| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Benoit David, Pascal Schneider, Philipp Schäfer, Jörg Pietruszka, Holger Gohlk. Discovery of new acetylcholinesterase inhibitors for Alzheimer's disease: virtual screening and Journal of enzyme inhibition and medicinal chemistry. vol 36. issue 1. 2021-06-24. PMID:33478277. |
discovery of new acetylcholinesterase inhibitors for alzheimer's disease: virtual screening and for more than two decades, the development of potent acetylcholinesterase (ache) inhibitors has been an ongoing task to treat dementia associated with alzheimer's disease and improve the pharmacokinetic properties of existing drugs. |
2021-06-24 |
2023-08-13 |
Not clear |
| Monica A Silva, Alessandra S Kiametis, Werner Trepto. Donepezil Inhibits Acetylcholinesterase via Multiple Binding Modes at Room Temperature. Journal of chemical information and modeling. vol 60. issue 7. 2021-06-17. PMID:32096991. |
donepezil is a second generation acetylcholinesterase (ache) inhibitor for treatment of alzheimer's disease (ad). |
2021-06-17 |
2023-08-13 |
Not clear |
| Huan-Huan Zhao, Ying-Qian Liu, Juan Che. Screening acetylcholinesterase inhibitors from traditional Chinese medicines by paper-immobilized enzyme combined with capillary electrophoresis analysis. Journal of pharmaceutical and biomedical analysis. vol 190. 2021-06-17. PMID:32866747. |
discovering acetylcholinesterase (ache) inhibitors is one of the important ways to develop new drugs for the treatment of alzheimer's disease. |
2021-06-17 |
2023-08-13 |
Not clear |
| Bashir Akhlaq Akhoon, Sushil Choudhary, Harshita Tiwari, Ajay Kumar, Manas Ranjan Barik, Laxmi Rathor, Rakesh Pandey, Amit Nargotr. Discovery of a New Donepezil-like Acetylcholinesterase Inhibitor for Targeting Alzheimer's Disease: Computational Studies with Biological Validation. Journal of chemical information and modeling. vol 60. issue 10. 2021-06-17. PMID:32955256. |
so far, donepezil is the only food and drug administration-approved dual-binding site inhibitor of acetylcholinesterase (ache) that can amplify the cholinergic activity and also decrease aβ aggregation in alzheimer patients. |
2021-06-17 |
2023-08-13 |
Not clear |
| Leila Sadeghi, Reza Yekta, Gholamreza Dehgha. The inhibitory effects of bile acids on catalytic and non‑catalytic functions of acetylcholinesterase as a therapeutic target in Alzheimer's disease. Acta neurobiologiae experimentalis. vol 80. issue 2. 2021-06-07. PMID:32602852. |
acetylcholine is a fast-acting neurotransmitter in synapses and neuromuscular junctions that is decreased in alzheimer's disease (ad) by hyper‑activation of acetylcholinesterase (ache), which leads to progressive loss of memory and neurobehavioral abnormalities. |
2021-06-07 |
2023-08-13 |
rat |
| Zhipeng Yu, Huizhuo Ji, Juntong Shen, Ruotong Kan, Wenzhu Zhao, Jianrong Li, Long Ding, Jingbo Li. Identification and molecular docking study of fish roe-derived peptides as potent BACE 1, AChE, and BChE inhibitors. Food & function. vol 11. issue 7. 2021-06-03. PMID:32656560. |
acetylcholinesterase (ache), butyrylcholinesterase (bche), and beta-secretase 1 (bace 1) play vital roles in the development and progression of alzheimer's disease (ad). |
2021-06-03 |
2023-08-13 |
Not clear |
| Rahman Abdizadeh, Farzin Hadizadeh, Tooba Abdizade. Molecular Modeling Studies of Anti-Alzheimer Agents by QSAR, Molecular Docking and Molecular Dynamics Simulations Techniques. Medicinal chemistry (Shariqah (United Arab Emirates)). vol 16. issue 7. 2021-06-02. PMID:31385775. |
acetylcholinesterase (ache), a serine hydrolase, is an important drug target in the treatment of alzheimer's disease (ad). |
2021-06-02 |
2023-08-13 |
Not clear |
