| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Pratibha Sharma, Varinder Singh, Manjinder Sing. N-methylpiperazinyl and piperdinylalkyl-O-chalcone derivatives as potential polyfunctional agents against Alzheimer's disease: Design, synthesis and biological evaluation. Chemical biology & drug design. 2023-08-20. PMID:37599098. |
the series of n-methylpiperazinyl and piperdinylalkyl-o-chalcone derivatives as potential polyfuctional agents against alzheimer's disease that have been designed, synthesized and then evaluated biologically using in vitro assays for the inhibition of acetylcholinesterase (ache) activity, ages, and free radical formation. |
2023-08-20 |
2023-09-07 |
Not clear |
| Urvi Budhbhatti, Chaitanya Joshi, Ajay Chauhan, Deeptiben Bhatt, Chirag Parmar, Vishalbhai Damani, Amrutlal Pate. Association of NOTCH4 and ACHE gene polymorphism in Alzheimer's disease of Gujarat cohort. Neuroscience letters. 2023-08-06. PMID:37544578. |
association of notch4 and ache gene polymorphism in alzheimer's disease of gujarat cohort. |
2023-08-06 |
2023-08-14 |
Not clear |
| Xu-Fei Chen, Shan-Shan Li, Yu-Jun Bai, Ze-Feng Zhao, Ya-Jun Bai, Gu Gong, Xi-Rui He, Xiao-Hui Zhen. Design and synthesis of ligustrazine derivatives as potential anti-Alzheimer's agents. Natural product research. 2023-07-28. PMID:37505222. |
a novel series of ligustrazine derivatives was designed, synthesized, and evaluated as acetylcholinesterase (ache) and butylcholinesterase (buche) inhibitors for the treatment of alzheimer's disease (ad). |
2023-07-28 |
2023-08-14 |
Not clear |
| Victoria Richmond, Bruno N Falcone, Marta S Maier, Pau Arroyo Máñe. Putting the Puzzle Together To Get the Whole Picture: Molecular Basis of the Affinity of Two Steroid Derivatives to Acetylcholinesterase. ACS omega. vol 8. issue 28. 2023-07-24. PMID:37483177. |
alzheimer's disease (ad) is a progressive neurodegenerative disorder that has no cure because its etiology is still unknown, and its main treatment is the administration of acetylcholinesterase (ache) inhibitors. |
2023-07-24 |
2023-08-14 |
Not clear |
| Sowmya Andole, Husna Sd, Srija Sudhula, Lavanya Vislavath, Hemanth Kumar Boyina, Kiran Gangarapu, Vasudha Bakshi, Krishna Prasad Devarakond. 3D QSAR based Virtual Screening of Flavonoids as Acetylcholinesterase Inhibitors. Advances in experimental medicine and biology. vol 1424. 2023-07-24. PMID:37486499. |
in an attempt to develop therapeutic agents to treat alzheimer's disease, a series of flavonoid analogues were collected, which already had established acetylcholinesterase (ache) enzyme inhibition activity. |
2023-07-24 |
2023-08-14 |
Not clear |
| Yan-Jun Li, Cai-Cai Liang, Ling Jin, Juan Che. Inhibition mechanisms of four ellagitannins from terminalia chebula fruits on acetylcholinesterase by inhibition kinetics, spectroscopy and molecular docking analyses. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. vol 302. 2023-07-15. PMID:37453379. |
acetylcholinesterase (ache) is an important therapeutic target for the treatment of alzheimer's disease (ad), and the development of natural ache inhibitors as candidates has played a significant role in drug discovery. |
2023-07-15 |
2023-08-14 |
Not clear |
| Ana Matošević, Dejan M Opsenica, Marta Spasić, Nikola Maraković, Antonio Zandona, Suzana Žunec, Marija Bartolić, Zrinka Kovarik, Anita Bosa. Evaluation of 4-aminoquinoline derivatives with an n-octylamino spacer as potential multi-targeting ligands for the treatment of Alzheimer's disease. Chemico-biological interactions. 2023-07-05. PMID:37406982. |
the most successful therapeutic strategy in the treatment of alzheimer's disease (ad) is directed toward increasing levels of the neurotransmitter acetylcholine (ach) by inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes responsible for its hydrolysis. |
