| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bhuvaneswari Sivaraman, Vijaykumar R, Bala Aakash Velmurugan, Ramalakshmi Nataraja. Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease. CNS & neurological disorders drug targets. 2021-11-23. PMID:34602041. |
recent findings involved the inhibition of ache that could aid in the treatment of alzheimer's. |
2021-11-23 |
2023-08-13 |
Not clear |
| Bhuvaneswari Sivaraman, Vijaykumar R, Bala Aakash Velmurugan, Ramalakshmi Nataraja. Acetylcholinesterase Enzyme Inhibitor Molecules with Therapeutic Potential for Alzheimer's Disease. CNS & neurological disorders drug targets. 2021-11-23. PMID:34602041. |
these novel compounds may assist the future perspectives in the discovery of novel moieties against alzheimer's disease by the inhibition of ache. |
2021-11-23 |
2023-08-13 |
Not clear |
| Fanny C F Ip, Guangmiao Fu, Fengzhi Yang, Fangyuan Kang, Peiran Sun, Choi Ying Ling, Kit Cheung, Fangzhou Xie, Yueqing Hu, Lei Fu, Nancy Y I. A tacrine-tetrahydroquinoline heterodimer potently inhibits acetylcholinesterase activity and enhances neurotransmission in mice. European journal of medicinal chemistry. vol 226. 2021-11-22. PMID:34530383. |
acetylcholinesterase (ache) inhibitors have been used to improve cholinergic transmission in the brain for two decades and have proven effective for alleviating symptoms in the early stages of alzheimer's disease. |
2021-11-22 |
2023-08-13 |
mouse |
| Maria I Lazarova, Daniela S Tsekova, Lyubka P Tancheva, Kiril T Kirilov, Diamara N Uzunova, Lyubomir T Vezenkov, Elina R Tsvetanova, Albena V Alexandrova, Almira P Georgieva, Petja T Gavrilova, Stela T Dragomanova, Maria G Papazova, Yordan S Handzhiyski, Reni E Kalfi. New Galantamine Derivatives with Inhibitory Effect on Acetylcholinesterase Activity. Journal of Alzheimer's disease : JAD. vol 83. issue 3. 2021-11-19. PMID:34420968. |
inhibitors of acetylcholinesterase (ache) are used to treat many disorders, among which are neurodegenerative upsets, like alzheimer's disease (ad). |
2021-11-19 |
2023-08-13 |
Not clear |
| Ghada Mahmoud Abdelwahab, Amira Mira, Yuan-Bin Cheng, Tarek A Abdelaziz, Mohamed Farid I Lahloub, Ashraf Taha Khali. Acetylcholine esterase inhibitory activity of green synthesized nanosilver by naphthopyrones isolated from marine-derived Aspergillus niger. PloS one. vol 16. issue 9. 2021-11-16. PMID:34506550. |
for the first time, some isolated naphtho-γ-pyrones from marine-derived aspergillus niger, flavasperone (1), rubrofusarin b (2), aurasperone a (3), fonsecinone a (4) in addition to one alkaloid aspernigrin a (7) were invistigated for their inhibitory activity of acetylcholine esterase ache, a hallmark of alzheimer's disease (ad). |
2021-11-16 |
2023-08-13 |
Not clear |
| Fatima Y Adeowo, Tosin P Oyetunji, Murtala A Ejalonibu, Umar Ndagi, Hezekiel M Kumalo, Monsurat M Lawa. Tailored Modeling of Rivastigmine Derivatives as Dual Acetylcholinesterase and Butyrylcholinesterase Inhibitors for Alzheimer's Disease Treatment. Chemistry & biodiversity. vol 18. issue 11. 2021-11-15. PMID:34547176. |
herein, we integrate computational and theoretical methodologies to unveil rivastigmine derivatives as dual inhibitors of acetylcholinesterase (ache) and butyrylcholinesterase (buche) for alzheimer's disease (ad) management. |
2021-11-15 |
2023-08-13 |
human |
| Patricia A Vignaux, Eni Minerali, Thomas R Lane, Daniel H Foil, Peter B Madrid, Ana C Puhl, Sean Ekin. The Antiviral Drug Tilorone Is a Potent and Selective Inhibitor of Acetylcholinesterase. Chemical research in toxicology. vol 34. issue 5. 2021-11-12. PMID:33400519. |
