| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tânia Melo, Romeu A Videira, Sónia André, Elisabete Maciel, Carla S Francisco, Ana M Oliveira-Campos, Lígia M Rodrigues, Maria R M Domingues, Francisco Peixoto, M Manuel Oliveir. Tacrine and its analogues impair mitochondrial function and bioenergetics: a lipidomic analysis in rat brain. Journal of neurochemistry. vol 120. issue 6. 2012-06-01. PMID:22192081. |
tacrine is an acetylcholinesterase (ache) inhibitor used as a cognitive enhancer in the treatment of alzheimer's disease (ad). |
2012-06-01 |
2023-08-12 |
rat |
| Wenhai Huang, Li Tang, Ying Shi, Shufang Huang, Lei Xu, Rong Sheng, Peng Wu, Jia Li, Naiming Zhou, Yongzhou H. Searching for the Multi-Target-Directed Ligands against Alzheimer's disease: discovery of quinoxaline-based hybrid compounds with AChE, H₃R and BACE 1 inhibitory activities. Bioorganic & medicinal chemistry. vol 19. issue 23. 2012-05-23. PMID:22019465. |
searching for the multi-target-directed ligands against alzheimer's disease: discovery of quinoxaline-based hybrid compounds with ache, h₃r and bace 1 inhibitory activities. |
2012-05-23 |
2023-08-12 |
Not clear |
| Ilkay Erdogan Orhan, Ipek Pesin Suntar, Esra Kupeli Akko. In vitro neuroprotective effects of the leaf and fruit extracts of Juglans regia L. (walnut) through enzymes linked to Alzheimer's disease and antioxidant activity. International journal of food sciences and nutrition. vol 62. issue 8. 2012-05-22. PMID:21627404. |
anticholinesterase activity was determined against acetylcholinesterase (ache) and butyrylcholinesterase (bche), the enzymes vital for alzheimer's disease, at 50, 100 and 200 μg ml(-1). |
2012-05-22 |
2023-08-12 |
Not clear |
| Preet Anand, Baldev Singh, Nirmal Sing. A review on coumarins as acetylcholinesterase inhibitors for Alzheimer's disease. Bioorganic & medicinal chemistry. vol 20. issue 3. 2012-05-16. PMID:22257528. |
acetylcholinesterase (ache) enzyme inhibition is an important target for the management of alzheimer disease (ad) and ache inhibitors are the main stay drugs for its management. |
2012-05-16 |
2023-08-12 |
Not clear |
| Preet Anand, Baldev Sing. Synthesis and evaluation of novel 4-[(3H,3aH,6aH)-3-phenyl)-4,6-dioxo-2-phenyldihydro-2H-pyrrolo[3,4-d]isoxazol-5(3H,6H,6aH)-yl]benzoic acid derivatives as potent acetylcholinesterase inhibitors and anti-amnestic agents. Bioorganic & medicinal chemistry. vol 20. issue 1. 2012-05-08. PMID:22172310. |
the present study was designed to synthesize and evaluate pyrrolo-isoxazole benzoic acid derivatives as potential acetylcholinesterase (ache) inhibitors for the management of alzheimer's disease. |
2012-05-08 |
2023-08-12 |
mouse |
| A T Isik, E Bozoglu, D Eke. aChE and BuChE inhibition by rivastigmin have no effect on peripheral insulin resistance in elderly patients with Alzheimer disease. The journal of nutrition, health & aging. vol 16. issue 2. 2012-05-07. PMID:22323348. |
ache and buche inhibition by rivastigmin have no effect on peripheral insulin resistance in elderly patients with alzheimer disease. |
2012-05-07 |
2023-08-12 |
Not clear |
| Dorothea Kaufmann, Anudeep Kaur Dogra, Michael Win. Myrtenal inhibits acetylcholinesterase, a known Alzheimer target. The Journal of pharmacy and pharmacology. vol 63. issue 10. 2012-03-08. PMID:21899553. |
inhibition of acetylcholinesterase (ache) is a common treatment for early stages of the most general form of dementia, alzheimer's disease. |
2012-03-08 |
2023-08-12 |
Not clear |
| Connor Keller, Ahmadul Kadir, Anton Forsberg, Omar Porras, Agneta Nordber. Long-term effects of galantamine treatment on brain functional activities as measured by PET in Alzheimer's disease patients. Journal of Alzheimer's disease : JAD. vol 24. issue 1. 2012-03-06. PMID:21157026. |
the effects of galantamine (16 to 24 mg/day) treatment on brain functional activities (blood flow and glucose metabolism) were examined in 18 patients with mild alzheimer's disease (ad) in relation to brain acetylcholinesterase (ache) activity and nicotinic receptors and cognitive function. |
2012-03-06 |
2023-08-12 |
Not clear |
| I Erdogan Orhan, G Orhan, E Gurka. An overview on natural cholinesterase inhibitors--a multi-targeted drug class--and their mass production. Mini reviews in medicinal chemistry. vol 11. issue 10. 2012-02-15. PMID:21762104. |
cholinesterase enzyme family consisting of acetylcholinesterase (ache) and butrylcholinesterase (bche) is important in pathogenesis of alzheimer's disease (ad), explained by "cholinergic hypothesis". |
2012-02-15 |
2023-08-12 |
Not clear |
| C Harrington, S Sawchak, C Chiang, J Davies, C Donovan, A M Saunders, M Irizarry, B Jeter, M Zvartau-Hind, C H van Dyck, M Gol. Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: two phase 3 studies. Current Alzheimer research. vol 8. issue 5. 2011-12-05. PMID:21592048. |