2023-07-05 |
2023-08-14 |
human |
| Ana Paula Murray, Brunella Biscussi, Valeria Cavallaro, Martina Donozo, Silvana A Rodrigue. Naturally Occurring Cholinesterase Inhibitors from Plants, Fungi, Algae, and Animals: A Review of the Most Effective Inhibitors Reported in 2012-2022. Current neuropharmacology. 2023-06-26. PMID:37357520. |
since the development of the "cholinergic hypothesis" as an important therapeutic approach in the treatment of alzheimer's disease (ad), the scientific community has made a remarkable effort to discover new and effective molecules with the ability to inhibit the enzyme acetylcholinesterase (ache). |
2023-06-26 |
2023-08-14 |
Not clear |
| Iman Touati, Mohnad Abdalla, Naif H Ali, Raed AlRuwaili, Mubarak Alruwaili, Mohammed Reda Britel, Amal Maurad. Constituents of Stachys plants as potential dual inhibitors of AChE and NMDAR for the treatment of Alzheimer's disease: a molecular docking and dynamic simulation study. Journal of biomolecular structure & dynamics. 2023-06-16. PMID:37325873. |
constituents of stachys plants as potential dual inhibitors of ache and nmdar for the treatment of alzheimer's disease: a molecular docking and dynamic simulation study. |
2023-06-16 |
2023-08-14 |
Not clear |
| Dileshwar Kumar, Sukesh Narayan Sinha, Sangaraju Rajendra, Kanika Sharm. Assessing farmer's exposure to pesticides and the risk for non-communicable diseases: A biomonitoring study. The Science of the total environment. 2023-05-28. PMID:37245816. |
the ache levels were significantly lower in exposed samples than in controls (p < 0.001), which is considered to be an effect of long-term pesticide exposure, and is the cause of alzheimer's disease (p < 0.001), parkinson's disease (p < 0.001), and obesity (p < 0.05). |
2023-05-28 |
2023-08-14 |
human |
| Pratap G Kenchappa, Yalpi Karthik, Poornima D Vijendra, Raghavendra L S Hallur, Ajay S Khandagale, Ashok K Pandurangan, Sathisha G Jayanna, Mohammed Ali Alshehri, Abdulrahman Alasmari, Samy Sayed, Manjula Shantaram, Muntazir Mushta. Frontiers in pharmacology. vol 14. 2023-05-26. PMID:37234712. |
alzheimer's disease (ad) is a type of neurodegenerative disease, associated with the hastening of ros, acetylcholinesterase (ache) activity, and amyloid β peptides plaques in the brain. |
2023-05-26 |
2023-08-14 |
Not clear |
| Fatemeh Pishgouii, Safa Lotfi, Ebrahim Sedaghat. Anti-AChE and Anti-BuChE Screening of the Fermentation Broth Extracts from Twelve Aspergillus Isolates and GC-MS and Molecular Docking Studies of the Most Active Extracts. Applied biochemistry and biotechnology. 2023-05-02. PMID:37129742. |
nowadays, the administration of cholinesterase enzyme (acetylcholinesterase: ache and butyrylcholinesterase: buche) inhibitors is very common for the symptomatic treatment of alzheimer's disease and the other forms of dementia and cns disorders. |
2023-05-02 |
2023-08-14 |
Not clear |
| Le-Quang Bao, Daniel Baecker, Do Thi Mai Dung, Nguyen Phuong Nhung, Nguyen Thi Thuan, Phuong Linh Nguyen, Phan Thi Phuong Dung, Tran Thi Lan Huong, Bakhtiyor Rasulev, Gerardo M Casanola-Martin, Nguyen-Hai Nam, Hai Pham-Th. Development of Activity Rules and Chemical Fragment Design for In Silico Discovery of AChE and BACE1 Dual Inhibitors against Alzheimer's Disease. Molecules (Basel, Switzerland). vol 28. issue 8. 2023-04-28. PMID:37110831. |
development of activity rules and chemical fragment design for in silico discovery of ache and bace1 dual inhibitors against alzheimer's disease. |
2023-04-28 |
2023-08-14 |
Not clear |