acetylcholinesterase (ache) is an important drug target in neurological disorders like alzheimer's disease, lewy body dementia, and parkinson's disease dementia as well as for other conditions like myasthenia gravis and anticholinergic poisoning. |
2021-11-12 |
2023-08-13 |
human |
| Yuki Takada-Takator. [Donepezil Reduces Amyloid Precursor Protein Endocytosis by Resulting from Increase in the Expression of Sorting Nexin Protein 33]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. vol 141. issue 6. 2021-11-11. PMID:34078793. |
donepezil, the most widely used drug for the treatment of alzheimer's disease (ad), is an acetylcholinesterase (ache) inhibitor and is thought to improve cognition by stimulating cholinergic neurotransmission. |
2021-11-11 |
2023-08-13 |
rat |
| Hongwei Gao, Yingying Jiang, Jiuyu Zhan, Yingni Su. Pharmacophore-based drug design of AChE and BChE dual inhibitors as potential anti-Alzheimer's disease agents. Bioorganic chemistry. vol 114. 2021-11-09. PMID:34252860. |
the result of best compound zinc08751495 with ache estimate activity (0.028), bche estimate activity (1.55), ache fit value (9.369), bche fit value (8.415), ache -cdocker energy (30.22), bche -cdocker energy (33.13) has the potential for further development as a supplement to treat alzheimer's disease. |
2021-11-09 |
2023-08-13 |
Not clear |
| Ivan Sanchis, Roque Spinelli, Nicolas Aschemacher, Alvaro Sebastían Sian. Rational design and synthesis of modified natural peptides from Boana pulchella (anura) as acetylcholinesterase inhibitors and antioxidants. Amino acids. 2021-11-05. PMID:34738177. |
the use of acetylcholinesterase (ache) inhibitors, antioxidants or multitarget compounds are among the main strategies against alzheimer's disease (ad). |
2021-11-05 |
2023-08-13 |
Not clear |
| Selin S Suner, Mehtap Sahiner, Ramesh S Ayyala, Venkat R Bhethanabotla, Nurettin Sahine. Versatile Fluorescent Carbon Dots from Citric Acid and Cysteine with Antimicrobial, Anti-biofilm, Antioxidant, and AChE Enzyme Inhibition Capabilities. Journal of fluorescence. vol 31. issue 6. 2021-10-26. PMID:34424483. |
finally, cys cds were also shown to inhibit the acetylcholinesterase (ache) enzyme, which is used in the treatment of alzheimer's disease, even at the low concentration of 100 μg/ml. |
2021-10-26 |
2023-08-13 |
Not clear |
| Zheng Fu, Xue Li, Yipu Miao, Kenneth M Mer. Conformational analysis and parallel QM/MM X-ray refinement of protein bound anti-Alzheimer drug donepezil. Journal of chemical theory and computation. vol 9. issue 3. 2021-10-21. PMID:23526889. |
the recognition and association of donepezil with acetylcholinesterase (ache) has been extensively studied in the past several decades because of the former's use as a palliative treatment for mild alzheimer disease. |
2021-10-21 |
2023-08-12 |
Not clear |
| Noopur Khare, Sanjiv Kumar Maheshwari, Abhimanyu Kumar Jh. Screening and identification of secondary metabolites in the bark of Journal of biomolecular structure & dynamics. vol 39. issue 16. 2021-10-21. PMID:32720564. |
screening and identification of secondary metabolites in the bark of acetylcholinesterase (ache) and butyrylcholinesterase (bche) acts as a promising protein targets for which drug as an inhibitor can be designed to treat alzheimer's disease. |
2021-10-21 |
2023-08-13 |
Not clear |
| Hong Zhang, Chengyao Wu, Xing Chen, Ziwen Zhang, Xia Jiang, Hua-Li Qin, Wenjian Tan. Novel Pyridine-Containing Sultones: Structure-Activity Relationship and Biological Evaluation as Selective AChE Inhibitors for the Treatment of Alzheimer's disease. ChemMedChem. vol 16. issue 20. 2021-10-19. PMID:34036731. |
novel pyridine-containing sultones: structure-activity relationship and biological evaluation as selective ache inhibitors for the treatment of alzheimer's disease. |
2021-10-19 |
2023-08-13 |
