholinesterase (bche) inhibitors is described. |
2022-09-19 |
2023-08-14 |
Not clear |
| Şevval Karaca, Derya Osmaniye, Begum Nurpelin Sağlık, Serkan Levent, Sinem Ilgın, Yusuf Özkay, Ahmet Çağrı Karaburun, Zafer Asım Kaplancıklı, Nalan Gundogdu-Karaburu. Synthesis of novel benzothiazole derivatives and investigation of their enzyme inhibitory effects against Alzheimer's disease. RSC advances. vol 12. issue 36. 2022-09-12. PMID:36090440. |
the use of dual acetylcholinesterase (ache)-monoamine oxidase b (mao-b) inhibitors is a new approach in the treatment of alzheimer disease (ad). |
2022-09-12 |
2023-08-14 |
Not clear |
| Philipp Spatz, Thomas Zimmermann, Sophie Steinmüller, Julian Hofmann, Tangui Maurice, Michael Decke. Novel benzimidazole-based pseudo-irreversible butyrylcholinesterase inhibitors with neuroprotective activity in an Alzheimer's disease mouse model. RSC medicinal chemistry. vol 13. issue 8. 2022-09-12. PMID:36092149. |
as levels of acetylcholinesterase (ache) decrease while levels of butyrylcholinesterase (bche) increase in later stages of alzheimer's disease (ad), bche stands out as a promising target for treatment of ad. |
2022-09-12 |
2023-08-14 |
mouse |
| Hormoz Pourtaher, Alireza Hasaninejad, Aida Iraj. Design, synthesis, in silico and biological evaluations of novel polysubstituted pyrroles as selective acetylcholinesterase inhibitors against Alzheimer's disease. Scientific reports. vol 12. issue 1. 2022-09-08. PMID:36075926. |
the objective of this study was to design new polysubstituted pyrrole derivatives as selective acetylcholinesterase (ache) inhibitors to target alzheimer's disease. |
2022-09-08 |
2023-08-14 |
Not clear |
| Xian Zhang, Dan Luo, You-Wei Zheng, Xiao-Qiong Li, Juan Song, Wei-Wei Zhao, Hong-Yuan Chen, Jing-Juan X. Translocation of Specific DNA Nanocarrier through an Ultrasmall Nanopipette: Toward Single-Protein-Molecule Detection with Superior Signal-to-Noise Ratio. ACS nano. 2022-09-01. PMID:36047811. |
the kinetic interaction between tdn-apt and ache was studied and the practical applicability of the as-developed spmd toward real samples was validated using serum samples from patients with alzheimer's disease. |
2022-09-01 |
2023-08-14 |
Not clear |
| Saikat Mitra, Maniza Muni, Nusrat Jahan Shawon, Rajib Das, Talha Bin Emran, Rohit Sharma, Deepak Chandran, Fahadul Islam, Md Jamal Hossain, Sher Zaman Safi, Sherouk Hussein Sweila. Tacrine Derivatives in Neurological Disorders: Focus on Molecular Mechanisms and Neurotherapeutic Potential. Oxidative medicine and cellular longevity. vol 2022. 2022-08-29. PMID:36035218. |
tacrine is a drug used in the treatment of alzheimer's disease as a cognitive enhancer and inhibitor of the enzyme acetylcholinesterase (ache). |
2022-08-29 |
2023-08-14 |
Not clear |
| Robert R Redman, Harry Mackenzie, Kosala N Dissanayake, Michael Eddleston, Richard R Ribcheste. DONEPEZIL INHIBITS NEUROMUSCULAR JUNCTIONAL ACETYLCHOLINESTERASE AND ENHANCES SYNAPTIC TRANSMISSION AND FUNCTION IN ISOLATED SKELETAL MUSCLE. British journal of pharmacology. 2022-08-26. PMID:36028305. |
donepezil, a piperidine antagonist of acetylcholinesterase (ache) prescribed for treatment of alzheimer's disease, has adverse neuromuscular effects in humans, including requirement for higher concentrations of non-depolarising neuromuscular blockers during surgery. |
2022-08-26 |
2023-08-14 |
mouse |
| Jie Guo, Maojun Cheng, Peng Liu, Duanyuan Cao, Jinchong Luo, Yang Wan, Yuanying Fang, Yi Jin, Sai-Sai Xie, Jing Li. A multi-target directed ligands strategy for the treatment of Alzheimer's disease: Dimethyl fumarate plus Tranilast modified Dithiocarbate as AChE inhibitor and Nrf2 activator. European journal of medicinal chemistry. vol 242. 2022-08-20. PMID:35987018. |
a multi-target directed ligands strategy for the treatment of alzheimer's disease: dimethyl fumarate plus tranilast modified dithiocarbate as ache inhibitor and nrf2 activator. |
2022-08-20 |
2023-08-14 |
Not clear |
| Remya R S, N Ramalakshmi, Nalini C N, Niraimathi V, Amuthalakshmi . Design synthesis and In vitro evaluation of Tacrine- Flavone hybrids as Multifunctional Cholinesterase inhibitors for Alzheimer's disease. Current computer-aided drug design. 2022-08-05. PMID:35927818. |
alzheimer's disease(ad) is a multifactorial neurodegenerative disorder.the multifactorial etiology of ad have led to the design of multitarget directed ligands(mtdl) for ad.tacrine an acetylcholinesterase(ache) inhibitor was the first fda approved drug for ad but is discontinued due to hepatotoxicity. |
2022-08-05 |
2023-08-14 |
Not clear |
| Marco Paolino, Mariagrazia Rullo, Samuele Maramai, Modesto de Candia, Leonardo Pisani, Marco Catto, Claudia Mugnaini, Antonella Brizzi, Andrea Cappelli, Massimo Olivucci, Federico Corelli, Cosimo D Altomar. Design, synthesis and biological evaluation of light-driven on-off multitarget AChE and MAO-B inhibitors. RSC medicinal chemistry. vol 13. issue 7. 2022-08-04. PMID:35923722. |
to this aim, we designed and synthesized a small library of cinnamic acid-inspired isomeric compounds with light modulated activity able to inhibit acetylcholinesterase (ache) and monoamine oxidase b (mao-b), with remarkable selectivity over butyrylcholinesterase (bche) and mao-a, which have been investigated as the enzyme targets related to alzheimer's disease (ad). |
2022-08-04 |
2023-08-14 |
Not clear |