| Emilio Mateev, Magdalena Kondeva-Burdina, Maya Georgieva, Alexander Zlatko. Repurposing of FDA-approved drugs as dual-acting MAO-B and AChE inhibitors against Alzheimer's disease: An in silico and in vitro study. Journal of molecular graphics & modelling. vol 122. 2023-04-23. PMID:37087882. |
repurposing of fda-approved drugs as dual-acting mao-b and ache inhibitors against alzheimer's disease: an in silico and in vitro study. |
2023-04-23 |
2023-08-14 |
Not clear |
| Mengli Zhang, Cui Wang, Yongqi Wang, Feng Li, Dangqiang Zh. Visual evaluation of acetylcholinesterase inhibition by an easy-to-operate assay based on N-doped carbon nanozyme with high stability and oxidase-like activity. Journal of materials chemistry. B. 2023-04-17. PMID:37067450. |
acetylcholinesterase (ache) is the key enzyme associated with neurotransmission, and thus many drugs have been explored for their inhibitory effect on ache, such as donepezil for alzheimer's disease and organophosphorus pesticides (ops). |
2023-04-17 |
2023-08-14 |
Not clear |
| Qazi Mohammad Sajid Jamal, Mohammad Imran Khan, Ali H Alharbi, Varish Ahmad, Brijesh Singh Yada. Identification of Natural Compounds of the Apple as Inhibitors against Cholinesterase for the Treatment of Alzheimer's Disease: An In Silico Molecular Docking Simulation and ADMET Study. Nutrients. vol 15. issue 7. 2023-04-13. PMID:37049419. |
the key enzymes involved in alzheimer's disease pathways are acetylcholinesterase (ache) and butyrylcholinesterase (buche). |
2023-04-13 |
2023-08-14 |
Not clear |
| Tuan Xu, Shuaizhang Li, Andrew J Li, Jinghua Zhao, Srilatha Sakamuru, Wenwei Huang, Menghang Xia, Ruili Huan. Identification of Potent and Selective Acetylcholinesterase/Butyrylcholinesterase Inhibitors by Virtual Screening. Journal of chemical information and modeling. 2023-04-03. PMID:37011147. |
acetylcholinesterase (ache) and butyrylcholinesterase (bche) play important roles in human neurodegenerative disorders such as alzheimer's disease. |
2023-04-03 |
2023-08-14 |
human |
| Aman Thakur, Bhanu Sharma, Arun Parashar, Vivek Sharma, Ajay Kumar, Vineet Meht. 2D-QSAR, molecular docking and MD simulation based virtual screening of the herbal molecules against Alzheimer's disorder: an approach to predict CNS activity. Journal of biomolecular structure & dynamics. 2023-03-27. PMID:36970779. |
acetylcholinesterase (ache) is one of the key enzyme targets that have been used clinically for the management of alzheimer's disorder (ad). |
2023-03-27 |
2023-08-14 |
Not clear |
| Seyyed Majid Bagheri, Mohammad Allahtavakoli, Alireza Morad. Acetylcholinesterase inhibitory activity of Ferula plants and their potential for treatment of Alzheimer's disease. Journal of complementary & integrative medicine. 2023-03-01. PMID:36857494. |
one of the current strategies in the treatment of alzheimer's disease is using drugs with acetylcholinesterase (ache) inhibitory property. |
2023-03-01 |
2023-08-14 |
Not clear |
| Zhiyang Zhang, Jianwu Lv, Yu Wang, Hongli Yu, Baolin Guo, Jihang Zhai, Chaojie Wang, Yuan Zhao, Fangfang Fan, Wen Lu. Static Binding and Dynamic Transporting-Based Design of Specific Ring-Chain-Ring Acetylcholinesterase Inhibitor: From Galantamine to Natural Product. Chemistry (Weinheim an der Bergstrasse, Germany). 2023-02-24. PMID:36826395. |
acetylcholinesterase (ache) is a key target for the current symptomatic treatment of alzheimer's disease, and galantamine is a clinical anticholinesterase drug with transiently acting characteristic and good selectivity for ache. the present theoretical-experimental work improves the drug's residence time without reducing inhibition effect, thus provides crucial breakthrough for modifying the inhibitor of ache with better-kinetic behavior. |
2023-02-24 |
2023-08-14 |
Not clear |