| Daniela Corrêa Santos, Ruan Roberto Henriques, Marcos Antonio de Abreu Lopes Junior, André Borges Farias, Thayssa Lisboa do Couto Nogueira, João Victor Fernandes Quimas, Nelilma Correia Romeiro, Leandro Louback da Silva, Andréa Luzia Ferreira de Souz. Acylhydrazones as isoniazid derivatives with multi-target profiles for the treatment of Alzheimer's disease: Radical scavenging, myeloperoxidase/acetylcholinesterase inhibition and biometal chelation. Bioorganic & medicinal chemistry. vol 28. issue 10. 2021-06-01. PMID:32278712. |
acylhydrazones 1a-o, derived from isoniazid, were synthesized and evaluated for myeloperoxidase (mpo) and acetylcholinesterase (ache) inhibition, as well as their antioxidant and metal chelating activities, with the purpose of investigating potential multi-target profiles for the treatment of alzheimer's disease. |
2021-06-01 |
2023-08-13 |
Not clear |
| Mahdi Abbas-Mohammadi, Mahdi Moridi Farimani, Peyman Salehi, Samad Nejad Ebrahimi, Ali Sonboli, Celine Kelso, Danielle Skropet. Molecular networking based dereplication of AChE inhibitory compounds from the medicinal plant Journal of biomolecular structure & dynamics. 2021-05-28. PMID:33054569. |
molecular networking based dereplication of ache inhibitory compounds from the medicinal plant alzheimer's disease (ad) is a devastating neurodegenerative disease affecting 47 million people worldwide. |
2021-05-28 |
2023-08-13 |
Not clear |
| Ümit M Koçyiğit, Parham Taslimi, Burak Tüzün, Hasan Yakan, Halit Muğlu, Emre Güze. 1,2,3-Triazole substituted phthalocyanine metal complexes as potential inhibitors for anticholinesterase and antidiabetic enzymes with molecular docking studies. Journal of biomolecular structure & dynamics. 2021-05-28. PMID:33292060. |
in recent years, acetylcholinesterase (ache) and α-glycosidase (α-gly) inhibition have emerged as a promising and important approach for pharmacological intervention in many diseases such as glaucoma, epilepsy, obesity, cancer, and alzheimer's. |
2021-05-28 |
2023-08-13 |
Not clear |
| Sania Pervaiz, Sadaf Mutahir, Islam Ullah, Muhammad Ashraf, Xiao Liu, Sidrah Tariq, Bao-Jing Zhou, Muhammad Asim Kha. Organocatalyzed Solvent Free and Efficient Synthesis of 2,4,5-Trisubstituted Imidazoles as Potential Acetylcholinesterase Inhibitors for Alzheimer's Disease. Chemistry & biodiversity. vol 17. issue 3. 2021-05-25. PMID:31968151. |
to explore the potential of these compounds against alzheimer's disease, their inhibitory activities against acetylcholinesterase (ache) were evaluated. |
2021-05-25 |
2023-08-13 |
Not clear |
| Teresa Delerue, M Fátima Barroso, Mónica Dias-Teixeira, Maria Figueiredo-González, Cristina Delerue-Matos, Clara Gross. Interactions between Ginkgo biloba L. and Scutellaria baicalensis Georgi in multicomponent mixtures towards cholinesterase inhibition and ROS scavenging. Food research international (Ottawa, Ont.). vol 140. 2021-05-24. PMID:33648175. |
this study gives new insights to understand the type of interactions between ginkgo biloba l. and scutellaria baicalensis georgi, two chinese medicinal plants with well documented neuroprotective effects, on three targets in alzheimer's disease (ad): acetylcholinesterase (ache) and butyrylcholnesterase (buche) inhibition and hydrogen peroxide scavenging. |
2021-05-24 |
2023-08-13 |
Not clear |
| F Sezer Senol Deniz, Gokcen Eren, Ilkay Erdogan Orhan, Bilge Sener, Ufuk Ozgen, Randa Aldaba, Ihsan Cali. Outlining In Vitro and In Silico Cholinesterase Inhibitory Activity of Twenty-Four Natural Products of Various Chemical Classes: Smilagenin, Kokusaginine, and Methyl Rosmarinate as Emboldening Inhibitors. Molecules (Basel, Switzerland). vol 26. issue 7. 2021-05-24. PMID:33916300. |
cholinesterase (che) inhibition is an important treatment strategy for alzheimer's disease (ad) as acetylcholinesterase (ache) and butyrylcholinesterase (bche) are involved in the pathology of ad. |
2021-05-24 |
