| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| V Lakshmi, V Santhosh Kannan, R Boopath. Identification of potential bivalent inhibitors from natural compounds for acetylcholinesterase through in silico screening using multiple pharmacophores. Journal of molecular graphics & modelling. vol 40. 2013-08-01. PMID:23353586. |
the symptomatic cure observed in the treatment of alzheimer's disease (ad) by fda approved drugs could possibly be due to their specificity against the active site of acetylcholinesterase (ache) and not by targeting its pathogenicity. |
2013-08-01 |
2023-08-12 |
Not clear |
| Abdul Hai, Nadeem A Kizilbash, Syedahuma H Zaidi, Jamal Alruwail. Porphyrin derivatives as inhibitors for acetylcholinesterase from Drosophila melanogaster. Bioinformation. vol 9. issue 12. 2013-08-01. PMID:23904743. |
regional cerebral blood flow can be increased in patients with alzheimer's disease by acetylcholinesterase (ache) inhibitors. |
2013-08-01 |
2023-08-12 |
drosophila_melanogaster |
| Heng Luo, Changtian Li, Jin Cheol Kim, Yanpeng Liu, Jae Sung Jung, Young Jin Koh, Jae-Seoun Hu. Biruloquinone, an acetylcholinesterase inhibitor produced by lichen-forming fungus Cladonia macilenta. Journal of microbiology and biotechnology. vol 23. issue 2. 2013-07-26. PMID:23412057. |
at present, acetylcholinesterase (ache) inhibitors are the first group of drugs to treat mild to moderate alzheimer's disease (ad). |
2013-07-26 |
2023-08-12 |
Not clear |
| Yanhong Shen, Baoli Li, Hu Xu, Guoqiang Zhan. Design, synthesis, and biological evaluation of acetophenone derivatives as dual binding acetylcholinesterase inhibitors. Die Pharmazie. vol 68. issue 5. 2013-07-25. PMID:23802426. |
as part of a project aimed at developing new agents for potential application in alzheimer's disease, a new series of acetophenone derivatives which possess alkylamine side chains were designed, synthesized and assayed as acetylcholinesterase (ache) inhibitors that could simultaneously bind to the peripheral and catalytic sites of the enzyme. |
2013-07-25 |
2023-08-12 |
Not clear |
| Ahmad Mohammadi-Farani, Aram Ahmadi, Hamid Nadri, Alireza Aliabad. Synthesis, docking and acetylcholinesterase inhibitory assessment of 2-(2-(4-Benzylpiperazin-1-yl)ethyl)isoindoline-1,3-dione derivatives with potential anti-Alzheimer effects. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. vol 21. issue 1. 2013-07-09. PMID:23758724. |
in recent years, acetylcholinesterase (ache) inhibitors like donepezil with prevention of acetylcholine hydrolysis can enhance the duration of action of acetylcholine in synaptic cleft and improve the dementia associated with alzheimer's disease. |
2013-07-09 |
2023-08-12 |
Not clear |
| Manuela Bartolini, Marina Naldi, Dan V Nicolau, Falco C M J M van Delft, Jeroen van Zijl, Jaap Snijder, Eric F C van den Heuvel, Emile P Naburgh, Natalia Calonghi, Vincenza Andrisan. Fluorescence biosensing micropatterned surfaces based on immobilized human acetylcholinesterase. Analytical and bioanalytical chemistry. vol 405. issue 2-3. 2013-07-05. PMID:22814970. |
human acetylcholinesterase (ache) is a widely studied target enzyme in drug discovery for alzheimer's disease (ad). |
2013-07-05 |
2023-08-12 |
human |
| Nibha Mishra, Dinakar Sasma. Additional acetyl cholinesterase inhibitory property of diaryl pyrazoline derivatives. Bioorganic & medicinal chemistry letters. vol 23. issue 3. 2013-06-25. PMID:23276831. |
mao-b and ache are the two validated targets for alzheimer's disease. |
2013-06-25 |
2023-08-12 |
Not clear |