rosiglitazone does not improve cognition or global function when used as adjunctive therapy to ache inhibitors in mild-to-moderate alzheimer's disease: two phase 3 studies. |
2011-12-05 |
2023-08-12 |
Not clear |
| Francisco J Carvajal, Nibaldo C Inestros. Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949501. |
interactions of ache with aβ aggregates in alzheimer's brain: therapeutic relevance of idn 5706. |
2011-11-10 |
2023-08-12 |
mouse |
| Francisco J Carvajal, Nibaldo C Inestros. Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949501. |
furthermore, ache activity is altered in brain and blood of alzheimer's patients. |
2011-11-10 |
2023-08-12 |
mouse |
| Francisco J Carvajal, Nibaldo C Inestros. Interactions of AChE with Aβ Aggregates in Alzheimer's Brain: Therapeutic Relevance of IDN 5706. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949501. |
our results show that treatment with idn 5706 for 10 weeks increases brain ache activity in 7-month-old double transgenic mice (app(swe)-ps1) and decreases the content of ache associated with different types of amyloid plaques in this alzheimer's model. |
2011-11-10 |
2023-08-12 |
mouse |
| María-Salud García-Ayllón, David H Small, Jesús Avila, Javier Sáez-Valer. Revisiting the Role of Acetylcholinesterase in Alzheimer's Disease: Cross-Talk with P-tau and β-Amyloid. Frontiers in molecular neuroscience. vol 4. 2011-11-10. PMID:21949503. |
a common feature in the alzheimer's disease (ad) brain is the presence of acetylcholinesterase (ache) which is commonly associated with β-amyloid plaques and neurofibrillary tangles (nft). |
2011-11-10 |
2023-08-12 |
Not clear |
| L Parnetti, D Chiasserini, U Andreasson, M Ohlson, C Hüls, H Zetterberg, L Minthon, A K Wallin, N Andreasen, V N Talesa, K Blenno. Changes in CSF acetyl- and butyrylcholinesterase activity after long-term treatment with AChE inhibitors in Alzheimer's disease. Acta neurologica Scandinavica. vol 124. issue 2. 2011-11-02. PMID:20880294. |
changes in csf acetyl- and butyrylcholinesterase activity after long-term treatment with ache inhibitors in alzheimer's disease. |
2011-11-02 |
2023-08-12 |
Not clear |
| L Parnetti, D Chiasserini, U Andreasson, M Ohlson, C Hüls, H Zetterberg, L Minthon, A K Wallin, N Andreasen, V N Talesa, K Blenno. Changes in CSF acetyl- and butyrylcholinesterase activity after long-term treatment with AChE inhibitors in Alzheimer's disease. Acta neurologica Scandinavica. vol 124. issue 2. 2011-11-02. PMID:20880294. |
to measure cerebrospinal fluid (csf) activity of acetylcholinesterase (ache) and butyrylcholinesterase (bche) in patients with alzheimer's disease (ad) participating in randomized clinical trials from three european centers, before and after long-term treatment with different ache inhibitors (acheis). |
2011-11-02 |
2023-08-12 |
Not clear |
| Jocley Queiroz Araújo, Josélia Alencar Lima, Angelo da Cunha Pinto, Ricardo Bicca de Alencastro, Magaly Girão Albuquerqu. Docking of the alkaloid geissospermine into acetylcholinesterase: a natural scaffold targeting the treatment of Alzheimer's disease. Journal of molecular modeling. vol 17. issue 6. 2011-09-16. PMID:20844909. |
this study provides the basis to propose structural changes to the gsp structure, such as molecular simplification and isosteric replacement, in order to aid the design of new potential ache inhibitors that are relevant to the treatment of alzheimer's disease. |
2011-09-16 |
2023-08-12 |
rat |
| Jana Hroudová, Zdenĕk Fisar, Jan Korábečný, Kamil Kuč. In vitro effects of acetylcholinesterase inhibitors and reactivators on Complex I of electron transport chain. Neuro endocrinology letters. vol 32. issue 3. 2011-09-15. PMID:21712782. |
inhibition of the enzyme acetylcholinesterase (ache) is the main mechanism both of therapeutic action of drugs for the treatment of alzheimer's disease and toxic action of organophosphorus compounds. |
2011-09-15 |
2023-08-12 |
Not clear |
| Marta Weinstock, Lisandro Luques, Tatyana Poltyrev, Corina Bejar, Shai Shoha. Ladostigil prevents age-related glial activation and spatial memory deficits in rats. Neurobiology of aging. vol 32. issue 6. 2011-09-13. PMID:19625104. |
ladostigil is a new monoamine oxidase (mao) and acetylcholinesterase (ache) inhibitor designed for the treatment of alzheimer's disease. |
2011-09-13 |
2023-08-12 |
rat |
| Janaína Drawanz Pereira, Afonso Caricati-Neto, Regiane Miranda-Ferreira, Soraya Shoubi Smaili, Rosely Oliveira Godinho, Cristobal de los Rios, Rafael Léon, Mercedes Villaroya, Abdelouahid Samadi, José Marco-Contelles, Neide Hyppolito Jurkiewicz, Antonio G Garcia, Aron Jurkiewic. Effects of novel tacripyrines ITH12117 and ITH12118 on rat vas deferens contractions, calcium transients and cholinesterase activity. European journal of pharmacology. vol 660. issue 2-3. 2011-09-06. PMID:21497158. |
these compounds were designed to target ache and l calcium channels in the brain, as potential therapeutic agents in alzheimer's disease. |
2011-09-06 |
2023-08-12 |
rat |