2023-08-13 |
Not clear |
| Vinay Kumar, Achintya Saha, Kunal Ro. In silico modeling for dual inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) enzymes in Alzheimer's disease. Computational biology and chemistry. vol 88. 2021-05-20. PMID:32801088. |
in silico modeling for dual inhibition of acetylcholinesterase (ache) and butyrylcholinesterase (buche) enzymes in alzheimer's disease. |
2021-05-20 |
2023-08-13 |
Not clear |
| Guilherme M Bousada, Bianca L de Sousa, Gabriela Furlani, Ana Paula Agrizzi, Priscila G Ferreira, João Paulo V Leite, Tiago Antônio de O Mendes, Eduardo V V Varejão, Eduardo J Pilau, Marcelo H Dos Santo. Tyrosol 1,2,3-triazole analogues as new acetylcholinesterase (AChE) inhibitors. Computational biology and chemistry. vol 88. 2021-05-20. PMID:32853899. |
the study of ache inhibition is important for the development of new drugs and pesticides, and especially the research for managing alzheimer's disease. |
2021-05-20 |
2023-08-13 |
Not clear |
| Marco Catto, Leonardo Pisani, Eugenio de la Mora, Benny Danilo Belviso, Giuseppe Felice Mangiatordi, Andrea Pinto, Annalisa De Palma, Nunzio Denora, Rocco Caliandro, Jacques-Philippe Colletier, Israel Silman, Orazio Nicolotti, Cosimo Damiano Altomar. Chiral Separation, X-ray Structure, and Biological Evaluation of a Potent and Reversible Dual Binding Site AChE Inhibitor. ACS medicinal chemistry letters. vol 11. issue 5. 2021-05-14. PMID:32435398. |
acetylcholinesterase (ache) inhibitors (acheis) still remain the leading therapeutic options for the symptomatic treatment of cognitive deficits associated with mild-to-moderate alzheimer's disease. |
2021-05-14 |
2023-08-13 |
Not clear |
| Diogo Alexandre Siebert, Juliana Soares Campos, Michele Debiasi Alberton, Luciano Vitali, Gustavo Amadeu Mick. Dual electrophoretically-mediated microanalysis in multiple injection mode for the simultaneous determination of acetylcholinesterase and α-glucosidase activity applied to selected polyphenols. Talanta. vol 224. 2021-05-14. PMID:33379009. |
acetylcholinesterase (ache) and α-glucosidase (α-glu) are key target enzymes in the search for novel strategies in the treatment of alzheimer's disease and type ii diabetes. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chang Liu, Yuxin Luo, Huijie Wen, Yanxia Qi, Guoyue Shi, Jingjing Deng, Tianshu Zho. Red-to-blue paper-based colorimetric sensor integrated with smartphone for point-of-use analysis of cerebral AChE upon Cd Nanoscale. vol 13. issue 2. 2021-05-14. PMID:33406172. |
this obvious red-to-blue fluorescent color changes of cds@eu/gmp icps on test paper could then be integrated with the smartphone for point-of-use analysis of cerebral ache upon cd2+ exposure, which not only offers a new analytical platform for a better understanding of the environmental risk of alzheimer's dementia (ad), but also holds great potential in the early diagnosis of ad even at the asymptomatic stage with the decrease in csf ache as an early biomarker. |
2021-05-14 |
2023-08-13 |
Not clear |
| Chang Liu, Chunyu Huang, Ruixue Ma, Wanying Zhai, Jingjing Deng, Tianshu Zho. Cu The Analyst. vol 145. issue 24. 2021-05-14. PMID:33410430. |
using the method established herein, the cerebrospinal ache fluctuation of rats with acute organophosphorus pesticide (op) poisoning or chronic alzheimer's disease (ad) could be monitored. |
2021-05-14 |
2023-08-13 |
rat |
| Amit Kumawat, Shabnam Raheem, Fasil Ali, Tanveer Ali Dar, Suman Chakrabarty, Masood Ahmad Rizv. Organoselenium Compounds as Acetylcholinesterase Inhibitors: Evidence and Mechanism of Mixed Inhibition. The journal of physical chemistry. B. vol 125. issue 6. 2021-05-14. PMID:33538163. |
acetylcholinesterase (ache) inhibitors are actively used for the effective treatment of alzheimer's disease. |
2021-05-14 |
2023-08-13 |
Not clear |