| B Vellas, L Hausner, L Frölich, C Cantet, V Gardette, E Reynish, S Gillette, E Agüera-Morales, S Auriacombe, M Boada, R Bullock, J Byrne, V Camus, A Cherubini, M Eriksdotter-Jönhagen, G B Frisoni, S Hasselbalch, R W Jones, P Martinez-Lage, M O Rikkert, M Tsolaki, P-J Ousset, F Pasquier, J M Ribera-Casado, A S Rigaud, P Robert, G Rodriguez, E Salmon, A Salva, P Scheltens, A Schneider, A Sinclair, L Spiru, J Touchon, D Zekry, B Winblad, S Andrie. Progression of Alzheimer disease in Europe: data from the European ICTUS study. Current Alzheimer research. vol 9. issue 8. 2013-06-21. PMID:22742853. |
the clinical progression of alzheimer disease (ad) was studied in european subjects under treatment with ache inhibitors (ache-i) in relation to geographical location over a 2-years period. |
2013-06-21 |
2023-08-12 |
human |
| Alessandra Marcone, Valentina Garibotto, Rosa Maria Moresco, Ioana Florea, Andrea Panzacchi, Assunta Carpinelli, Jere R Virta, Marco Tettamanti, Barbara Borroni, Alessandro Padovani, Alessandra Bertoldo, Karl Herholz, Juha O Rinne, Stefano Francesco Cappa, Daniela Peran. [11C]-MP4A PET cholinergic measurements in amnestic mild cognitive impairment, probable Alzheimer's disease, and dementia with Lewy bodies: a Bayesian method and voxel-based analysis. Journal of Alzheimer's disease : JAD. vol 31. issue 2. 2013-06-04. PMID:22596267. |
non-invasive approaches for positron emission tomography (pet) parametric imaging of acetylcholinesterase (ache) activity have been developed and applied to the investigation of dementia, mainly alzheimer's disease (ad), but also dementia with lewy bodies (dlb), not including, however, patients in the early disease stage. |
2013-06-04 |
2023-08-12 |
human |
| Francisco Prado-Prado, Xerardo García-Mera, Manuel Escobar, Nerea Alonso, Olga Caamaño, Matilde Yañez, Humberto González-Día. 3D MI-DRAGON: new model for the reconstruction of US FDA drug- target network and theoretical-experimental studies of inhibitors of rasagiline derivatives for AChE. Current topics in medicinal chemistry. vol 12. issue 16. 2013-06-04. PMID:23030618. |
an important protein in this sense is the acetylcholinesterase (ache), which is the target of many alzheimer's dementia drugs. |
2013-06-04 |
2023-08-12 |
Not clear |
| Daiane Priscila Simão-Silva, Paulo Henrique Ferreira Bertolucci, Roger William de Labio, Spencer Luiz Marques Payão, Lupe Furtado-Alle, Ricardo Lehtonen Rodrigues Souz. Association analysis between K and -116A variants of butyrylcholinesterase and Alzheimer's disease in a Brazilian population. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23022600. |
in alzheimer's disease (ad) a reduction in acetylcholinesterase (ache) and an increase in butyrylcholinesterase (bche) activity are observed. |
2013-05-28 |
2023-08-12 |
human |
| Kevin B Temeyer, Alexander P Tuckow, Danett K Brake, Andrew Y Li, Adalberto A Pérez de Leó. Acetylcholinesterases of blood-feeding flies and ticks. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23036311. |
acetylcholinesterase (ache) is the biochemical target of organophosphate (op) and carbamate pesticides for invertebrates, vertebrate nerve agents, and ache inhibitors used to reduce effects of alzheimer's disease. |
2013-05-28 |
2023-08-12 |
human |
| David A Hicks, Natalia Z Makova, Natalia N Nalivaeva, Anthony J Turne. Characterisation of acetylcholinesterase release from neuronal cells. Chemico-biological interactions. vol 203. issue 1. 2013-05-28. PMID:23047022. |
ache has been implicated in the pathogenesis of alzheimer's disease and it has been shown that it accelerates formation and increases toxicity of amyloid fibrils, which have been closely linked to the pathology of ad. |
2013-05-28 |
2023-08-12 |
mouse |