Not clear |
| Xueyang Jiang, Chang Liu, Manxing Zou, Huanfang Xie, Tailiang Lin, Weiping Lyu, Jian Xu, Yuan Li, Feng Feng, Haopeng Sun, Wenyuan Li. Discovery of 2-(cyclopropanecarboxamido)-N-(5-((1-(4-fluorobenzyl)piperidin-4-yl)methoxy)pyridin-3-yl)isonicotinamide as a potent dual AChE/GSK3β inhibitor for the treatment of Alzheimer's disease: Significantly increasing the level of acetylcholine in the brain without affecting that in intestine. European journal of medicinal chemistry. vol 223. 2021-10-12. PMID:34198150. |
acetylcholinesterase (ache) inhibitors are currently the first-line drugs approved by the fda for the treatment of alzheimer's disease (ad). |
2021-10-12 |
2023-08-13 |
Not clear |
| Khalil El Khatabi, Reda El-Mernissi, Ilham Aanouz, Mohammed Aziz Ajana, Tahar Lakhlifi, Abbas Khan, Dong-Qing Wei, Mohammed Bouachrin. Identification of novel acetylcholinesterase inhibitors through 3D-QSAR, molecular docking, and molecular dynamics simulation targeting Alzheimer's disease. Journal of molecular modeling. vol 27. issue 10. 2021-10-12. PMID:34581863. |
acetylcholinesterase (ache) is a potential target for the development of small molecules as inhibitors for the therapy of alzheimer's disease (ad). |
2021-10-12 |
2023-08-13 |
Not clear |
| Ahsaan Ahmed, Shamim Akhtar, Nousheen Mushtaq, Shazia Haider, Rabya Munawar, Hassaan Ahmed Siddique, Arifa Akram, Zafar Saeed Saify, Muhammad Ari. 1,3-di-4-piperidylpropane derivatives as potential acetyl cholinesterase antagonists: Molecular docking, synthesis, and biological evaluation. Pakistan journal of pharmaceutical sciences. vol 34. issue 3. 2021-10-04. PMID:34602406. |
acetylcholine esterase (ache) is a key biological target responsible for the management of cholinergic transmission, and its inhibitors are used for the therapy of alzheimer's disease. |
2021-10-04 |
2023-08-13 |
Not clear |
| E Shamsi, A Rahati, E Dehghania. A modified binary particle swarm optimization with a machine learning algorithm and molecular docking for QSAR modelling of cholinesterase inhibitors. SAR and QSAR in environmental research. vol 32. issue 9. 2021-09-27. PMID:34494463. |
the acetylcholinesterase (ache) and butyrylcholinesterase (buche) inhibitors play a key role in treating alzheimer's disease. |
2021-09-27 |
2023-08-13 |
Not clear |
| Rosa Purgatorio, Larisa N Kulikova, Leonardo Pisani, Marco Catto, Modesto de Candia, Antonio Carrieri, Saverio Cellamare, Annalisa De Palma, Andrey A Beloglazkin, Ghulam Reza Raesi, Leonid G Voskressensky, Cosimo D Altomar. Scouting around 1,2,3,4-Tetrahydrochromeno[3,2-c]pyridin-10-ones for Single- and Multitarget Ligands Directed towards Relevant Alzheimer's Targets. ChemMedChem. vol 15. issue 20. 2021-09-20. PMID:32716595. |
a number of 1,2,3,4-tetrahydrochromeno[3,2-c]pyridin-10-one derivatives have been synthesized and screened against different targets involved in the onset and progression of alzheimer's disease (ad), such as acetyl- and butyrylcholinesterase (ache and bche), monoamine oxidases a and b (mao a and b), aggregation of β-amyloid (aβ) and reactive oxygen species (ros) production. |
2021-09-20 |
2023-08-13 |
human |
| Félix Viñuela, Angeles Barr. Assessment of a Potential Synergistic Effect of Souvenaid® in Mild Alzheimer's Disease Patients on Treatment with Acetylcholinesterase Inhibitors: An Observational, Non-Interventional Study. Journal of Alzheimer's disease : JAD. vol 80. issue 4. 2021-09-17. PMID:33682712. |
we evaluated the efficacy and safety of souvenaid (a multinutrient supplement) in patients with mild alzheimer's disease (ad) in real clinical practice and assessed a potential synergistic effect of acetylcholinesterase (ache) inhibitors. |
2021-09-17 |
2023-08-13 |
Not clear |