| Pran Kishore Deb, Anuradha Sharma, Poonam Piplani, Raghuram Rao Akkinepall. Molecular docking and receptor-specific 3D-QSAR studies of acetylcholinesterase inhibitors. Molecular diversity. vol 16. issue 4. 2013-05-16. PMID:22996404. |
the reversible inhibition of acetylcholinesterase (ache) has become a promising target for the treatment of alzheimer's disease (ad) which is mainly associated with low in vivo levels of acetylcholine (ach). |
2013-05-16 |
2023-08-12 |
Not clear |
| Abdelouahid Samadi, Martín Estrada, Concepción Pérez, María Isabel Rodríguez-Franco, Isabel Iriepa, Ignacio Moraleda, Mourad Chioua, José Marco-Contelle. Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling. European journal of medicinal chemistry. vol 57. 2013-05-09. PMID:23078965. |
pyridonepezils, new dual ache inhibitors as potential drugs for the treatment of alzheimer's disease: synthesis, biological assessment, and molecular modeling. |
2013-05-09 |
2023-08-12 |
human |
| E L Konrath, B M Neves, C Dos S Passos, P S Lunardi, M G Ortega, J L Cabrera, C A Gonçalves, A T Henrique. Huperzia quadrifariata and Huperzia reflexa alkaloids inhibit acetylcholinesterase activity in vivo in mice brain. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 19. issue 14. 2013-04-26. PMID:23022390. |
huperzine a, a lycopodium alkaloid produced by chinese folk herb huperzia serrata (lycopodiaceae), has been shown to be a promising agent for the treatment of alzheimer's disease due to its potent acetylcholinesterase (ache) activity, as well its efficacy in the treatment of memory of aged patients. |
2013-04-26 |
2023-08-12 |
mouse |
| Kuldeep K Roy, Santoshkumar Tota, Tusha Tripathi, Subhash Chander, Chandishwar Nath, Anil K Saxen. Lead optimization studies towards the discovery of novel carbamates as potent AChE inhibitors for the potential treatment of Alzheimer's disease. Bioorganic & medicinal chemistry. vol 20. issue 21. 2013-04-05. PMID:23026084. |
lead optimization studies towards the discovery of novel carbamates as potent ache inhibitors for the potential treatment of alzheimer's disease. |
2013-04-05 |
2023-08-12 |
mouse |
| Da-Hua Shi, Zhi-Qiang Yan, Li-Na Zhang, Yu-Rong Wang, Chun-Ping Jiang, Jun-Hua W. A novel 7-O-modified genistein derivative with acetylcholinesterase inhibitory effect, estrogenic activity and neuroprotective effect. Archives of pharmacal research. vol 35. issue 9. 2013-03-19. PMID:23054722. |
to find the multi-target-directed compounds for the treatment of alzheimer's disease (ad), we synthesized 7-(4-(diethylamino)butoxy)-5-hydroxy-3-(4-hydroxyphenyl)-4h-chromen-4-one, a novel 7-o-modified genistein derivative (gs-14), and investigated its acetylcholinesterase (ache) inhibitory effect, estrogenic activity and neuroprotective effect. |
2013-03-19 |
2023-08-12 |
Not clear |
| Diego Muñoz-Torrero, Pelayo Camp. Huprines for Alzheimer's disease drug development. Expert opinion on drug discovery. vol 3. issue 1. 2013-03-14. PMID:23480140. |
so far, acetylcholinesterase (ache) inhibitors have dominated the therapeutic arsenal for alzheimer's disease. |
2013-03-14 |
2023-08-12 |
Not clear |
| Jonah Cheung, Michael J Rudolph, Fiana Burshteyn, Michael S Cassidy, Ebony N Gary, James Love, Matthew C Franklin, Jude J Heigh. Structures of human acetylcholinesterase in complex with pharmacologically important ligands. Journal of medicinal chemistry. vol 55. issue 22. 2013-02-05. PMID:23035744. |
here we present high resolution crystal structures of human ache, alone and in complexes with drug ligands; donepezil, an alzheimer's disease drug, binds differently to human ache than it does to torpedo ache. |
2013-02-05 |
2023-08-12 |
human |